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| 1 | Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf显示文摘Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. | Mahendra Jain Rakhee Kapadia Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 2 | Traditional uses,phytochemistry and pharmacology of Clerodendron glandulosum Coleb - a review显示文摘Present review for the first time provides a complete botanical description and information on ethnomcdicinal uses of Clerodendron glandulosum.Coleb(CG:Fam.Verbenaceae).Recent studies conducted from our laborator) provide pharmacological evidence for its anti-hypertensive,antidiabetic and anti-obesity potentials.Further,its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hcpatoprotective and free radical scavenging abilities along with its acute and sub- chronic toxicologiesl evaluations are also reported from our laboratory.In keeping with its traditional uses,CG extract was capable of ameliorating experimentally induced hypertension,diabetes and obesity.Its beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging potential.Non—toxic nature of CG leaf extract further provides added merit to its reported pharmacological properties.The present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension,diabetes and obesity along with anti oxidant potential and beneficial elicits against non alcoholic steatohepatitis. | Ravirajsinh N Jadeja Menaka C Thounaojam Thouchom Brojendro Singh Ranjitsinh V Devkar AV Ramachandran | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 3 |
| 3 | Management of human factors engineering-associated hemochromatosis: A 2015 update显示文摘This review focuses on the management of iron metabolism and iron overload experienced in the hereditary condition, human factors engineering(HFE)-associated hemochromatosis. Hemochromatosis refers to a group of genetic diseases that result in iron overload; the major one globally is HFE-associated hemochromatosis. The evolution in understanding of the most common form of hereditary hemochromatosis, being the substation of cysteine to a tyrosine at position 282 in the HFE gene, has been extensively studied Novel mutations in both HFE and non-HFE genes have been indicated in this disease which hold significance in its application for the Asia-Pacific region. In conditions with iron overload, the storage of excess iron in various body tissues leads to complications and toxic damage. The most common presenting complaint for this disease is malaise, lethargy and other non-specific symptoms. In order to diagnose hereditary hemochromatosis, there are biochemical, imaging and genetic testing options. Currently, cascade screening of affected families is preferred over population-level screening. The mainstay of treatment is venesection and the appropriate approach to treatment has been consolidated over the years. Recently, the indications for venesection therapy of hemochromatosis have been challenged and are the subject of ongoing research. | Menaka Sivakumar Lawrie W Powell | 2016 | World Journal of Hepatology2016，8，8： | 2 |
| 4 | Chediak-Higashi syndrome: a case report 显示文摘 | ayaranee S Menaka N | 2004 | Malays J Pathol2004，26，1： | 1 |
| 5 | Interleukin‐1β orchestrates underlying inflammatory responses in microglia via Krüppel‐like factor 4显示文摘 | Deepak K. Kaushik Menaka C. Thounaojam Kanhaiya L. Kumawat Malvika Gupta Anirban Basu | 2013 | J Neurochem2013，，2： | 1 |
| 6 | Anti-obesity potential of Clerodendron glandulosum .Coleb leaf aqueous extract显示文摘 | Ravirajsinh N. Jadeja Menaka C. Thounaojam Umed V. Ramani Ranjitsinh V. Devkar A.V. Ramachandran | 2011 | Journal of Ethnopharmacology2011，，2： | 1 |
| 7 | Chediak-Higashi syndrome : a case report 显示文摘 | Jayaranee S Menaka N | 2004 | Malays J Pathol2004，26，1： | 1 |
| 8 | Security analysis in hierarchical resourceArrangements in grid computing显示文摘 | Menaka R Wahidha Banu | 2011 | International Journal of Computer Applications2011，24，6： | 1 |
| 9 | Effi- cient feature point detection in CT images using discrete curve let transform显示文摘 | MENAKA R CHELLAMUTHU C KARTHICK R | 2013 | Journal of Scientific & Industrial Research2013，72，5： | 1 |
| 10 | 显示文摘 | Menaka R Nandhini M Subhashini S | 2014 | Research Journal of Recent Sciences2014，3，： | 1 |
| 11 | Euphorbiaceae latex induced green synthesis of non-cytotoxic metallic nanoparticle solutions: A rational approach to antimicrobial applications显示文摘 | Mayur Valodkar Padamanabhi S. Nagar Ravirajsinh N. Jadeja Menaka C. Thounaojam Ranjitsinh V. Devkar Sonal Thakore | 2011 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2011，，1： | 1 |
| 12 | Study on the Inclusion Interactions of /3-Cyclodextrin with Rhodamine B Base显示文摘 | Bakkialakshmi S Menaka T | 2012 | Int J ChemTech fe2012，4，1： | 1 |
| 13 | Forest Fire Detection Using Texture A- nalysis显示文摘 | Menaka E Kumar S S | 2011 | International Journal of Computer Applications in Engineering Sciences2011，1，1： | 1 |
| 14 | Single antigen detects both immunoglobulin M (IgM) and lgG antibodies elicited by all four dengue virus serotypes 显示文摘 | Menaka D Hapugoda Gaurav Batra W Abeyewickreme | 2007 | Clin Vaccine Immunol2007，14，11： | 1 |
| 15 | Effect of defect size on defect depth quantification in pulsed thermography显示文摘 | Sharath D Menaka M Venkatraman B | 2013 | Measurement Science and Technology2013，，24： | 1 |
| 16 | Defect characterization using pulsed thermography显示文摘 | Sharath D Menaka M Venkatraman B | 2013 | Journal of Nondestructive Evaluation2013，32，2： | 1 |
| 17 | Realization of dynamic thermal emission control 显示文摘 | Takuya I Menaka D Z Takashi A | 2014 | Nature Material2014，13，10： | 1 |
| 18 | A new low temperatrue methodology to obtain pure nanocrystalline nickel borate显示文摘 | Menaka L S E Ramanujachary K V Ganguli A K | 2010 | ] Organomet Chem2010，695，7： | 1 |
| 19 | Epigenetic control of autophagy in women’s tumors:role of non-coding RNAs显示文摘Cancer remains the second leading cause of death worldwide and a major public health and economic issue.To reduce the burden,new approaches are necessary to diagnose the disease at early stages and improve clinical outcomes of cancer patients,for which understanding the molecular mechanisms of carcinogenesis is crucial.Autophagy is a pro-survival pathway that ensures the removal and renewal of cellular macromolecular structures,thus playing a crucial role in the maintenance of cellular homeostasis.Dysregulation of autophagy can favor chemoresistance and survival of dormant cancer cells,thus favoring cancer progression and relapse.Several studies report dysregulated expression of long non-coding RNAs and micro-RNAs acting as tumor suppressors or tumor promoters by targeting genes involved in the autophagy pathway.Here,we focus on the role played by non-coding RNAs-mediated regulation of autophagy in development and progression of cancers in women.Understanding how epigenetics can impact autophagy might open novel therapeutic strategies in the fight against cancers in women. | Chiara Vidoni Letizia Vallino Alessandra Ferraresi Eleonora Secomandi Amreen Salwa Menaka Chinthakindi Alessandra Galetto Danny N Dhanasekaran Ciro Isidoro | 2021 | Journal of Cancer Metastasis and Treatment2021，7，1： | 0 |
| 20 | Charcoal Production as a Means of Forest Management, Biodiversity Conservation and Livelihood Support in Nepal显示文摘 | Menaka Panta Neupane Kishor Prasad Bhatta Suman Ghimire | 2017 | Journal of Agricultural Science and Technology(B)2017，7，3： | 0 |
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