|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer显示文摘The goal of this investigation was to develop and demonstrate a polymer/paclitaxel selfassembly(PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size of formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy and flow cytometry studies exhibited that polyvinylpyrrolidone(PVP)-based PTX-SAs(PVP/PTX-SAs) had superior cellular internalization capability in MCF7 and MDA-MB-231 breast cancer cells. The optimized PVP/PTXSAs exhibited less toxicity to human red blood cells indicating a suitable formulation for reducing systemic toxicity. The formation of PVP and PTX self-assemblies was confirmed using fluorescence quenching and transmission electron microscopy which indicated that the PVP/PTX-SAs were spherical in shape with an average size range of 53.81 nm as detected by transmission electron microscopy(TEM).FTIR spectral analysis demonstrates incorporation of polymer and paclitaxel functional groups in PVP/PTX-SAs. Both proliferation(MTS) and clonogenic(colony formation) assays were used to validate superior anticancer activity of PVP/PTX-SAs in breast cancer cells over paclitaxel. Such superior anticancer activity was also demonstrated by downregulation of the expression of pro-survival protein(Bcl-x L), upregulation of apoptosis-associated proteins(Bid, Bax, cleaved caspase 7, and cleaved PARP)and β-tubulin stabilization. These results support the hypothesis that PVP/PTX-SAs improved paclitaxel delivery to cancer cells. | Pallabita Chowdhury Prashanth K.B.Nagesh Sheema Khan Bilal B.Hafeez Subhash C.Chauhan Meena Jaggi Murali M.Yallapu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 7 |
| 2 | Milk exosomes:Nature’s abundant nanoplatform for theranostic applications显示文摘Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles.Exosomes have proven to be excellent nanocarriers for carrying lipids,proteins,mRNAs,non-coding RNAs,and DNAs,and disseminating long-distance intercellular communications in various biological processes.Among various cell-line or biological fluid derived exosomes,milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications.To be an effective delivery carrier for their clinical translation,exosomes must inbuilt loading,release,targeting,and imaging/tracking characteristics.Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging applications.This review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery approaches.It is emphasized on possible modifications of exosomes towards increasing the stability and delivery of agents.This article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle. | Benilde Adriano Nycol M.Cotto Neeraj Chauhan Meena Jaggi Subhash C.Chauhan Murali M.Yallapu | 2021 | Bioactive Materials2021，6，8： | 2 |
| 3 | Prognostic value of cy- cle exercise testing prior to and after outpatient cardiac rehabilita- tion显示文摘 | Di Valentino M Maeder MT Jaggi S | 2010 | Int J Cardio]2010，140，1： | 1 |
| 4 | Pollution disclosures, pollution performance and economic performance显示文摘 | Freedman M Jaggi B | 1982 | Omega1982，，10： | 1 |
| 5 | Ordering policies of deteriorating items under permissible delay in payments显示文摘 | Aggarwal SP Jaggi CK | 1995 | European Journal of the Operational Research1995，46，5： | 1 |
| 6 | Mechanisms in cancer-chemo- therapeutic drugs-induced peripheral neuropathy显示文摘 | Jaggi AS Singh N | 2012 | Toxicology2012，291，1： | 1 |
| 7 | Polynomial time algo- rithms for multicast network code construction显示文摘 | Jaggi S Sanders P Chou P A | 2005 | IEEE Transactions on Information Theory2005，51，6： | 1 |
| 8 | An examination of the impact of pollution performance on economic and market performance: pulp and paper firms显示文摘 | Jaggi B Freedman M | 1992 | Journal of Business Finance and Ac- counting1992，19，5： | 1 |
| 9 | Retailer's optimal replenishment decisions with credit-linked demand under permissible delay in payments显示文摘 | Jaggi C K Goyal S K Goel S K | 2008 | European Journal of Operational Research2008，，190： | 1 |
| 10 | A joint approach for setting unit price and the length of the credit period for a seller when end demand is price sensitive显示文摘 | Abad P L Jaggi C K | 2003 | International Journal of Production Economics2003，83，： | 1 |
| 11 | Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats显示文摘 | KAUR G JAGGI A S SINGH N | 2010 | J Brachial Plex Peripher Nerve Inj2010，5，： | 1 |
| 12 | Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-II) in combination with quercetin: possible contribution of P-glycoprotein显示文摘 | BANSAL T A W ASTHI A JAGGI M | 2008 | Life Sci2008，83，78： | 1 |
| 13 | Curcumin nanoformulations:a future nanomedicine for cancer显示文摘 | Yallapu MM Jaggi M Chauhan SC | 2012 | Drug Discovery Today2012，7，12： | 1 |
| 14 | Animal models of dementia and cognitive dysfunction显示文摘 | Neha Sodhi RK Jaggi AS | 2014 | Life Sci2014，109，2： | 1 |
| 15 | Polynomial time algorithms for multicast network code construction显示文摘 | JAGGI S SANDERS P CHOU P A | 2005 | IEEE Trans on Information Theory2005，51，6： | 1 |
| 16 | Ameliorative role of Atrovastatin and Pitavastatin in L-Methionine induced vascular dementia in rats 显示文摘 | Koladiya RU Jaggi AS Singh N | 2008 | BMC Pharmacology2008，8，14： | 1 |
| 17 | Polynomial time algo- rithms for multicast network coding construction 显示文摘 | JAGGI S SANDERS P CHOU P A | 2005 | IEEE Trans- actions on Information Theory2005，51，6： | 1 |
| 18 | Ameliorative effects of Ocimum sanctum in sciatic nerve transection-induced neuropathy in rats显示文摘 | Muthuraman A Diwan V Jaggi AS Singh N Singh D | 2008 | J Ethnopharmacol2008，120，1： | 1 |
| 19 | Retailer’s optimal replenishment decisions with credit-linked demand under permissible delay in payments显示文摘 | Chandra K. Jaggi S.K. Goyal S.K. Goel | 2007 | European Journal of Operational Research2007，，1： | 1 |
| 20 | Poly(ADP-ribose)polymerases-1 (PARP-1) and its therapeutic implications显示文摘 | Sodhi R K Nirmal Singh Jaggi A S | 2010 | Vascular Pharmacology2010，53，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员