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| 1 | Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf显示文摘Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. | Mahendra Jain Rakhee Kapadia Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 2 | Traditional uses,phytochemistry and pharmacology of Clerodendron glandulosum Coleb - a review显示文摘Present review for the first time provides a complete botanical description and information on ethnomcdicinal uses of Clerodendron glandulosum.Coleb(CG:Fam.Verbenaceae).Recent studies conducted from our laborator) provide pharmacological evidence for its anti-hypertensive,antidiabetic and anti-obesity potentials.Further,its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hcpatoprotective and free radical scavenging abilities along with its acute and sub- chronic toxicologiesl evaluations are also reported from our laboratory.In keeping with its traditional uses,CG extract was capable of ameliorating experimentally induced hypertension,diabetes and obesity.Its beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging potential.Non—toxic nature of CG leaf extract further provides added merit to its reported pharmacological properties.The present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension,diabetes and obesity along with anti oxidant potential and beneficial elicits against non alcoholic steatohepatitis. | Ravirajsinh N Jadeja Menaka C Thounaojam Thouchom Brojendro Singh Ranjitsinh V Devkar AV Ramachandran | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 3 |
| 3 | Inter-observer reliability of detecting Dynesys pedicle screw using plain X-rays:a study on 50 post-operative patients显示文摘 | Jerew F Jadeja H Cohen A | | 0，，10： | 1 |
| 4 | Darbepoetina alfa given every1or 2 weeks alleviates anaemia associated with cancer chemotherapy显示文摘 | Glaspy JA Jadeja JS Justice G | 2002 | Br J Cancer2002，87，3： | 1 |
| 5 | Optimization of environmental and nutritional factors for alkaline protease production显示文摘 | BHATIYA R JADEJA G R | 2010 | Electronic Journal of Environmental Agricultural and Food Chemistry2010，9，3： | 1 |
| 6 | Darbepoetinα given every 1 or 2 weeks alleviates anemia associated with cancer chemotherapy 显示文摘 | Glaspy JA Jadeja JS Justice G | 2002 | Br J Cancer2002，87，： | 1 |
| 7 | Inter-observer reliability of detecting Dynesys pedicle screw using plain X-rays:a study on 50 post-operative patients显示文摘 | Dakhil-Jerew F Jadeja H Cohen A | 2009 | Eur Spine J2009，18，10： | 1 |
| 8 | A randomized, multi-center study of subcutaneous and intravenous darbepoetin alfa for the treatment of chemotherapy-induced anemia 显示文摘 | Justice G Kessler JF Jadeja J | 2005 | Ann One2005，16，： | 1 |
| 9 | lmmunomagnetic sepa- ration of Vibrio vulnificus with antiflagellar monoclonal antibody 显示文摘 | JADEJA R JANES M E SIMONSON J G | 2010 | J Food Prot2010，73，7： | 1 |
| 10 | Cloud computing-concepts, architec- ture and challenges显示文摘 | Y JADEJA K MODI | 2012 | Electronics and Electrical Technol- ogies2012，，4： | 1 |
| 11 | Anti-obesity potential of Clerodendron glandulosum .Coleb leaf aqueous extract显示文摘 | Ravirajsinh N. Jadeja Menaka C. Thounaojam Umed V. Ramani Ranjitsinh V. Devkar A.V. Ramachandran | 2011 | Journal of Ethnopharmacology2011，，2： | 1 |
| 12 | Hepatopro- tective potential of Tecomella undulata stem bark is par- tially due to the presence of betulinic acid显示文摘 | JAIN M KAPADIA R JADEJA R N | 2012 | Journal of ethnopharmacology2012，143，1： | 1 |
| 13 | Immunomagnetic separation of Vibrio vulnificus with antiflagellar monoclonal antibody显示文摘 | JADEJA R JANES M E SIMONSON J G | | 0，，07： | 1 |
| 14 | Immunomagnetic separation of Vibrio vulnificus with antiflagellar monoclonal antibody显示文摘 | JADEJA R JANES M E SIMONSON J G | | 0，，07： | 1 |
| 15 | Immunomagnetic separation ofVibrio vulnificus with antiflagellar monoclonal antibody 显示文摘 | Jadeja R Janes ME Simonson JG | 2010 | J FoodPrat2010，73，7： | 1 |
| 16 | Efficient inducible cre-recombinase activation in vascular endothelium 显示文摘 | CLAXTON S KOSTOUROU V JADEJA S | 2008 | Genesis2008，46，2： | 1 |
| 17 | Nanomaterials for photo-based diagnostic and therapeutic applications 显示文摘 | MENON J U JADEJA P TAMBE P | 2013 | Theranostics2013，3，3： | 1 |
| 18 | Effica- cy of aqueous and methanol extracts of some medicinal plants for potential antibacterial activity 显示文摘 | Jigna Parekh Darshana Jadeja Sumitra Chanda | 2005 | Turk J Bi- ol2005，29，： | 1 |
| 19 | Euphorbiaceae latex induced green synthesis of non-cytotoxic metallic nanoparticle solutions: A rational approach to antimicrobial applications显示文摘 | Mayur Valodkar Padamanabhi S. Nagar Ravirajsinh N. Jadeja Menaka C. Thounaojam Ranjitsinh V. Devkar Sonal Thakore | 2011 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2011，，1： | 1 |
| 20 | Protein energy wasting in chronic kidney disease: An update with focus on nutritional interventions to improve outcomes 显示文摘 | Jadeja Y P Kher V | 2012 | Indian J Endocrinol Metab2012，16，2： | 1 |
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