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| 1 | Global methylation status of sperm DNA in carriers of chromosome structural aberrations显示文摘男不孕可能清楚地在人的精子与异常 DNA methylation 模式被联系。在氧化应力和精子染色体的全球 methylation 地位之间的一个协会也被建议了。现在的学习的目的是决定全球精子 DNA methylation 地位是否在染色体的搬运人的精子被影响结构的错误。在 5-methylcytosine 之间的关系(m 5 C ) 在精子和染色质正直地位的层次被评估。学习病人包括了染色体的男搬运人有繁殖失败的结构的错误(n = 24 ) ,并且控制包括了 normozoospermic 精子志愿者(n = 23 ) 。全球 m 5 C 水平用薄层的层析(TLC ) 和 immunofluorescence 被测量(如果) 技术。精子染色质正直用染色的苯胺蓝色(AB ) 和 TUNEL 试金被估计。吝啬的 m 5 C 层次在调查染色体之间是类似的结构的错误搬运人(P) 和控制(K) 。然而,精子染色质完整测试比在控制在 chromosomal 重新整理搬运人揭示了显著地更高的值(P <0.05 ) 。尽管在精子染色质正直地位和精子 DNA 破碎和 m 5在两个都分析的组( P 对 K )并列的 C 水平以一种清楚地相反的方式被代表,低染色质正直可能与在染色体的搬运人观察的精子 DNA 的高 hypomethylation 地位被联系结构的错误。 | Marta Olszewska Miroslawa Z Barciszewska Monika Fraczek Nataliya Huleyuk Vyacheslav B chernykh Danuta Zastavna Jan Barciszewski Maciej Kurpisz | 2017 | Asian Journal of Andrology2017，19，1： | 8 |
| 2 | A new frontier for molecular medicine: Noncoding RNAs显示文摘 | Maciej Szymanski Miroslawa Z. Barciszewska Volker A. Erdmann Jan Barciszewski | 2005 | BBA - Reviews on Cancer2005，，1： | 1 |
| 3 | Kinetin- A multiactive molecule显示文摘 | JAN BARCISZEWSKI FRANK MASSINO BRIAN F C CLARK | 2007 | International Journal of Biological Macromolecules2007，40，18： | 1 |
| 4 | Effect of desiccation on the dynamics of genome-wide DNA methylation in orthodox seeds of Acer platanoides L显示文摘 | Beata P. Plitta Marcin Michalak Barbara Bujarska-Borkowska Miros?awa Z. Barciszewska Jan Barciszewski Pawe? Chmielarz | 2014 | Plant Physiology and Biochemistry2014，，： | 1 |
| 5 | Effect of high hydrostatic pressure on hydration and activity of ribozymes显示文摘 | Ma?gorzata Giel-Pietraszuk Agnieszka Fedoruk-Wyszomirska Jan Barciszewski | 2010 | Molecular Biology Reports2010，，8： | 1 |
| 6 | Reducing SARS-CoV-2 pathological protein activity with small molecules显示文摘Coronaviruses are dangerous human and animal pathogens.The newly identified coronavirus SARS-CoV-2 is the causative agent of COVID-19 outbreak,which is a real threat to human health and life.The world has been struggling with this epidemic for about a year,yet there are still no targeted drugs and effective treatments are very limited.Due to the long process of developing new drugs,reposition of existing ones is one of the best ways to deal with an epidemic of emergency infectious diseases.Among the existing drugs,there are candidates potentially able to inhibit the SARS-CoV-2 replication,and thus inhibit the infection of the virus.Some therapeutics target several proteins,and many diseases share molecular paths.In such cases,the use of existing pharmaceuticals for more than one purpose can reduce the time needed to design new drugs.The aim of this review was to analyze the key targets of viral infection and potential drugs acting on them,as well as to discuss various strategies and therapeutic approaches,including the possible use of natural products.We highlighted the approach based on increasing the involvement of human deaminases,particularly APOBEC deaminases in editing of SARS-CoV-2 RNA.This can reduce the cytosine content in the viral genome,leading to the loss of its integrity.We also indicated the nucleic acid technologies as potential approaches for COVID-19 treatment.Among numerous promising natural products,we pointed out curcumin and cannabidiol as good candidates for being antiSARS-CoV-2 agents. | Donata Pluskota-Karwatka Marcin Hoffmann Jan Barciszewski | 2021 | Journal of Pharmaceutical Analysis2021，11，4： | 0 |
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