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| 1 | Paleogene-Neogene stratigraphic realm and sedimentary sequence of the Qinghai-Tibet Plateau and their response to uplift of the plateau显示文摘Based on the data of 1:250000 geological mapping completed by CGS and the previous literature of the Cenozoic strata, 98 remnant basins and 5 stratigraphic realms with 13 stratigraphic subrealms have been recognized on the Qinghai-Tibet Plateau and its adjacent area. Through the research of the types of remnant basins, tectonic setting, stratigraphic sequence and sedimentary characteristics, contact relationship between the strata, the formation time and evolution history of sediments, we divided the uplift process and sedimentary response of the Qinghai-Tibet Plateau into 3 stages and 8 sub-stages, namely, subduction-collision uplift stage (65-34 Ma) with three sub-stages, intercontinental convergence and compressive uplift stage (34-13 Ma) with three sub-stages, and intercontinental isostatic adjustment uplift stage (since 13 Ma) with two sub-stages. | ZHANG KeXin WANG GuoCan JI JunLiang LUO ManSheng KOU XiaoHu WANG YueMing XU YaDong CHEN FenNing CHEN RuiMing SONG BoWen ZHANG JianYu LIANG YinPing | 2010 | Science China Earth Sciences2010，53，9： | 49 |
| 2 | Magnetostratigraphy and Anisotropy of Magnetic Susceptibility of the Lulehe Formation in the Northeastern Qaidam Basin显示文摘The timing of onset of deposition of the Lulehe Formation is a significant factor in understanding the genesis of the Qaidam basin and the evolution of the Tibetan Plateau. Here, we describe a detailed magnetostratigraphic and magnetic fabric study of the middle and lower parts of the Lulehe Formation. A total of 234 samples were collected from 117 sites throughout a thickness of almost 460 m of fluvial and lacustrine deposits at the Xitieshan section in the northeastern Qaidam basin. Out of these sites, 94 sites yielded well-defined characteristic remanent magnetization components by stepwise thermal demagnetization and were used to establish the magnetostratigraphy of the studied section. Based on correlation with the geomagnetic polarity timescale, the studied section spans the period from 53.8 Ma to 50.7 Ma. Our results show a three-fold decrease in sedimentation rates as well as marked change in facies from braided river to delta and shore-shallow lake around 52.6 Ma, which suggests tectonic uplift of the northeastern Qaidam basin margin ridge was rapid at the onset of formation of the Qaidam basin and subsequently weakened after 52.6 Ma. The anisotropy of magnetic susceptibility results indicate that tectonic compression stress had reached the northeastern Tibetan Plateau by the early stages of Indo-Eurasian plate collision and that the direction of stress in the study area was NE-SW. Furthermore, a weakening of tectonic compression stress around 52.6 Ma is consistent with sedimentary records. The age of initial deposition of the Qaidam basin (around 53.8 Ma) was almost synchronous with that of the Qiangtang, Hoh Xil, Xining, and Lanzhou basins, which implies that stress was transferred rapidly through the Tibetan Plateau during or immediately after the onset of Indo-Eurasian collision. | KE Xue JI Junliang ZHANG Kexin KOU Xiaohu SONG Bowen WANG Chaowen | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 18 |
| 3 | High-resolution carbon isotope record for the Paleocene-Eocene thermal maximum from the Nanyang Basin,Central China显示文摘古新始新世的热最大值(PETM ) 是全球温暖的一个短暂事件,与发生在古新 / 始新世的边界的巨大的大气的温室气体输入联系了。Biostratigraphic 和同位素 stratigraphic 研究显示 PETM 事件很好在 Nanyang 盆在 Yuhuangding 节的泥土存款被记录,华中,与碳同位素,在 19-m-thick 泥土以内的锝 ?.1 鈥 ? 的否定旅行扔。这是到目前为止在世界上发现的 PETM 的最高的分辨率记录。PETM 事件在 2-cm-thick 泥土沉积以内被触发,与未 1 3C (稳定的碳同位素比率) 从的减少 ? 3.2 鈥 ? 到 ? 5.2 鈥吗?为是的一个短暂时期建议一个巨大的甲烷水合物版本可能由一个灾难的事件引起了。在海洋、陆上的记录之间的比较为 PETM 事件显示鈥淭h ree 阶段模型鈥 ? 。开始在未 1 3C 记录有一次快速的否定旅行,由一个慢慢地减少的趋势,然后渐渐的积极恢复列在后面,相应分别地到海洋的甲烷水合物的快速的分离,由甲烷然后释放甲烷的消费的一个慢版本列在后面。 | ZHU Min DINGZhongLi WANG Xu CHEN ZuoLing JIANG HanChao DONG XinXin JI JunLiang TANG ZiHua LUO Pan | 2010 | Chinese Science Bulletin2010，55，31： | 6 |
| 4 | Sedimentary Evolution of the Qinghai-Tibet Plateau in Cenozoic and its Response to the Uplift of the Plateau显示文摘We have studied the evolution of the tectonic lithofacies paleogeography of Paleocene-Eocene, Oligocene, Miocene, and Pliocene of the Qinghai-Tibet Plateau by compiling data regarding the type, tectonic setting, and lithostratigraphic sequence of 98 remnant basins in the plateau area. Our results can be summarized as follows. (1) The Paleocene to Eocene is characterized by uplift and erosion in the Songpan-Garzê and Gangdisê belts, depression (lakes and pluvial plains) in eastern Tarim, Qaidam, Qiangtang, and Hoh Xil, and the Neo-Tethys Sea in the western and southern Qinghai-Tibet Plateau. (2) The Oligocene is characterized by uplift in the Gangdisê-Himalaya and Karakorum regions (marked by the absence of sedimentation), fluvial transport (originating eastward and flowing westward) in the Brahmaputra region (marked by the deposition of Dazhuka conglomerate), uplift and erosion in western Kunlun and Songpan-Garzê, and depression (lakes) in the Tarim, Qaidam, Qiangtang, and Hoh Xil. The Oligocene is further characterized by depressional littoral and neritic basins in southwestern Tarim, with marine facies deposition ceasing at the end of the Oligocene. (3) For the Miocene, a widespread regional unconformity (ca. 23 Ma) in and adjacent to the plateau indicates comprehensive uplift of the plateau. This period is characterized by depressions (lakes) in the Tarim, Qaidam, Xining-Nanzhou, Qiangtang, and Hoh Xil. Lacustrine facies deposition expanded to peak in and adjacent to the plateau ca. 18-13 Ma, and north-south fault basins formed in southern Tibet ca. 13-10 Ma. All of these features indicate that the plateau uplifted to its peak and began to collapse. (4) Uplift and erosion occurred during the Pliocene in most parts of the plateau, except in the Hoh Xil-Qiangtang, Tarim, and Qaidam. The continuous uplift and intensive taphrogeny in the plateau divided the original large basin into small basins, deposition of lacustrine facies decreased considerably, and boulderstone accumulated, indicating a response to the overall uplift of the plateau. Here, we discuss the evolution of tectonic lithofacies paleogeography in Cenozoic and its response to the tectonic uplift of the Qinghai-Tibet Plateau in relation to the above characteristics. We have recognized five major uplift events, which occurred during 58-53 Ma, 45-30 Ma, 25-20 Ma, 13-7 Ma, and since 5 Ma. The results presented here indicate that the paleogeomorphic configurations of the Qinghai-Tibet Plateau turned over during the late Miocene, with high elevations in the east during the pre-Miocene switching to high contours in the west at the end of Miocene. | ZHANG Kexin WANG Guocan XU Yadong LUO Mansheng JI Junliang XIAO Guoqiao WANG An SONG Bowen LIANG Yinpin JIANG Shangsong CAO Kai CHEN Fenning CHEN Ruiming YANG Yongfeng | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 6 |
| 5 | Cenozoic Evolution of Sediments and Climate Change and Response to Tectonic Uplift of the Northeastern Tibetan Plateau显示文摘Through a comprehensive study of magnetostratigraphy and sedimentology of several basins in the northeastern Tibetan Plateau, we reveal that the study area mainly experienced six tectonic uplift stages at approximately 52 Ma, 34–30 Ma, 24–20 Ma, 16–12 Ma, 8–6 Ma, and 3.6–2.6 Ma. Comprehensive analyses of pollen assemblages from the Qaidam, Linxia, Xining, and West Jiuquan Basins show that the northeastern Tibetan Plateau has undergone six major changes in vegetation types and climate: 50–40 Ma for the warm-humid forest vegetation, 40–23 Ma for the warm-arid and temperate-arid forest steppe vegetation, 23–18.6 Ma for the warm-humid and temperatehumid forest vegetation, 18.6–8.5 Ma for the warm-humid and cool-humid forest steppe vegetation, 8.6–5 Ma for the temperate sub-humid savanna steppe vegetation, and 5–1.8 Ma for the cold-arid steppe vegetation. Comprehensive comparisons of tectonic uplift events inferred from sedimentary records, climatic changes inferred from pollen, and global climate changes show that in the northeastern Tibetan Plateau the climate in the Paleogene at low altitude was mainly controlled by the global climate change, while that in the Neogene interval with high altitude landscapes of mountains and basins is more controlled by altitude and morphology. | LIANG Xia JI Junliang LU Jingfang KE Xue AI Keke XU Yadong SONG Bowen | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 5 |
| 6 | Synchronous drying and cooling in central Asia duringlate Oligocene显示文摘Aridification of central Asia during late Oligocene and Early Miocene has been documented by numerous eolian records from the North Pacific and central Asia. However, direct evidence of aridity from the interior of the arid zone is still rather scarce. To better reconstruct the climate history in central Asia during the late Oligocene, we have analyzed ostracod assemblages and gypsum content in the sediments from the lacustrine Jingou River section in the northern Tianshan Mountains. Our results show that the cold water species Candona cf. Neglecta and Pseudocandona albicans replaced the warm water species Ilyocypris bradyi and Ilyocypris sp. to become the dominant species at 23.8 Ma, indicating significant cooling in central Asia at that time. At the same time, a substantial increase in gypsum content indicates the intensification of central Asian drying. The synchronous cooling and drying approximately coincided with the Oi2b.1 and/or Mi1 events, implying a causal linkage between late Oligocene global cooling and central Asian aridity. | DONG XinXin DING ZhongLi YANG ShiLing LUO Pan WANG Xu JI JunLiang | 2013 | Chinese Science Bulletin2013，58，25： | 3 |
| 7 | The Mid-Miocene Pollen Record of the Xunhua Basin, NE Tibetan Plateau: Implications for Global Climate Change显示文摘The northeastern Tibetan Plateau is located at the convergence of the Asian winter and summer monsoons and westerlies; thus, this area has witnessed historic climate changes.The Xunhua basin is an intermontane basin on the northeastern margin of the Tibetan Plateau.The basin contains more than 2000 m of Cenozoic fluvial–lacustrine sediments, recording a long history of climate and environmental changes.We collected the mid-Miocene sediments from the Xunhua basin and used palynological methods to discuss the relationship between aridification in the interior of Asia, global cooling, and uplift of the Tibetan Plateau.Based on the palynological analysis of the Xigou section, Xunhua basin, the palynological diagram is subdivided into three pollen zones and past vegetation and climate are reconstructed.Zone I, Ephedripites–Nitraridites–Chenopodipollis–Quercoidites(14.0–12.5 Ma), represents mixed shrub–steppe vegetation with a dry and cold climate.In zone II, Pinaceae–Betulaepollenites–Ephedripites–Chenopodipollis–Graminidites(12.5–8.0 Ma), the vegetation and climate conditions improved, even though the vegetation was still dominated by shrub–steppe taxa.Zone III, Ephedripites–Nitrariadites–Chenopodipollis(8.0–5.0 Ma), represents desert steppe vegetation with drier and colder climate.The palynological records suggest that shrub–steppe dominated the whole Xigou section and the content gradually increased, implying a protracted aridification process, although there was an obvious climate improvement during 12.5–8.0 Ma.The aridification in the Xunhua basin and surrounding mountains during 14.0–12.5 Ma was probably related to global cooling induced by the rapid expansion of the East Antarctic ice-sheets and the relatively higher evaporation rate.During the 12.5–8.0 Ma period, although topographic changes(uplift of Jishi Shan) decreased precipitation and strengthened aridification in the Xunhua basin on leeward slopes, the improved vegetation and climate conditions were probably controlled by the decrease in evaporation rates as a result of continuous cooling.From 8.0 to 5.0 Ma, the rapid development of the desert steppe can be attributed to global cooling and uplift of the Tibetan Plateau. | XU Zenglian ZHANG Jianyu JI Junliang ZHANG Kexin | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 3 |
| 8 | Occurrence of Middle Miocene Fossil Cyprinid Fish in the Northern Qaidam Basin and its Paleoenvironmental Implications显示文摘With a thick sequence of early Eocene to Pleistocene terrestrial records, the Qaidam Basin on the northern Tibetan Plateau provides an important sedimentary archive for understanding the paleoenvironmental evolution of the northeast Tibetan Plateau. In this study, specimens of fossil fish remains are collected from the late Middle Miocene(Serravallian, ~12 Ma) of the middle member of the Shang Youshashan Formation, Dahonggou(DHG) section, in the northern Qaidam Basin. Based on a systematic study of these materials, the remains have assigned to Cyprinidae, with typical pharyngeal teeth and dorsal fin spines with serrations on the posterior edge. Our discovery improves understanding of the cyprinid fish distribution characteristics in the Qaidam Basin during the Cenozoic. Cooccurrences of terrestrial brackish ostracod species Cyprideis and long chain alkenonesin the layer indicate that the studied cyprinid fish lived in a generally large brackish to saline water body during the late middle Miocene(Serravallian), when the climate of Qaidam Basin was still not sufficiently dry to form an extreme saline water lake. | SONG Bowen ZHANG Kexin JI Junliang HAN Fang WANG Chaowen WANG Jiaxuan AI Keke | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 3 |
| 9 | Late Pleistocene sedimentary sequences and paleoclimate changes in Xunhua basin in the upper reach of Yellow River in China显示文摘黄河的第三个平台很好在西藏的高原的东北方边缘在 Xunhua 盆被开发。平台在 ca 被形成由光学地刺激的光(OSL ) 同样过时的 75 ka 方法。根据谷物尺寸,磁性的危险性和 palynological 数据,气候的变化的六个事件在 Xunhua 盆被识别;他们在 120-114 ka 期间包括很温暖、潮湿的时期,冷却并且弄干在 114-105 ka 期间的时期,温暖、潮湿的时期在 105-98 ka 期间,逐渐地在 98-85 ka 期间使时期凉下来,温暖、潮湿的时期在 85-75 ka 期间,很冷、干燥的时期在 75-63 ka 期间。在 Xunhua 盆记录的气候的变化的六个阶段对应于 5e 的海洋的氧同位素阶段(MIS ) , 5d, 5c, 5b, 5a 并且 4,分别地[出版摘要] | Fang HAN Kexin ZHANG Junliang JI Yadong XU Fenning CHEN Xiaohu KOU | 2012 | Frontiers of Earth Science2012，6，3： | 1 |
| 10 | Ultra-high rates of loess sedimentation at Zhengzhou since Stage 7: Implication for the Yellow River erosion of the Sanmen Gorge 显示文摘 | Zheng Hongbo Huang Xiangtong Ji Junliang | 2007 | Geomorphology2007，85，13： | 1 |
| 11 | Partial delamination of the organo-montmorillonite with surfactant containing hydroxyl groups in maleated poly(propylene carbonate)显示文摘 | Zhihao Zhang Qiang Shi Juan Peng Jianbin Song Qingyong Chen Junliang Yang Yumei Gong Ronghua Ji Xiaofeng He Joong-Hee Lee | 2006 | Polymer2006，，26： | 1 |
| 12 | Paleomagnetic constraints on Paleogene-Neogene rotation and paleo-stress in the northern Qaidam Basin显示文摘Knowing the rotation and paleo-stress history in Qaidam Basin is a fundamental parameter to quantify the mechanism of intracontinental deformation in Tibetan Plateau.However,few studies have been conducted on tectonic rotation and stress evolution over long timescales in the Qaidam Basin.Here,we report new magnetic declination and the anisotropy of magnetic susceptibility(AMS)from a~52–7 Ma sequence of fluvial and lacustrine sediments in the Dahonggou(DHG)section in the northern Qaidam Basin.The magnetic declination revealed that the northern Qaidam Basin underwent a clockwise rotation 25.1°±8.6°during~33–17 Ma,followed by a counterclockwise rotation 16.9°±6.8°during~17–13.5 Ma.The AMS results showed that the“earliest deformation”fabrics were interrupted by the“pencil structure”fabrics in the intervals of~52–45 and~21–15 Ma.The interruption,synchronous with the marked deceleration of the India-Asia convergence rate,indicates pulse of strong tectonic compressive stress.In addition,the AMS results documented a transition in stress direction from S-N to SW-NE at~15 Ma,suggesting a kinematic shift in the northeastern TP.Our constraints on the rotation and stress from the northern Qaidam Basin support the two-stage evolution of the Altyn Tagh Fault(ATF).The fast-rate slip motion on the ATF during the early Oligocene caused the clockwise rotation in the northern Qaidam Basin;the second stage with enhanced thrusting since the middle Miocene caused extensive crustal shortening and dispersive NW-trending folds and faults in the Qaidam Basin and the northeastern TP. | Ling SUN Junliang JI Bingshuai LI Xingbo LI Wujun WU Kexin ZHANG | 2022 | Science China Earth Sciences2022，65，12： | 1 |
| 13 | Response of C:N:P in the plant-soil system and stoichiometric homeostasis of Nitraria tangutorum leaves in the oasis-desert ecotone,Northwest China显示文摘Nitraria tangutorum nebkhas are widely distributed in the arid and semi-arid desert areas of China.The formation and development of N.tangutorum nebkhas are the result of the interaction between vegetation and the surrounding environment in the process of community succession.Different successional stages of N.tangutorum nebkhas result in differences in the community structure and composition,thereby strongly affecting the distribution of soil nutrients and ecosystem stability.However,the ecological stoichiometry of N.tangutorum nebkhas in different successional stages remains poorly understood.Understanding the stoichiometric homeostasis of N.tangutorum could provide insights into its adaptability to the arid and semi-arid desert environments.Therefore,we analyzed the stoichiometric characteristics of N.tangutorum in four successional stages,i.e.,rudimental,developing,stabilizing,and degrading stages using a homeostasis model in an oasis-desert ecotone of Northwest China.The results showed that soil organic carbon(SOC),total nitrogen(TN),and total phosphorus(TP)contents and their ratios in the 0-100 cm soil depth were significantly lower than the averages at regional and global scales and were weakly influenced by successional stages in the oasis-desert ecotone.TN and TP contents and C:N:P in the soil showed similar trends.Total carbon(TC)and TN contents in leaves were 450.69-481.07 and 19.72-29.35 g/kg,respectively,indicating that leaves of N.tangutorum shrubs had a high storage capacity for C and N.Leaf TC and TN contents and N:P ratio increased from the rudimental stage to the stabilizing stage and then decreased in the degrading stage,while the reverse trend was found for leaf C:N.Leaf TP content decreased from the rudimental stage to the degrading stage and changed significantly in late successional stages.N:P ratio was above the theoretical limit of 14,indicating that the growth of N.tangutorum shrubs was limited by P during successional stages.Leaf N,P,and N:P homeostasis in four successional stages was identified as''strictly homeostasis''.Redundancy analysis(RDA)revealed that soil acidity(pH)and the maximum water holding capacity were the main factors affecting C:N:P stoichiometric characteristics in N.tangutorum leaves.Our study demonstrated that N.tangutorum with a high degree of stoichiometric homeostasis could better cope with the arid desert environment. | WEI Yajuan DANG Xiaohong WANG Ji GAO Junliang GAO Yan | 2021 | Journal of Arid Land2021，13，9： | 1 |
| 14 | Ming-Phos/Gold(Ⅰ)-Catalyzed Stereodivergent Synthesis of Highly Substituted Furo[3,4-d][i,2]oxazines显示文摘A gold(Ⅰ)-catalyzed asymmetric intermolecular tandem[3+3]-cyclization reaction of 2-(l-alkynyl)-2-alken-l-ones with nitrones has been developed by using Ming-Phos as a chiral ligand.This method enables access to the stereodivergent synthesis of highly substituted furo[3,4-d][l,2]oxazines in excellent efficiency and stereoselectivity(up to 99% yield,99% ee,>20:1 dr). | Lujia Zhou Bing Xu Danting Ji Zhan-Ming Zhang Junliang Zhang | 2020 | Chinese Journal of Chemistry2020，38，6： | 0 |
| 15 | Training Strategies for Applied German-speaking Talents in the'One Belt One Road'Initiative显示文摘Under the'One Belt One Road”initiative,China and Germany have become closer in cooperation and have made substantial progress in the fields of economy,trade,culture,science,and technology.The close cooperation between China and Germany has raised the demands for diversified German-speaking talents.After years of development and continuous exploration,China's educational institutions with German majors have established a mature talent training model but it is not enough to meet the country's growing demands for applied talents along with the economic development.With the advancement of the national education reform,many majors in various schools are thinking of reform plans suitable for their own development.Although German as a uminor^^language major is not very widely used,it plays an active and effective role in China's trade and cultural exchanges.Hence,there is a need to comprehensively improve students9 overall quality,advocate diversified training methods,adopt German-English bilingualism and professional German teaching methods,increase the cooperation of education between companies and institutions,as well as strive to train more applied German-speaking talents for the country. | Junliang Ji | 2021 | Journal of Contemporary Educational Research2021，5，7： | 0 |
| 16 | Synthesis,DNA binding and cleavage studies of the copper(Ⅱ) complexes of PNA-cyclen conjugates显示文摘Two dinucleotide PNA-cyclen copper(II) complexes with α-PNA (P1) and classical PNA (P2) backbones were synthesized and characterized.The interactions between title complexes and DNA were investigated under physiological conditions.Fluorescence studies indicate that the binding ability of complex P1 to CT-DNA is as twice as that of P2.DNA melting experiments were also carried out and the results show that ΔTm caused by P1 is higher than that caused by P2.Agarose gel electrophoresis experiments demonstrate that P1 is an excellent chemical nuclease,which can cleavage plasmid DNA completely in 12 h. | ZHANG Yu HUANG Yu ZHANG Ji ZHANG DaWei LIU JunLiang LIU Qiang LIN HongHui YU XiaoQi | 2011 | Science China Chemistry2011，54，1： | 0 |
| 17 | Development of environment-insensitive and highly emissive BODIPYs via installation of N,N'-dialkylsubstituted amide at meso position显示文摘Fluorescent dyes play a crucial role in fluorescence imaging and sensing technology.However,there is a dilemma that they are usually intrinsically hydrophobic which lacks of emission in water and modification with ionic groups to access water solubility may result in poor membrane permeability.Fluorescent dyes with strong fluorescence emission in both nonpolar and polar solvents are highly desirable.In this manuscript,we reported a strategy to develop fluorescent BODIPY dyes via installation of amide moiety at meso position of 1,3,5,7-tetramethyl-BODIPY and discovered that N,N'-dialkylsubstituted BODIPY amides possessed highly fluorescent emission with favorable environment-insensitive properties. | Junping Bai Junliang Zhou Xin Ji Nannan Wang Xiaochun Dong Wei Wu Weili Zhao | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 18 | Research on German Translation from a Cross-cultural Perspective显示文摘Translation is a kind of cross-cultural propagation process and communication activity.When there is culture,there will be cultural propagation.The propagation of foreign cultures belongs to cross-language propagation and must be achieved through translation.It can be said that without translation,there will be no propagation of foreign cultures,and various cultures cannot be better integrated and developed.Whether it was the Renaissance in Europe or the spread of Western learning in the late Ming and early Qing dynasties,they all fully explained the huge effects yielded by translation in the development of social culture. | Junliang Ji | 2021 | Journal of Contemporary Educational Research2021，5，1： | 0 |
| 19 | Clinical Epidemiology,Illness Profiles,and the Implication of COVID-19 Before and After the Nationwide Omicron Outbreak During the Winter of 2022显示文摘China.In this study,we aimed to investigate the clinical characteristics and outcomes of patients with coronavirus disease 2019(COVID-19)in the Beijing region.Methods:In this retrospective study,we enrolled inpatients admitted for COVID-19 in the Fifth Medical Center of Chinese PLA General Hospital in Beijing between November 10,2022,and January 30,2023.Demographic and clinical features and treatment outcomeswere comprehensively analyzed.We used logistic regression and linear regression analyses to explore the risk factors associated with disease severity and time of nucleic acid conversion,respectively.Results:A total of 1010 hospitalized patients with COVID-19 were enrolled.The median age was 43.0 years(interquartile range,28.0–63.0),and patients aged<60 years and≥60 years comprised 71.2%and 28.8%of total included patients,respectively.The clinical classification of mild(74.6%,753/1010),moderate(21.0%,212/1010),severe(2.7%,27/1010),and unidentified(1.8%,18/1010)was separately recorded;1005 patients were discharged,and 5 patients died in the hospital.The outbreak of the emerging epidemic witnessed an evident increase in the proportion of moderate(42.9%vs.16.4%)and severe(10.3%vs.1.1%)cases after December 7,2022.Patients with a moderate/severe classification had higher levels of procalcitonin,IL-6,serum ferritin,C-reactive protein,lactic dehydrogenase,serum urea nitrogen,and D-dimer and lower counts of CD4+T,CD8+T,and B cells(all P<0.001).Multivariable regression analysis revealed that increased odds of disease severity were associated with the following factors:age≥60 years,IL-6>7 pg/mL,lactic dehydrogenase level>245 U/L,cough,and fever at admission.Age≥80 years and chronic lung diseasewere independent risk factors in the nonmild group in elderly patients.In addition,the duration for nucleic acid to turn negativewas approximately 5.0 d(interquartile range,3.0–7.0).Prolonged time of nucleic acid conversion was associated with age≥60 years,serum urea nitrogen level>8.2 mmol/L,neutrophil count>7×10^(9)/L,and the presence of a chronic lung disease or carcinoma.Finally,unvaccinated patients accounted for 37.3%of enrolled patients;children and the elder people accounted for approximately half of that.The univariable analysis found that booster doses reduced disease severity and shortened the time of nucleic acid conversion in elderly patients.Conclusions:The outbreak ofOmicron rapidly increased the number of patientswith COVID-19 in Beijing.In elderly patients,booster doses may reduce disease severity and shorten the time of nucleic acid conversion.Healthcare systems should be optimized before an emerging epidemic outbreak. | Yuming Guo Zhe Xu Wen-Xin Wang Cheng Zhen Jinhua Hu Jinsong Mu Chengcheng Ji Xin Yuan Ruonan Xu Lei Huang Lei Shi Fanping Meng Junliang Fu Shuangnan Zhou Siyu Wang Fengyi Li Bo Tu Dawei Zhang Huihuang Huang Yufeng Mao Wen Xu Chao Zhang Xiuying Mu Jun Zhao Bo Jin Haibin Su Yinying Lu Yongqian Cheng Dong Ji Shaoli You Jinghui Dong Changchun Liu Mengmeng Zhang Yuanyuan Li Tianjun Jiang Yonggang Li Fu-Sheng Wang | 2023 | Infectious Diseases & Immunity2023，3，4： | 0 |
| 20 | Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2显示文摘Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2.Here we report that nelfinavir,an FDA approved drug for the treatment of HIV infection,is effective against SARS-CoV-2 and COVID-19.Preincubation of nelfinavir could inhibit the activity of the main protease of the SARS-CoV-2(IC50=8.26μM),while its antiviral activity in Vero E6 cells against a clinical isolate of SARS-CoV-2 was determined to be 2.93μM(EC50).In comparison with vehicle-treated animals,rhesus macaque prophylactically treated with nelfinavir had significantly lower temperature and significantly reduced virus loads in the nasal and anal swabs of the animals.At necropsy,nelfinavir-treated animals had a significant reduction of the viral replication in the lungs by nearly three orders of magnitude.A prospective clinic study with 37 enrolled treatment-naive patients at Shanghai Public Health Clinical Center,which were randomized(1:1)to nelfinavir and control groups,showed that the nelfinavir treatment could shorten the duration of viral shedding by 5.5 days(9.0 vs.14.5 days,P=0.055)and the duration of fever time by 3.8 days(2.8 vs.6.6 days,P=0.014)in mild/moderate COVID-19 patients.The antiviral efficiency and clinical benefits in rhesus macaque model and in COVID-19 patients,together with its well-established good safety profile in almost all ages and during pregnancy,indicated that nelfinavir is a highly promising medication with the potential of preventative effect for the treatment of COVID-19. | Zhijian Xu Danrong Shi Jian-Bao Han Yun Ling Xiangrui Jiang Xiangyun Lu Chuan Li Likun Gong Guangbo Ge Yani Zhang Yi Zang Tian-Zhang Song Xiao-Li Feng Ren-Rong Tian Jia Ji Miaojin Zhu Nanping Wu Chunhui Wu Zhen Wang Yechun Xu Cheng Peng Min Zheng Junling Yang Feifei Du Junliang Wu Peipei Wang Jingshan Shen Jianliang Zhang Yong-Tang Zheng Hangping Yao Weiliang Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
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