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| 1 | The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens显示文摘 | Kitchen S G Whitmire J K Jones N R | 2005 | Proc Natl Acad Sci USA2005，102，： | 1 |
| 2 | Habitat-correlated variation in seed germination response to chilling in Penstem on Section Glabri(Scrophulariaceae) 显示文摘 | Meyer S E Kitchen S G | 1994 | American Midland Naturalist1994，132，： | 1 |
| 3 | Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load显示文摘 | Deeks S G Kitchen C M Liu L | 2004 | {H}Blood2004，，04： | 1 |
| 4 | The CCR5 and CXCR4 coreceptors-central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection显示文摘 | Moore J P Kitchen S G Pugach P Zack A | 2004 | AIDS Res Hum Retrovir2004，20，1： | 1 |
| 5 | Calcium hydroxide sprays for the control of black spot on apples-treatment effects on fruit quality显示文摘 | Brown G S Kitchener A E Barness S | 2000 | Acta Horticulturae2000，513，： | 1 |
| 6 | Relationshipbetween the level of N-acetyl-beta-D-glucosaminidase(NAGase)in bovine milk and the presence of mastitis pathogens显示文摘 | KITCHEN B J KWEE W S MIDDLETON G | 1984 | J Dairy Res1984，51，1： | 1 |
| 7 | 人乳头瘤病毒16/18型AS04佐剂疫苗预防肿瘤基因型HPV引起的宫颈感染和癌前病变的效应(PATRICIA):一项在年轻女性中进行的双盲、随机研究的最终分析显示文摘背景在年轻成人中进行的Ⅲ期随机、双盲对照PATRICIA试验(PApilloma TRial)的事件驱动期中分析显示,人乳头瘤病毒(HPV)16/18AS04佐剂疫苗具有免疫原性,且总体耐受性良好,对HPV16或HPV18感染及相关的癌前病变具有预防效应。本文作者旨在评估最终事件驱动分析中的疫苗效应。方法将在基线、1个月和6个月接种疫苗的15~25岁女性分类为符合方案的效应队列(ATP-E队列;疫苗组8093例,对照组8069例)、总接种队列(TVC;包括至少接种1剂疫苗的所有女性,而不考虑其基线HPV状态;代表普遍的年轻女性人群,包括性活跃者;疫苗组9319例,对照组9325例)和TVC-naive(无证据表明基线时存在肿瘤基因型HPV感染;代表无性行为女性;疫苗组5822例,对照组5819例)。主要终点是。在基线时血清和DNA均为阴性且在6个月时为相应类型(ATP-E队列)的女性中,评估疫苗对HPV16或HPV18相关性宫颈上皮内瘤变≥2级(CIN2+)的预防效应。该试验在ClinicalTrial.gov上的注册编码为NCT00122681.结果第3剂疫苗接种后平均随访34.9个月(s=6.4)。在主要分析中疫苗对HPV16/18相关性CIN2+的预防效应为92.9%(96.1%CI79.9%~98.3%),在对可能因多种肿瘤基因型HPV引起的病变(ATP-E队列)的分析中,其预防效应为98.1%(96.1%CI88.4%~100%)。不考虑病变HPVDNA时,疫苗对CIN2+的预防效应在TVC中为30.4%(96.1%CI16.4%~42.1%),在TVC-naive中为70.2%(96.1%CI54.7%~80.9%);而对CIN3+的相应效应在TVC中为33.4%(96.1%CI9.1%~51.5%).在TVC-naive中为87.0%(96.1%CI54.9%~97.7%).在预防12种非疫苗肿瘤基因型HPv相关性CIN2+的效应为54.0%(96.1%CI34.0%~68.4%:ATP-E队列)。在TVC中可见对HPV31、33和45相关性CIN2+的个体交叉保护效应。结论HPV16/18 AS04佐剂疫苗表现出对HPV16/18和非疫苗肿瘤基因型HPV相关性CIN2+较强的预防效应,而要获得整体预防效应就需要在更广泛的人群中进行大面积强化免疫计划。基金 葛兰素史克。 | J Paavonen P Naud J Salmeron C M Wheeler S-N Chow D Apter H Kitchener X Castellsague J C Teixeira S R Skinner J Hedrick U Jaisamrarn G Limson S Garland A Szarewski B Romanowski F Y Aoki T F Schwarz W A J Poppe F X Bosch D Jenkins K Hardt T Zahaf D Descamps F Struyf M Lehtinen G Dubin 周彩虹(译) | 2009 | 世界临床医学2009，，12： | 1 |
| 8 | The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens显示文摘 | KITCHEN S G WHITMIRE J K JONES N R | 2005 | Proc Natl Acad Sci USA2005，102，10： | 1 |
| 9 | Forage Kochia seed germination response to storage time and temperature显示文摘 | Kitchen S G Monsen S B | 2001 | Journal of Range Management2001，54，： | 1 |
| 10 | Costimulation of naive of CD8(+) lymphoeytes induces CD4 expression and allows human immunodeficiency virus type 1 infection显示文摘 | Kitchen S G Korin Y D Roth M D | 1998 | J Virology1998，72，11： | 1 |
| 11 | Germination rate and emer- gence success in Bluebunch wheatgrass显示文摘 | Kitchen S G Monsen S B | 1994 | Journal of Range Management1994，47，： | 1 |
| 12 | Seed germination timing patterns in intermountain Penstemon (Scrophulariaceae)显示文摘 | MEYER S E KITCHEN S G CARLSON S L | | 0，，03： | 1 |
| 13 | The CCR5 and CXCR4 coreceptors-central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection 显示文摘 | Moore J P Kitchen S G Pugach P | 2004 | AIDS Res Hum Retroviruses2004，20，1： | 1 |
| 14 | Generation of T lineage cells from human embryonic stem cells in a feeder free system 显示文摘 | Galic Z Kitchen S G Subramanian A | 2009 | Stem Cells2009，27，1： | 1 |
| 15 | Seed ger- mination timing patterns in intermountain Penstemon (Scrophulariaceae) 显示文摘 | MEYER S E KITCHEN S G CARLSON S L | 1995 | American Journal of Botany1995，82，3： | 1 |
| 16 | Calcium hydroxide sprays for the control of black spot on apples-treatment effects on fruit quality显示文摘 | BROWN G S KITCHENER A E BARNESS S | 2000 | Acta Hort2000，513，： | 1 |
| 17 | CD4 on CD8+ T ceils directly enhances effector function and is a target for HIV infection显示文摘 | Kitchen S G Jones N R LaForge S | 2004 | Proc Natl Acad SCi USA2004，101，： | 1 |
| 18 | Habitat-correlated variation in seed germination response to chill- ing in Penstemon Section Glabri (Scrophular- iaceae)显示文摘 | MEYER S E KITCHEN S G | 1994 | American Midland Naturalist1994，132，2： | 1 |
| 19 | Habitat-correlated variation in seed germination response to chilling in Penstemon section Glabri(Scrophulariaceae)显示文摘 | Meyer S E Kitchen S G | 1994 | American Midland Naturalist1994，132，： | 1 |
| 20 | T lineage differentiation from human embryonic stem cells显示文摘 | Galic Z Kitchen S G Kacena A | 2006 | Proc Natl Acad Sci USA2006，103，11： | 1 |
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