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| 1 | Management of pancreaticobiliary disease using a new intra-ductal endoscope:The Texas experience显示文摘AIM:To evaluate a new single-operator mini-endoscope, Spyglass,for its performance,feasibility and safety in the management of pancreaticobiliary disease. METHODS:In a multicenter retrospective analysis of patients undergoing intraductal endoscopy,we evaluated 128 patients(71 men,mean age 57.6 years).Indications were therapeutic(TX)in 72(56%) and diagnostic(DX)in 56(44%). RESULTS:Peroral endoscopy was performed in 121 and percutaneous in seven.TX indications included CBD stones in 41,PD stones in six,and biliary strictures in 25.DX indications included abnormal LFT’s in 15, abnormal imaging in 38 and cholangiocarcinoma staging in three.Visualization of the stone(s)was considered good in 31,fair in six,and poor in four. Advancement of the electrohydraulic lithotripsy probe was not possible in three patients and proper targeting of the lesion was partial in four patients.A holmium laser was used successfully in three patients.Ductal clearance was achieved in 37 patients after one procedure and in four patients after two procedures.Diagnosis of biliary strictures was modified in 20/29 and confirmed to be malignant in 10/23.Of the modified patients,no diagnosis was available in 17.Spyglass demonstrated malignancy in 8/17 and non-malignancy in nine.Suspected pathology by imaging studies and abnormal LFT’s was modified in 43/63(66%).Staging of cholangiocarcinoma demonstrated multicentric cholangiocarcinoma in 2/3.There was no morbidity associated with the use of Spyglass. CONCLUSION:Spyglass Spyscopeis a first generation, single operator miniature endoscope that can evaluate and treat various biliary and pancreatic tract diseases. | Douglas S Fishman Paul R Tarnasky Sandeep N Patel Isaac Raijman | 2009 | World Journal of Gastroenterology2009，15，11： | 22 |
| 2 | Hyperglycemia:an independent marker of in-hospital mortality in patients with undiagnosed diabetes显示文摘 | Umpierrez GE Isaacs SD Bazargan N | | J Ciin Endocrinol Metab0，，： | 2 |
| 3 | Hypergl ycemia: AnIndependent marker of in-hospital mortality in patients with undiagnosed diabetes显示文摘 | UMPIERREZ GE ISAACS SD BAZARGAN N | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 4 | Improving doctor - patient communication in the outpatient setting using a facil- itation tool: a preliminary study 显示文摘 | Neeman N Isaac T Leveille S | 2012 | Int J Quality Health Care2012，24，4： | 1 |
| 5 | Histopathologie features of o- ral submucous fibrosis : a study of 35 biopsy specimens 显示文摘 | Isaac U Issac JS Ahmed Khoso N | 2008 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2008，106，4： | 1 |
| 6 | Crystal structure of the response regulator 02 receiver domain, the dssential YyeF two-component system of Streptococcus pneumoniae in both complexed and native states 显示文摘 | Bent C J Isaacs N W Mitchell T J | 2004 | J Bacteriol2004，186，9： | 1 |
| 7 | Microbial diversity and resistance to copper in metal-contaminated lake sediment 显示文摘 | Konstantinidis K T Isaacs N Fett J | 2003 | Microbial Ecology2003，45，2： | 1 |
| 8 | Crystal structure of an integral membrane light-harvesting complex from photosynthtic bacteria显示文摘 | McDermott G Prince S M Freer A A Hawthorthwaite-Lawless A M Papiz M Z Cogdell R J Isaacs N W | 1995 | Nature1995，374，6： | 1 |
| 9 | Effect of pressure on processes modelling the Maillard reaction显示文摘 | Isaacs N S Coulson M | 1996 | Journal of Physical Organic Chemistry1996，，9： | 1 |
| 10 | Mycoplasma pneumonice infectionsin Australian Children显示文摘 | Othman N isaacs D Kesson A | 2005 | Paediatr Child Health2005，41，12： | 1 |
| 11 | Concurrent cyclophosphamide,methotrexate,and 5-fluorouracil chemotherapy and radiotherapy for breast carcinoma:a well tolerated adjuvant regimen显示文摘 | Isaac N Panzarella T Lau A | 2002 | Cancer2002，95，4： | 1 |
| 12 | Hhyperglucomia and independed marker of in hospital mortality in patients with undiagnosed diabete显示文摘 | Umpirrez CE Isaacs SD Bazargan N | 2002 | Clin Endocrinol Metab2002，87，： | 1 |
| 13 | Hypergly- cemia: An independent marker of in-hospital mortality in patients with undiagnosed diabetes显示文摘 | Umpierrez G E Isaacs S D Bazargan N | 2002 | J Clin Endocrinol Metab2002，87，3： | 1 |
| 14 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 15 | Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction 显示文摘 | Sotoodehnia N Isaacs A de Bakker PI | 2010 | Nature Genetics2010，42，12： | 1 |
| 16 | Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western C?te d’Ivoire显示文摘 | Giovanna Raso Eliézer K N'Goran Abale Toty Anne Luginbühl Cynthia A Adjoua Norbert T Tian-Bi Isaac I Bogoch Penelope Vounatsou Marcel Tanner Jürg Utzinger | 2003 | Transactions of the Royal Society of Tropical Medicine and Hygiene2003，，1： | 1 |
| 17 | Hyperglycemia:an independent marker of in-hospital mortality in patients with undiagnosed diabetes显示文摘 | Umpierrez GE Isaacs SD Bazargan N | 2002 | J Clin Endocrinol Metab2002，87，3： | 1 |
| 18 | Randomized placebo- controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast receiving dose-intensive cyclophosphamide and doxorubicin 显示文摘 | Isaacs C Robert N J Bailey FA | 1997 | J Clin Oncol1997，15，11： | 1 |
| 19 | Hyperglycemia:an independent marker of in-hospital mortality in patients with undiagnosed diabetes显示文摘 | Umpierrez GE Isaacs SD Bazargan N | | 0，，： | 1 |
| 20 | The application of high pressure to some difficult wittig reactions 显示文摘 | ISAACS N S EL-DIN G N | 1987 | Tetrahedron Lett1987，28，19： | 1 |
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