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| 1 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Highly selective conversion of ethene to propene over SAPO-34 as a solid acid catalyst显示文摘 | OIKAWA H SHIBATA Y INAZU K | 2006 | Appl Catal A: Gen2006，312，1： | 1 |
| 4 | Effects of leflunomide on glomerulonephritis induced by antibasement membrane antibody in rats显示文摘 | Ogawa T Inazu M Gotoh K | | 0，，： | 1 |
| 5 | Hypolipidemic effect ofPleurotus eryngii extract in fat-loaded mice 显示文摘 | MIZUTANI T INATOMI S INAZU A | 2010 | J Nutr Sci Vitaminol2010，56，1： | 1 |
| 6 | Development of high efficiency 255- 355 nm A1GaN-based light-emitting diodes 显示文摘 | Pernot C Fukahori S Inazu T | 2011 | Phys Status Solidi A2011，208，： | 1 |
| 7 | Chemo-enzymatic synthesis of the glycosylated α-mating factor of Saccharomyces cerevisiae and analysis of its biological activity显示文摘 | Saskiawan I Mizuno M Inazu T | 2002 | Arch Biochem Biophys2002，406，： | 1 |
| 8 | Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol显示文摘 | Inazu A Jiang XC Haraki T | 1994 | J Clin Invest1994，94，5： | 1 |
| 9 | Steam reforming ofacetic acid as a biomass derived oxygenate: Bifunctionalpathway for hydrogen formation over Pt/Zr02catalysts显示文摘 | Takanabe K Aika K Inazu K | 2006 | Journal of Catalysis2006，243，2： | 1 |
| 10 | Cholesteryl ester transfer protein (CETP) deficiency and CETP inhibitors 显示文摘 | MABUCHI H NOHARA A INAZU A | 2014 | Mol Cells2014，37，11： | 1 |
| 11 | A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels,including those with plasma cholesteryl ester transfer protein deficiency显示文摘 | Moriyama Y Okamura T Inazu A | 1998 | Prev Med1998，27，51： | 1 |
| 12 | Functional expression of the norepinephrine transporter in cultured rat astrocytes显示文摘 | Inazu M Takeda H Matsumiya T | 2003 | J Neurochem2003，84，： | 1 |
| 13 | Dichlorodifluoromethane decomposition to CO2 with simultaneous halogen fixation by calcium oxide based materials 显示文摘 | Tamai T Inazu K Aika K | 2006 | Environ Sci Technol2006，40，4： | 1 |
| 14 | Electronic and structural promotion of barium hexaaluminate as a ruthenium catalyst support for ammonia synthesis显示文摘 | You Zhixiong Inazu Koji Aika Kenichi | 2007 | Journal of Catalysis2007，251，： | 1 |
| 15 | Mathematical evaluation of effective moisture diffusivity in fresh Japanese noodle (udon) by regular theory显示文摘 | Tadao Inazu Ken-ichi Iwasaki | 2000 | Journal of Food Science2000，65，3： | 1 |
| 16 | Hy-polipidemic effect of Pleurotus eryngii extract in fat -loadedmice显示文摘 | Tomohiro Mizutani Satoshi Inatomi Akihiro Inazu | 2010 | J Nutr Sci Vitaminol2010，，56： | 1 |
| 17 | Desorption isotherms for Japanese noodle(udon)显示文摘 | Tadao Inazu Ken-ichi Iwasaki Takeshi Furuta | 2001 | Drying Technology2001，19，7： | 1 |
| 18 | Steam reforming of acetic as a biomass derived oxygenate:Bifunctional pathway for hydrogen formation over Pt/ ZrO2 catalysts 显示文摘 | Kazuhiro Takanabe Ken -ichi Aika Koji Inazu | 2006 | Journal of Catalysis2006，243，2： | 1 |
| 19 | Monkey 3-deoxyglucosone reductase : tissue distribution and purification of three multiple forms of the kidney enzyme that are identical with dihydrodiol dehydrogen- ase, aldehyde reductase, and aldose reductase 显示文摘 | Sato K Inazu A Yamaguchi S | 1993 | Archives of biochemistry and biophysics1993，307，2： | 1 |
| 20 | Detection of eumelanogenic and pheomelanogenic melanosome in the same normal human melanocyte显示文摘 | Inazu M Mishima Y | 1993 | J Invest Dermatol1993，100，2： | 1 |
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