|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Leukemic stromal hematopoietic microenvironment negatively regulates the normal hematopoiesis in mouse model of leukemia显示文摘Background and Objective: Leukemic microenvironment has a major role in the progression of leukemia. Leukemic cells can induce reversible changes in microenvironmental components, especially the stromal function which results in improved growth conditions for maintaining the malignant leukemic cells. This study aimed to investigate the survival advantage of leukemic cells over normal hematopoietic cells in stromal microenvironment in long term. Methods: The mice were injected intraperitoneally with N-N’ ethylnitrosourea (ENU) to induce leukemia; the mice received injection of normal saline were used as control. At 180 days after ENU induction, the mice were killed and the bone marrows were cultured for 19 days. Colony-forming assays were used to analyze the formation of various cell colonies. The expression of Sca-1, CD146, VEGFR2, CD95, pStat3, pStat5, and Bcl-xL in marrow cells were detected by flow cytometry. Results: Long-term leukemic bone marrow culture showed abnormal elongated stromal fibroblasts with almost absence of normal hematopoietic cells. Adherent cell colonies were increased, but CFU-F and other hematopoietic cell colonies were significantly decreased in leukemia group (P< 0.001). Primitive progenitor-specific Sca-1 receptor expression was decreased with subsequent increased expression of CD146 and VEGFR-2 in leukemic bone marrow cells. Decreased Fas antigen expression with increased intracellular pStat3, pStat5 and Bcl-xL proteins were observed in leukemic bone marrow cells. Conclusions: Stromal microenvironment shows altered morphology and decreased maturation in leukemia. Effective progenitor cells are decreased in leukemia with increased leukemia-specific cell population. Leukemic microenvironment plays a role in promoting and maintaining the leukemic cell proliferation and survivability in long term. | Pratima Basak Sumanta Chatterjee Prosun Das Madhurima Das Jacintha Archana Pereira Ranjan Kumar Dutta Malay Chaklader Samaresh Chaudhuri Sujata Law | 2010 | Chinese Journal of Cancer2010，29，12： | 3 |
| 2 | The effect of different dietary sugars and honey on longevity and fecundity in two hyperparasitoid wasps显示文摘 | Jeffrey A. Harvey Josianne Cloutier Bertanne Visser Jacintha Ellers Felix L. W?ckers Rieta Gols | 2012 | Journal of Insect Physiology2012，，6： | 1 |
| 3 | Lack of lipogenesis in parasitoids: A review of physiological mechanisms and evolutionary implications显示文摘 | Bertanne Visser Jacintha Ellers | 2008 | Journal of Insect Physiology2008，，9： | 1 |
| 4 | Wolbachia endosymbiont is essential for egg hatching in a parthenogenetic arthropod显示文摘 | Martijn J. T. N. Timmermans Jacintha Ellers | 2009 | Evolutionary Ecology2009，，6： | 1 |
| 5 | Could Signal Transducer and Activator of Transcription 3 be a Therapeutic Target in Obesity-Related Gastrointestinal Malignancy?显示文摘 | Katie E. O’Sullivan John V. Reynolds Ciara O’Hanlon Jacintha N. O’Sullivan Joanne Lysaght | 2014 | Journal of Gastrointestinal Cancer2014，，1： | 1 |
| 6 | Determinants of short- and long-term survival from colorectal cancer in very elderly patients显示文摘 | Juliette Sheridan Paul Walsh David Kevans Therese Cooney Shane O’Hanlon Blathnaid Nolan Anne White Edel McDermott Kieran Sheahan Diarmuid O’Shea John Hyland Diarmuid O’Donoghue Jacintha O’Sullivan Hugh Mulcahy Glen Doherty | 2014 | Journal of Geriatric Oncology2014，，： | 1 |
| 7 | Persistent net bone formation at one year due to local elution of zoledronic acid from porous tantalum implants显示文摘 | Michael T Dorota K Jacintha R | | 0，，： | 1 |
| 8 | Stage II colonic adenocarcinoma: a detailed study of pT4N0 with emphasis on peritoneal involvement and the role of tumour budding显示文摘 | Aoife L Canney David Kevans Lai Mun Wang John M P Hyland Hugh E Mulcahy Diarmuid P O’Donoghue Jacintha O’Sullivan Robert Geraghty Kieran Sheahan | 2012 | Histopathology2012，，3： | 1 |
| 9 | Histopathologic retrieval analysis of clinically failed porous tantalum osteonecrosis implants显示文摘 | Michael T Dorota K Jacintha R | | 0，，： | 1 |
| 10 | Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma显示文摘BACKGROUND In the contemporary era of cancer immunotherapy,an abundance of clinical and translational studies have reported radiotherapy(RT)and immunotherapies as a viable option for immunomodulation of many cancer subtypes,with many related clinical trials ongoing.In locally advanced disease,chemotherapy or chemoradiotherapy followed by surgical excision of the tumour remain the principal treatment strategy in oesophageal adenocarcinoma(OAC),however,the use of the host immune system to improve anti-tumour immunity is rapidly garnering increased support in the curative setting.AIM To immunophenotype OAC patients’immune checkpoint(IC)expression with and without radiation and evaluate the effects of checkpoint blockade on cell viability.METHODS In the contemporary era of cancer immunotherapy,an abundance of studies have demonstrated that combination RT and IC inhibitors(ICIs)are effective in the immunomodulation of many cancer subtypes,with many related clinical trials ongoing.Although surgical excision and elimination of tumour cells by chemotherapy or chemoradiotherapy remains the gold standard approach in OAC,the propagation of anti-tumour immune responses is rapidly garnering increased support in the curative setting.The aim of this body of work was to immunophenotype OAC patients’IC expression with and without radiation and to establish the impact of checkpoint blockade on cell viability.This study was a hybrid combination of in vitro and ex vivo models.Quantification of serum immune proteins was performed by enzyme-linked immunosorbent assay.Flow cytometry staining was performed to evaluate IC expression for in vitro OAC cell lines and ex vivo OAC biopsies.Cell viability in the presence of radiation with and without IC blockade was assessed by a cell counting kit-8 assay.RESULTS We identified that conventional dosing and hypofractionated approaches resulted in increased IC expression(PD-1,PD-L1,TIM3,TIGIT)in vitro and ex vivo in OAC.There were two distinct subcohorts with one demonstrating significant upregulation of ICs and the contrary in the other cohort.Increasing IC expression post RT was associated with a more aggressive tumour phenotype and adverse features of tumour biology.The use of anti-PD-1 and anti-PD-L1 immunotherapies in combination with radiation resulted in a significant and synergistic reduction in viability of both radiosensitive and radioresistant OAC cells in vitro.Interleukin-21(IL-21)and IL-31 significantly increased,with a concomitant reduction in IL-23 as a consequence of 4 Gray radiation.Similarly,radiation induced an anti-angiogenic tumour milieu with reduced expression of vascular endothelial growth factor-A,basic fibroblast growth factor,Flt-1 and placental growth factor.CONCLUSION The findings of the current study demonstrate synergistic potential for the use of ICIs and ionising radiation to potentiate established anti-tumour responses in the neoadjuvant setting and is of particular interest in those with advanced disease,adverse features of tumour biology and poor treatment responses to conventional therapies. | Noel E Donlon Maria Davern Fiona O'Connell Andrew Sheppard Aisling Heeran Anshul Bhardwaj Christine Butler Ravi Narayanasamy Claire Donohoe James J Phelan Niamh Lynam-Lennon Margaret R Dunne Stephen Maher Jacintha O'Sullivan John V Reynolds Joanne Lysaght | 2022 | World Journal of Gastroenterology2022，28，21： | 1 |
| 11 | γ–aminobutyric acid promotes stem elongation in Stellaria longipes: The role of ethylene显示文摘 | Arumugam Kathiresan Jacintha Miranda C.C. Chinnappa D.M. Reid | 1998 | Plant Growth Regulation1998，，2： | 1 |
| 12 | Taxol Content of Irish Yews显示文摘 | Jacintha Gruffin Ingrid Hook | 1996 | Planta Med1996，，62： | 1 |
| 13 | Modeling and stability analysis of the spread of novel coronavirus disease COVTD-19显示文摘Towards the end of 2019,the world witnessed the outbreak of Severe Acute Respiratory Syndrome Coronavirus-2(COVID-19),a new strain of coronavirus that was unidentified in humans previously.In this paper,a new fractional-order Susceptible-Exposed-Infected-Hospitalized-Recovered(SEIHR)model is formulated for COVID-19,where the population is infected due to human transmission.The fractional-order discrete version of the model is obtained by the process of discretization and the basic reproductive number is calculated with the next-generation matrix approach.All equilibrium points related to the disease transmission model are then computed.Further,sufficient conditions to investigate all possible equilibria of the model are established in terms of the basic reproduction number(local stability)and are supported with time series,phase portraits and bifurcation diagrams.Finally,numerical simulations are provided to demonstrate the theoretical findings. | A.George Maria Selvam Jehad Alzabut D.Abraham Vianny Mary Jacintha Fatma Bozkurt Yousef | 2021 | International Journal of Biomathematics2021，14，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员