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| 1 | PhaseⅠ/Ⅱtrial evaluating concurrent carbon-ion radiotherapy plus chemotherapy for salvage treatment of locally recurrent nasopharyngeal carcinoma显示文摘Background: After deinitive chemoradiotherapy for non-metastatic nasopharyngeal carcinoma(NPC), more than 10% of patients will experience a local recurrence. Salvage treatments present signiicant challenges for locally recurrent NPC. Surgery, stereotactic ablative body radiotherapy, and brachytherapy have been used to treat locally recurrent NPC. However, only patients with small-volume tumors can beneit from these treatments. Re-irradiation with X-ray—based intensity-modulated radiotherapy(IMXT) has been more widely used for salvage treatment of locally recurrent NPC with a large tumor burden, but over-irradiation to the surrounding normal tissues has been shown to cause frequent and severe toxicities. Furthermore, locally recurrent NPC represents a clinical entity that is more radioresistant than its primary counterpart. Due to the inherent physical advantages of heavy-particle therapy, precise dose delivery to the target volume(s), without exposing the surrounding organs at risk to extra doses, is highly feasible with carbon-ion radiotherapy(CIRT). In addition, CIRT is a high linear energy transfer(LET) radiation and provides an increased relative biological efectiveness compared with photon and proton radiotherapy. Our prior work showed that CIRT alone to 57.5 Gy E(gray equivalent), at 2.5 Gy E per daily fraction, was well tolerated in patients who were previously treated for NPC with a deinitive dose of IMXT. The short-term response rates at 3–6 months were also acceptable. However, no patients were treated with concurrent chemotherapy. Whether the addition of concurrent chemotherapy to CIRT can beneit locally recurrent NPC patients over CIRT alone has never been addressed. It is possible that the beneits of high-LET CIRT may make radiosensitizing chemotherapy unnecessary. We therefore implemented a phase I/II clinical trial to address these questions and present our methodology and results.Methods and design: The maximal tolerated dose(MTD) of re-treatment using raster-scanning CIRT plus concurrent cisplatin will be determined in the phase I, dose-escalating stage of this study. CIRT dose escalation from 52.5 to 65 Gy E(2.5 Gy E × 21–26 fractions) will be delivered, with the primary endpoints being acute and subacute toxicities. Eicacy in terms of overall survival(OS) and local progression-free survival of patients after concurrent chemotherapy plus CIRT at the determined MTD will then be studied in the phase II stage of the trial. We hypothesize that CIRT plus chemotherapy can improve the 2-year OS rate from the historical 50% to at least 70%.Conclusions: Re-treatment of locally recurrent NPC using photon radiation techniques, including IMXT, provides moderate eicacy but causes potentially severe toxicities. Improved outcomes in terms of eicacy and toxicity proile are expected with CIRT plus chemotherapy. However, the MTD of CIRT used concurrently with cisplatin-based chemotherapy for locally recurrent NPC remains to be determined. In addition, whether the addition of chemotherapy to CIRT is needed remains unknown. These questions will be evaluated in the dose-escalating phase I and randomized phase II trials. | Lin Kong Jing Gao Jiyi Hu Weixu Hu Xiyin Guan Rong Lu Jiade J.Lu | 2016 | Chinese Journal of Cancer2016，35，12： | 8 |
| 2 | New Zircon U-Pb Age of the Super-Large Lijiagou Spodumene Deposit in Songpan Garze Fold Belt, Eastern Tibet: Implications for Early Jurassic Rare-Metal Polymetallic Event显示文摘The Songpan-Garze Fold Belt (SGFB), located in theeastern part of the Tibet Plateau and west of the SichuanBasin, is an important pegmatite province in China. Somefamous pegmatite type deposits occur in the SGFB,including the Xuebaoding, Jiajika, Keeryin rare metaldeposits and Danba muscovite deposit (Li Jiankang et al.,2015). | FEI Guangchun TIAN Jingjing YANG Jiyi GAO Jianguo TANG Wenchun LI Jian GU Chenghui | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 5 |
| 3 | Nash Model Parameter Uncertainty Analysis by AM-MCMC Based on BFS and Probabilistic Flood Forecasting显示文摘A hydrologic model consists of several parameters which are usually calibrated based on observed hy-drologic processes. Due to the uncertainty of the hydrologic processes, model parameters are also uncertain, which further leads to the uncertainty of forecast results of a hydrologic model. Working with the Bayesian Forecasting System (BFS), Markov Chain Monte Carlo simulation based Adaptive Metropolis method (AM-MCMC) was used to study parameter uncertainty of Nash model, while the probabilistic flood forecasting was made with the simu-lated samples of parameters of Nash model. The results of a case study shows that the AM-MCMC based on BFS proposed in this paper is suitable to obtain the posterior distribution of the parameters of Nash model according to the known information of the parameters. The use of Nash model and AM-MCMC based on BFS was able to make the probabilistic flood forecast as well as to find the mean and variance of flood discharge, which may be useful to estimate the risk of flood control decision. | XING Zhenxiang RUI Xiaofang FU Qiang JIYi ZHU Shijiang | 2011 | Chinese Geographical Science2011，21，1： | 4 |
| 4 | Fe3O4 nanoparticles as a saturable absorber for a tunable Q-switched dysprosium laser around 3μm显示文摘We demonstrate for the first time to our knowledge the use of Fe3O4 nanoparticles for Q-switching a tunable midinfrared(Mid-IR)Dy^3+-doped ZBLAN fiber laser around 3μm.The Q-switcher was fabricated by depositing the prepared Fe3O4 nanoparticles solution onto an Au mirror.Its nonlinear optical response was characterized using a mode locked Ho^3+/Pr^3+-codoped ZBLAN fiber laser at 2.87μm,and showed a modulation depth of 11.9%as well as a saturation intensity of 1.44 MW/cm^2.Inserting the device into a tunable Dy^3+-doped ZBLAN fiber laser,stable Q-switched pulses within the tunable range of 2812.4-3031.6 nm were obtained.When tuning the wavelength to 2931.2 nm,a maximum Q-switching output power of 111.0 mW was achieved with a repetition rate of 123.0 kHz and a pulse width of 1.25μs.The corresponding pulse energy was 0.90μJ.This demonstration suggests that Fe3O4 nanoparticles are a promising broadband saturable absorption material for mid-infrared operation. | JIAN YANG JIYI HU HONGYU LUO JIANFENG LI JISHU LIU XIAOHUI LI YONG LIU | 2020 | Photonics Research2020，8，1： | 4 |
| 5 | Carbon ion radiotherapy boost in the treatment of glioblastoma:a randomized phase Ⅰ/Ⅲ clinical trial显示文摘Background: Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival < 15 months. Clearly, an improvement in treatment outcomes is needed. However, the emergence of these malignancies within the delicate brain parenchyma and their infiltrative growth pattern severely limit the use of aggressive local therapies. The particle therapy represents a new promising therapeutic approach to circumvent these prohibitive conditions with improved treatment efficacy. Methods and design: Patients with newly diagnosed malignant gliomas will have their tumor tissue samples submitted for the analysis of the status of O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation. In Phase I, the patients will undergo an induction carbon ion radiotherapy (CIRT) boost followed by 60 GyE of proton irradiation with concurrent temozolomide (TMZ) at 75 mg/m2. To determine the maximal dose of safe induction boost, the tolerance, and acute toxicity rates in a dose-escalation manner from 9 to 18 GyE in three fractions will be used. In Phase III, GBM-only patients will be randomized to receive either 60 GyE (2 GyE per fraction) of proton irradia-tion with concurrent TMZ (control arm) or a CIRT boost (dose determined in Phase I of this trial) followed by 60 GyE of proton irradiation with concurrent TMZ. The primary endpoints are overall survival (OS) and toxicity rates (acute and long-term). Secondary endpoints are progression-free survival (PFS), and tumor response (based upon assess-ment with C-methionine/fluoro-ethyl-tyrosine positron emission tomography [MET/FET PET] or magnetic resonance imaging [MRI] and detection of serologic immune markers). We hypothesize that the induction CIRT boost will result in a greater initial tumor-killing ability and prime the tumor microenvironment for enhanced immunologic tumor clearance, resulting in an expected 33% improvement in OS rates. Discussion: The prognosis of GBM remains grim. The mechanism underpinning the poor prognosis of this malig-nancy is its chronic state of tumor hypoxia, which promotes both immunosuppression/immunologic evasion and radio-resistance. The unique physical and biological properties of CIRT are expected to overcome these microenviron-mental limitations to confer an improved tumor-killing ability and anti-tumor immune response, which could result in an improvement in OS with minimal toxicity. Trial registration number This trial has been registered with the China Clinical Trials Registry, and was allocated the number ChiCTR-OID-17013702. | Lin Kong Jing Gao Jiyi Hu Rong Lu Jing Yang Xianxin Qiu Weixu Hu Jiade J.Lu | 2019 | Cancer Communications2019，39，1： | 3 |
| 6 | Image retrieval based on multi-concept detector and semantic correlation显示文摘With the rapid development of future network, there has been an explosive growth in multimedia data such as web images. Hence, an efficient image retrieval engine is necessary. Previous studies concentrate on the single concept image retrieval, which has limited practical usability. In practice, users always employ an Internet image retrieval system with multi-concept queries, but, the related existing approaches are often ineffective because the only combination of single-concept query techniques is adopted. At present semantic concept based multi-concept image retrieval is becoming an urgent issue to be solved. In this paper, a novel Multi-Concept image Retrieval Model(MCRM) based on the multi-concept detector is proposed, which takes a multi-concept as a whole and directly learns each multi-concept from the rearranged multi-concept training set. After the corresponding retrieval algorithm is presented, and the log-likelihood function of predictions is maximized by the gradient descent approach. Besides, semantic correlations among single-concepts and multiconcepts are employed to improve the retrieval performance, in which the semantic correlation probability is estimated with three correlation measures, and the visual evidence is expressed by Bayes theorem, estimated by Support Vector Machine(SVM). Experimental results on Corel and IAPR data sets show that the approach outperforms the state-of-the-arts. Furthermore, the model is beneficial for multi-concept retrieval and difficult retrieval with few relevant images. | XU HaiJiao HUANG ChangQin PAN Peng ZHAO GanSen XU ChunYan LU YanSheng CHEN Deng WU JiYi | 2015 | Science China Chemistry2015，58，12： | 3 |
| 7 | Hollow structured Cu@ZrO_(2) derived from Zr-MOF for selective hydrogenation of CO_(2) to methanol显示文摘The development of a highly efficient catalyst for CO_(2) activation and selective conversion to methanol is critical to address the issues associated with the high thermal stability of CO_(2) and controllable synthesis of methanol.Cu-based catalysts have been widely studied because of the low cost and excellent performance in mild conditions.However,the improvement of catalytic activity and selectivity remains challenging.Herein,we prepared hollow Cu@ZrO_(2) catalysts through pyrolysis of Cu-loaded Zr-MOF for CO_(2) hydrogenation to methanol.Low-temperature pyrolysis generated highly dispersed Cu nanoparticles with balanced Cu^(0)/Cu^(+)sites,larger amounts of surface basic sites and abundant Cu-ZrO_(2) interface in the hollow structure,contributing to enhanced catalytic capacity for adsorption/activation of CO_(2) and selective hydrogenation to methanol.In situ Fourier Transform Infrared Spectroscopy revealed the methanol formation followed the formate-intermediated pathway.This work would provide a guideline for the design of high-performance catalysts and the understanding of the mechanism and active sites for CO_(2) hydrogenation to methanol. | Xiaoyu Han Maoshuai Li Xiao Chang Ziwen Hao Jiyi Chen Yutong Pan Sibudjing Kawi Xinbin Ma | 2022 | Journal of Energy Chemistry2022，31，8： | 2 |
| 8 | Cloud Detection and Centroid Extraction of Laser Footprint Image of GF-7 Satellite Laser Altimetry显示文摘The laser altimeter loaded on the GaoFen-7(GF-7)satellite is designed to record the full waveform data and footprint image,which can obtain high-precision elevation control points for stereo image.The footprint camera equipped on the GF-7 laser altimetry system can capture the energy distribution at the time of laser emission and the image of the ground object where the laser falls,which can be used to judge whether the laser is affected by the cloud.At the same time,the centroid of laser spot on the footprint image can be extracted to monitor the change of laser pointing stability.In this manuscript,a data quality analysis scheme of laser altimetry based on footprint image is presented.Firstly,the cloud detection of footprint image is realized based on deep learning.The fusion result of the model is about 5%better than that of the traditional cloud detection algorithm,which can quickly and accurately determine whether the laser spot is affected by cloud.Secondly,according to the characteristics of footprint image,a threshold constrained ellipse fitting method for extracting the centroid of laser spot is proposed to monitor the pointing stability of long-period lasers.Based on the above method,the change of laser spot centroid since GF-7 satellite was put into operation is analyzed,and the conclusions obtained have certain reference significance for the quality control of satellite laser altimetry data and the analysis of pointing angle stability. | Jiaqi YAO Guoyuan LI Jiyi CHEN Genghua HUANG Xiongdan YANG Shuaitai ZHANG | 2021 | Journal of Geodesy and Geoinformation Science2021，4，3： | 2 |
| 9 | Controllable synthesis of nanosilica surface-grafted FMMA macromonomers via cata- lytic chain transfer polymerization显示文摘 | Zhen Lu Jiyi Wang Qing Li | 2009 | European Polymer Journal2009，45，： | 1 |
| 10 | Experimental studies on reburning of biomasses for redueing NO, in a drop tube furnace显示文摘 | Luan Jiyi Sun Rui Wu Shaohua | 2009 | Energy and Fuels2009，23，3： | 1 |
| 11 | Rapid synthesis of mesoporous ceria-zirconia solid solutions via a novel salt-assisted combustion process 显示文摘 | Chen Weifan Li Fengsheng Yu Jiyi Liu Leili Gao Hailian | 2006 | Materials Research Bulletin2006，41，12： | 1 |
| 12 | Application of Mobile Agent in Distance Educational Grid 显示文摘 | Wu Jiyi Huang Jiong | 2006 | Proceedings of 2006 International Conference on AI2006，，： | 1 |
| 13 | Experimental studies on reburning of biomasses for reducing NO, in a drop tube furnace 显示文摘 | LUAN Jiyi SUN Rui WU Shanhua | 2009 | Energy Fuels2009，23，： | 1 |
| 14 | Experimental studies on reburning of biomasses for reducing NOx in a drop tube furnace显示文摘 | Luan Jiyi Sun Rui Wu Shaohua | 2009 | Energy and Fuels2009，23，3： | 1 |
| 15 | Automated load curvedata cleansing in power systems 显示文摘 | Chen Jiyi Li Wenyuan Lau Af | 2010 | IEEE Trans on SmartGrid2010，1，2： | 1 |
| 16 | Automated load curve data cleansing in power systems显示文摘 | CHEN Jiyi LI Wenyuan LAU Adriel | 2010 | IEEE Trans on Smart Grids2010，1，2： | 1 |
| 17 | Controllable synthesis of nanosilica surface-grafted PMMA macromonomers via catalytic chain transfer polymerization 显示文摘 | Lu Zhen Wang Jiyi Chen Su | 2008 | European Polymer Journal2008，45，4： | 1 |
| 18 | Design and synthesis of microporous and micro/mesoporoussilica materials with excellent adsorption properties via self-assembly of silica species with tetraethyl ammonium in acidic aqueous media显示文摘 | JIYY WANG C Y ZOUYC SONG JW WANG JY LIF XIAO FS | 2008 | J Phys Chem C2008，112，19： | 1 |
| 19 | Diagnostic significance of hepatitis B viral antigens in patients with glomerulonephritis-associated hepatitis B virus infection显示文摘 | Chenggang Shi Jiyi Huang Xun Liu Xiaolin Zeng Cailian Cheng Qiongli Yin Mei Li Guifeng Cheng | 2012 | Diagnostic Microbiology & Infectious Disease2012，，2： | 1 |
| 20 | Effect of surface functionality of PAN-based carbon fibres on the mechanical performance of carbon/epoxy composites显示文摘 | Abdullah Kafi Mickey Huson Claudia Creighton Jiyi Khoo Luca Mazzola Thomas Gengenbach Frank Jones Bronwyn Fox | 2014 | Composites Science and Technology2014，，： | 1 |
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