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| 1 | 血管内皮生长因子936T/C基因多态性与结直肠癌及术后吻合口瘘的关系显示文摘目的通过研究血管内皮生长因子(VEGF)936T/C基因多态性了解该因子对结直肠癌生成及术后结肠吻合口瘘的影响。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测结直肠癌及正常对照的VEGF936T/C基因型。结果结直肠癌患者VEGF936T/C基因型或等位基因与对照组相比无差异。伴有术后结肠吻合口瘘的结直肠癌患者其VEGF936C/C基因型及C等位基因比例低于无术后结肠吻合口瘘的患者,两者差异有统计学意义(P<0·05)。结论VEGF936C/C基因型或936C等位基因与结直肠癌的发生无关,但提示术后结肠吻合口瘘的发生率降低。 | 吴国洋 王效民 Michael Keese Till Hasenberg Jrg W. Sturm | 2006 | 中华外科杂志2006，44，21： | 4 |
| 2 | Autoimmune pancreatitis associated with a large pancreatic pseudocyst显示文摘Pancreatic cystic lesions comprise various entities with different histopathological characteristics and their dif-ferential diagnosis is often a challenge for clinicians. Autoimmune pancreatitis (AIP) is usually not considered in the differential diagnosis of cystic lesions, but often mimics the morphological aspects of pancreatic neo-plasm. We report the case of a 64-year-old male patient with a cystic pancreatic head lesion (diameter 5 cm) and stenosis of the distal bile duct requiring repeated stent-ing. Because of the clinical presentation together with moderate elevation of serum CA19-9 and massive eleva-tion of cyst fluid CA19-9 (122.695 U/L; normal range: < 37.0 U/L), the patient underwent explorative laparotomy and pylorus preserving partial pancreaticoduodenectomy. Histology revealed surprisingly AIP with an inflammatory pseudocyst. In conclusion, cyst fluid analysis of tumor markers and cyst fluid cytology lack high accuracy to clearly differentiate cystic pancreatic lesions. Although AIP is rarely associated with pseudocysts, the disease has to be considered in the differential diagnosis of cys-tic pancreatic lesions. Early examination of serum IgG, IgG4 and auto-antibodies might save these patients from unnecessary endoscopical and surgical procedures. | Thilo Welsch Jrg Kleeff Irene Esposito Markus W Büchler Helmut Friess | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 3 | “Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases显示文摘Aside from Polo and Aurora, a third but less studied kinase family involved in mitosis regulation is the never in mitosis-gene A(NIMA)-related kinases(Neks). The founding member of this family is the sole member NIMA of Aspergillus nidulans, which is crucial for the initiation of mitosis in that organism. All 11 human Neks have been functionally assigned to one of the three core functions established for this family in mammals:(1) centrioles/mitosis;(2) primary ciliary function/ciliopathies; and(3) DNA damage response(DDR). Recent findings, especially on Nek 1 and 8, showed however, that several Neks participate in parallel in at least two of these contexts: primary ciliary function and DDR. In the core section of this in-depth review, we report the current detailed functional knowledge on each of the 11 Neks. In the discussion, we return to the cross-connections among Neks and point out how our and other groups' functional and interactomics studies revealed that most Neks interact with protein partners associated with two if not all three of the functional contexts. We then raise the hypothesis that Neks may be the connecting regulatory elements that allow the cell to fine tune and synchronize the cellular events associated with these three core functions. The new and exciting findings on the Nek family open new perspectives and should allow the Neks to finally claim the attention they deserve in the field of kinases and cell cycle biology. | Gabriela Vaz Meirelles Arina Marina Perez Edmárcia Elisa de Souza Ferna Luisa Basei Priscila Ferreira Papa Talita Diniz Melo Hanchuk Vanessa Bomfim Cardoso Jrg Kobarg | 2014 | World Journal of Biological Chemistry2014，5，2： | 2 |
| 4 | Mobile NMR for geophysical analysis and materials testing显示文摘Initiated by well logging NMR,portable NMR instruments are being developed for a variety of novel applications in materials testing,process analysis and control,which provides new opportunities for geophysical investigations.Small-diameter cylindrical sensors can probe short distances into the walls of slim-line logging holes,and single-sided sensors enable non-destructive testing of large objects.Both sensors are characterized by small sensitive volumes.Barrel-shaped magnets that accommodate the sample in their center have higher sensitivity due to a larger sensitive volume but can accommodate only samples like drill cores,which fit in size to the diameter of the magnet bore.Both types of magnets can be scaled down to the size of a coffee mug to arrive at sub-compact NMR equipment.Portable NMR magnets are reviewed in the context of applications related to geophysics. | BLüMICH Bernhard MAULER Jrg HABER Agnes PERLO Juan DANIELI Ernesto CASANOVA Federico | 2009 | Petroleum Science2009，6，1： | 2 |
| 5 | Solid fieeform fabrication of ceramics显示文摘 | Tay BY Evans JRG | 2003 | International Materials Reviews2003，48，6： | 1 |
| 6 | The use of a D-dimer assay in patients undergoing CT pulmonary angiography for suspected pulmonary embolus 显示文摘 | Burkill GJC Bell JRG Chinn RJS | 2002 | Clin Radio2002，57，： | 1 |
| 7 | The characterization of human amnion epithelid and mesenchymal cells: the cellular expression, activity and glucocorticoid regulation of prostaglandin outpat显示文摘 | Whittle WL Gibb W Challis JRG | 2000 | Placenta2000，21，4： | 1 |
| 8 | ^99mTechnetium ethyl cysteinate dlmer single-photon emission CT can predict fatal ischemic brain edema显示文摘 | Jrg B Henryk B Rudiger yon K | 1998 | Stroke1998，29，： | 1 |
| 9 | Metering and dispensing of powder; the quest for new solid freeforming techniques 显示文摘 | Yang S Evans JRG | 2007 | Powder Technology2007，178，1： | 1 |
| 10 | Current topic:the placental corticotropin - releasing hormone - adrenoco - rticotrop in axis显示文摘 | Challis JRG M atthew s SG V an M eir C | 1995 | Placenta1995，16，6： | 1 |
| 11 | Endocrine and para- crine regulation of birth at term and preterm显示文摘 | Challis JRG Matthews SG Gibb W | 2000 | Endocr Rev2000，21，5： | 1 |
| 12 | A practical note on the use of cytotoxicity assays显示文摘 | Jrg Weyermann Dirk Lochmann Andreas Zimmer | 2005 | International Journal of Pharmaceutics2005，288，1： | 1 |
| 13 | Marrow involvement with T cell lymphoma initially presenting as abnormal myelopeiesis显示文摘 | Nash JRG Mackie MJ | 1986 | J Clin Pathol1986，39，2： | 1 |
| 14 | Survey of the present state of the art of piezoelectric linear motors显示文摘 | Tobias Hemsel Jrg Wallaschek | 2000 | Ultrasonics2000，38，1： | 1 |
| 15 | Meclmnisms of tmnor immune escape in triple -negative breast cancers (TNBC) with and without mutated BRCA 1 显示文摘 | Jrg B Engel Arnd Honig Michaela Kapp | 2014 | Arch Gynecol Obstct2014，289，1： | 1 |
| 16 | Towards an operational MODIS continuous field of percent tree cover agorithrm:examples using AVHRR and MODIS data显示文摘 | Hansen MC Defries RS Townshend JRG Sohlberg R Dimiceli C Carroll M | | 0，，： | 1 |
| 17 | Mechanism of parturition and preterrn labor显示文摘 | Challis JRG | 2000 | Obstet Gynecol Surv2000，55，10： | 1 |
| 18 | On the machinability of ceramic compacts显示文摘 | Song JH Evans JRG | 1997 | J Eur Ceram Soc1997，17，8： | 1 |
| 19 | The moderate resolution imaging spectroradiometer (MODIS):land remote sensing for global change research 显示文摘 | Justice CO Vermote E Townshend JRG | 1998 | IEEE Transactions on Geoscience and Remote Sensing1998，36，4： | 1 |
| 20 | Analysis of dynamics of African vegetation using the normalized difference vegetation index显示文摘 | Townshend JRG Justice CO | | 0，，： | 1 |
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