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| 1 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 2 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 3 | Compositional complexity dependence of dislocation density and mechanical properties in high entropy alloy systems显示文摘This study focuses on a quantitative analysis of dislocation accumulation after cold plastic deformation and mechanical properties of FeNiCoCrMn and TiNbHfTaZr high entropy alloys(HEAs)which are single phase/cc and bcc solid solutions,respectively.In order to study the role of compositional complexity from unary to quinary compositions on dislocation accumulation and mechanical properties after plastic deformation,the single solid solution phase forming sub-alloys of the two HEAs were investigated.All studied samples revealed a large plastic deformability under cold-rotary swaging process by 85-90%area reduction without intermediate annealing.The dislocation density of all studied samples,determined by Williamson-Hall method on synchrotron X-ray diffraction patterns,were between 1014-1015 m^-2 dependent on the alloy composition.The level of dislocation density after plastic deformation is not only affected by the number of constituent element but the lattice distortion and intrinsic properties in terms of stacking fault energy,modulus misfit,and melting point also impact the dislocation storage.The level of dislocation density determines the level of mechanical properties because of a resistance to dislocation motions.The hardness and yield compressive strength of the studied samples are proportional to the level of dislocation density. | P.T hirathipviwat G.Song J.Bednarcik U.Kiihn T.Gemming K.Nielsch J.Han | 2020 | Progress in Natural Science:Materials International2020，30，4： | 3 |
| 4 | Posterior circulation ischemic stroke in Korean population显示文摘 | J.‐H.Lee S.‐J.Han Y.‐H.Yun H.‐C.Choi S.Jung S.‐J.Cho K.‐H.Yu S. M.Lee S.‐H.Hwang H.‐K.Song K. H.Kwon B.‐C.Lee | 2006 | European Journal of Neurology2006，，7： | 2 |
| 5 | Data Mining:an overview from database perspective显示文摘 | M.S.Chen J.Han P.S.Yu | | 0，，06： | 1 |
| 6 | A survey on content-oriented networking for efficient content delivery显示文摘 | J.Choi J.Han E.Cho | | 0，，03： | 1 |
| 7 | Localization of γ-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease显示文摘 | Irfan Rahman Annemarie A.M van Schadewijk Pieter S Hiemstra Jan Stolk J.Han J.M van Krieken William MacNee Willem I de Boer | 2000 | Free Radical Biology and Medicine2000，，： | 1 |
| 8 | Modified transjugular intrahepatic portosystemic shunt in the treatment of Budd‐Chiari syndrome显示文摘 | X.Wu W.Ding J.Cao J.Han J.Li | 2010 | International Journal of Clinical Practice2010，，4： | 1 |
| 9 | First-principles study of Li-intercalated carbon nanotube ropes显示文摘 | J.J.Zhao A.Buldum J.Han J.P.Lu | | 0，，08： | 1 |
| 10 | Effect of high-temperature annealing on the structural and optical properties of ZnO films显示文摘 | L.Wang J.Han H.Tain | | 0，，： | 1 |
| 11 | Polymorphisms in the ovine myostatin gene (MSTN) and their association with growth and carcass traits in New Zealand Romney sheep显示文摘 | J. G. H.Hickford R. H.Forrest H.Zhou Q.Fang J.Han C. M.Frampton A. L.Horrell | 2010 | Animal Genetics2010，，1： | 1 |
| 12 | Mining Access Patterns efficiently from Web Logs显示文摘 | Pei J.Han | | 0，，： | 1 |
| 13 | Theoretical Solution for Consolidation Rates of Stone Column-Reinforced Foundation Accounting for Smear and Wel Resistance Effects显示文摘 | J.Han S.I.Ye | | 0，，： | 1 |
| 14 | Posterior circulation ischemic stroke in Korean population显示文摘 | J.‐H.Lee S.‐J.Han Y.‐H.Yun H.‐C.Choi S.Jung S.‐J.Cho K.‐H.Yu S. M.Lee S.‐H.Hwang H.‐K.Song K. H.Kwon B.‐C.Lee | 2006 | European Journal of Neurology2006，，7： | 1 |
| 15 | Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients显示文摘 | Seunggu J.Han IsaacYang Brian J.Ahn Jose J.Otero TarikTihan Michael W.McDermott Mitchel S.Berger Michael D.Prados Andrew T.Parsa | 2010 | Cancer2010，，5： | 1 |
| 16 | Posterior circulation ischemic stroke in Korean population显示文摘 | J.‐H.Lee S.‐J.Han Y.‐H.Yun H.‐C.Choi S.Jung S.‐J.Cho K.‐H.Yu S. M.Lee S.‐H.Hwang H.‐K.Song K. H.Kwon B.‐C.Lee | 2006 | European Journal of Neurology2006，，7： | 1 |
| 17 | Understanding super-enhancers显示文摘Super-enhancers are defined as cluster of enhancers with dense TF binding,which can activate proximal cell-identity gene expression.Here we review the identification,functional significance of super-enhancers,and their relationships with cancer.With the current intense interests in super-enhancers,more super-enhancers will be defined | Hao Cheng Xiaoyang Dou Jing-Dong J.Han | 2016 | Science China(Life Sciences)2016，59，3： | 1 |
| 18 | AlGaN deep ultraviolet LEDs on bulk AlN substrates显示文摘 | ZaiyuanRen Q.Sun S.‐Y.Kwon J.Han K.Davitt Y. K.Song A. V.Nurmikko W.Liu J.Smart L.Schowalter | 2007 | Phys Status Solidi (c)2007，，7： | 1 |
| 19 | Associated comorbidities in psoriasis and inflammatory bowel disease显示文摘 | A.M.Binus J.Han A.A.Qamar E.A.Mody E.W.Holt A.A.Qureshi | 2012 | Journal of the European Academy of Dermatology and Venereology2012，，5： | 1 |
| 20 | Data mining:an overview from a database perspective显示文摘 | M-S.Chen J.Han P.S.Yu | | 0，，08： | 1 |
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