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| 1 | Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects显示文摘AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).METHODS: We carried out a non-matched case-controlled study in a university hospital in Mexico City. Two hundred and eighty-seven subjects were included: 97 cases with gallstones and 190 controls. Body mass index (BMI), fasting plasma leptin, insulin, serum lipid, and lipoprotein levels were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Unconditional logistic regression analysis (univariate and multivariate)stratified by BMI was used to calculate the risk of GD.RESULTS: The multivariate conditional regression analysis revealed a model for those patients with BMI <30. The selected variables in the model were HOMA-IR index with OR = 1.31, P= 0.02 and leptin higher than median with OR = 2.11, P= 0.05. In the stratum of BMI ≥30, we did not find a useful model.CONCLUSION: We concluded that insulin resistance and the development of GD appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles. | Nahum Méndez-Sánchez Luisa B Bermejo-Martínez Yolanda Vi(n|~)als Norberto C Chavez-Tapia Irina Vander Graff Guadalupe Ponciano-Rodríguez Martha H Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，39： | 11 |
| 2 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 3 | Differentiastion normal myelinatin from hyproxic ischemic encephalopathy on T1-weighted MR images:A new approach显示文摘 | Liauw L Palm M I H Vander G J | 2007 | AJNR Am J Neuroradiol2007，28，4： | 1 |
| 4 | Isopentenyl diphosphate isomerase and prenyltransferase activities in rubiaceous and apocynaceous cultures显示文摘 | Ramos V A C Vander H R Verpoorte R | 1998 | Phytochemistry1998，48，： | 1 |
| 5 | Simple Heuristics for Push and Pull Remanufacturing Policies 显示文摘 | Erwin A Vander Laan Ruud H Teunter | 2006 | European Journal of Operational Research2006，，175： | 1 |
| 6 | Uncertainty calculations for the preparation of primary gas mixtures 1 Gravimetry 显示文摘 | Alink A Vander Veen A M H | 2000 | Metrologia2000，37，： | 1 |
| 7 | The coupled problem in electromagnetic ac contactors显示文摘 | Abdul-Rahman A Mary J Vander H | 1997 | IEEE Transactions on Magnetics1997，33，3： | 1 |
| 8 | Evaluation of the biocompatibility of a chitosan scaffold in mice显示文摘 | vander Vord P J Matthew H W DeSilva S P et aI | 2002 | Biomed Mater Res2002，59，3： | 1 |
| 9 | The stimulation of cell proliferation by quercetin is mediates by the estrogen receptor显示文摘 | Vander Woude H Ter Veld MG Jacobs N | 2005 | Mol Nutr Food Res2005，49，8： | 1 |
| 10 | Preparation and chemical composition of difluorodiphe nyltrichloroethane显示文摘 | Leon Bradlow H Vander Werf Calvin A | 1947 | J Am Chem Soc1947，69，66： | 1 |
| 11 | Physico chemistry of initial microbial adhesive interactions -Its mechanisms and methods for study 显示文摘 | Bos R Vander Mei H C Busscher H J | 1999 | FEMS Microbiology Review1999，23，2： | 1 |
| 12 | A randomized clinical trial of intermittent subglottic secretion drainage in patients receiving mechanical venti- lation 显示文摘 | Smulders K vander Hoeven H | 2002 | Chest2002，121，3： | 1 |
| 13 | Evaluation of diagnostic criteria for ankylosing spondylitis:A proposal for modification of the New York criteria显示文摘 | Vander L S Valkenburg H A Cats A | 1984 | Athritis Rheum1984，27，： | 1 |
| 14 | Mossbauer study of several ferromagnetic spinals 显示文摘 | Sawatzky G A Vander W F Morrish A H | 1969 | Phys Rev1969，187，： | 1 |
| 15 | Vibrational properties of double tungstates of the M Ⅰ MⅢ (WO4) 2 family (M Ⅰ =Li,Na,K;MⅢ =Bi,Cr)显示文摘 | Hanuza J Maczka M vander Mass J H | | 0，，01： | 1 |
| 16 | Influence of roadside infrastructure on driving behavior: driving simulator study 显示文摘 | VANDER H R DE R S | 2007 | Transportation Research Record2007，2018，1： | 1 |
| 17 | A novel phosphodiesterase type 4 inhibitor, HT-0712,enhances rehabilitation-dependent motor recovery and eortical reorganization after focal cortical ischemia 显示文摘 | MacDonald E Vander Lee H Pocock D | 2007 | Neurorehabil Neural Repair2007，21，6： | 1 |
| 18 | Outpatient antibiotic use in Europe and association with resistance: a crossnational database study 显示文摘 | Goossens H Ferech M Vander Stichele R | 2005 | Lancet2005，365，： | 1 |
| 19 | Heat shock- induced cardioprotection activates cytoskeletal-based cell survival pathways 显示文摘 | WEI H CAMPBELL W VANDER HEIDE R S | 2006 | Am J Physiol Heart Circ Physiol2006，291，2： | 1 |
| 20 | Isolation of a capsid protein of bluetongue virus that induces a protective immune re- sponse in sheep显示文摘 | Huismans H Vander W N T Cloete M | 1987 | Virology1987，157，： | 1 |
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