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| 1 | Liver disease and erythropoietic protoporphyria:A concise review显示文摘The porphyries are a group of metabolic disorders characterized by deficiencies in the activity of enzymes involved in the biosynthesis of heme.In erythropoietic protoporphyria(EPP),in the majority of cases an autosomal dominant disease,there is a mutation of the gene that encodes ferrochelatase(FECH).FECH deficiency is associated with increased concentrations of protoporphyrin in erythrocytes,plasma,skin and liver.The prevalence of this inherited disorder oscillates between 1:75 000 and 1:200 000.Clinical manifestations of EPP appear in early infancy upon first exposure to the sun.Nevertheless,approximately 5%-20% of patients with EPP develop liver manifestations.Retention of protoporphyrin in the liver is associated with cholestatic phenomena and oxidative stress that predisposes to hepatobiliary disease of varying degrees of severity,such as cholelithiasis,mild parenchymal liver disease,progressive hepatocellular disease with end-stage liver disease and acute liver failure.Liver damage is the major risk in EPP patients,so surveillance and frequent clinical and biochemical liver follow-up is mandatory.The diagnostic approach consists in detecting increased levels of protoporphyrin,decreased activity of FECH and genetic analysis of the FECH gene.A variety of nonsurgical therapeutic approaches have been adopted for the management of EPP associated with liver disease,but none of these has been shown to be unequivocally efficacious.Nevertheless,some may have a place in preparing patients for liver transplantation.Liver transplantation does not correct the constitutional deficiency of FECH.Consequently,there is a risk of recurrence of liver disease after liver transplantation as a result of continuing overproduction of protoporphyrin.Some authors recommend that bone marrow transplantation should be considered in liver allograft recipients to prevent recurrence of hepatic disease. | María José Casanova-González María Trapero-Marugán E Anthony Jones Ricardo Moreno-Otero | 2010 | World Journal of Gastroenterology2010，16，36： | 7 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Transcriptomic and metabolomic analyses of cucumber fruit peels reveal a developmental increase in terpenoid glycosides associated with age-related resistance to Phytophthora capsici显示文摘The oomycete,Phytophthora capsici,infects cucumber(Cucumis sativus L.)fruit.An age-related resistance(ARR)to this pathogen was previously observed in fruit of cultivar‘Vlaspik’and shown to be associated with the peel.Young fruits are highly susceptible,but develop resistance at~10–12 days post pollination(dpp).Peels from resistant(16 dpp)versus susceptible(8 dpp)age fruit are enriched with genes associated with defense,and methanolic extracts from resistant age peels inhibit pathogen growth.Here we compared developing fruits from‘Vlaspik’with those of‘Gy14’,a line that does not exhibit ARR.Transcriptomic analysis of peels of the two lines at 8 and 16 dpp identified 80 genes that were developmentally upregulated in resistant‘Vlaspik’16 dpp versus 8 dpp,but not in susceptible‘Gy14’at 16 dpp.A large number of these genes are annotated to be associated with defense and/or specialized metabolism,including four putative resistance(R)genes,and numerous genes involved in flavonoid and terpenoid synthesis and decoration.Untargeted metabolomic analysis was performed on extracts from 8 and 16 dpp‘Vlaspik’and‘Gy14’fruit peels using Ultra-Performance Liquid Chromatography and Quadrupole Time-of-Flight Mass Spectrometry.Multivariate analysis of the metabolomes identified 113 ions uniquely abundant in resistant‘Vlaspik’16 dpp peel extracts.The most abundant compounds in this group had relative mass defects consistent with terpenoid glycosides.Two of the three most abundant ions were annotated as glycosylated nor-terpenoid esters.Together,these analyses reveal potential mechanisms by which ARR to P.capsici may be conferred. | Ben N Mansfeld Marivi Colle Yunyan Kang A Daniel Jones Rebecca Grumet | 2017 | Horticulture Research2017，4，1： | 3 |
| 4 | Die Montreal-Definition und -Klassifikation der gastro?sophagealen Refluxkrankheit: Ein globales evidenzbasiertes Konsensus-Papier显示文摘 | N Vakil S van Zanten P Kahrilas J Dent R Jones | 2007 | Z Gastroenterol2007，，11： | 3 |
| 5 | Factors affecting the success of human blastocyst development and pregnancy following in vitro fertilization and embryo transfer 显示文摘 | Jones G M Trounson A O Lolatgis N | 1998 | Fertil Steril1998，70，6： | 2 |
| 6 | Molecular cloning of the human XRCC1 gene,which corrects defective DNA strand break repair and sister chromatid exchange显示文摘 | Thompson L H Brookman K W Jones N J | 1990 | Mol Cell Biol1990，10，12： | 2 |
| 7 | The diffusion of zinc in cadmium telluride 显示文摘 | ASLAM N JONES E NOAKES T Q | 1992 | J Cryst Growth1992，117，： | 2 |
| 8 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 9 | 欧洲鼻腔鼻窦解剖术语意见书(二)显示文摘2014年,Rhinology刊登了European Position Paper on the Anatomical Terminology of the Internal Nose and Paranasal Sinuses,对于认识鼻科解剖名词具有重要的普及意义。考虑到国内耳鼻喉科医师获取和阅读英文文献的能力有限,但是又急需及时掌握学科领域内解剖名词的表述,我们通过与Rhinology编辑部及作者联系征得同意,翻译而成《欧洲鼻腔鼻窦解剖术语规范意见书》(以下简称《意见书》)。《意见书》中的所有解剖名词同时参考国内《英汉汉英医学分科词典(耳鼻咽喉科学分册)》进行统一,对于《英汉汉英医学分科词典(耳鼻咽喉科学分册)》中没有提及的名词给出了相应的补充。希望《意见书》对国内耳鼻喉科医师掌握并规范应用鼻科名词提供参考。《中国眼耳鼻喉科杂志》从第17卷第2期开始以连载形式刊登《意见书》。 | 王德辉 王德云 于华鹏 孙希才 李晗 刘琢扶 刘全 张焕康 Lund VJ Stammberger H Fokkens WJ Beale T Bernal-Sprekelsen M Eloy P Georgalas C Gerstenberger C Hellings PW Herman P Hosemann WG Jankowski R Jones N Jorissen M Leunig A Onerci M Rimmer J Rombaux P Simmen D Tomazic PV Tschabitscher M Welge-Luessen A | 2017 | 中国眼耳鼻喉科杂志2017，17，3： | 2 |
| 10 | Extracellular matrix and integrin signalling:the shape of things to come显示文摘 | Boudreau N J Jones P L | 1999 | Biochem J1999，339，3： | 2 |
| 11 | Building solid models from boreholes and user-defined cross-section显示文摘 | LEMON A M JONES N L | 2003 | Computer and Geosciences2003，5，29： | 1 |
| 12 | Human pharmaceuticals in wastewater treatment processes 显示文摘 | O A H Jones N Voulvoulis J N Lester | 2005 | Critical Reviews in Environmental Science and Technology2005，35，： | 1 |
| 13 | Production of alkylesters from tallow and grease using lipase immobilized in a phyllosilicate sol-gel显示文摘 | HS U A F JONES K MARMERW N | 2001 | Journal of the American Oil Chemists Society2001，78，6： | 1 |
| 14 | Novel e-functionally substituted amino aeids: diphenylphosphinoglycines 显示文摘 | Heinicke J Peulecke N Jones P G | 2005 | Chem Commum2005，，： | 1 |
| 15 | Tie receptors:new modulators of angiogenic and lymphangiogenic responses显示文摘 | Jones N Iljin K Dumont DJ | 2001 | Nat Rev Mol Cell Biol2001，2，： | 1 |
| 16 | The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens显示文摘 | Kitchen S G Whitmire J K Jones N R | 2005 | Proc Natl Acad Sci USA2005，102，： | 1 |
| 17 | Impacts of harvest residue management on soil carbon stocks in a plantation forest 显示文摘 | Jones H S Garrett L G Beets P N | 2008 | Soil Science Society of America Journal2008，72，6： | 1 |
| 18 | Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality显示文摘 | Kilgannon J H Jones A E Shapiro N I | 2010 | JAMA2010，303，： | 1 |
| 19 | Management of composite defects of the nose,cheek,eyelids and upper lip显示文摘 | JONES N S RAGHAVAN U | 2009 | J Laryngol Otol2009，123，32： | 1 |
| 20 | Resistance patterns among nosocomial pathogens: Trends over the past few years显示文摘 | Jones R N | 2001 | Chest2001，119，： | 1 |
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