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| 1 | Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection: Time Trends in a Spanish Multicenter Study of 1000 Patients显示文摘 | Javier P. Gisbert ángeles Pérez-Aisa Fernando Bermejo Manuel Castro-Fernández Pedro Almela Jesús Barrio ángel Cosme Inés Modolell Felipe Bory Miguel Fernández-Bermejo Luis Rodrigo Jesús Ortu?o Pilar Sánchez-Pobre Sam Khorrami Alejandro Franco Albert Tomas | 2013 | Journal of Clinical Gastroenterology2013，，2： | 5 |
| 2 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma显示文摘AIM: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in vivo.METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase.RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO.CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method. | Borja Hernández-Breijo Jorge Monserrat Sara Ramírez-Rubio Eva P Cuevas Diana Vara Inés Díaz-Laviada M Dolores Fernández-Moreno Irene D Román Javier P Gisbert Luis G Guijarro | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 3 | 原因不明的脑卒中患者心房纤维化增加:心脏磁共振成像研究显示文摘一些被归类为原因不明的缺血性脑卒中患者可能有左心房和左心耳结构或功能的改变,增加了他们的血栓栓塞风险。该研究使用心脏磁共振成像比较不同病因的缺血性脑卒中患者的左心房和左心耳结构及功能。研究人员前瞻性连续纳入缺血性脑卒中患者样本。 | 刘莉 叶鹏 Fonseca AC Alves P Inácio N Marto JP Viana-Baptista M Pinho-E-Melo T Ferro JM Almeida AG | 2018 | 中华高血压杂志2018，26，3： | 2 |
| 4 | Comparison of Two Spectrofluorimetric Methods Applied to Water Samples 显示文摘 | Eiroa A A Blanco E V Machia P L Resolution of Benzo(a)pyrene in Complex Mixtures of Other Polycyclic Aromatic Hydrocarbons | 2000 | Analyst2000，125，7： | 1 |
| 5 | Effect on hepatitis B virus DNA levds in children infected with different genotypes显示文摘 | Sangfelt P Norder H Magnius LO Interferon - alpha 2b treament in hepatitis B carriers | 1997 | Acta Paediatr1997，86，2： | 1 |
| 6 | Emulsifying propertyof whey peptide fractions as a function of pH and IonicStrength显示文摘 | Turgeon S L Cauthier SF Paqu in P | 1992 | Food Sci1992，57，60： | 1 |
| 7 | Drug targeting显示文摘 | TORCH IL IN J VLAD IM IR P | 2000 | Eur J Pharm Sci2000，11，2： | 1 |
| 8 | , manipulation of insulin-like growth factor binding protein-3 levels显示文摘 | CHEUNG C W TAYLOR P J KIRKPATRICK C M et aL Therapeutic value of orally administered silibinin in renal cell carcinoma | 2007 | Br J Urol Inter2007，100，2： | 1 |
| 9 | patient with multiple sclerosis显示文摘 | Valsasina P Rocca MA Agosta F Mean diffusivity and frac- tional anisotropy histograms of the cervical cord in MS patients | 2005 | Neuroimage2005，26，3： | 1 |
| 10 | Within-farm variability in resource allocation, nutrient flows and soil fertility status 显示文摘 | Tittonell P Vanlauwe B Leffelaar P A Exploring diversity in soil fertility management of smallholder farms in western Kenya Ⅱ | 2005 | Agric Ecosyst Environ2005，110，324： | 1 |
| 11 | a quantitative analysis显示文摘 | LASLETT G M GREEN P F DUDDY I R et' al Thermal annealing of fission tracks in apatite 2 | 1987 | Chemical Geology1987，65，1： | 1 |
| 12 | Efficacy of periodontal treatment on glycaemic control in diabetic patients: A meta-analysis of interventional studies显示文摘 | Darre L Vergnes IN Gourdy P | 2008 | Diabetes Metab2008，34，5： | 1 |
| 13 | Cross-national variation in the gender gap in depression 显示文摘 | Van de Velde S Bracke P Levecque Gender differences in de- pression in 23 European countries | 2010 | Soc Sci Med2010，71，2： | 1 |
| 14 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 15 | Low-density geochemical mapping in Portugal显示文摘 | Ferreira M M In?cio P Morgado M J | 2001 | Applied Geochemistry2001，16，： | 1 |
| 16 | Results using a prognostic computed tomography scan classification 显示文摘 | Sanders R Fortin P DiPasquale T Operative treatment in 120 displaced intraarticular calcaneal fractures | 1993 | Clin Orthop Relat Res1993，，290： | 1 |
| 17 | Management of adult idiopathic thrombocytopenic purpura显示文摘 | NAKHOUL IN KOZUCH P VARMA M | 2006 | Clin Adv2006，4，： | 1 |
| 18 | The hypercalciuria of diabets mellitus:its amelio ration with insulin显示文摘 | Rask in P | 1978 | Clin Endocrino 11978，9，： | 1 |
| 19 | 3MoO3显示文摘 | MACHADO-CHARRY E ORDEJON P CANADELL E Analysis of scanning tunneling microscopy images of the charge-density-wave phase in quasi-one-dimensional Rb 0 | 2006 | Phys Rev B2006，74，15： | 1 |
| 20 | Nonexpanded Primary Lung and Bone Marrow-derived Mesenchymal Cells Promote the Engraftment of Umbilical Cord Blood-derived CD34^+ Cells in NOD/SCID Mice显示文摘 | In't Ankera P S Noortb W A Kruisselbrinkb A B | 2003 | Experimental Hematology2003，31，： | 1 |
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