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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Municipaltreated wastewater reuse for plant nurseries irrigation 显示文摘 | CLAUDIO L RICCARDO G FRANCESCO P N | 2004 | Water Research2004，38，12： | 1 |
| 3 | Coutinho critical assessment of the formation of ionic-liquid-based aqueous two-phase systems in acidic media显示文摘 | CLAUDIO A F M FERREIRA A M SHAHRIARI S FREIRE M G JOAO A P | 2011 | J Phys Chem B2011，115，11： | 1 |
| 4 | Effect of Ultra-high Hydrostatic Pressure Treatments on the Quality of Tomato Juice显示文摘 | Sebastiano P Aless Er B Claudio G | 1995 | Food Chemistry1995，52，1： | 1 |
| 5 | Topological mapping of the cyteine residues of N-carbamyl-D-amino acid amidohydrolase and their role in enzymatic qctivity显示文摘 | RENATA G CLAUDIO P GIULIANO G | 1996 | American Society for Biochemistry and Molecular Biology1996，271，16： | 1 |
| 6 | Effect of the pesticide 2,4-Dmicro-bial activity of the soil monitored by micocalorimetry显示文摘 | Alexandre G S P Claudio A | 2000 | Thermochimica Acta2000，349，： | 1 |
| 7 | Retinoblas- toma - related protein pRb2/p130 and suppression of tumor growth in vivo显示文摘 | HOWARD C M CLAUDIO P P GALLIA G L | 1998 | J Natl Cancer Inst1998，90，19： | 1 |
| 8 | Olive Phenol Hydroxytyrosol Prevents Passive Smoking-Induced Oxidative Stress显示文摘 | FRANCESCO V CLAUDIO G ELENA P | 2000 | Circulation2000，102，： | 1 |
| 9 | Effect of soil potassium a- vailability on soybean aphid ( Hemiptera: Aphididae ) population dynamics and soybean yield显示文摘 | Scott W M Claudio G Richard P | 2005 | Field and Forage Crops2005，98，1： | 1 |
| 10 | Effect of the pesticide 2,4 - D microbial activity of the soil monitored by micocalorimetry显示文摘 | Alexandre G S P Claudio A | 2000 | Thermochimica Acta2000，349，： | 1 |
| 11 | Effect of Pesticide 2,4-D on Microbial Activity of the Soil Monitored by Microcalorimetry显示文摘 | ALEXAMDRE G S P CLAUDIO A | 2000 | The rmochim Acta2000，349，： | 1 |
| 12 | Equilib- rium and extraction kinetics of tannins from chestnut tree wood in water solutions 显示文摘 | Claudio C Fausto G Vincenzo P | 2011 | Asia - Pac J Chem Eng2011，6，4： | 1 |
| 13 | On-line non-destructive determination of proteins and infiltrated fat in Iberian pork loin by near infrared spectrometry with a remote reflectance fibre optic probe 显示文摘 | INMACULADA G M CLAUDIO G P JESUS H M | 2002 | Analytica Chimica Acta2002，453，2： | 1 |
| 14 | Effect of the pesticide 2,4 -D on microbial activity of the soil monitored by microcalorimetry 显示文摘 | Claudio A | 2000 | Thermochimica Acta2000，349，： | 1 |
| 15 | Antioxidant and other biological activities of phenols from olives and olive oil 显示文摘 | Francesco V Andrea P Claudio G | 2002 | Medicinal Research Reviews2002，22，1： | 1 |
| 16 | Effect of the pesticide 2,4-1) on microbial activity of the soil monitored by microcalorimetry 显示文摘 | Alexandre G S P Claudio A | 2000 | Thermohimica Acta2000，349，： | 1 |
| 17 | Rb2/p130, vascular endothelial growth factor, p27 ( KIP1 ) , and proliferating cell nuclear antigen expression in hepatocellular carcinoma: their clinical significance显示文摘 | Claudio P P Russo G Christine A C | 2004 | Clin Cancer Res2004，10，10： | 1 |
| 18 | On the effects of different strategies in modeling balloon-expandable slenting by means of finite element method 显示文摘 | Francesca G Claudio C Lorenza P Luca D V Francesco M | 2008 | Journal of Biomechanics2008，41，： | 1 |
| 19 | Impact of annealing on the physicochemical properties of unfermented cassava starch 显示文摘 | ANIDA M M G CLAUDIO E M S NAGILA M P S | 2004 | Starch2004，56，9： | 1 |
| 20 | Natural vermiculite as an exchanger support for heavy cations in aqueous solution显示文摘 | Maria G da Fonseca Michelle M de Oliveira Luiza N H Arakaki Jose G P Espinola Claudio Airoldi | 2005 | Journal of Colloid of Interface Science2005，285，： | 1 |
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