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| 1 | Histopathologie features of o- ral submucous fibrosis : a study of 35 biopsy specimens 显示文摘 | Isaac U Issac JS Ahmed Khoso N | 2008 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2008，106，4： | 1 |
| 2 | Hsp90 as a gatekeeper of tumor angiogenesis:clinical promise and potential pitfalls显示文摘 | Bohonowych J E Gopal U Isaacs J S | | 0，，： | 1 |
| 3 | The life-space diary: a measure of mobility in old people at home 显示文摘 | May D Nayak U S Isaacs B | 1985 | Int Rehabil Med1985，7，4： | 1 |
| 4 | Language dysfunction in children with Rolandic epilepsy显示文摘 | Staden U Isaacs E Boyd SG | 1998 | Neuropediatrics1998，29，5： | 1 |
| 5 | Hsp90 as a gatekeeper of tumor angiogenesis:clinical promise and potential pitfalls显示文摘 | Bohonowych J Gopal U Isaacs J | 2010 | J O ncol2010，2010，41： | 1 |
| 6 | UniPron is A Fully Effective Non-hormonal Reversible Contraceptive in Baboon Model (Papio Anubis)显示文摘Objective To determine the safety and efficacy of UniPron as a reversible contraceptive. Methods Vaginal swabs were obtained before and after UniPron administration, cultured onto appropriate culture media and bacteria identification was done based on type of media used, Gram stain reactions, colony morphology and biochemical tests. Vaginal biopsy tissues were processed using paraffin wax method, stained with hematoxylin and eosin and examined under light microscopy to determine the effect of the product on vaginal tissues. The effect of UniPron on sperm was examined by mixing the product with electroejaculated spermatozoa in vitro at different concentrations. For efficacy studies, male baboons of proven fertility were mated with UniPron treated or untreated females of proven fertility during the fertile stages. Results All the five females (100%) that were treated with UniPron did not conceive and they regained total fertility when the treatment was stopped while all the controls conceived. At a concentration of 40%,UniPron completely immobilized spermatozoa in an in-vitro system. UniPron mechanism of action was by lowering the vaginal pH and on application in baboon, the pH was lowered for at least 3 h after which it went back to normal. Conclusions As we plan for a study to test UniPron as a microbicide to prevent STIs including HIV, our current study has established that this novel product is effective in contraception and harmless to vaginal tissues and vaginal microbial flora in a baboon model (Papio anubis). | Jael A.Obiero Maureen N.Mburu Benson M.Ndung'u Kenneth K.Waititu Isaac Mulei Idle O.Farah Peter G.Mwethera | 2008 | Journal of Reproduction and Contraception2008，19，2： | 1 |
| 7 | Language dysfunction in children with rolandic epileppsy 显示文摘 | Staden U Isaacs E Boyd SG | 1998 | Neuropediatrics1998，29，5： | 1 |
| 8 | Histopathologic features of oral submucous fibrosis: a study of 35 biopsy specimens 显示文摘 | Isaac U Issac JS Ahmed KN | 2008 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2008，106，4： | 1 |
| 9 | Language dysfunction in chil- dren with Rolandic epilepsy 显示文摘 | Staden U Isaacs E Boyd SG | 1998 | Neuropediatrics1998，29，5： | 1 |
| 10 | How dangerous are falls in old people at home 显示文摘 | WILD D NAYAK U S ISAACS B | 1981 | British Medical Journal1981，282，6260： | 1 |
| 11 | Histopathologic features of oral submucous fibrosis: a study of 35 biopsy specimens 显示文摘 | Isaac U Issac JS Ahmed Khoso N | 2008 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2008，106，4： | 1 |
| 12 | Language dysfunc- tion in children with Rolandic epilepsy 显示文摘 | STADEN U ISAACS E BOYD S G | 1998 | Neuropediatrics1998，29，5： | 1 |
| 13 | Balance in elderly patients: the 'get-up and go' test 显示文摘 | Mathias S Nayak U S Isaacs B | 1986 | Arch Phys Med Rehabil1986，67，6： | 1 |
| 14 | Safety of symptom-limited cardiopulmonary exercise testing in patients with chronic heart failure due to severe left ventricular systolic dysfunction 显示文摘 | KETEYIAN S J ISAAC D THADANI U | 2009 | Am Heart J2009，158，4： | 1 |
| 15 | High-throughput single cell arrays as a novel tool in biopreservation显示文摘 | Kenneth L R Kevin R K Korkut U Steven C H Isaac S K Martin L Y Mehmet T | 2009 | Cryobiology2009，58，3： | 1 |
| 16 | Effect of Gongronema latifolium on gastric emptying in healthy dogs显示文摘AIM:To investigate sonographically the effect of Gonogronema latifolium (G.latifolium) on gastric emptying of semi-solid meals in healthy dogs.METHODS:In a randomized,placebo-controlled experiment,twenty-five clinically healthy dogs were randomly allotted into five groups of five dogs in each group.The placebo group served as the control,and the low,moderate and high dose groups ingested the methanolic leaf extract of G.latifolium in capsules at 100 mg/kg,250 mg/kg and 500 mg/kg,respectively,while the prokinetic group ingested 0.5 mg/kg capsules of metoclopramide.After a 12-h fast,each group ingested its treatment capsules 30 min before the administration of a test meal.Measurements of gastric emptying and blood glucoselevels were obtained 30 min before and immediately after the ingestion of the test meal and thereafter every 15 min for 4 h.This was followed by further measurements every 30 min for another 2 h.RESULTS:The gastric emptying times of the placebo,low dose,moderate dose,high dose and prokinetic dose groups were 127.0 ± 8.2 min,135.5 ± 3.7 min,155.5 ± 3.9 min,198.0 ± 5.3 min and 59.0 ± 2.5 min,respectively.Gastric emptying times of the moderate and high dose groups were significantly slower than in the placebo control group (155.5 ± 3.9 min,198.0 ± 5.3 min vs 127.0 ± 8.2 min,P=0.000).No significant difference in gastric emptying between the low dose and placebo control groups was noted (135.5 ± 3.7 min vs 127.0 ± 8.2 min,P=0.072).Gastric emptying of the prokinetic group was significantly faster than that of the control group (59.0 ± 2.5 min vs 127.0 ± 8.2 min,P=0.000).The hypoglycaemic effect of G.latifolium and gastric emptying were inversely related (r=-0.95,P=0.000).CONCLUSION:G.latifolium delays gastric emptying and lowers postprandial blood glucose in healthy dogs.It reduces the postprandial blood glucose by delaying gastric emptying. | Sylvester O Ogbu Kenneth K Agwu Isaac U Asuzu | 2013 | World Journal of Gastroenterology2013，19，6： | 0 |
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