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| 1 | Antioxidants,inflammation and cardiovascular disease显示文摘Multiple factors are involved in the etiology of cardiovascular disease(CVD). Pathological changes occur in a variety of cell types long before symptoms become apparent and diagnosis is made. Dysregulation of physiological functions are associated with the activation of immune cells,leading to local and finally systemic inflammation that is characterized by production of high levels of reactive oxygen species(ROS). Patients suffering from inflammatory diseases often present with diminished levels of antioxidants either due to insufficient dietary intake or,and even more likely,due to increased demand in situations of overwhelming ROS production by activated immune effector cells like macrophages. Antioxidants are suggested to beneficially interfere with diseases-related oxidative stress,however the interplay of endogenous and exogenous antioxidants with the overall redox system is complex. Moreover,molecular mechanisms underlying oxidative stress in CVD are not fully elucidated. Metabolic dybalances are suggested to play a major role in disease onset and progression. Several central signalingpathways involved in the regulation of immunological,metabolic and endothelial function are regulated in a redox-sensitive manner. During cellular immune response,interferon γ-dependent pathways are activated such as tryptophan breakdown by the enzyme indoleamine 2,3-dioxygenase(IDO) in monocyte-derived macrophages,fibroblasts,endothelial and epithelial cells. Neopterin,a marker of oxidative stress and immune activation is produced by GTP-cyclohydrolase Ⅰ in macrophages and dendritic cells. Nitric oxide synthase(NOS) is induced in several cell types to generate nitric oxide(NO). NO,despite its low reactivity,is a potent antioxidant involved in the regulation of the vasomotor tone and of immunomodulatory signaling pathways. NO inhibits the expression and function of IDO. Function of NOS requires the cofactor tetrahydrobiopterin(BH4),which is produced in humans primarily by fibroblasts and endothelial cells. Highly toxic peroxynitrite(ONOO-) is formed solely in the presence of superoxide anion(O2-). Neopterin and kynurenine to tryptophan ratio(Kyn/Trp),as an estimate of IDO enzyme activity,are robust markers of immune activation in vitro and in vivo. Both these diagnostic parameters are able to predict cardiovascular and overall mortality in patients at risk. Likewise,a significant association exists between increase of neopterin concentrations and Kyn/Trp ratio values and the lowering of plasma levels of vitamin-C,-E and-B. Vitamin-B deficiency is usually accompanied by increased plasma homoycsteine. Additional determination of NO metabolites,BH4 and plasma antioxidants in patients with CVD and related clinical settings can be helpful to improve the understanding of redox-regulation in health and disease and might provide a rationale for potential antioxidant therapies in CVD. | Harald Mangge Kathrin Becker Dietmar Fuchs Johanna M Gostner | 2014 | World Journal of Cardiology2014，6，6： | 25 |
| 2 | Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound显示文摘AIM: To establish an ultrasonographic classification based on a large sample of patients with confirmed hepatic alveolar echinococcosis(AE).METHODS: Clinical data and ultrasonography(US) findings of 185 patients(100 males; 85 females; mean age at diagnosis: 51.4 ± 17.6 years; mean age at time of US examination: 58.7 ± 18.2 years) were retrospectively reviewed with respect to the US morphology of hepatic AE lesions. The sonomorphological findings were grouped according to a five-part classification scheme.RESULTS: Application of the new classification resulted in the following distribution of sonomorphological patterns among the patients examined: hailstorm(54.1%); pseudocystic(13.5%); ossification(13.0%); hemangioma-like(8.1%); and metastasis-like(6.5%). Only 4.9% of lesions could not be assigned to a sonomorphological pattern.CONCLUSION: The sonomorphological classification proposed in the present study facilitates the diagnosis,interpretation and comparison of hepatic alveolar echinococcosis in routine practice and in the context of scientific studies. | Wolfgang Kratzer Beate Gruener Tanja EM Kaltenbach Sarina Ansari-Bitzenberger Peter Kern Michael Fuchs Richard A Mason Thomas FE Barth Mark M Haenle Andreas Hillenbrand Suemeyra Oeztuerk Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 3 | 维生素D对心力衰竭患者全因死亡率的影响:4000U/d维生素D口服3年随机临床试验结果显示文摘循环25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]〈75nmol/L与死亡率风险的非线性增加相关。这种低25(OH)D水平在心力衰竭患者中很常见。因此,Zittermann等进行研究检查口服维生素D补充剂能否降低晚期心力衰竭患者的死亡率。 | 刘莉 叶鹏 Zittermann A Ernst JB Prokop S Fuchs U Dreier J Kuhn J Knabbe C Birschmann I Schulz U Berthold HK Pilz S Gouni-Berthold I Gummert JF Dittrich M Brgermann J | 2017 | 中华高血压杂志2017，25，10： | 7 |
| 4 | Recent advances in osteosarcoma显示文摘 | Sander M Botter Dario Neri Bruno Fuchs | 2014 | Current Opinion in Pharmacology2014，，： | 2 |
| 5 | Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi) 显示文摘 | Wilda M Fuchs U Wossmann W | 2002 | Oncogene2002，21，37： | 1 |
| 6 | Estimating absorbed photosynthetically active radiation and leaf area index from spectral reflectance in wheat显示文摘 | ASRAR G M FUCHS E T KANEMASU J HATFIELD L | 1984 | Agronomy Journal1984，76，： | 1 |
| 7 | PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression显示文摘 | Fischer AN Fuchs E Mikula M | 2007 | Oncogene2007，26，23： | 1 |
| 8 | In vivo damage and recA - dependent repair of plasmid and chromosomal DNA in the radiation -resistant bacterium Deinococcus radiodurans 显示文摘 | Daly M J Ouyang L Fuchs P | 1994 | J Bacteriol1994，176，： | 1 |
| 9 | New perspectives of satisfaction re- search in tourism destinations 显示文摘 | Fuchs M Weiermair K | 2003 | The Tourism Review2003，58，3： | 1 |
| 10 | Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi) 显示文摘 | Wilda M Fuchs U Wossmann W | 2002 | Oncogene2002，21，37： | 1 |
| 11 | Cantaloupe line CZW-30 containing coat protein genes of cucumber mosaic virus , zucchini yellow mosaic virus , and water- melon mosaic virus-2 is resistant to these three viruses in the field 显示文摘 | Fuchs M McFerson JR Tricoli DM | 1997 | Molecular Breeding1997，3，4： | 1 |
| 12 | Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi)显示文摘 | Wilda M Fuchs U Wossmann W | 2002 | Oncogene2002，21，37： | 1 |
| 13 | Risk factors for pediattic ventriculoperitoneal shunt infection and predictors of infectious pathogens 显示文摘 | McGirt M J Zaas A Fuchs HE | 2003 | Clin Infect Dis2003，36，7： | 1 |
| 14 | Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference(RNAi) 显示文摘 | Wilda M Fuchs U Wossmann W | 2002 | Oncogene2002，21，37： | 1 |
| 15 | Salinomycin over- comes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-la cells显示文摘 | Fuchs D Daniel V Sadeghi M | 2010 | Biochem Bioph Res Co2010，394，4： | 1 |
| 16 | Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide显示文摘 | P.V O'Donnell L Luznik R.J Jones G.B Vogelsang M.S Leffell M Phelps P Rhubart K Cowan S Piantadosi E.J Fuchs | 2002 | Biology of Blood and Marrow Transplantation2002，，7： | 1 |
| 17 | Active damping for three-phase PWM rectifiers with high-order line-side filters显示文摘 | BIERHOFF M H FUCHS F W | 2009 | IEEE Trans on Industry Electronics2009，56，2： | 1 |
| 18 | Cantaloupe lineCZW-30 containing coat protein genes of cucumber mosaic virus,zucchini yellow mosaic virus,and watermelon mosaic virus-2 is re-sistant to these three viruses in the field显示文摘 | Fuchs M McFerson J R Tricoli D M | 1997 | Molecular Breeding1997，3，4： | 1 |
| 19 | Evaporation from unsaturated surfaces:a generalized combination method 显示文摘 | Tanner C B Fuchs M | 1968 | Journal of Geophysical Research1968，73，4： | 1 |
| 20 | Encapsulation of oil inpowder using spray drying and fluidized bed agglomeration 显示文摘 | M Fuchs C Turchiuli M Hohin | 2006 | Journal of Food Engineering2006，，： | 1 |
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