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| 1 | Ultraviolet radiation-induced non-melanoma skin cancer:Regulation of DNA damage repair and inflammation显示文摘Exposure to ultraviolet(UV)radiation is associated with approximately 65%of melanoma cases,and 90%of non-melanoma skin cancers(NMSC),including basal cell carcinoma(BCC)and squamous cell carcinoma(SCC).While the incidence of most other malignancies has either stabilized or declined,that of NMSC has increased and is developing even in younger age groups.NMSCs account for nearly 15,000 deaths,3.5 million new cases,and more than 3 billion dollars a year in medical costs in the United States alone,representing a major public health concern.As sun protection efforts have not been proven effective,targeted chemoprevention strategies are much needed.Skin carcinogenesis by DNA damage is considered a predominant paradigm for UV toxicity.Exposure to UV radiation can activate various oncogenes while inactivating tumor suppressor genes,resulting in inappropriate survival and proliferation of keratinocytes that harbor these damages.Moreover,increasing evidence demonstrate that inflammatory responses by the immune cells within the tumor microenvironment also contribute significantly to skin tumorigenesis.Initiation and progression of skin carcinogenesis mediated by UV radiation involve complex pathways,including those of apoptosis,proliferation,autophagy,DNA repair,checkpoint signaling,metabolism,and inflammation.In this review,we highlight the recent advances in two of these key molecular processes that result in UV-mediated skin carcinogenesis.In particular,we discuss 1)pathways that regulate DNA damage repair and 2)the regulation of the inflammatory process its crosstalk with DNA repair potentially leading to non-melanoma skin carcinogenesis. | InYoung Kim Yu-Ying He | 2014 | Genes & Diseases2014，1，2： | 8 |
| 2 | Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy显示文摘AIM: To study the contribution of tonicity response element binding protein(Ton EBP) in retinal ganglion cell(RGC) death of diabetic retinopathy(DR).METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin(STZ). Control mice received vehicle(phosphate-buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of Ton EBP and aldose reductase(AR) were examined.RESULTS: The Ton EBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase(Td T)-mediated d UTP nick end labeling(TUNEL)-positive signals co-localized with Ton EBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with controls.CONCLUSION: The present data show that AR and Ton EBP are upregulated in the DR and Ton EBP may contribute to apoptosis of RGC in the DR. | Seong-Jae Kim Hwajin Kim Jeongsook Park Inyoung Chung Hyug-Moo Kwon Wan-Sung Choi Ji-Myong Yoo | 2014 | International Journal of Ophthalmology(English edition)2014，7，6： | 5 |
| 3 | Percutaneous radiofrequency ablation of hepatocellular carcinoma abutting the diaphragm and gastrointestinal tracts with the use of artificial ascites: safety and technical efficacy in 143 patients显示文摘 | Inyoung Song Hyunchul Rhim Hyo K. Lim Young-sun Kim Dongil Choi | 2009 | European Radiology2009，，11： | 1 |
| 4 | Development of deformation structures in low carbon steel by equal channel angular pressing 显示文摘 | KIM Jongryol KIM Inyoung SHIN Dong hyuk | 2001 | Scripta Mater2001，45，4： | 1 |
| 5 | A study on the enhancement of printing location accuracy in a roll-to-roll gravure offset printing system 显示文摘 | Noh Jae-Ho Kim Inyoung Park Sang Ho | 2013 | International Journal of Advanced Manufacturing Technology2013，68，58： | 1 |
| 6 | A study on the electrical and mechanical properties of printed Ag thin films for flexible device application 显示文摘 | Kim Inyoung Lee Taik-Min Kim Jongryou | 2014 | Journal of Alloys and Compounds2014，596，5： | 1 |
| 7 | Grain refinement mechanism during equal-channel angular pressing of a low-carbon steel显示文摘 | Dong Hyuk Shin Inyoung Kim Jongryoul Kim | 2001 | Acta mater2001，49，： | 1 |
| 8 | Development of deformation structures in low carbon steel by equal channel angularpressing显示文摘 | KIM Jongryol KIM Inyoung SH N Dung hyuk | 2001 | Scrip ta Mater2001，45，4： | 1 |
| 9 | Grain Refinement Mechanical During Equal-Channel Angular Pressing of a Low Carbon Steel显示文摘 | Dong Hyuk Shin Inyoung Kim Jongryoul Kim | 2001 | Acta Materialia2001，49，1： | 1 |
| 10 | Transparent conductive film with printable embedded patterns for organic solar cells显示文摘 | Jong-Su Yu Gwan Ho Jung Jeongdai Jo Jung Su Kim Jun Woo Kim Sun-Woo Kwak Jong-Lam Lee Inyoung Kim Dojin Kim | 2013 | Solar Energy Materials and Solar Cells2013，，： | 1 |
| 11 | Deformation structure of pure Ti produced by equal channel angular pressing 显示文摘 | Kim Inyoung Jeong Won-Sik Kim jongryoul Kyung-T Park Dong Hyuk Shin | 2001 | Scripta Materialia2001，45，： | 1 |
| 12 | Design of W buffer layer for adhesion improvement of DLC films on tool steels显示文摘 | Lee Kwang-Ryeol Eun Kwang Yong Kim Inyoung | 2000 | Thin Solid Films2000，，： | 1 |
| 13 | Grain refinement mechanism during Equal-channel Angular Pressing of a low-carbon steel显示文摘 | Dong Hyuk Shin Inyoung Kim Jongryoul Kim | 2001 | Acta mater2001，49，： | 1 |
| 14 | The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice显示文摘AIM: To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into mice. METHODS: Forty-eight 6-8-week-old C57BL/6J mice were used in this study. Simvastatin was intravitreally injected into the right eye of each mouse; the left eye was injected with vehicle and was used as a control. Bilateral dark-adapted electroretinography(ERG) was performed 1 and 7d following injection. Histology was examined using a combination of light, fluorescence and electron microscopy. Highperformance liquid chromatography(HPLC) was used to determine the decay in the retinal simvastatin concentration.RESULTS: ERG revealed no significant changes in the simvastatin-injected eyes compared to control. Histologic studies showed normal retinal morphology in eyes injected with simvastatin up to a final vitreal concentration of 200 μmol/L. No significant changes in the number of photoreceptors, bipolar cells or ganglion cells were found. The retinal simvastatin concentration decayed exponentially, with a half-life of 1.92-2.41 h.CONCLUSION: Intravitreal injection of up to 200 μmol/L simvastatin produced no signs of adverse effects in the mouse retina. Simvastatin reaches the retina shortly after intravitreal injectionand has a short half-life. | Dennis Y.Tse Seong Jae Kim Inyoung Chung Feng He Theodore G.Wensel Samuel M.Wu | 2017 | International Journal of Ophthalmology(English edition)2017，10，9： | 0 |
| 15 | Scalable nanolaminated SERS multiwell cell culture assay显示文摘This paper presents a new cell culture platform enabling label-free surface-enhanced Raman spectroscopy(SERS)analysis of biological samples.The platform integrates a multilayered metal-insulator-metal nanolaminated SERS substrate and polydimethylsiloxane(PDMS)multiwells for the simultaneous analysis of cultured cells.Multiple cell lines,including breast normal and cancer cells and prostate cancer cells,were used to validate the applicability of this unique platform.The cell lines were cultured in different wells.The Raman spectra of over 100 cells from each cell line were collected and analyzed after 12h of introducing the cells to the assay.The unique Raman spectra of each cell line yielded biomarkers for identifying cancerous and normal cells.A kernel-based machine learning algorithm was used to extract the high-dimensional variables from the Raman spectra.Specifically,the nonnegative garrote on a kernel machine classifier is a hybrid approach with a mixed nonparametric model that considers the nonlinear relationships between the higher-dimension variables.The breast cancer cell lines and normal breast epithelial cells were distinguished with an accuracy close to 90%.The prediction rate between breast cancer cells and prostate cancer cells reached 94%.Four blind test groups were used to evaluate the prediction power of the SERS spectra.The peak intensities at the selected Raman shifts of the testing groups were selected and compared with the training groups used in the machine learning algorithm.The blind testing groups were correctly predicted 100% of the time,demonstrating the applicability of the multiwell SERS array for analyzing cell populations for cancer research. | Xiang Ren Wonil Nam Parham Ghassemi Jeannine S.Strobl Inyoung Kim Wei Zhou Masoud Agah | 2020 | Microsystems & Nanoengineering2020，6，1： | 0 |
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