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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 3 | Aircra显示文摘 | WEAVER T L | 1996 | SPIE Proceedings1996，2840，1： | 1 |
| 4 | Multilevel temperature - cont rolled radiof requency for obst ructive sleep apnea: extend2 ed follow - up 显示文摘 | Steward D L Weaver E M Woodson B T | 2005 | Otolaryngol Head Neck Surg2005，132，4： | 1 |
| 5 | Fiber optic control system integration program: for optical flight control system development显示文摘 | WEAVER T L | 1994 | SPIE Proceedings1994，2295，2： | 1 |
| 6 | Expandingthe Effeetor CD4 T-Cell Repertoire:the Thl7 Lineage 显示文摘 | Harrington L E Mangan P R Weaver C T | 2006 | Curr Opin Immunol2006，18，3： | 1 |
| 7 | Thl7 : an effector CD4 T eell lineage with regulatory T cell ties 显示文摘 | WEAVER C T HARRINGTON L E MANGAN P R | 2006 | Immunity2006，24，6： | 1 |
| 8 | Novel Brφnsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | Ntai I Tran K L T Weaver K J | 2002 | J Am Chem Soc2002，124，： | 1 |
| 9 | Th17:an effeetor CD4 T cell lineage with regulatory T cell ties 显示文摘 | Weaver C T Harrington L E Mangan P R | 2006 | Immunity2006，24，6： | 1 |
| 10 | Expanding the effector CD4 T-cell repertoire:the Th17 lineage显示文摘 | Harrington L E Mangan P R Weaver C T | 2006 | Curr Opin Immunol2006，18，3： | 1 |
| 11 | Expanding the effec tor CD4 T cell repertoire=the Thl 7 lineage显示文摘 | Harrington L E Mangan P R Weaver C T | 2006 | Curt Opin Immu nol2006，18，3： | 1 |
| 12 | Th17:an effec tor CD4 T cell lineage with regulatory T cell ties显示文摘 | Weaver C T Harrington L E Mangan P R et ai | 2006 | Imnmnity2006，24，6： | 1 |
| 13 | Precipitation of calcite by indigenous microorganisms to strengthen liquefiable soils显示文摘 | BURBANK M B WEAVER T J GREEN T L | 2011 | Geomicrobiology Journal2011，28，： | 1 |
| 14 | Precipitation of Calcite by Indigenous Microorganisms to Strengthen Liquefiable Soils显示文摘 | Burbank M B Weaver T J Green T L | 2011 | Geomierobiology Journal2011，28，4： | 1 |
| 15 | Expanding the effector CD4 T-cell repertoire: the Thl7 lineage显示文摘 | Harrington L E Mangan P R Weaver C T | 2006 | Current opinion in im- munology2006，18，3： | 1 |
| 16 | Expanding the effector CIM ~ T cell repertoire:the Th17 lineage 显示文摘 | Harrington L E Mangan P R Weaver C T | 2006 | Curr Opin Immunol2006，，3： | 1 |
| 17 | Outcomes after nasal septoplasty:results from thenasal obstruction septoplasty effectiveness(NOSE)study显示文摘 | STEWART M G SMITH T L WEAVER E M | 2004 | Otolaryngol Head Neck Surg2004，130，： | 1 |
| 18 | Th17:an effector CD4 T cell lineage with regulatory T cell ties显示文摘 | WEAVER C T HARRINGTON L E MANGAN P R | 2006 | Immunity2006，24，6： | 1 |
| 19 | Preventing unintentional pediatric injuries:A tailored intervention for parents and providers显示文摘 | Nansel T R Weaver N L Jacobsen H A | 2008 | Health Educ Res2008，23，4： | 1 |
| 20 | Uptake and transport of epidermal growth factor by the small intestinal epithelium of the fetal rat显示文摘 | Weaver L T Gonnella P A Israel E J | 1990 | Gastroenterology1990，98，8： | 1 |
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