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| 1 | 对内嗅皮质和内侧颞叶萎缩的阿尔茨海默病与遗忘型轻度认知功能障碍患者的研究显示文摘目的探讨阿尔茨海默痛(AD)与遗忘型轻度认知功能障碍(aMCD)患者内嗅皮质和内侧颞叶萎缩(MTA)的关系。方法选择轻中度AD患者18例(AD组),aMC1患者1 7例(aMCI组)。认知功能通过长谷川痴呆量表修订版(HDS-R)和AD评定量表认知部分(ADAS-cog)评价。通过基于体素的AD特异性局部分析系统的Z评分来评价内嗅皮质的萎缩程度。同时视觉评分系统对MTA程度进行分级。结果 AD组HDS R评分明显低于aMCI组,ADAS-cog和MTA评分明显高于aMCI组(P<0.01)。AD组Z评分与MTA评分呈正相关(P<0.01)。aMCI组Z评分与年龄、MTA评分呈正相关(P<0.01),MTA评分与年龄呈正相关(P<0.05)。结论 aMCI患者中,内嗅皮质萎缩与认知功能改变相关;而AD患者中;MTA更可能的与认知功能相关。MTA评分比Z评分能更有效地区别aMCI和AD患者。在aMCI阶段,内嗅皮质萎缩起了主要的作用;而AD阶段海马等结构作用更突出。 | 李旭东 焦劲松 Jibiki Itsuki | 2012 | 中华老年心脑血管病杂志2012，14，3： | 3 |
| 2 | Resected tumor seeding in stomach wall due to endoscopic ultrasonography-guided fine needle aspiration of pancreatic adenocarcinoma显示文摘Endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) is a useful and relatively safe tool for the diagnosis and staging of pancreatic cancer. However, there have recently been several reports of tumor seeding after EUS-FNA of adenocarcinomas. A 78-year-old man was admitted to our hospital due to upper gastric pain. Examinations revealed a 20 mm mass in the pancreatic body, for which EUS-FNA was performed. The cytology of the lesion was adenocarcinoma, and the stage of the cancer was T3N0M0. The patient underwent surgery with curative intent, followed by adjuvant chemotherapy with S-1. An enlarging gastric submucosal tumor was found on gastroscopy at 28 mo after surgery accompanied by a rising level of CA19-9. Biopsy result was adenocarcinoma, consistent with a pancreatic primary tumor. Tumor seeding after EUS-FNA was strongly suspected. The patient underwent surgical resection of the gastric tumor with curative intent. The pathological result of the resected gastric specimen was adenocarcinoma with a perfectly matched mucin special stain result with the previously resected pancreatic cancer. This is the first case report of tumor seeding after EUS-FNA which was surgically resected and inspected pathologically. | Akiko Tomonari Akio Katanuma Tomoaki Matsumori Hajime Yamazaki Itsuki Sano Ryuki Minami Manabu Sen-yo Satoshi Ikarashi Toshifumi Kin Kei Yane Kuniyuki Takahashi Toshiya Shinohara Hiroyuki Maguchi | 2015 | World Journal of Gastroenterology2015，21，27： | 3 |
| 3 | Oxalic acid in ginger specifically denatures the acrid raphides in the unprocessed dried tuber of Pinellia ternata显示文摘Objective:Pinellia Tuber,the dried tuber of Pinellia ternata,is widely used in Japanese Kampo medicines and traditional Chinese medicines.The unprocessed Pinellia Tuber is known to cause very strong acrid irritation at oral and laryngopharynx mucosa.Recent studies have shown that the sharp needle-like crystals called raphides,that are composed of calcium oxalate and proteins,are the main causative substances of the irritation.Ginger,the rhizome of Zingiber officinale,has been used in the processing to reduce the acridity of Pinellia Tuber since before the sixth century,however,the mechanisms of reducing acridity have not been scientifically proved yet.Methods:We developed the raphides denaturation assay(RDA)to quantify the degree of denaturation in the raphides to cause irritation.By their lipophilic characters,the raphides could be extracted in petroleum ether(PE)layer from powdered Pinellia Tuber suspended in water,and the contents of the raphides in PE layer were measured by the absorbance.By this assay,we conducted the activity-guided fractionation from the boiling water extract of ginger to find the ingredients to denature the raphides.We also conducted the gustatory tests to detect the change of the irritation of the denatured raphides.Results:The treatment of powdered Pinellia Tuber suspension with ginger extract reduced the distribution of raphides in PE layer in RDA in a concentration-dependent manner.The activity-guided fractionation using RDA revealed that oxalic acid was the main active ingredient in ginger extract to denature the raphides of Pinellia Tuber.Oxalic acid reduced the lipophilicity of the raphides in the thermo-,time-,and concentration-dependent manners,and its activity was affected by pH.The treatment of powdered Pinellia Tuber suspension with oxalic acid significantly reduced its acrid irritation in gustatory test in human.Conclusions:We found that oxalic acid is the main active ingredient in ginger to reduce the acrid irritation of Pinellia Tuber. | Tsukasa Fueki Itsuki Nose Yan Liu Koichiro Tanaka Takao Namiki Toshiaki Makino | 2022 | Acupuncture and Herbal Medicine2022，2，1： | 2 |
| 4 | The RoboCup Soccer Server and CMUnited Clients:Implemented Infrastructure for MAS Research显示文摘 | Peter Stone | 2003 | Autonomous Agents and Multi-Agent Systems2003，7，12： | 1 |
| 5 | Phase structure of V-based solution containing Ti and Ni and their hydrogen absorption-desorption properties显示文摘 | Tsukahara M Fakahashi K Mishima T Tetsuo Sakai Hiroshi Miyamura Nobuhiro Kuriyama Itsuki Uehara | 1995 | Journal of Alloys and Compounds1995，224，： | 1 |
| 6 | Fe-MCM-41 for selective epoxidation of styrene with hydrogen peroxide显示文摘 | Zhang Q H Wang Y Itsuki S | 2001 | Chem Lett2001，30，9： | 1 |
| 7 | Phase structure of V-based solid solutions containing Ti and Ni and their hydrogen absorption-desorption properties显示文摘 | Tsukahara M Takahashi K M ishima T Tetsuo Sakai Hiroshi Miyamura Nobuhiro Kuriyama Itsuki Uehara | 1995 | Journal of Alloys and Compounds1995，224，： | 1 |
| 8 | Phase structure of V-based solid solutions containing Ti and Ni and their hydrogen absorption-desorption properties显示文摘 | Makoto Tsukahara Kunio Takahashi Takahiro Mishima Tetsuo Sakai Hiroshi Miyamura Nobuhiro Kuriyama Itsuki Uehara | 1995 | Journal of Alloys and Compounds1995，，1： | 1 |
| 9 | RoboCup:A challenge for AI显示文摘 | Hiroaki Kitano YasuoKuniyoshi Itsuki Noda Minoru Asada Hito-shi Matsubara and Eiichi Osawa | 1997 | AI Magazine1997，18，1： | 1 |
| 10 | Correlations between Zscores of VSRAD and regional cerebral blood flow of SPECT in patients with Alzheimer's disease and mild cognitive impairment显示文摘 | Xudong L Satoru S Itsuki J | 2010 | Psychiatry and Clinical Neuroscience2010，64，： | 1 |
| 11 | Coordination of proliferation and neuronal differentiation by the retinoblastoma protein family显示文摘 | Itsuki Ajioka | 2014 | Develop. Growth Differ2014，，： | 1 |
| 12 | Evaluation of decision support systems for emergency management显示文摘 | Itsuki Noda Masayuki Ohta etc | 2002 | Proceedings of the 41st SICE Annual Conference2002，2，57： | 1 |
| 13 | RoboCup:today and tomorrow-what we have learned显示文摘 | Asada Minoru Kitano Hiroaki Noda Itsuki Veloso Manuela | 1999 | Artificial Intelligence1999，，： | 1 |
| 14 | Cloning and Expression of Canine Interferon-a Geges in Escherichia coli显示文摘 | Osamu T Itsuki W Yuto H | 2005 | J Vet Med Sci2005，67，10： | 1 |
| 15 | Effect of a hypolipidemic drug, di (2-ethylhexyl) phthalate, on mRNA-expression associated fatty acid and acetate metabolism in rat tissues 显示文摘 | Itsuki YA Kimoto M Tsuji H | 2007 | Biosci Biotechnol Biochem2007，71，： | 1 |
| 16 | Temporary anchorage device with interchangeable superstructure for mandibular tooth movement 显示文摘 | Itsuki Y Imamura E Sugawar J | 2013 | Journal of the World Federation of Or- thodontists2013，2，1： | 1 |
| 17 | Cloning and expression of canine interferon-c genes in Escherichia coil 显示文摘 | Osamu taira Itsuki watanugi Yuko hagiwara | 2005 | J Vet Med Sci2005，67，10： | 1 |
| 18 | Akira Ando Ethanol production by repeated-batch simuhaneous saccharification and fermentation ( SSF ) of alkali-treated rice straw using immobilized Saccharomyces cerevisiae cells 显示文摘 | Itsuki Watanabe Naonori Miyata Riki Shiroma | 2012 | Bioresource Technology2012，123，： | 1 |
| 19 | Differentiated Horizontal Interneurons Clonally Expand to Form Metastatic Retinoblastoma in Mice显示文摘 | Itsuki Ajioka Rodrigo A.P. Martins Ildar T. Bayazitov Stacy Donovan Dianna A. Johnson Sharon Frase Samantha A. Cicero Kelli Boyd Stanislav S. Zakharenko Michael A. Dyer | 2007 | Cell2007，，2： | 1 |
| 20 | Elec- trochemical impedance and deterioration behavior of metal hydride electrodes 显示文摘 | Nobuhiro K Tetsuo S Hiroshi M Itsuki U Hiroshi I | 1993 | Journal of Alloys and Compounds1993，202，12： | 1 |
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