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| 1 | Piperine,an active ingredient of black pepper attenuates acetaminophen-induced hepatotoxicity in mice显示文摘Objective:To explore the hepatoprotective and antioxidant effects of piperine against acetaminophen-induced hepatotoxicity in mice.Methods:In mice,hepatotoxicity was induced by a single dose of acetaminophen(900 mg/kg b.w.i.p.).Piperine(25 mg/kg b.w.i.p.) and standard drug silymarin(25 mg/kg b.w.i.p.) were given to mice,30 min after the single injection of acetaminophen.After 4 h,the mice were decapitated.Activities of liver marker enzymes [(aspartate transaminase(AST),alanine transaminase(ALT),and alkaline phosphatase(ALP)]and inflammatory mediator tumour necrosis factor-alpha(TNF-α) were estimated in serum,while lipid peroxidation and antioxidant status(superoxide dismutase,catalase,glutathione peroxidase, glutathione reductase,glutathione-s-transferase and glutathione) were determined in liver homogenate of control and experimental mice.Results:Acetaminophen induction(900 mg/kg b.w.i.p.) significantly increased the levels of liver marker enzymes,TNF-α,and lipid peroxidation,and caused the depletion of antioxidant status.Piperine and silymarin treatment to acetaminophen challenged mice resulted in decreased liver marker enzymes activity,TNF-αand lipid peroxidation levels with increase in antioxidant status.Conclusions:The results clearly demonstrate that piperine shows promising hepatoprotective effect as comparable to standard drug silymarin. | Evan Prince Sabina Annie Deborah Harris Souriyan Deborah Jackline Mahaboob Khan Rasool | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 7 |
| 2 | 盆底功能障碍的预防和非手术治疗:NICE指南总结显示文摘盆底功能障碍是一种复杂的疾病,与尿失禁、膀胱排空障碍、盆腔器官脱垂、性功能障碍、慢性盆腔疼痛、大便失禁和肠道排空障碍有关。在英国,大约500万女性曾患盆底功能障碍。年龄对盆底功能障碍有显著影响,20岁女性中出现相关症状者仅占6%,60岁女性中,这一比例增加到40%。这些症状可能会严重影响生活质量。2020年7月,《独立医学和医疗器械安全审查》声明强调了盆腔补片手术的主要并发症。预防性和非手术治疗可以减少重症和需要侵入性治疗的患者数量。 | Nicola Adanna Okeahialam Katharina Dworzynski Paul Jacklin Doreen McClurg 黄峻(译) | 2022 | 英国医学杂志中文版2022，25，9： | 2 |
| 3 | A Limited Dependent Variable Analysis of Integrated Pest Management Adoption in Uganda显示文摘 | Jackline Bonabana-Wabbt Daniel Blaine Taylor | 2012 | Journal of Agricultural Science and Technology(A)2012，2，10： | 2 |
| 4 | Registration of 'Dawn' Kentucky Bluegrass显示文摘 | Brede A D Jacklin A W Brilman L A | 1990 | Crop Science1990，30，： | 1 |
| 5 | Density,Social Networks and Job Search Methods:Theory and Application to Egypt显示文摘 | Jackline Wahba Yves Zenou | | 0，，11： | 1 |
| 6 | Performance monitoring and assessment of neuro-adaptive controllers for aerospace applications using a bayesian approach 显示文摘 | Guenther Kurt Hodgkinson John Jacklin Stephen | 2005 | Collection of Technical Papers-AIAA Guidance Navigation and Control Conference2005，8，： | 1 |
| 7 | Distinguishing panics and information-based bank runs:Welfare and policy implications显示文摘 | Jacklin C Bhattacharya S | 1998 | Journal of Politieal Economy1998，96，3： | 1 |
| 8 | Distinguishing panics and information-based bank runs:Welfare and policy implication显示文摘 | Jacklin C Bhattacharya S | | 0，，： | 1 |
| 9 | Distinguishing Panics and Information-based Bank Runs:Welfare and Policy Implications显示文摘 | JACKLIN CHARLES J BHATTACHARYA | 1988 | The Journal of Political Economy1988，96，3： | 1 |
| 10 | Perioperative diagnosis of cystos arcoma phyllodes of the breast may be enhanced by MIB-1 index显示文摘 | Ridgway PF Jacklin RK Ziprin P | | 0，，01： | 1 |
| 11 | Optimising preoperative diagnosis in phyllodes tumour of the breast显示文摘 | Jacklin PK Ridgway PF Ziprin P | 2006 | J Clin patlwl2006，59，5： | 1 |
| 12 | Modified CelliGenpacked bed bioreactors for hybridoma cell cultures显示文摘 | Wang G Zhang W Jacklin C | 1992 | Cytotechnology1992，9，13： | 1 |
| 13 | Distinguishing Panics and Information - Based Bank Runs : Welfare and Policy Implications 显示文摘 | Jacklin C J Bhattaeharya S | 1988 | The Journal of Political Economy1988，96，3： | 1 |
| 14 | Optimising preoperative diagnosis in phyllodes tumour of the breast 显示文摘 | Jacklin RK Ridgway PF Ziprin P | 2006 | J Clin Pathol2006，59，5： | 1 |
| 15 | Density, social networks and job search methods: Theory and application to Egypt显示文摘 | Jackline Wahba Yves Zenou | 2005 | Journal of Development Economics2005，，2： | 1 |
| 16 | Optimising preoperative diagnosis in phyllodes tumour of the breast显示文摘 | Jacklin R K Ridgway P F Ziprin P | | 0，，5： | 1 |
| 17 | Distinguishing panics and information-hased hank runs:welfare and policy impli-cations显示文摘 | Jacklin C J Bhattacharya S | | 0，，03： | 1 |
| 18 | Overseas Work Experience,Savings and Entrepreneurship amongst Return Migrants to LDCs显示文摘 | McCormick Barry Wahba Jackline | | 0，，02： | 1 |
| 19 | Optimising preoperative diagnosis in phyllodes tumour of the breast 显示文摘 | Jacklin RK Ridgway PF Ziprin P | 2006 | J Clin Pathol2006，59，5： | 1 |
| 20 | Distinguishing panics and information-based bank runs: welfare and policy implications 显示文摘 | Jacklin C J Sudipto B | 1988 | Journal of Political Economy1988，96，3： | 1 |
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