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| 1 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 2 | Geological and engineering characteristics of expensive soils and rocks in Northern Oman显示文摘 | AMER A AI-RAWAS INGEBORG GUBA MCGOWN A | 1998 | Engineering geology1998，，50： | 1 |
| 3 | The impact of bilateral sagittal split osteotomy on mandibular width and morphology 显示文摘 | Ingeborg M Watzke 1M Heinrich A | 2002 | J Oral Maxillofac Surg2002，60，5： | 1 |
| 4 | De- tection of noroviruses in shellfish in the Netherlands显示文摘 | INGEBORG L A JEROEN J H C NATHALIE A J M | 2006 | Interna- tional Journal of Food Microbiology2006，108，： | 1 |
| 5 | Geological and engine-ering characteristics of expansive soils and rocks in northern Oman显示文摘 | Amer A Al-Rawas Ingeborg Guba | 1998 | Engineering Geology1998，50，： | 1 |
| 6 | Geological and Engineering Characteristics of Expansive Soils and Rocks in Northern Oman显示文摘 | Amer A Al Rawas Ingeborg Guba | 1998 | Engineering Geology1998，50，： | 1 |
| 7 | Supplemental Calcium Attenuates the Colitis-Related Increase in Diarrhea, Intestinal Permeability, and Extracellular Matrix Breakdown in HLA-B27 Transgenic Rats1-3显示文摘 | Schepens Marloes A A Schonewille Arjan J Vink Carolien van Schothorst Evert M Kramer Evelien Hendriks Thijs Brummer Robert-Jan Keijer Jaap van der Meer Roelof Bovee-Oudenhoven Ingeborg M J | 2009 | The Journal of Nutrition2009，，8： | 1 |
| 8 | Cyclopentenone Isoprostanea induced by reactive oxygen species trigger defense geneactivation and phytoalexin accumulation in plants显示文摘 | Ingeborg Thoma Christiane Loeffler A lok K Sinha | 2003 | The Plant J2003，34，3： | 1 |
| 9 | The combination of medical treatment plus multicomponent behavioral therapy is superior to medical treatment alone in the therapy of irritable bowie syndrome显示文摘 | Rudolf A | 2000 | Am J Gastraenterol2000，95，： | 1 |
| 10 | Determination of Iodine in Food Samples by Inductively Coupled Plasma Mass Spectrometry after Alkaline Extraction显示文摘 | Peter A Fecher Ingeborg Goldmann Anto Nagengast | 1998 | J Anal At Spectrom1998，13，： | 1 |
| 11 | Vitamin Supplementation Reduces Blood homocysteine levels Arteiosc Lerosis显示文摘 | Martin Heijer Ingeborg A Brouwer Gerard MJ | 1998 | Thrombosis and vasvular Biology1998，18，： | 1 |
| 12 | Influence of pesticides onnitrogen transformations in soil显示文摘 | INGEBORG A ANDERSON J P E | 1991 | Toxicological&EnvironmentalChemistry1991，30，34： | 1 |
| 13 | Brain perfusion spect in impulsivity-related personality disorders 显示文摘 | Ingeborg G Kurt A Filip J | 2005 | Behav Brain Res2005，157，1： | 1 |
| 14 | Saturated fat and heart disease 显示文摘 | Martijn B Katan Ingeborg A Brouwer Robert Clarke | 2010 | American Journal of Clinical Nutrition2010，92，2： | 1 |
| 15 | The impact of bilateral sagittal split osteotomy on mandibular width and morphology显示文摘 | Ingeborg M Watzke 1M Heinrich A | | 0，，05： | 1 |
| 16 | Novel pyrogen tests based on the human fever reaction显示文摘 | Thomas H Ingeborg A Susanne B | 2001 | Altern Lab Anim2001，29，2： | 1 |
| 17 | Geolog-ical and engineering characteristics of expansive soils and rocks in northern oman显示文摘 | AMER A INGEBORG G MCGOWN A | 1998 | Engineering Geology1998，50，： | 1 |
| 18 | The combination of medical treatment plus multicomponent behavioral therapy is superior to medical treatment alone in the therapy of irritable bowle syndrome显示文摘 | Ingeborg HM Rudolf A | 2000 | Am J Gastraenterol2000，95，： | 1 |
| 19 | Cyclopentenone isopros- tanes induced by reactive oxygen species trigger defense gene ac- tivation and phytoalex in accumulation in plants 显示文摘 | Ingeborg T Christiane L Sinha A | 2003 | The plant J2003，34，3： | 1 |
| 20 | Novel pyrogen tests based on the human fever reaction显示文摘 | Thomas H Ingeborg A Susanne B | 2001 | ATLA2001，29，： | 1 |
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