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| 1 | Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis显示文摘AIM:To study the activation of pancreatic and pulmonary mast cells and the effect of mast cell inhibition on the activation of peritoneal and alveolar macrophages during acute pancreatitis.METHODS:Pancreatitis was induced by intraductal infusion of 5% sodium taurodeoxycholate in rats.The mast cell inhibitor cromolyn was administered intraperitoneally(i.p.) 30 min before pancreatitis induction.The pancreatic and pulmonary tissue damage was evaluated histologically and mast cells and their state of activation were evaluated.Peritoneal and alveolar macrophages were obtained and the expression of tumor necrosis factor α was determined.Myeloperoxidase activity was measured to evaluate the effect of mast cell inhibition on the progression of the inflammatory process.Finally,the effect of plasma on cultured mast cells or macrophages was evaluated in vitro.RESULTS:The mast cell stabilizer signif icantly reduced inflammation in the pancreas and lung and the activation of alveolar macrophages but had no effect on peritoneal macrophages.Mast cell degranulation was observed in the pancreas during pancreatitis but no changes were observed in the lung.Plasma from rats with pancreatitis could activate alveolar macrophages but did not induce degranulation of mast cells in vitro.CONCLUSION:Pancreatic mast cells play an important role in triggering the local and systemic inflammatory response in the early stages of acute pancreatitis.In contrast,lung mast cells are not directly involved in the inflammatory response related to pancreatic damage. | Inmaculada Lopez-Font Sabrina Gea-Sorlí Enrique de-Madaria Luis M Gutiérrez Miguel Pérez-Mateo Daniel Closa | 2010 | World Journal of Gastroenterology2010，16，27： | 10 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | High performance work systems and export performance显示文摘 | Martin-Tapia Inmaculada Aragon-Correa J.Alberto Guthrie James P | | 0，，03： | 1 |
| 4 | High incidence of cardiovascuLar events in a rheumatoid arthritis cohort not expLained by traditionaL cardiac risk factors显示文摘 | InmacuLada deL Rincon Ken WiLLiams MichaeL P S | 2001 | Arthritis Rheum2001，44，： | 1 |
| 5 | Brain aminopeptidases and hypertension显示文摘 | Isabel P Francisco V | 2006 | J RAAS2006，7，： | 1 |
| 6 | High performance work systems and export performance显示文摘 | Martin-Tapia Inmaculada Aragon-Correa J.Alberto Guthrie James P | | 0，，03： | 1 |
| 7 | Purification and biological characterization of haloein H1 from Haloferax mediterranei M2a显示文摘 | Gonzalo P Inmaculada M Ricardo A | 2002 | Int Mierobiol2002，67，5： | 1 |
| 8 | High performance work systems and export performance显示文摘 | Martin-Tapia Inmaculada Aragon-Correa J.Alberto Guthrie James P | | 0，，03： | 1 |
| 9 | Multidetector CT in the Evaluation of Potential Living Donors for Liver Transplantation 显示文摘 | Ana AT Jaime FC Inmaculada P | 2005 | RadioGraphics2005，25，4： | 1 |
| 10 | Barriers to Non-Viral Vector-Mediated Gene Delivery in the Nervous System 显示文摘 | Francisco CPM Javier G Inmaculada P | 2011 | Pharm Res2011，28，： | 1 |
| 11 | Multidetector CT in the evaluation of potential living donors for liver transplantation显示文摘 | Ana AT Jaime FC Inmaculada P | 2005 | RadioGraphics2005，25，4： | 1 |
| 12 | Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen al(I)gene expression in cultured hepatic stellate cell显示文摘 | INMACULADA GR TORRE P TERESA D | 2002 | J Biol Chem2002，277，30： | 1 |
| 13 | Multidetector CT in the evaluation of potential living donors for liver transplantation显示文摘 | Ana AT Jaime FC Inmaculada P | 2005 | Radiographics2005，25，4： | 1 |
| 14 | Integration of CFD codes and advanced combustion models for quantitative burnout determination 显示文摘 | Javier P Inmaculada A Alan W | 2007 | Fuel2007，86，15： | 1 |
| 15 | On-line non-destructive determination of proteins and infiltrated fat in Iberian pork loin by near infrared spectrometry with a remote reflectance fibre optic probe 显示文摘 | INMACULADA G M CLAUDIO G P JESUS H M | 2002 | Analytica Chimica Acta2002，453，2： | 1 |
| 16 | Development of an engineering system for unburned carbon prediction 显示文摘 | JAVIER P INMACULADA A ENRIQUE T | 2009 | Fuel2009，88，1： | 1 |
| 17 | Numerical prediction of unburned carbon levels in large pulverized coal utility boilers显示文摘 | Javier P Inmaculada A Luis I D | | 0，，18： | 1 |
| 18 | Multi detector CT in the evaluation of potential living donors for liver transplantation 显示文摘 | Ana AT JaimeFC Inmaculada P | 2005 | Radio Graphics2005，25，4： | 1 |
| 19 | Integration of CFD codes and advanced combustion models for quantitative burnout determination显示文摘 | JAVIER P INMACULADA A ALAN W | 2007 | Fuel2007，86，15： | 1 |
| 20 | Prognostic Value of Cystatin C on Admission in Heart Failure With Preserved Ejection Fraction显示文摘 | Francisco Javier Carrasco-Sánchez Luis Galisteo-Almeda Inmaculada Páez-Rubio Francisco Javier Martínez-Marcos Crescencio Camacho-Vázquez Carlos Ruiz-Frutos Emilio Pujol-De La Llave | 2011 | Journal of Cardiac Failure2011，，1： | 1 |
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