|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Assessing the estrogenic potency in a Portuguese wastewater treatment plant using an integrated approach显示文摘The estrogenic potency of a wastewater treatment plant(WWTP) was evaluated using chemical and biological analyses,which showed that after the station treatment processes some of the selected endocrine disruptor compounds(EDCs) were still present in the treated effuent(e.g.,bisphenol A,alkylphenols,estrone) .Thus,the most common endocrine EDCs were identified and quantified and the overall estrogenicity of the treated effuent assessed by integrating the results.Male goldfish(Carassius auratus) were used as biological indicators in a 28-day experiment.Vitellogenin(Vtg) ,gonadosomatic and hepatosomatic indices,steroids(17β-estradiol and 11-ketotestosterone) and histopathology were biomarkers used in fish to evaluate WWTP treated effuent estrogenicity,in combination with instrumental analyses.The results showed a significant increase(P<0.01) in plasma and liver Vtg,which were significantly correlated(r=0.66;P<0.01) .The gonadosmatic index was significantly(P<0.01) reduced in exposed fish.The steroid analyses revealed significant elevations in 17β-estradiol and depressed 11-ketotestosterone concentrations.The histological examinations show changes in exposed fish gonads,such as regressed testes and in some cases(43%to 75%) the development of ovo-testis in fish exposed to 50% and 100% treated effuent. | Mário S.Diniz Rita Maurício Mira Petrovic Maria J.López De Alda Leonor Amaral Isabel Peres Damiá Barceló Fernando Santana | 2010 | Journal of Environmental Sciences2010，22，10： | 2 |
| 2 | Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress显示文摘 | Ana Faria Rosário Monteiro Nuno Mateus Isabel Azevedo Concei??o Calhau | 2007 | European Journal of Nutrition2007，，5： | 1 |
| 3 | Colonic Metastasis of a Lung Carcinoma With Ileocolic Fistula显示文摘 | Isabel Bastos Dário Gomes Hermano Gouveia Diniz de Freitas | 1998 | Journal of Clinical Gastroenterology1998，，4： | 1 |
| 4 | The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression显示文摘 | Philippe Pinton Jean-Philippe Nougayrède Juan-Carlos Del Rio Carolina Moreno Daniela E. Marin Laurent Ferrier Ana-Paula Bracarense Martine Kolf-Clauw Isabelle P. Oswald | 2009 | Toxicology and Applied Pharmacology2009，，1： | 1 |
| 5 | Atypical nonprogressive pneumonia in goais显示文摘 | Gonalves Ros a rio Mariano Isabel N 6 ez Alejandro | 2010 | Veterinary Journal2010，183，2： | 1 |
| 6 | Montreal Cognitive Assessment (MoCA): Validation Study for Vascular Dementia显示文摘 | Sandra Freitas Mário R. Sim?es Lara Alves Margarida Vicente Isabel Santana | 2012 | Journal of the International Neuropsychological Society2012，，： | 1 |
| 7 | Species zonation in Corroios salt marsh in the Tagus estuary (Portugal) and its dynamics in the past fifty years显示文摘 | Isabel Cacador Tibe rio S Cabral H N | 2007 | Hydrobiologia2007，587，： | 1 |
| 8 | Lipidomic characterization of streptozotocin-induced heart mitochondrial dysfunction显示文摘 | Rita Ferreira Gabriela Guerra Ana Isabel Padr?o Tania Melo Rui Vitorino José Alberto Duarte Fernando Remi?o Pedro Domingues Francisco Amado M. Rosário Domingues | 2013 | Mitochondrion2013，，： | 1 |
| 9 | Species zonation in Corroios salt marsh in the Tagus estuary(Portugal)and its dynamics in the past fifty years显示文摘 | ISABEL C TIBE'RIO S CABRAL H N | 2007 | Hydrobiologia2007，587，： | 1 |
| 10 | Species zonation in Corroios salt marsh in the Tagus estuary(Portugal)and its dynamics in the past fifty years显示文摘 | Cacador Isabel Tibe′rio S Cabral H N | | 0，，： | 1 |
| 11 | Atypical non-progressive pneumonia in goats显示文摘 | Rosário Gon?alves Isabel Mariano Alejandro Nú?ez Sandra Branco Graham Fairfoul Robin Nicholas | 2009 | The Veterinary Journal2009，，2： | 1 |
| 12 | Genotypes and prevalence of HPV single and multiple concurrent infections in women with HSIL显示文摘 | Francisco Beca Jorge Pinheiro Elisabete Rios Patricia Pontes Isabel Amendoeira | 2014 | Diagn. Cytopathol2014，，11： | 1 |
| 13 | Influence of administration of long-chain polyunsaturated fatty acids on process of histological recovery in liver cirrhosis produced by oral intake of thioacetamide显示文摘 | Isabel Fernández BSc Isabel Torres PhD Eliane Moreira PhD Luis Fontana PhD Angel Gil PhD Antonio Rios PhD | 1996 | Digestive Diseases and Sciences1996，，1： | 1 |
| 14 | Seed protein deterioration by storage fungi 显示文摘 | JOSE-LUIS RIOS ISABEL ANDUJAR MARIA-CARMENRECIO | 2012 | Journal of Natural Products2012，，11： | 1 |
| 15 | Neuropsychological features of progranulin-associated frontotemporal dementia: a nested case-control study显示文摘The distinction between sporadic and genetic behavioural-variant frontotemporal dementia(bvFTD)regarding some neuropsychological(NP)features remains challenging.Specifically,progranulin(GRN)-associated bvFTD frequently presents with early episodic memory impairment and some degree of parietal dysfunction which are supporters of Alzheimer’s disease(AD)diagnosis.In this context,we aimed to characterize the NP profile of GRN-bvFTD as compared to sporadic-bvFTD and AD in patients with mild dementia(Mini-Mental State Examination score≥17 and Clinical Dementia Rating Scale score≤1.We identified 21 patients at Centro Hospitalar e Universitário de Coimbra,Portugal with GRN mutations belonging to fifteen different families.As our focus was bvFTD variants,FTD-related aphasic forms(3 patients)were excluded.The remaining 18 GRN-bvFTD were further matched with 18 sporadic-bvFTD and 18 AD patients according to disease staging,age and education.All patients completed the Mini-Mental State Examination,Montreal Cognitive Assessment(MoCA)and a comprehensive NP assessment battery.Results were converted into z-scores.Differences between groups in individual NP measures and NP domains were assessed through non-parametric tests(Kruskal-Wallis test analysis)and eta squared(ŋ2)was calculated as a measure of effect size.Group comparisons show that GRN patients have worse performances on verbal retrieval processes(P=0.039,ŋ2=0.110)and visuoconstructive abilities(P=0.039,ŋ2=0.190)than sporadic bvFTD forms.When compared to AD,GRN patients present a higher impairment in frontal(P=0.001,ŋ2=0.211)and parietal(P=0.041,ŋ2=0.129)measures and a better performance in memory tasks(P=0.020,ŋ2=0.120).Sporadic-bvFTD forms are worse than AD in frontal measures(P=0.032,ŋ2=0.200),being better in both memory(P=0.010,ŋ2=0.131)and visuospatial skills(P=0.023,ŋ2=0.231).Considering these results,we conclude that GRN-bvFTD patients present a NP profile that associates the typical patterns of FTD and AD deficits.This is particularly expressive in visuoconstructive abilities,which was the more discriminative feature between groups,followed by episodic verbal memory.This study was approved by the Institutional Ethics Committee of Centro Hospitalar e Universitário de Coimbra,Portugal(CE-029/2019)on June 24,2019. | Marisa Lima Miguel Tábuas-Pereira Diana Duro João Durães Daniela Vieira Inês Baldeiras Maria Rosário Almeida Isabel Santana | 2021 | Neural Regeneration Research2021，16，5： | 0 |
| 16 | Effect of dichloromethylene diphosphonate on liver regeneration following thioacetamide-induced necrosis in rats显示文摘AIM: To study the effect of dichloromethylene diphos-phonate (DMDP), a selective Kupffer cell toxicant in reference to liver damage and postnecrotic liver regeneration in rats induced by sublethal dose thioacetamide (TA). METHODS: Rats, intravenously (iv ) pre-treated with a single dose of DMDP (10 mg/kg), were intraperitoneally (ip ) injected with TA 6.6 mmol/kg (per 500 mg/kg body weight). Hepatocytes were isolated from rats at 0, 24, 48 and 72 h following TA intoxication and blood and liver samples were obtained. To evaluate the mecha-nisms involved in the postnecrotic regenerative state, DNA distribution and ploidy time course were assayed in isolated hepatocytes. Circulating cytokine tumor necrosis factor-alpha (TNF-α) was assayed in serum and determined by reverse transcriptase-polymerase chain reaction in liver extract. RESULTS: The effect of DMDP induced noticeable changes in postnecrotic regeneration, causing an increased percentage of hepatocytes in the cell cycle S phase. The increase at 24 h in S1 population in rats pretreated with DMDP + TA was significantly (P < 0.05) different compared with that of the TA group (18.07% vs 8.57%). Hepatocytes increased their proliferation as a result of these changes. Also, TNF-α expression and serum level were increased in rats pre-treated with DMDP. Thus, DMDP pre-treatment reduced TA-induced liver injury and accelerated postnecrotic liver regeneration. CONCLUSION: These results demonstrate that Kupffer cells are involved in TA-induced liver, as well as in post-necrotic proliferative liver states. | Mirandeli Bautista María ngeles Gómez del Rio Juana Benedí María Isabel Sánchez-Reus José A Morales-González Ana María Téllez-López Maricela López-Orozco | 2013 | World Journal of Hepatology2013，5，7： | 0 |
| 17 | Not all liver tumors are alike—an accidentally discovered primary hepatic leiomyosarcoma:A case report显示文摘BACKGROUND Primary hepatic leiomyosarcoma is a very rare entity that originates from smooth muscle.Preoperative diagnosis requires a high degree of suspicion due to atypical clinical presentation and non-specific imaging features.CASE SUMMARY We report the case of a 42-year-old man,with no relevant past medical history,accidentally diagnosed with a nodular liver lesion on a routine abdominal ultrasound.Liver function tests and hematology parameters as well as tumor markers were normal.A contrast-enhanced abdominal computed tomography scan revealed a heterogenous hepatic lesion measuring 40 mm 30 mm,adjacent to the left branch of the portal vein and the round ligament.Due to the unclear diagnosis,the patient underwent surgical resection.Histopathological and immunohistochemical examinations confirmed complete(R0)resection of a hepatic leiomyosarcoma.The patient remains without any signs of tumor recurrence for more than 2 years.CONCLUSION We report a rare case of accidentally diagnosed primary hepatic leiomyosarcoma originating from the portal vein or the round ligament.Although this tumor has aggressive metastatic potential,a tumor-free resection margin is essential to improve survival. | Isabel Garrido Patrícia Andrade João Pacheco Elisabete Rios Guilherme Macedo | 2022 | World Journal of Hepatology2022，14，4： | 0 |
| 18 | 地理编码方法对长期城市空气污染暴露与肺功能之间关联的影响显示文摘[背景]地址地理编码中的错误可能会影响空气污染对健康影响的估计。[目的]研究4种地理编码技术对采用小尺度(10m×10m)分散模型估计的城市空气污染与成人肺功能之间关联的影响。[方法]测量法国格勒诺布尔市354名成年居民的1秒用力呼气容积(FEV1)与用力肺活量(FVC)。这些居民参加了两个特征明确的研究:遗传和环境对哮喘影响的流行病学研究(EGEA)和欧洲共同体呼吸系统健康调查(ECRHS)。使用单个建筑物匹配作为参考方法以及三种空间插值方法编码家庭地址。使用扩散模型估计在进行肺功能测量前的12个月期间,每个参加者住址的PM10和二氧化氮的平均浓度。以个体混杂因素及同日空气污染物暴露校正暴露与肺功能参数之间的关联。对地理编码技术在地理坐标之间距离、暴露估值以及暴露估值与健康影响之间关联等方面进行比较。[结果]利用建筑物匹配和三种插值技术估计坐标之间的中位数距离分别为26.4、27.9、35.6m。相对于基于建筑匹配的暴露估值,基于三种插值技术的PM10浓度往往被高估。当使用建筑物匹配估计暴露估值时,PM10每增加一个四分位数间距(3.0μg/m3),FVC%预测值下降3.72点(95%CI:-0.56~-6.88)、FEV1%预测值下降3.86点(95%CI:-0.14~-3.24)。当使用其他地理编码方法时,关联的幅度下降[例如,使用NavTEQ预测FVC%-2.81(95%CI:-0.26,-5.35),或者使用谷歌地图预测FVC%-2.08(95%CI:-4.63~0.47,P=0.11)。[结论]研究结果表明,当使用小尺度暴露模型估算空气污染暴露时,地理编码技术的选择可能会对健康影响的评估产生影响。 | Bénédicte Jacquemin Johanna Lepeule Anne Boudier Caroline Arnould Meriem Benmerad Claire Chappaz Joane Ferran Francine Kauffmann Xavier Morelli Isabelle Pin Christophe Pison Isabelle Rios Sofia Temam Nino Künzli Rémy Slama Valérie Siroux | 2013 | 环境与职业医学2013，30，12： | 0 |
| 19 | Genoprotection and metabolic benefits of marine macroalgae-Insights into the concept of functional foods through direct and indirect consumption显示文摘The consumption of marine macroalgae has been linked with health benefits,albeit some actions,including genoprotection,remain underexplored.Hence,we evaluated the genoprotective potential of a mixture of Ulva rigida,Fucus vesiculosus and Gracilaria gracilis,through direct consumption or via indirect intake using fish(Sparus aurata)as a vector of algal phytocompounds.Mice(Mus musculus)were subjected to a 1-month dietary supplementation with 5%of macroalgae mix or 10%of fillet of fish previously fed with an algae-supplemented aquafeed(for comparison purposes,10%supplementation with fillet of fish standardly fed was also considered).Thereafter,mice were challenged by the genotoxicant methyl methanesulfonate(MMS),and the genetic damage was evaluated through the micronuclei test.Complementarily,a wider evaluation was carried out encompassing the assessment of energy metabolism,haematological and histological parameters,as well as growth performance.Macroalgae unequivocally protected against MMS-induced genotoxicity.The activity profile of hepatic lactate and isocitrate dehydrogenases promoted by the supplemented diets reflected an improved energy balance.Genoprotection properties were not transferred via fish fed with the algae-supplemented aquafeed,though the transference of phytocomponents with beneficial properties(viz.energy balance improvement)should not be disregarded.Overall,these findings highlighted the genoprotection afforded by marine macroalgae,likely promoted by desmutagenic factors,reinforcing their definition as functional food.The possibility of using fish as an indirect source of algae-borne phytocomponents proved to be plausible and worthy of further investigations. | Ana Marques João Ferreira Ana Cerqueda-Pacheco Vitória Pereira Helena Abreu Rui Pereira Maria João Pires Fernanda Seixas Paula Oliveira Isabel Gaivão Mário Pacheco | 2022 | Food Bioscience2022，47，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员