|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber显示文摘Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–4.Advances in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–7.We report a compact and highly optimized approach for minimally invasive in vivo brain imaging applications.The volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core MMF.Here,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+responses.These results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo. | Sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren Martin Plöschner Zahid Padamsey Martin J.Booth TomášČižmár Nigel J.Emptage | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | Polarisation optics for biomedical and clinical applications:a review显示文摘Many polarisation techniques have been harnessed for decades in biological and clinical research,each based upon measurement of the vectorial properties of light or the vectorial transformations imposed on light by objects.Various advanced vector measurement/sensing techniques,physical interpretation methods,and approaches to analyse biomedically relevant information have been developed and harnessed.In this review,we focus mainly on summarising methodologies and applications related to tissue polarimetry,with an emphasis on the adoption of the Stokes-Mueller formalism.Several recent breakthroughs,development trends,and potential multimodal uses in conjunction with other techniques are also presented.The primary goal of the review is to give the reader a general overview in the use of vectorial information that can be obtained by polarisation optics for applications in biomedical and clinical research. | Chao He Honghui He Jintao Chang Binguo Chen Hui Ma Martin J.Booth | 2021 | Light(Science & Applications)2021，10，11： | 4 |
| 3 | Adaptive optics in laser processing显示文摘Adaptive optics are becoming a valuable tool for laser processing,providing enhanced functionality and flexibility for a range of systems.Using a single adaptive element,it is possible to correct for aberrations introduced when focusing inside the workpiece,tailor the focal intensity distribution for the particular fabrication task and/or provide parallelisation to reduce processing times.This is particularly promising for applications using ultrafast lasers for threedimensional fabrication.We review recent developments in adaptive laser processing,including methods and applications,before discussing prospects for the future. | Patrick S.Salter Martin J.Booth | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 4 | Revealing complex optical phenomena through vectorial metrics显示文摘Advances in vectorial polarization-resolved imaging are bringing new capabilities to applications ranging from fundamental physics through to clinical diagnosis.Imaging polarimetry requires determination of the Mueller matrix(MM)at every point,providing a complete description of an object’s vectorial properties.Despite forming a comprehensive representation,the MM does not usually provide easily interpretable information about the object’s internal structure.Certain simpler vectorial metrics are derived from subsets of the MM elements.These metrics permit extraction of signatures that provide direct indicators of hidden optical properties of complex systems,while featuring an intriguing asymmetry about what information can or cannot be inferred via these metrics.We harness such characteristics to reveal the spin Hall effect of light,infer microscopic structure within laser-written photonic waveguides,and conduct rapid pathological diagnosis through analysis of healthy and cancerous tissue.This provides new insight for the broader usage of such asymmetric inferred vectorial information. | Chao He Jintao Chang Patrick S.Salter Yuanxing Shen Ben Dai Pengcheng Li Yihan Jin Samlan Chandran Thodik Mengmeng Li Aziz Tariq Jingyu Wang Jacopo Antonello Yang Dong Ji Qi Jianyu Lin Daniel S.Elson Min Zhang Honghui He Hui Ma Martin J.Booth | 2022 | Advanced Photonics2022，4，2： | 2 |
| 5 | On-chip beam rotators,adiabatic mode converters,and waveplates through low-loss waveguides with variable cross-sections显示文摘Photonics integrated circuitry would benefit considerably from the ability to arbitrarily control waveguide cross-sections with high precision and low loss,in order to provide more degrees of freedom in manipulating propagating light.Here,we report a new method for femtosecond laser writing of optical-fiber-compatible glass waveguides,namely spherical phase-induced multicore waveguide(SPIM-WG),which addresses this challenging task with three-dimensional on-chip light control.Fabricating in the heating regime with high scanning speed,precise deformation of cross-sections is still achievable along the waveguide,with shapes and sizes finely controllable of high resolution in both horizontal and vertical transversal directions.We observed that these waveguides have high refractive index contrast of 0.017,low propagation loss of 0.14 dB/cm,and very low coupling loss of 0.19 dB coupled from a single-mode fiber.SPIM-WG devices were easily fabricated that were able to perform on-chip beam rotation through varying angles,or manipulate the polarization state of propagating light for target wavelengths.We also demonstrated SPIM-WG mode converters that provide arbitrary adiabatic mode conversion with high efficiency between symmetric and asymmetric nonuniform modes;examples include circular,elliptical modes,and asymmetric modes from ppKTP(periodically poled potassium titanyl phosphate)waveguides which are generally applied in frequency conversion and quantum light sources.Created inside optical glass,these waveguides and devices have the capability to operate across ultra-broad bands from visible to infrared wavelengths.The compatibility with optical fiber also paves the way toward packaged photonic integrated circuitry,which usually needs input and output fiber connections. | Bangshan Sun Fyodor Morozko Patrick S.Salter Simon Moser Zhikai Pong Raj B.Patel Ian A.Walmsley Mohan Wang Adir Hazan Nicolas Barré Alexander Jesacher Julian Fells Chao He Aviad Katiyi Zhen-Nan Tian Alina Karabchevsky Martin J.Booth | 2022 | Light(Science & Applications)2022，11，8： | 1 |
| 6 | Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens显示文摘Dear Editor,The global monkeypox(Mpox)outbreak leads to a surge in demand for vaccine.The Mpox vaccine in short supply is JYNNEOS(modified vaccinia ankara,MVA)due to less side effects,while ACAM2000 supply is abundant because of the strategic stockpile in U.s.1 The ACAM2000 replaced the first-generation smallpox vaccine Dryvax that has a questionable safety profile.However,the ACAM2000 is associated with high rate of myocarditis and pericarditis,and can cause severe illness in immunocompromised patients,foreshadowing the need to update the strategic stockpile. | Zhenhao Fang Valter S.Monteiro Paul A.Renauer Xingbo Shang Kazushi Suzuki Xinyu Ling Meizhu Bai Yan Xiang Andre Levchenko Carmen J.Booth Carolina Lucas Sidi Chen | 2023 | Cell Research2023，33，5： | 1 |
| 7 | Shrinking multiplexed orbital angular momentum to the nanoscale显示文摘Orbital angular momentum interactions at the nanoscale have remained elusive because the phase structure becomes unresolved.Now researchers have shown how to overcome this with tightly focused beams,demonstrating a recordhigh six-dimensional encoding in an ultra-dense nanoscale volume. | Chao He Yijie Shen Andrew Forbes Martin J.Booth | 2021 | Light(Science & Applications)2021，10，11： | 1 |
| 8 | Universal adaptive optics for microscopy through embedded neural network control显示文摘The resolution and contrast of microscope imaging is often affected by aberrations introduced by imperfect optical systems and inhomogeneous refractive structures in specimens.Adaptive optics(AO)compensates these aberrations and restores diffraction limited performance.A wide range of AO solutions have been introduced,often tailored to a specific microscope type or application.Until now,a universal AO solution-one that can be readily transferred between microscope modalities-has not been deployed.We propose versatile and fast aberration correction using a physics-based machine learning assisted wavefront-sensorless AO control(MLAO)method.Unlike previous ML methods,we used a specially constructed neural network(NN)architecture,designed using physical understanding of the general microscope image formation,that was embedded in the control loop of different microscope systems.The approach means that not only is the resulting NN orders of magnitude simpler than previous NN methods,but the concept is translatable across microscope modalities.We demonstrated the method on a two-photon,a three-photon and a widefield three-dimensional(3D)structured illumination microscope.Results showed that the method outperformed commonly-used modal-based sensorless AO methods.We also showed that our ML-based method was robust in a range of challenging imaging conditions,such as 3D sample structures,specimen motion,low signal to noise ratio and activity-induced fluorescence fluctuations.Moreover,as the bespoke architecture encapsulated physical understanding of the imaging process,the internal NN configuration was no-longer a'black box',but provided physical insights on internal workings,which could influence future designs. | Qi Hu Martin Hailstone Jingyu Wang Matthew Wincott Danail Stoychev Huriye Atilgan Dalia Gala Tai Chaiamarit Richard M.Parton Jacopo Antonello Adam M.Packer Ilan Davis Martin J.Booth | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 9 | 生活在不平静的行星上的计划设立美国航空航天局的固体地球研究议程显示文摘现在和未来20年固体地球科学所面临的最大挑战是什么?而对美国国家航空航天局(NASA)来说,在与其他机构合作时,什么又是解决这些挑战的最好途径呢?一份《在不平静的行星上生活》的新报告,为回答这些问题提供了一份蓝图。根据这份报告,未来5年,固体地球科学领域最优先的一次新的宇宙飞船飞行行动是发射一颗干涉测量合成孔径雷达(inSAR)卫星。在NASA的要求下,固体地球科学工作组(SESWG)为太空机构未来25年固体地球科学的最优先目标制定了一个战略。该战略提出6个挑战,它们都具有基础科学的重要性,对社会有着重要意义并且能够通过在太空进行一系列共同的科学观测而取得实质性的进展。成功应对这些挑战将有赖于在其他的NASA计划方面与许多美国联邦机构以及国际合作伙伴之间进行密切合作和协作。固体地球科学工作组提出的计划分为5个观测方面,每一方面都将面对众多的科学挑战:陆地表面的形变、高分辨率地形和地形的变化、地球磁场的变异性、地球重力场的变异性以及地球变化表面的成像光谱。该工作组的评议工作已进行了两年(2000~2002年),包括与广泛的地球物理学团体之间进行卓有成效的对话。AGU2000年秋季和2001年春季会议的代表帮助达成了广泛的共识,并设立了网站,用于给出委员会的进展报告并邀请所有感兴趣的人士反馈意见。由华盛顿卡内基研究所的Solomon任主席的固体地球科学工作组由19位代表组成,分别来自大学、研究机构、美国航空航天局和美国地质调查局。总报告可以在http://gffzz214303114d034a7dhwb5pqc6v5x9p6fkq.ffgz.tsg.suse.edu.cn/nasa.gov上找到。 | S.C.Solomon V.R.Baker J.Bloxham J.Booth A.Donnellan C.Elachi D.Evans E.Rignot D.Burbank B.F.Chao A.Chave A.Gillespie T.Herring R.Jeanloz J.LaBrecque B.Minster W.C.Pitman Ⅲ M.Simons D.L.Turcotte M.L.C.Zoback 盛菊琴 | 2004 | 世界地震译丛2004，35，5： | 0 |
| 10 | Zwitterion-doped liquid crystal speckle reducers for immersive displays and vectorial imaging显示文摘Lasers possess many attractive features(e.g.,high brightness,narrow linewidth,well-defined polarization)that make them the ideal illumination source for many different scientific and technological endeavors relating to imaging and the display of high-resolution information.However,their high-level of coherence can result in the formation of noise,referred to as speckle,that can corrupt and degrade images.Here,we demonstrate a new electro-optic technology for combatting laser speckle using a chiral nematic liquid crystal(LC)dispersed with zwitterionic dopants.Results are presented that demonstrate when driven at the optimum electric field conditions,the speckle noise can be reduced by>90%resulting in speckle contrast(C)values of C=0.07,which is approaching that required to be imperceptible to the human eye.This LC technology is then showcased in an array of different display and imaging applications,including a demonstration of speckle reduction in modern vectorial laser-based imaging. | Yihan Jin Nathan P.Spiller Chao He Grahame Faulkner Martin J.Booth Steve J.Elston Stephen M.Morris | 2023 | Light(Science & Applications)2023，12，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员