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| 1 | Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry显示文摘瞄准:为颜色检测新浆液简历标记由浆液蛋白质与提高表面的激光解吸附作用 ionisation 介绍的表面的癌症(CRC )-- 飞行团分光术(SELDI-TOF MS ) 的时间。方法:二个独立浆液样品集合与 ProteinChip 技术独立被分析(集合 A:40 CRC+49 健康控制;集合 B:37 CRC+31 健康控制) ,有一个弱阳离子的使用的芯片交换一半和缓冲区 pH 5。差别的歧视的力量表示了蛋白质与一个分类树算法被估计。产生分类树的敏感和特性被盲目地从集合 B 并且反过来也如此从集合 A 把数据用于产生的树获得。CRC 浆液蛋白质侧面也与从胸的那些相比,卵巢,前列腺,和非小的房间肺癌症。结果:Mass-to-charge 比率(m/z ) 3.1x10 (3 ) , 3.3x10 (3 ) , 4.5x10 (3 ) , 6.6x10 (3 ) 和 28x10 (3 ) 在最好执行的分类树上被用作分类器。树敏感和特性在 65% 和 90% 之间。大多数这些歧视的 m/z 价值在调查的另外的瘤类型也是不同的。M/z 3.3x10 (3 ) ,在大多数树上的主要分类器,是 6.6x10 (3 ) 的一种二倍地控告的形式 -Da 蛋白质。后者作为 apolipoprotein C-I 被识别。M/z 3.1x10 (3 ) 作为 apolipoprotein A-I 作为白朊,和 m/z 28x10 (3 ) 的 N 终端碎片被识别。结论:分类树模式分析跟随的 SELDI-TOF MS 是为为 CRC 发现新浆液标记的一种合适的技术。Biomarkers 能与高敏感和特性在独立样品集合被识别并且 reproducibly 检测了。尽管为 CRC 不特定,这些简历标记在监视的疾病和治疗有一个潜在的角色。 | Judith YMN Engwegen Helgi H Helgason Annemieke Cats Nathan Harris Johannes MG Bonfrer Jan HM Schellens Jos H Beijnen | 2006 | World Journal of Gastroenterology2006，12，10： | 45 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | How will Earth’s surface temperature change in future decades?显示文摘 | Lean Judith L. Rind David H | 2009 | Geophysical Research Letters2009，，15： | 2 |
| 4 | GM1 ganglioside administration combined with physical therapy restores ambulation in humans with chronic spinal cord injury显示文摘 | Judith BW Michelle H | 1993 | Neuroscience Letters1993，161，： | 1 |
| 5 | Toward the Development of Metal-based Synthetic Nucleases and Pep-tidases:A Rationale and Progress Report in App lying the Principles of Coordination Chemistry显示文摘 | JUDITH N B | 1998 | Coordination Chemistry Reviews1998，173，： | 1 |
| 6 | The growth and interaction of yeasts and lactic acid bacteria isolated from Zombabwean naturally fermented milkin UHT milk显示文摘 | Tendekayi H Gadaga Anthony N Mutukumira Judith A Narvhus | 2001 | International Journal of Food Microbiology2001，，68： | 1 |
| 7 | Low doses of reactive oxygen species protect endothelial cells from apoptosis by increasing thioredoxin-1 expression显示文摘 | Judith H Verena T Jong H | 2004 | FEBS Letters2004，577，： | 1 |
| 8 | CO2 control on carbon isotope fractionation during aqueous photosynthesis:A paleo-pCO2 barometer显示文摘 | David J H Judith A M | 1991 | Geology1991，19，： | 1 |
| 9 | Mim- icking live flavivirus immunization with a noninfectious RNA vac- cine显示文摘 | REGINA M K JUDITH H A STEPHAN W A | 2014 | Proc Natal Acad Sci USA2014，101，7： | 1 |
| 10 | In situ treatment to reduce the phytoand bioavailability of lead,zinc,and cadmium显示文摘 | Sally B Chancy R Judith H | 2004 | J Environ Qual2004，33，： | 1 |
| 11 | Contracting and Patterns of Nonprofit Governance显示文摘 | SHARON L H | 1998 | Nonprofit management & leadership1998，8，3： | 1 |
| 12 | Effect of Bcl-2 on the primordial follicle endowment in the mouse ovary 显示文摘 | Flaws J A Hirshfield A N Judith A H | 2001 | Biol Reprod2001，64，4： | 1 |
| 13 | A laboratory resuspension chamber to measure fugitive dust size distributions and chemical compositions显示文摘 | JUDITH C C JOHN G W JAMES E H | 1994 | Atmospheric Environment1994，28，21： | 1 |
| 14 | An interfaculty pain curriculum:Lessons learned from six years experience显示文摘 | Judith H Judy WW Michael M | 2008 | Pain2008，7，： | 1 |
| 15 | The epidemiology of myelodysplastic syndromes显示文摘 | Ulrich G Judith N Rainer H | 2008 | Clinical Leukemia2008，2，1： | 1 |
| 16 | Metabolic flux engineering of l-lysine production in Corynebacterium glutamicumover expression and modification ofG6P dehydrogenase显示文摘 | Judith B Corinna K Andrea H Oskar Z | | 0，，： | 1 |
| 17 | Diffuse backscattering Mueller matrices of highly scattering media显示文摘 | Andreas H H Angelia A E Judith R M | 1997 | Optics Express1997，1，13： | 1 |
| 18 | Mushrooms,tumors,and immmity显示文摘 | Andrea T B Judith S S Robert M H | 1999 | Proceedings of the Society for Experimental Biology and Medicine1999，221，： | 1 |
| 19 | A Novel Role of Complement Factor Clq in Augmenting the Presentation of Antigen Captured in Immune Complexes to CD8^+ T Lymphocytes 显示文摘 | Monffoort N V Judith M H Sehuurhuis D H | 2007 | The Journal of Immunology2007，178，6： | 1 |
| 20 | Diffuse backscattering Mueller matrices of highly scattering media显示文摘 | Hielscher Andreas H Eick Angelia A Mourant Judith R | 1997 | Optics Express1997，1，13： | 1 |
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