|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | FGF2和VEGF对食管鳞癌、腺癌荷瘤裸鼠肿瘤组织结构血管、灌注血管及缺氧程度的影响分析显示文摘目的 探索FCG2及VEGF对食管癌结构血管和灌注血管的影响,阐明与食管癌快速生长、转移密切相关的血管生成调节机制。方法 本实验采用人食管癌细胞系TE-1(鳞状细胞癌),SEG-1和BIC-1(腺癌)及其荷瘤动物模型。利用体外细胞培养技术观察重组人FGF2、VEGF对三种细胞系生长增殖的影响,采用多探针RNA酶保护性分析方法检测FGF2和VEGFmRNA水平,采用免疫组织化学和免疫荧光方法观察食管癌组织结构血管、灌注血管密度及瘤内缺氧程度的影响。结果 ①体外细胞培养实验中,不同浓度FGF2(10ng,100ng)对人食管癌细胞系TE-1,SEG-1和BIG-1的增殖速度和生长曲线无影响。②FGF2和VEGRmRNA基础水平的定量检测显示食管鳞癌细胞系TE-1的FGF2为4.92,VEGF为57.57。食管腺癌细胞系SEG-1的FGF2、VEGF分别为49和53.62;BIC-1不表达FGF2,VEGF为17.04。③在TE-1、SEG-1、BIC-1三种食管癌荷瘤裸鼠模型中,FGF2、VFGF对食管癌结构血管(CD31)以及灌注血管(DIOC7)平均距离的影响分析显示:VEGF处理组结构血管和灌注血管密度较对照组显著增加(P<0.05),FGF2处理组结构血管和灌注血管密度在SEG-1模型中显著增加(P<0.05)。④在TE-1和BIC-1模型中,FGF2处理组EF5/Cy3染色的平均强度与对照组无明显差别,VEGF处理组EF5/Cy3染色的平均强度明显降低。 | 郭敏 IvanDing 王立东 | 2003 | 胃肠病学和肝病学杂志2003，12，2： | 3 |
| 2 | 胃窦部腺癌和慢性胃炎组织 Maspin 的表达显示文摘采用免疫组化方法,取胃窦部粘膜上皮,对29例慢性胃炎和腺癌组织肿瘤抑制基因Maspin的表达变化进行比较研究。结果:Maspin蛋白在慢性胃炎中的表达率为53%(8/15),在胃癌中的表达率为21%(3/14),两者差异有显著性(P<0.05),且Maspin蛋白在慢性胃炎和腺癌病变中的免疫反应类型不同,前者免疫反应部位以胞浆为主,后者主要位于胞核。提示:Maspin的表达是胃癌癌变早期阶段的一种重要分子学改变。 | 王立东 韦俊萍 周琦 邹建湘 IvanDing | 1997 | 河南医科大学学报1997，32，1： | 3 |
| 3 | Analysis of simple sequence repeats (SSRs) in wild barley from the Fertile Crescent: associations with ecology, geography and flowering time显示文摘 | Victor Ivandic Christine A. Hackett Eviatar Nevo Richard Keith William T.B. Thomas Brian P. Forster | 2002 | Plant Molecular Biology (-)2002，，5： | 1 |
| 4 | Determination of clopidogrel resistance by whole Bblood platelet aggregometry and inhibitors of the P2Y12 receptor显示文摘 | Ivandic BT Schlick P Staritz P | 2006 | Clin Chem2006，52，3： | 1 |
| 5 | Determination of aspirin responsiveness by use of whole blood platelet aggregometry显示文摘 | Ivandic BT Giannitsis E Schlick P | 2007 | Clin Chem2007，53，4： | 1 |
| 6 | Physiopathology of proteinuria and laboratory diagnostic strategy based on single protein analysis显示文摘 | Guder WG Ivandic M Hofmann W | 1998 | Clin Chem Lab Med1998，36，2： | 1 |
| 7 | Complex genetic control of HDL levels in mice in response to an atherogenic diet显示文摘 | Machleder D Ivandic B Welch C | 1997 | J Clin Invest1997，99，3： | 1 |
| 8 | 食管鳞癌组织中肿瘤抑制基因 Maspin 的表达显示文摘采用免疫组织化学(ABC)法检测河南食管癌高发区新乡市居民食管鳞癌组织中肿瘤抑制基因Maspin的表达。结果:食管癌组织中Maspin免疫阳性表达率为12%(3/25),免疫阳性反应主要位于癌组织的细胞浆中,其中2例呈局灶型分布,1例呈弥漫型分布。提示:肿瘤抑制基因Maspin可能在食管癌变过程中起一定的作用。 | 王立东 周琦 杨万才 贾云英 IvanDing | 1997 | 河南医科大学学报1997，32，1： | 1 |
| 9 | High-sensitivity troponin T improves the prognostic value of N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: results from the LURIC Study显示文摘 | Ivandic BT Spanuth E Kleber M | 2011 | Clin Chem Lab Med2011，49，6： | 1 |
| 10 | Insulin resistance and androgens in healthy women with different body fat distributions显示文摘 | IVANDIC A PRPIC- KRIZEVAC I BOZIC D | 2002 | Wien Klin Wochenschr2002，114，89： | 1 |
| 11 | Analysis of Simple Sequence Repeats(SSRs) in Wild Barley from the Fertile Crescent: Associations with Ecology, Geography and Flowering Time显示文摘 | Ivandic V Hackett C A | 2002 | Plant Mol Biol2002，48，56： | 1 |
| 12 | Analysis of simple sequence repeats (SSRs) in wild barley from the Fertile Crecent: ssociations with ecology, geography and flowering time显示文摘 | Ivandic V Hackett C A Nevo E | 2002 | Plant Molecular Biology2002，48，56： | 1 |
| 13 | Analysis of simple sequence repeats (SSRs) in wild barley from the Fertile Crescent: Associations with ecology,geography and flowering time显示文摘 | IVANDIC V HACKETT C A NEVO E | 2002 | Plant Mol Biol2002，48，56： | 1 |
| 14 | Phenotypic responses of wild barley to experimentally imposed water stxess显示文摘 | Ivandic V,Hackett C A Zhang Z J | 2000 | Journal of Experimental Botany2000，，51： | 1 |
| 15 | Analysis of simple sequence re-peats(SSRs)in wild barley from the Fertile Crescent:Associations withecology,geography and flowering time显示文摘 | IVANDIC V HACKETT C A NEVO E | 2002 | Plant Molecular Biology2002，48，3： | 1 |
| 16 | Analysis of simple sequence repeats (SSRs) in wild barley from the Fertile Crecent :associations with ecology, geography and flowering time显示文摘 | Ivandic V Hackett C A Nevo E | 2002 | Plant Molecular Biology2002，48，： | 1 |
| 17 | Biliary cholesterol hypersecre- tion ingal|stone - susceptible mice is associated with hepatic up - reg- ulation of the high - density lipoprotein receptor SRBI 显示文摘 | Fuchs M Ivandic B Muller O | 2001 | Hepatolo- gy2001，33，： | 1 |
| 18 | Complex genetic control of HDL levels in mice in response to an atherogenic diet 显示文摘 | Machleder D Ivandic B Welch C | 1997 | J Clin Invest1997，99，3： | 1 |
| 19 | Performance of the AQTg0 FLEX cTnI point-of-care assay for the rapid diagnosis of acute myocardial infarction in the emergency room显示文摘 | Ivandic BT Spanuth E Giannitsis E | 2014 | Clin Lab2014，60，6： | 1 |
| 20 | Biliary cholesterol hypersecretion in gallstone-susceptible mice is associated with hepatic up-regulation of the high-density lipoprotein receptor SRBI 显示文摘 | Fuchs M Ivandic B Mtiller O | 2001 | Hepatology2001，33，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员