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| 1 | Role of quorum sensing in bacterial infections显示文摘Quorum sensing(QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed. | Israel Castillo-Juárez Toshinari Maeda Edna Ayerim Mandujano-Tinoco María Tomás Berenice Pérez-Eretza Silvia Julieta García-Contreras Thomas K Wood Rodolfo García-Contreras | 2015 | World Journal of Clinical Cases2015，3，7： | 15 |
| 2 | Excretion of the Epstein-Barr virus from the genital tract of men显示文摘 | Israele V Shirley P Sixbey JW | 1991 | J Infect Dis1991，163，： | 1 |
| 3 | Molecular cloning of polyoma virus DNA in Escherichia coli: plasmid vector system显示文摘 | Israel M A Chan H W Rowe W P | 1979 | Science1979，203，4383： | 1 |
| 4 | Phase II study of liposomal doxorubicin in advanced gynecologic cancers 显示文摘 | ISRAEL V P GARCIA A A ROMAN L | 2000 | Gynecol Oncol2000，78，2： | 1 |
| 5 | Diagnosis of diaphragmatic trauma with helical CT in a swinemodel 显示文摘 | Israel R S McDaniel P A Primack S L | 1996 | Am J Roentgenol1996，167，3： | 1 |
| 6 | Excretion of the Epstein-Barr virus from the genital tract of men显示文摘 | Israele V Shirley P Sixbey JW | 1991 | J Infect Dis1991，163，： | 1 |
| 7 | Vanadium-51 NMR study of vanadate binding to myosin and its subfragment 1显示文摘 | Israel R Michael P Andras M | | 0，，： | 1 |
| 8 | Molecular cloning of polyoma virus DNA in Escherichia coli:plasmid vector system显示文摘 | Israel M A Chan H W Rowe W P | 1997 | Science1997，203，4383： | 1 |
| 9 | Genomic rearrangement in NEMO impairs NF- kappaB activation and is a cause of incontinentia pigmenti: The International Incontinentia Pigmenti (IP) Consortium 显示文摘 | Smahi A Courtois G Vabres P Yamaoka S Heuertz S Munnich A Israel A | 2000 | Nature2000，405，： | 1 |
| 10 | Uptake and transport of epidermal growth factor by the small intestinal epithelium of the fetal rat显示文摘 | Weaver L T Gonnella P A Israel E J | 1990 | Gastroenterology1990，98，8： | 1 |
| 11 | Modulation of the Activities of Catalase, Cu-Zn, Mn Superoxide Dismutase, and Glutathione Peroxidase in Adipocyte from Ovariectomised Female Rats with Metabolic Syndrome显示文摘 | Rebeca Cambray Guerra Alejandra Zu?iga-Mu?oz Verónica Guarner Lans Eulises Díaz-Díaz Carlos Alberto Tena Betancourt Israel Pérez-Torres Joseph R. Vasselli | 2014 | International Journal of Endocrinology2014，，： | 1 |
| 12 | XMM-Newton and swift observation sprove GRBO90709A to be a distant, standard, long GRB 显示文摘 | LUCA A D ESPOSITE P ISRAEL G L | 2009 | Arxiv2009，152，3： | 1 |
| 13 | Adaptation of a simple flow cytometric assay to identifydifferent stages during apoptosis显示文摘 | Hamel W Dazin P Israel MA | 1996 | Cytometry1996，25，2： | 1 |
| 14 | Effect of Sex Hormones on Non-Esterified Fatty Acids, Intra-Abdominal Fat Accumulation, and Hypertension Induced by Sucrose Diet in Male Rats显示文摘 | Mohammed El Hafidi Israel Pérez Silvia Carrillo Guillermo Cardoso José Zamora Roberto Chavira Guadalupe Ba?os | 2006 | Clinical and Experimental Hypertension2006，，8： | 1 |
| 15 | Use of wrist activity for monitoring sleep/wake in demented nursing - home patients显示文摘 | ANCOLI ISRAEL S CLOPTON P KLAUBER M R | 1997 | Sleep1997，20，1： | 1 |
| 16 | Pyruvate and lactate protect striatal neurons against N-methyl-d-aspartate-induced neurotoxicity显示文摘 | MAUS M MAEIN P ISRAEL M | 1999 | Eur J Neurosci1999，11，9： | 1 |
| 17 | A prospective, randomized, multicenter clinical trial to evaluate the safety and effectiveness of a new lesion localization device 显示文摘 | Israel P Gittleman M Fenoglio M | 2002 | Am J Surg2002，184，4： | 1 |
| 18 | Residual dentin thickness in bifurcated maxillary first premolars after root canal and post space preparation with parallel-sided drills显示文摘 | Raphael P Eugine S Israel L | | 0，，04： | 1 |
| 19 | J Infect DIS显示文摘 | Israele V Shirley P Sixbeyjw | 1991 | 163:1341-13431991，163，： | 1 |
| 20 | Response of low seed phytic acid soybeans to increases in external phosphorus supply显示文摘 | Israel D W Kwanyuen P | | 0，，05： | 1 |
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