|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors:Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take'toll'?显示文摘煽动性的肠疾病(IBD ) 的致病仅仅部分被理解。各种各样环境并且主人(例如基因 -- ,上皮 -- ,有免疫力、非有免疫力) 因素被包含。它是有可能的基因异质的多因素的复合基因疾病。一些基因自己与 IBD 被联系,当其它增加 ulcerative (UC ) 或 Crohn 的疾病(CD ) 的风险或与疾病地点或行为被联系时。这评论在 IBD 的遗传探讨最近的进展。文章在在微生物引起、基因的因素之间的串音上讨论当前的信息(例如 NOD2/CARD15, SLC22A46A5 和 DLG5 ) 。在理解 IBD 和罐头的致病在最近的年帮助获得的基因数据为治疗学的干预识别很多个潜在的目标。以后,遗传可以更精确地帮助在 IBD 诊断并且预言疾病路线。 | Peter Laszlo Lakatos Simon Fischer Janos Papp Laszlo Lakatos Istvan Gal | 2006 | World Journal of Gastroenterology2006，12，12： | 18 |
| 2 | Perianal disease,small bowel disease,smoking,prior steroid or early azathioprine/biological therapy are predictors of disease behavior change in patients with Crohn's disease显示文摘AIM:To assess the combined effect of disease phenotype, smoking and medical therapy [steroid, azathioprine(AZA), AZA/biological therapy] on the probability of disease behavior change in a Caucasian cohort of patients with Crohn's disease(CD).METHODS:Three hundred and forty well-characterized, unrelated, consecutive CD patients were analyzed(M/F:155/185, duration:9.4 ± 7.5 years) with a complete clinical follow-up.Medical records including disease phenotype according to the Montreal classification, extraintestinal manifestations, use of medications and surgical events were analyzed retrospectively.Patients were interviewed on their smoking habits at the time of diagnosis and during the regular follow-up visits.RESULTS:A change in disease behavior was observed in 30.8% of patients with an initially non-stricturing, non-penetrating disease behavior after a mean diseaseduration of 9.0 ± 7.2 years.In a logistic regression analysis corrected for disease duration, perianal disease, smoking, steroid use, early AZA or AZA/ biological therapy use were independent predictors of disease behavior change.In a subsequent Kaplan-Meier survival analysis and a proportional Cox regression analysis, disease location(P = 0.001), presence of perianal disease(P < 0.001), prior steroid use(P = 0.006), early AZA(P = 0.005) or AZA/biological therapy(P = 0.002), or smoking(P = 0.032) were independent predictors of disease behavior change.CONCLUSION:Our data suggest that perianal disease, small bowel disease, smoking, prior steroid use, early AZA or AZA/biological therapy are all predictors of disease behavior change in CD patients. | Peter Laszlo Lakatos Zsofia Czegledi Tamas Szamosi Janos Banai Gyula David Ferenc Zsigmond Tunde Pandur Zsuzsanna Erdelyi Orsolya Gemela Janos Papp Laszlo Lakatos | 2009 | World Journal of Gastroenterology2009，15，28： | 14 |
| 3 | Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations显示文摘AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD.METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing highperformance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP.RESULTS: NOD2/CARD15 mutations were found in 185patients (35.1%) and in 33 controls (16.5%, P<0.0001).SNP8/R702W (10.8% vs 6%, P = 0.02), SNP13/3020insC (19.4% vs 5%, P<0.0001) and exon4 R703C (2.1% vs 0%, P = 0.02) mutations were more frequent in CD, while the frequency of SNP12/G908R was not increased. The frequency of TLR4 D299G was not different (CD: 9.9% vscontrols: 12.0%). Variant NOD2/CARD15 allele was associated with an increased risk for CD (ORhet = 1.71,95%CI = 1.12-2.6, P= 0.0001, ORtwo-riskalleles = 25.2,95%CI = 4.37- , P<0.0001), early disease onset (carrier:26.4 years vs non-carrier: 29.8 years, P = 0.0006), ileal disease (81.9% vs 69.5%, OR = 1.99, 95%CI = 1.29-3.08,P = 0.02, presence of NOD2/CARD15 and TLR4: 86.7% vs64.8%), stricturing behavior (OR = 1.69, 95%CI = 1.13-2.55,P = 0.026) and increased need for resection (OR=1.71,95%CI: 1.13-2.62, P= 0.01), but not with duration, extraintestinal manifestations, familial disease or smoking. TLR4exhibited a modifier effect: age of onset in wt/TLR4 D299G carriers: 27.4 years vs NOD2mut/TLR D299G: 23 years (P= 0.06), in NOD2mut/wt: 26.7 years.CONCLUSION: These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease,stricturing disease behavior in Hungarian CD patients. In contrast, although the frequency of TLR4 D299G polymorphism was not different from controls, NOD2/TLR4mutation carriers tended to present at earlier age. | Peter Laszlo Lakatos Laszlo Lakatos Ferenc Szalay Claudia Willheim-Polli Christoph (O|¨)sterreicher Zsolt Tulassay Tamas Molnar Walter Reinisch Janos Papp Gyula Mozsik Hungarian IBD Study Group Peter Ferenci | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 4 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats显示文摘瞄准:决定 melatonin 预告的处理的效果并且在 L 精氨酸(L-Arg ) 的严厉上处理以后在老鼠的导致的试验性的胰腺炎。方法:男 Wistar 老鼠(25 ) 被划分成五个组。那些在 1h 的间隔在组 A 收到了 3.2g/kg 体重 L-Arg i.p 的二注射。在组麻省,老鼠与 50 mg/kg 体重 melatonin i.p 被对待在 L-Arg 管理以前的 30 min。在组 AM,在 L-Arg 被给以后,老鼠收到了 melatonin 1h 的一样的剂量。在组 M, melatonin 的单次量是以前描述了被管理。在组 C,对照动物收到了生理盐水注射 i.p 所有老鼠被给在第二 L-Arg 注射以后的 24 h。结果:引起严重引起坏死胰腺炎的 L-Arg 管理在浆液淀粉酶水平,胰腺的重量 / 身体重量比率(pw/bw ) ,胰腺的 IL-6 内容和 myeloperoxidase 由重要举起证实了活动,相对控制值。浆液淀粉酶水平的举起显著地在与仅仅与 L-Arg 注射的老鼠相比给 melatonin 追随者 L-Arg 的老鼠被减少。胰腺的抗氧化剂酶(Cu/Zn-superoxide 歧化酶(Cu/Zn-SOD ) 和过氧化氢酶(猫)) 的活动显著地被增加在胰腺炎以后的 24 h 感应。显著地在 L-Arg 之前给的 Melatonin 在独自与 L-Arg 对待的老鼠相对那减少了胰腺的猫活动。在肝, L-Arg 显著地每氧化水平,和谷胱甘肽过氧化物酶和 Cu/Zn-SOD 活动增加了类脂化合物,而 Mn 草皮活动作为与控制老鼠相比被减少。Melatonin 预告的处理阻止了这些变化。结论:Melatonin 是能在尖锐胰腺炎期间抵抗一些 L-Arg-induced 变化的一种抗氧化剂,并且可能因此在有尖锐引起坏死胰腺炎的病人的支持的治疗有用。 | Annamaria Szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga Katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas Takacs | 2006 | World Journal of Gastroenterology2006，12，2： | 13 |
| 5 | Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families:Implications for genetic testing显示文摘AIM: To analyze the prevalence of germline MLH1 and MSH2 gene mutations and evaluate the clinical characteristics of Hungarian hereditary non-polyposis colorectal cancer (HNPCC) families. METHODS: Thirty-six kindreds were tested for mutations using conformation sensitive gel electrophoreses, direct sequencing and also screening for genomic rearrangements applying multiplex ligation-dependent probe amplifi cation (MLPA). RESULTS: Eighteen germline mutations (50%) were identifi ed, 9 in MLH1 and 9 in MSH2. Sixteen of these sequence alterations were considered pathogenic, the remaining two were non-conservative missense alterations occurring at highly conserved functional motifs. The majority of the defi nite pathogenic mutations (81%, 13/16) were found in families fulfilling the stringent Amsterdam Ⅰ/Ⅱ criteria, including three rearrangements revealed by MLPA (two in MSH2 and one in MLH1). However, in three out of sixteen HNPCC-suspected families (19%), a disease-causing alteration could be revealed. Furthermore, nine mutations described here are novel, and none of the sequence changes were found in more than one family.CONCLUSION: Our study describes for the f irst time the prevalence and spectrum of germline mismatch repair gene mutations in Hungarian HNPCC and suspected-HNPCC families. The results presented here suggest that clinical selection criteria should be relaxed and detection of genomic rearrangements should be included in genetic screening in this population. | Janos Papp Marietta E Kovacs Edith Olah | 2007 | World Journal of Gastroenterology2007，13，19： | 9 |
| 6 | RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells显示文摘LIN28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells and developing tissues.Increasing evidence demonstrates that LIN28B is activated in cancer and serves as a critical oncogene.However,the underlying molecular mechanisms of LIN28B function in tumorigenesis are still largely unknown.Here we report that LIN28B was expressed in over half of the patients with epithelial ovarian cancer who were examined(n=584).Functional experiments demonstrated that LIN28B inhibited ovarian cancer cell apoptosis.Furthermore,we showed that the proapoptotic factor BIM played an essential role in the antiapoptotic function of LIN28B.RNA-IP microarray analysis suggested that LIN28B binds to mRNAs that are associated with the DNA damage pathway,such as AKT2,in ovarian cancer cells.By binding to AKT2 mRNA and enhancing its protein expression,LIN28B regulated FOXO3A protein phosphorylation and decreased the transcriptional level of BIM,which antagonized the antiapoptosis activity of LIN28B.Taken together,these results mechanistically linked LIN28B and the AKT2/FOXO3A/BIM axis to the apoptosis pathway.The findings may have important implications in the diagnosis and therapeutics of ovarian cancer. | Xiaojuan Lin Jianfeng Shen Dan Peng Xinhong He Congjian Xu Xiaojun Chen Janos LTanyi Kathleen Montone Yi Fan Qihong Huang Lin Zhang Xiaomin Zhong | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 8 |
| 7 | 改性γ-聚谷氨酸去除重金属Pb^(2+)性能研究显示文摘研究了不同改性水平的γ-聚谷氨酸(以下简写为γ-PGA)吸附去除水体中重金属离子Pb2+的性能影响。研究结果表明,交联改性后的γ-PGA与未改性的γ-PGA相比,具有更好的Pb2+吸附性能,在将改性γ-PGA加入到含有Pb2+的水体中并均匀混合之后,随着交联度的提高,改性γ-PGA吸附Pb2+的性能逐渐增加,但在吸附最终结束时,不同改性的γ-PGA对Pb2+吸附去除率均在99%以上。在吸附去除Pb2+影响因素分析中发现Pb2+初始质量浓度和溶液pH对不同改性的γ-PGA吸附去除Pb2+性能的影响较大。随着Pb2+质量浓度的增加,不同改性水平γ-PGA对Pb2+的去除率均略有一定程度的下降。当溶液的pH控制在中性或者偏碱性时,25%改性γ-PGA对Pb2+的去除率能够保持在99%以上,当pH降至4.5和3时,Pb2+去除率分别降为90.76%和78.46%。 | 史伟 任蓉 Hajdu Istvan Janos Borbely | 2012 | 水处理技术2012，38，8： | 6 |
| 8 | BLOC-2 subunit HPS6 deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells显示文摘Hermansky-Pudlak syndrome(HPS) is a recessive disorder with bleeding diathesis, which has been linked to platelet granule defects. Both platelet granules and endothelial Weibel-Palade bodies(WPBs)are members of lysosome-related organelles(LROs) whose formation is regulated by HPS protein associated complexes such as BLOC(biogenesis of lysosome-related organelles complex)-1,-2,-3, AP-3(adaptor protein complex-3) and HOPS(homotypic fusion and protein sorting complex). Von Willebrand factor(VWF) is critical to hemostasis, which is stored in a highly-multimerized form as tubules in the WPBs. In this study, we found the defective, but varying, release of VWF into plasma after desmopressin(DDAVP) stimulation in HPS1(BLOC-3 subunit), HPS6(BLOC-2 subunit), and HPS9(BLOC-1 subunit)deficient mice. In particular, VWF tubulation, a critical step in VWF maturation, was impaired in HPS6 deficient WPBs. This likely reflects a defective endothelium, contributing to the bleeding tendency in HPS mice or patients. The differentially defective regulated release of VWF in these HPS mouse models suggests the need for precise HPS genotyping before DDAVP administration to HPS patients. | Jing Ma Zhe Zhang Lin Yang Janos Kriston-Vizi Daniel F.Cutler Wei Lia | 2016 | Journal of Genetics and Genomics2016，43，12： | 4 |
| 9 | 激光弯曲机理的试验研究显示文摘通过对试件在激光与材料非熔凝作用下动态变形过程的实时测量及光斑中心处横截面的金相分析 ,得知激光弯曲变形是热应变和相变共同作用的结果 .试验结果表明 :激光弯曲变形的大小和方向取决于材料吸收的能量、材料特性和材料的厚度 ,并给出了这些影响因素的变化规律 .研究结果进一步完善了激光弯曲的变形机理 。 | 王秀凤 Janos Takacs Gyorgy Krallics | 2002 | 北京航空航天大学学报2002，28，4： | 4 |
| 10 | 改性γ-聚谷氨酸络合重金属离子性能显示文摘研究了不同控制条件(温度、Pb2+浓度、pH)对交联改性γ-聚合谷氨酸(γ-PGA)吸附重金属离子所形成的絮凝颗粒性质的影响,对于治理水中重金属污染的相关研究有一定参考价值。实验表明,C-L-γ-PGA絮凝吸附Pb2+的最佳温度段在30℃附近。随着交联度的增加,不同的Pb2+浓度影响絮凝颗粒的大小,当处于较低浓度时,静电引力成为影响絮凝颗粒粒径最主要的因素,当Pb2+浓度增加到一定程度时,重金属的吸附量成为絮凝颗粒的粒径的决定因素。溶液pH达到7附近时,能够形成粒径最大的絮凝颗粒,并出现了最大的Pb2+去除率。C-L-γ-PGA对其他重金属离子也有类似的吸附絮凝作用,且絮凝吸附强弱顺序为Cu2+>Cr3+>Pb2+>Hg2+。吸附絮凝颗粒的粒径反映了重金属被吸附之后分离的难易程度,因此研究不同条件对絮凝颗粒粒径的影响对重金属离子的吸附和去除有重要意义。 | 史伟 陈晨 康小华 Hajdu Istvan Janos borely | 2012 | 环境工程学报2012，6，8： | 4 |
| 11 | Cerium dioxide as a new reactive sorbent for fast degradation of parathion methyl and some other organophosphates显示文摘Cerium dioxide was used for the first time as reactive sorbent for the degradation of the organophosphate pesticides parathion methyl,chlorpyrifos,dichlofenthion,fenchlorphos,and prothiofos,as well as of some chemical warfare agents—nerve gases soman and O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothioate(VX).CeO2 specimens were prepared by calcination of basic cerous carbonate obtained by precipitation from an aqueous solution.The CeO2 samples containing certain amounts(1 wt.%–5 wt.%) of the neighboring lanthanides(La,Pr,Nd) were prepared in a similar way from pure lanthanide salts.It was shown that ceria accelerated markedly the decomposition of parathion methyl causing the cleavage of the P-O-aryl bond in the pesticide molecule.A similar reaction mechanism was proposed for the degradation of other organophosphate pesticides and nerve agents.The degradation times(reaction half-times) were in an order of minutes in the presence of CeO2,compared to hours or days under common environmental conditions.The reaction in suitable organic solvents allowed conversions of about 90% for parathion methyl loading of 20 mg pesticide/g CeO2 within 2 h with a reactant half-life in the order of 0.1 min.The key parameter governing the degradation efficiency of CeO2 was the temperature during calcination.At optimum calcination temperature(about 773.15 K),the produced ceria retained a sufficiently high surface area,and attained an optimum degree of crystallinity(related to a number of crystal defects,and thus potential reactive sites).The presence of other lanthanides somewhat decreased the reaction rate,but this effect was not detrimental and permitted the possible use of chemically impure ceria as a reactive sorbent.A fast organophosphate degradation was demonstrated not only in non-polar solvents(such as heptane),but also in polar aprotic solvents(acetonitrile,acetone) that are miscible with water.This opens new possibilities for designing more versatile decontamination strategies.The cleavage of phosphate ester bonds is of a great importance not only for the degradation of dangerous chemicals(chemical weapons,pesticides),but also for interactions of ceria(especially the nano-sized one) in biologically relevant systems. | Pavel Janos Pavel Kuran Martin Kormunda Vaclav Stengl Tomas Matys Grygar Marek Dosek Martin Stastny Jakub Ederer Vera Pilarova Lubos Vrtoch | 2014 | Journal of Rare Earths2014，32，4： | 4 |
| 12 | Prolonged intestinal mucosal acidosis is associated with multiple organ failure in human acute pancreatitis: Gastric tonometry revisited显示文摘瞄准:评估是否在尖锐胰腺炎(AP ) 的 intramucosal pH (pHi ) 的多重决心病人们能在早住院期间提供疾病严厉的另外的信息。方法:受不了尖锐胰腺炎的 21 个病人被胃的张力测量法在医院承认以后在开始的 72 h 监视。结果:在幸存者组(n = 15 ) 还给正常的开始低的 pHi 值铺平(pHi >
或 = 7.32 ) 在 48 h 以内(中部的 pHi:d1:7.21;d2:7.32;d3:7.33 ) 。相反,在非幸存者的 pHi 值组织 n = 6 ) 固执地,下面或在里面,低正常变化(中部的 pHi 7.12;7.12;7.07 分别地) ,但是二个组之间的 pHi 差别仅仅在 24 h (P<0.01 ) 以后到达了意义。在监视时期期间在任何时间检测的粘膜酸中毒与单个或多重的机关机能障碍(P<0.01 ) 的出现被联系。结论:然而,延长胃的粘膜酸中毒在尖锐胰腺炎与遥远的机关机能障碍和失败被联系与致命的结果的关联变得重要仅仅在承认以后的 24 h。由于它的非侵略的性质,胃的张力测量法可以补充支持 inflammatory 标记完成疾病的滑稽得多的监视。 | Gabor C Kovacs Geza Telek Janos Hamar Jozsef Furesz Janos Regoly-Merei | 2006 | World Journal of Gastroenterology2006，12，30： | 4 |
| 13 | Mucocele of the appendix: An unusual cause of lower abdominal pain in a patient with ulcerative colitis-. A case report and review of literature显示文摘The authors report the case of a 60-year-old male patient.In November 2001 he developed intestinal symptoms of bloody diarrhea and abdominal pain. Colononoscopy and biopsy established the diagnosis of ulcerative colitis (proctosigmoiditis). The disease activity was moderate at the beginning.No significant laboratory alterations were found (including CEA, CA19-9),and mesalazine was started orally.He was in remission until November 2003, when he was admitted to our Outpatient Clinic for upper and right lower abdominal pain and bloody diarrhea. Colonoscopy found proctosigmoiditis with a moderate activity, gastroscopy revealed chronic gastritis,laboratory data was normal. Treatment was amended with mesalazine clysma and methylprednisolone (16 mg) orally. Symptoms ameliorated;however, right lower abdominal pain persisted. US and CT examination demonstrated a pericecal cystic mass (11 cmx3.5 cm). At first pericecal abscess was suspected, as the previous US examination (6 mo earlier) had revealed normal findings. Fine needle aspiration was performed. Cytology confirmed the diagnosis of mucocele.The patient underwent partial cecum resection and extirpation of the mucocele. He recovered well and the final histology revealed a cystadenoma of the appendix. Follow up was started. The patient is now free of symptoms.Although primary adenocarcinoma of the appendix is uncommon, the authors emphasize that preoperative diagnosis of an underlying malignancy in a mucocele is important for patient management; however, it is difficult on imaging studies. | Peter Laszlo Lakatos Gabriella Gyori Judit Halasz Peter Fuszek Janos Papp Balazs Jaray Peter Lukovich Laszlo Lakatos | 2005 | World Journal of Gastroenterology2005，11，3： | 4 |
| 14 | 激光点热源作用下动态微变形的数值模拟与校验显示文摘采用MSC.Marc非线性有限元软件,对试件在激光点热源作用下动态微变形过程进行了数值模拟。通过激光反射放大系统测量了试件在激光点热源作用下的动态微变形过程。模拟值与实测值的结果表明:热应力和相变应力的共同作用使得试件产生微变形,最终试件的变形方向取决于热应变和相变共同作用的结果,朝向激光束或背向激光束。比较实验值和模拟值,发现变形的最大值相近,变形过程却略有不同。考虑到激光点热源作用下有限厚度的试件内,温度场分布出现的反常效应,即内部的温度大于边界温度,提出采用波动理论修正经典的热传导计算模型,可望有效地提高模拟过程的计算精度。结论为进一步研究薄板激光弯曲的变形机理及变形过程奠定了基础。 | 王秀凤 陈光南 胡世光 Janos Takacs Gyorgy Krallics | 2004 | 中国激光2004，31，12： | 4 |
| 15 | 激光点热源作用下试件内部热传导的实验研究显示文摘通过红外热像仪测温装置,对有限厚度试件在激光点热源作用下热作用区侧面温度分布进行实时测量。结果表明:对于小厚度的试件,材料内部温度分布与用傅立叶定律得到的结果完全相反,材料内部的温度高于边界温度。对比短脉冲激光作用下产生非傅立叶效应的条件,它们之间有很大差异,由此提出将实验中出现的非常规现象定义为泛傅立叶效应,认为它是由于热量传播到边界时发生反射、叠加等波动行为所致。 | 王秀凤 胡世光 陈光南 Janos Takacs Gyorgy Krallics | 2004 | 光电子.激光2004，15，2： | 4 |
| 16 | Solubilization and purification of recombinant modified C-reactive protein from inclusion bodies using reversible anhydride modification显示文摘 | Lawrence A. Potempa Zhen-Yu Yao Shang-Rong Ji Janos G. Filep Yi Wu | 2015 | Biophysics Reports2015，1，1： | 3 |
| 17 | 流式细胞仪多参数分析白血病免疫表型显示文摘用流式细胞仪5种参数和单克隆抗体(McAh)12项指标,对105例急性白血病(AL)思考骨髓进行免疫学分型。先用3种McAb为一组染色,区分AL的主要系列:CD_(13)/CD_(33)急性髓系白血病(AML),CD_(19)-B淋巴细胞白血病,CD_7-T淋巴细胞白血病。然后进一步用各种AL亚型相关的McAb分析抗原表达,AML表现为低分化抗原表达型,分化抗原表达丰富型及异常分化抗原表达型。AL各亚型在流式细胞仪上的表现特征有助于了解白血病细胞恶性增殖和分化的程度,对白血病预后的判断有意义。 | 郝蕾 Jano G | 1994 | 中华血液学杂志1994，15，1： | 3 |
| 18 | Fractal analysis of retinal vasculature in normal subjects on ultra-wide field fluorescein angiography显示文摘AIM: To evaluate the fractal feature of the retinal vasculature of normal eyes on a stereographic projected and montaged ultra-wide field(UWF) fluorescein angiography(FA).METHODS: Prospective, observational, cross-sectional study. Totally 59 eyes of 31 normal subjects were imaged using the Optos 200 Tx. Images obtained at different gaze angles stereographically projected and montaged. The early-phase UWF FA frames were processed to segment the retinal vasculature and the results were exported as binary masks. The fractal dimension(FD) was calculated using the box-counting method.RESULTS: The global FD for the entire retina was 1.6±0.04, with no difference between males and females(1.59±0.04 vs 1.61±0.04, P=0.084) or between right and left eyes(1.6±0.04 vs 1.6±0.05, P=0.61). FD was nonuniformly distributed among four quadrants(P<0.001) and decreased as the distance from the fovea increased(P<0.001). A negative association was observed between FD and age(R=-0.37, P=0.006), and this relationship was observed in the posterior and mid-peripheral retina(P<0.05) but absent in far-periphery(P>0.05).CONCLUSION: Fractal geometry is non-uniformly distributed across the retina in normal eyes and decreases from the fovea to the far-periphery. Subjects with an older age tend to have a smaller FD, however, the FD in the farperiphery does not appear to be influenced by age. | Wen-Ying Fan Alan Fleming Gavin Robertson Akihito Uji Jano van Hemert Michael Singer Min Sagong Michael Ip SriniVas R.Sadda | 2020 | International Journal of Ophthalmology(English edition)2020，13，7： | 3 |
| 19 | IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer显示文摘 | Sergei Grivennikov Eliad Karin Janos Terzic Daniel Mucida Guann-Yi Yu Sivakumar Vallabhapurapu Jürgen Scheller Stefan Rose-John Hilde Cheroutre Lars Eckmann Michael Karin | 2009 | Cancer Cell2009，，2： | 3 |
| 20 | Double balloon enteroscopy examinations in general anesthesia显示文摘AIM:To demonstrate that the double balloon enteroscopy(DBE) can be safely performed in general anesthesia with intubation.METHODS:We performed a retrospective examination between August 2005 and November 2008 amongpatients receiving intubation narcosis due to DBE examination.The patients were grouped based on sex,age and physical status.Anesthesia records includedduration of anesthesia,quantity of medication usedand anesthesia-related complications.We determinedthe frequency of complications in the different groupsand their relation with the quantity of medication usedand the duration of anesthesia.RESULTS:We compiled data for 108 cases of general anesthesia with intubation.We did not observeany permanent anesthesia-related complications;themost frequent side effects of anesthesia were hypo-tension(30.55%),desaturation(21.29%),and apnea(17.59%).These complications were significantly more frequent among patients with multiple additional diseases [hypotension(23.1% vs 76.9%,P = 0.005),desaturation(12.3% vs 69.2%,P < 0.001) and apnea(7.7% vs 53.8%,P = 0.001)],however,their incidence was not proportional to the quantity of medication used or the duration of anesthesia.CONCLUSION:General anesthesia with intubation is definitely a viable option among DBE methods.It is highly recommended in patients with multiple additional diseases. | Laszlo Zubek Lena Szabo Peter Laszlo Lakatos Janos Papp Janos Gal Gabor Elo | 2010 | World Journal of Gastroenterology2010，16，27： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员