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| 1 | Erucic acid from Isatis indigotica Fort. suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-kB and p38 MAPK pathway显示文摘Isatis indigotica Fort.(Ban-Lan-Gen)is an herbal medicine prescribed for influenza treatment.However,its active components and mode of action remain mostly unknown.In the present study,erucic acid was isolated from Isatis indigotica Fort.,and subsequently its underlying mechanism against influenza A virus(IAV)infection was investigated in vitro and in vivo.Our results demonstrated that erucic acid exhibited broad-spectrum antiviral activity against IAV resulting from reduction of viral polymerase transcription activity.Erucic acid was found to exert inhibitory effects on IAV or viral(v)RNA-induced pro-inflam-matory mediators as well as interferons(IFNs).The molecular mechanism by which erucic acid with antiviral and anti-inflammatory properties was attributed to inactivation of NF-kB and p38 MAPK signaling.Furthermore,the NF-kB and p38 MAPK inhibitory effect of erucic acid led to diminishing the transcriptional activity of interferon-stimulated gene factor 3(ISGF-3),and thereby reducing IAV-triggered pro-inflammatory response amplification in IFN-β-sensitized cells.Additionally,IAV-or vRNA-triggered apoptosis of alveolar epithelial A549 cells was prevented by erucic acid.In vivo,erucic acid administration consistently displayed decreased lung viral load and viral antigens expression.Meanwhile,erucic acid markedly reduced CD8+cytotoxic T lymphocyte(CTL)recruitment,pro-apoptotic signaling,hyperactivity of multiple signaling pathways,and exacerbated immune inflammation in the lung,which resulted in decreased lung injury and mortality in mice with a mouse-adapted A/FM/1/47-MA(H1N1)strain infection.Our findings provided a mechanistic basis for the action of erucic acid against IAV-mediated inflammation and injury,suggesting that erucic acid may have a therapeutic potential in the treatment of influenza. | Xiaoli Liang Yuan Huang Xiping Pan Yanbing Hao Xiaowei Chen Haiming Jiang Jing Li Beixian Zhou Zifeng Yang | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 10 |
| 2 | Synthesis and light-emitting properties of 2-(N-phenyl-α-naphthylamino) and 2-dimesitylboron-7-(N-phenyl-α-naphthylamino)-9,9-diethylfluorene显示文摘A fluorescent organic triarylamine with a symmetric structure, 2,7-bis(N-α-naphthyl-phenylamino)-9,9- diethylfluorene (NPAEF) was synthesized using two methods, modified Ullmann coupling and modified palladium-catalyzed amination. An activated copper and a combination of Pd(OAc)2/P(t-Bu)3 and Pd(dba)2/P(t-Bu)3 were selected as catalysts to improve yields of reactions. These synthetic procedures were also successfully applied to an asymmetric 2-dimesitylboron-7-(N-phenyl-α-naphthylamino)-9,9-diethylfluorene (BNPEF). Photoluminescent emission peaks in solid film and in diluted solution of NPAEF were both observed at 461 nm, while the main emission peaks of BNPEF appeared at 422 nm in hexane, and at 480 nm in methanol. The double emission peaks of BNPEF in hexane reflected fine structure in the vibrational state. With an increasing polarity of solvent, the main PL emission peaks were red-shifted and vibrational fine structure disappeared. Additionally, energy levels of NPAEF were investigated and an electroluminescence (EL) device of ITO/PVK:NPAEF/Al was fabricated, which showed a turn-on voltage of 9 V and peaked at 462 nm. The EL spectrum was in good agreement with PL spectrum, which indicated that they were from the same emitting center in the device. | ZHANG WenGuan HE ZhiQun HUI GuanBao MU LinPing WANG YongSheng ZHAO ShengMin JING XiPing | 2009 | Science China Chemistry2009，52，7： | 3 |
| 3 | Dielectric loss spectrum of ceramic MgTiO3 investigated by AC impedance and microwave resonator measurements 显示文摘 | KUANG Xiaojan JING Xiping | 2006 | J Am Ceram Soc2006，89，1： | 1 |
| 4 | Influence of fluoride on f- f transitions of Eu^3+ in LiEuM2O8 ( M = Mo, W) 显示文摘 | Jiaguo Wang Xiping Jing Chunhua Yan | 2006 | Journal of Luminescence2006，121，： | 1 |
| 5 | Ca1-2x EuxLixMoO4: a novel red phosphor for solid state hghting based on a GaN LED 显示文摘 | Wang Jiaguo Jing Xiping Yan Chunhua | 2005 | Electrochem soc2005，152，3： | 1 |
| 6 | Study on the broadband tonpilz transducer with a single hole显示文摘 | He Xiping Hu Jing | 2009 | Ultrasonics2009，49，： | 1 |
| 7 | Energy transfer among Ce3+,Eu2+and Mn2+in CaSiO3显示文摘 | YE Shi WANG Xiaoming JING Xiping | 2008 | Electrochem Soc2008，155，6： | 1 |
| 8 | Influence of fluoride on f-f transitions of Eu^3+ in LiEuM2O8 (M=Mo,W)显示文摘 | WANG Jiaguo JING Xiping YAN Chunhua | 2006 | J Lumin2006，121，： | 1 |
| 9 | Influence of fluoride on f-f transitions of Eu3+in LiEuM2O8(M=Mo,W)显示文摘 | WANG Jiaguo JING Xiping YAN Chunhua | 2006 | J Lumin2006，121，1： | 1 |
| 10 | The impact of Typhoon Lekima (2019) on East China: a postevent survey in Wenzhou City and Taizhou City显示文摘Typhoon Lekima(2019)struck Zhejiang Province on 10 August 2019 as a supertyphoon,which severely impacted Zhejiang Province.The typhoon killed 45 people and left three others missing,and the total economic loss reached 40.71 billion yuan.This paper reports a postdisaster survey that focuses on the storm precipitation,flooding,landslides,and weather services associated with Typhoon Lekima(2019)along the southeastern coastline of Zhejiang Province.The survey was conducted by a joint survey team from the Shanghai Typhoon Institute and local meteorological bureaus from 26 to 28 August,2019,approximately two weeks after the disaster.Based on this survey and subsequent analyses of the results,we hope to develop countermeasures to prevent future tragedies. | Cong ZHOU Peiyan CHEN Shifang YANG Feng ZHENG Hui YU Jie TANG Yi LU Guoming CHEN Xiaoqing LU Xiping ZHANG Jing SUN | 2022 | Frontiers of Earth Science2022，16，1： | 1 |
| 11 | Novel phosphors of Eu^3+ ; Tb^3+ or Bi^3+ activated Gd2GeO5显示文摘 | Guo Peimin Zhao Fei Li Guobao Liao Fuhui Tian Shujian Jing Xiping | 2003 | Journal of Luminescence2003，66，： | 1 |
| 12 | Influence of fluoride on f-f transitions of Eu3+ in LiEuM2O8 (M=Mo,W)显示文摘 | Wang Jiaguo Jing Xiping Yan Chunhua | 2006 | J Lumin2006，121，： | 1 |
| 13 | Somatic embryogenesis and plant regeneration in centipedegrass (Eremochloa ophiuroides [Munro] Hack.)显示文摘 | Mingxi Liu Jing Yang Shaoyun Lu Zhenfei Guo Xiping Lin Hong Wu | 2008 | In Vitro Cellular & Developmental Biology - Plant2008，，2： | 1 |
| 14 | Dielectric loss spectrum of ceramic MgTiO3 investigated by AC impedance and microwave resonator measurements 显示文摘 | KUANG Xiaojun JING Xiping | 2006 | J Am Ceram Soc2006，89，1： | 1 |
| 15 | Colloidal Gold Test Strip for the Detection of Fluoroquinolones in Foods Using an Analyzer显示文摘A test strip was developed to rapidly detect fluoroquinolones in foods by colloidal gold immunochromatography method in combination with a food safety analyzer. The results showed that the test strip has the detection sensitivity of 20 μg/L for enrofloxacin, sarafloxacin, difloxacin, ofloxacin, norfloxacin, ciprofloxacin, pefloxacin, flumequine and danofloxacin, and the detection sensitivity of 40 μg/L for enoxacin and oxolinic acid. The test strip consumes only 10 min for detection, and the false positive rate and the false negative rate are both zero. The test strip can accurately, reliably and easily detect residual fluoroquinolones in foods, and is suitable for on-site detection of a large number of samples. | Fangfang JIA Yuping WAN Linchen WANG Xiping WANG Zhaoqin WANG Fangyang HE Haifeng CUI Jing LI | 2019 | Agricultural Biotechnology2019，8，2： | 0 |
| 16 | Regeneration: making muscle from hPSCs显示文摘 | Xiping Zhu Lina Fu Fei Yi Guang-Hui Liu Alejandro Oeampo Jing Qu Juan Carlos Izpisua Belmontel | 2014 | Cell Research2014，24，10： | 0 |
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