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| 1 | Management of recurrent rectal cancer:A population based study in greater Amsterdam显示文摘AIM: To analyze,retrospectively in a population-based study,the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision (TME). METHODS: All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection (632 patients) were selected from the Amsterdam Cancer Registry. For patients with recurrent disease,information on treatment of the recurrence was collected from the medical records. RESULTS: Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients (10%). Thirty-two patients had an isolated local recurrence. Ten of these 32 patients (31%) underwent radical re-resection and experienced the highest survival (three quarters survived for at least 3 years). Eight patients (25%) underwent non-radical surgery (median survival 24 mo),seven patients (22%) were treated with radio-and/or chemotherapy without surgery (median survival 15 mo) and seven patients (22%) only received best supportive care (median survival 5 mo). Distant dissemination occurred in 124 patients (20%) of whom 30 patients also had a local recurrence. The majority (54%) of these patients were treated with radio-and/or chemotherapy without surgery (median survival 15 mo). Twenty-seven percent of these patients only received best supportive care (median survival 6 mo),while 16% underwent surgery for their recurrence. Survival was best in the latter group (median survival 32 mo). CONCLUSION: Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TME,patients can benefit from additional treatment,especially if a radical resection is feasible. | Roel Bakx Otto Visser Judith Josso Sybren Meijer J Frederik M Slors J Jan B van Lanschot | 2008 | World Journal of Gastroenterology2008，14，39： | 17 |
| 2 | Global methylation status of sperm DNA in carriers of chromosome structural aberrations显示文摘男不孕可能清楚地在人的精子与异常 DNA methylation 模式被联系。在氧化应力和精子染色体的全球 methylation 地位之间的一个协会也被建议了。现在的学习的目的是决定全球精子 DNA methylation 地位是否在染色体的搬运人的精子被影响结构的错误。在 5-methylcytosine 之间的关系(m 5 C ) 在精子和染色质正直地位的层次被评估。学习病人包括了染色体的男搬运人有繁殖失败的结构的错误(n = 24 ) ,并且控制包括了 normozoospermic 精子志愿者(n = 23 ) 。全球 m 5 C 水平用薄层的层析(TLC ) 和 immunofluorescence 被测量(如果) 技术。精子染色质正直用染色的苯胺蓝色(AB ) 和 TUNEL 试金被估计。吝啬的 m 5 C 层次在调查染色体之间是类似的结构的错误搬运人(P) 和控制(K) 。然而,精子染色质完整测试比在控制在 chromosomal 重新整理搬运人揭示了显著地更高的值(P <0.05 ) 。尽管在精子染色质正直地位和精子 DNA 破碎和 m 5在两个都分析的组( P 对 K )并列的 C 水平以一种清楚地相反的方式被代表,低染色质正直可能与在染色体的搬运人观察的精子 DNA 的高 hypomethylation 地位被联系结构的错误。 | Marta Olszewska Miroslawa Z Barciszewska Monika Fraczek Nataliya Huleyuk Vyacheslav B chernykh Danuta Zastavna Jan Barciszewski Maciej Kurpisz | 2017 | Asian Journal of Andrology2017，19，1： | 8 |
| 3 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 4 | Microbiota alterations in acute and chronic gastrointestinal inflammation of cats and dogs显示文摘The intestinal microbiota is the collection of the living microorganisms(bacteria, fungi, protozoa, and viruses) inhabiting the gastrointestinal tract. Novel bacterial identification approaches have revealed that the gastrointestinal microbiota of dogs and cats is, similarly to humans, a highly complex ecosystem. Studies in dogs and cats have demonstrated that acute and chronic gastrointestinal diseases, including inflammatory bowel disease(IBD), are associated with alterations in the small intestinal and fecal microbial communities. Of interest is that these alterations are generally similar to the dysbiosis observed in humans with IBD or animal models of intestinal inflammation, suggesting that microbial responses to inflammatory conditions of the gut are conserved across mammalian host types. Studies have also revealed possible underlying susceptibilities in the innate immune system of dogs and cats with IBD, which further demonstrate the intricate relationship between gut microbiota and host health. Commonly identified microbiome changes in IBD are decreases in bacterial groups within the phyla Firmicutes and Bacteroidetes, and increases within Proteobacteia. Furthermore, a reduction in the diversity of Clostridium clusters XIVa and IV(i.e., Lachnospiraceae and Clostridium coccoides subgroups) are associated with IBD, suggesting that these bacterial groups may play an important role in maintenance of gastrointestinal health. Future studies are warranted to evaluate the functional changes associated with intestinal dysbiosis in dogs and cats. | Julia B Honneffer Yasushi Minamoto Jan S Suchodolski | 2014 | World Journal of Gastroenterology2014，20，44： | 6 |
| 5 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 6 | Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection显示文摘 | Maria Van der Sluis Barbara A.E. De Koning Adrianus C.J.M. De Bruijn Anna Velcich Jules P.P. Meijerink Johannes B. Van Goudoever Hans A. Büller Jan Dekker Isabelle Van Seuningen Ingrid B. Renes Alexandra W.C. Einerhand | 2006 | Gastroenterology2006，，1： | 3 |
| 7 | Mechanical circulatory support in cardiogenic shock and post-myocardial infarction mechanical complications显示文摘Despite advanced therapies,the mortality of patients with myocardial infarction(MI)complicated by cardiogenic shock(CS)remains around 50%.Mechanical complications of MI are rare nowadays but associated with high mortality in patients who present with CS.Different treatment strategies and mechanical circulatory support(MCS)devices have been increasingly used to improve the grim prognosis of refractory CS.This article discusses current evidence regarding the use of MCS in MI complicated by CS,ventricular septal rupture,free wall rupture and acute mitral regurgitation.Device selection should be tailored according to the cause and severity of CS.Early MCS initiation and multidisciplinary team cooperation is mandatory for good results.MCS associated bleeding remains a major complication and an obstacle to better outcomes.Ongoing prospective randomized trials will improve current knowledge regarding MCS indications,timing,and patient selection in the coming years. | Daniel Rob Jan Bělohlávek | 2022 | Journal of Geriatric Cardiology2022，19，2： | 3 |
| 8 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 9 | Pancreatic Resection for M1 Pancreatic Ductal Adenocarcinoma显示文摘 | Shailesh V. Shrikhande MD J?rg Kleeff MD Carolin Reiser MD Jürgen Weitz MD Ulf Hinz MSc Irene Esposito MD Jan Schmidt MD Helmut Friess MD Markus W. Büchler MD | 2007 | Annals of Surgical Oncology2007，，1： | 2 |
| 10 | Biocorrosion: towards understanding interactions between biofilms and metals显示文摘 | Iwona B Beech Jan Sunner | 2004 | Current Opinion in Biotechnology2004，，3： | 2 |
| 11 | Hepatocellular carcinoma: Surgeon's view on latest findings and future perspectives显示文摘Hepatocellular carcinoma(HCC) is the most common liver-derived malignancy with a high fatality rate. Risk factors for the development of HCC have been identified and are clearly described. However, due to the lack of tumor-specific symptoms, HCC are diagnosed at progressed tumor stages in most patients, and thus curative therapeutic options are limited. The focus of this review is on surgical therapeutic options which can be offered to patients with HCC with special regard to recent findings, not exclusively focused on surgical therapy, but also to other treatment modalities. Further, potential promising future perspectives for the treatment of HCC are discussed. | Jan Erik Slotta Otto Kollmar Volker Ellenrieder B Michael Ghadimi Kia Homayounfar | 2015 | World Journal of Hepatology2015，7，9： | 2 |
| 12 | Unlocking quality in endoscopic mucosal resection显示文摘A review of the development of the key performance metrics of endoscopic mucosal resection(EMR),learning from the experience of the establishment of widespread colonoscopy quality measurements.Potential future performance markers for both colonoscopy and EMR are also evaluated to ensure continued high quality performance is maintained with a focus service framework and predictors of patient outcome. | Eoin Keating Jan Leyden Donal B O'Connor Conor Lahiff | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，5： | 2 |
| 13 | Transthoracic versus transhiatal resection for carcinoma of the esophagus: a meta-analysis显示文摘 | Jan B.F Hulscher Jan G.P Tijssen Hugo Obertop J.Jan B van Lanschot | 2001 | The Annals of Thoracic Surgery2001，，1： | 2 |
| 14 | 快速凝固富钛Ti-V合金的微观组织和储氢性能(英文)显示文摘研究目的在于优化Ti0.8-0.9V0.2-0.1二元合金的相结构成分、微观组织和储氢性能。该合金主要用于从含有大量一氧化碳的高温气态混合物中吸收氢气。Ti0.8-0.9V0.2-0.1合金中的α-(HCP)和β-(BCC)相在纯氢气中基于氢化作用,形成单相FCC结构的氢化物,此过程与合金的化学成分无关。同步辐射X射线衍射的原位分析表明,在含有氢气和10%一氧化碳的混合气体中,只有β相转变成相应的氢化物。快速凝固(RS)处理细化了Ti0.8V0.2和Ti0.9V0.1合金的晶粒组织,而且,快速凝固处理增加了Ti0.9V0.1合金中的β相,其所占比例是普通熔铸条件下的两倍。扫描电子显微镜(SEM)分析表明,Ti0.9V0.1合金含有片状组织,层片的厚度约为300nm。热脱附谱(TDS)显示,微观组织的细化可以加快氢脱附的动力学过程。 | Suwarno SUWARNO Jan Ketil SOLBERG Jan Petter MAEHLEN Bente KROGH Bφrre Tore BφRRESEN Esther OCHOA-FERNANDEZ Erling RYTTER Mario WILLIAMS Roman DENYS Volodymyr A.YARTYS | 2012 | Transactions of Nonferrous Metals Society of China2012，22，8： | 2 |
| 15 | Relationship Governance in a Supply Chain Network显示文摘 | Jan B Heide | 2004 | Journal of Marketing2004，68，1： | 1 |
| 16 | Importance of mechanisms and processes of the stabilisation of soil organic matter for modelling carbon turnover 显示文摘 | EVELYN S K JEFFREY A B JAN O S | 2003 | Functional Plant Biology2003，30，2： | 1 |
| 17 | Biological treatment of kraft mill wastewater显示文摘 | Jan A Oleszkiewicz Waclaw Trebacz Dave B Thompson | 1992 | Water Environment Research1992，64，6： | 1 |
| 18 | Separation of duties for access control enforcement in workflow environments 显示文摘 | Reinhardt A B Jan H P E | 2001 | IBM Systems Journal2001，40，3： | 1 |
| 19 | Treating attention deficit/hyperactivitydisorder beyond symptomcontrol alone in children and ado-lescents:a review of long-acting sti mulants显示文摘 | Jan B Rossella M | 2010 | Eur ChildAdolesc Psychiatry2010，19，： | 1 |
| 20 | Metabolic engineering of microorganisms for the synthesis of plant natural products 显示文摘 | Jan M Michael B | 2013 | Journal of Biotechnology2013，163，： | 1 |
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