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| 1 | Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma显示文摘AIM To clarify the role of neoadjuvant concurrent chemoradiotherapy(NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma(CCA).METHODS We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows:(1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or(2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative staging. RESULTS The median disease-free survival(DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were26.0 and 15.1 mo, respectively(P = 0.91). The median overall survival(OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively(P = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis(P = 0.01). CONCLUSION NACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability. | Jang Han Jung Hyun Jik Lee Hee Seung Lee Jung Hyun Jo In Rae Cho Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Seungmin Bang | 2017 | World Journal of Gastroenterology2017，23，18： | 21 |
| 2 | Transarterial embolization ablation of hepatocellular carcinoma with a lipiodol-ethanol mixture显示文摘AIM: To determine the safety and effectiveness of transarterial embolization ablation (TEA) of hepatocellular carcinoma (HCC) with a lipiodol-ethanol mixture. METHODS: Between January 1 and December 31, 2009, 15 patients with HCC (13 men/two women, aged 38-75 years) accepted TEA treatment and were enrolled in this study, including five newly diagnosed patients and 10 with refractory disease. Two months after TEA, angiography and contrast computed tomography (CT) were performed, and responses were assessed using a modified version of Response Evaluation Criteria in Solid Tumors (RECIST version 1.1). The follow-up period was to June 30, 2010. RESULTS: Every new case was treated once. Angiography was performed immediately after TEA, and showed that the tumor-feeding vessels were completely embolized and that lipiodol was densely deposited inside tumors. Two months after treatment, contrast CT showed no enhanced lesions. Alpha fetoprotein levels returned to normal in four patients and markedly decreased in another. mean ± SD survival after treatment was 10.8 ± 4.5 mo. All five patients survived during the follow-up period. Ten patients with refractory disease were treated a total of 14 times. Angiography immediately after TEA showed that blood flow to the tumors was obviously decreased in all cases, and contrast CT showed obvious depositions of lipiodol. Two months after treatment, the tumors had shrunk (6/10) or were stable (3/10). One had progressed after 2 mo and died of tumor rupture 3 mo after TEA. mean ± SD survival after treatment was 8.6 ± 4.3 mo; two patients survived during the follow-up period. Adverse effects included reversible hepatic decompensation, upper abdominal pain, and fever. CONCLUSION: TEA is an effective therapy for patients with HCC and might be more effective than transcather arterial chemoembolization for treating refractory disease. | Yang-Kui Gu, Rong-Guang Luo, Jin-Hua Huang, Qi-Jiao Si Tu, Xiao-Xia Li, Fei Gao,State Key Laboratory of Oncology in Southern China,Department of Medical Imaging and Interventional Radiology,Cancer Center,Sun Yat-sen University,Guangzhou510060,Guangdong Province,China Department of Medical Imaging and Interventional Radiology, the First Affiliated Hospital of Nan-Chang University, 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, China | 2010 | World Journal of Gastroenterology2010，16，45： | 9 |
| 3 | FXR induces the UGT2B4enzyme in hepatocytes :A potential mechanism of negative feedback control of FXR activity显示文摘 | Oliver BA Ines PT Audrey SI | 2003 | Gastroenterology2003，124，7： | 1 |
| 4 | Gas chromatography -high -resolution mass spectrometric method for determination of methamphetamine and its major metabolite amphetamine in human hair 显示文摘 | Kim JY Suh SI In MK | 2005 | J Anal Toxicol2005，29，5： | 1 |
| 5 | Psychosoeial Aspects of Ache Vulgaris: A Community-based Study with Korean Adolescents 显示文摘 | Do JE Cho SM In SI | 2009 | Ann Dermatol2009，21，2： | 1 |
| 6 | Graft polymerization of acrylic acid onto corn starch in aqueous isopropanol solution显示文摘 | PARK In hwan SONG Si yong SONG Bong kewn | 1999 | Die Angew Makromol Chemie1999，267，： | 1 |
| 7 | Clinical and histopathological characteristics of pityriasis alba显示文摘 | In SI Yi SW Kang HY | 2009 | Clin Exp Dermatol2009，34，5： | 1 |
| 8 | , com- parison with those in patients with type I diabetes mellitus显示文摘 | JH Lee YJMO Si Pharmacokinetics of drugs in rats with diabetes mellitus induced by aUoxan or streptozocin | 2010 | JPharmPharmacol2010，62，1： | 1 |
| 9 | Effect of 2% chlorhexidine gel mixed with calcium hydroxide as an intracanal medication on sealing ability of permanent root canal filling: a 6-month follow-up 显示文摘 | Kontakiotis EG Tsatsoulis IN Papanakou SI | 2008 | J Endod2008，34，7： | 1 |
| 10 | Curcumin reverses chemoresistance of human gastric cancer cells by downregulatingthe NF-κB transcription factor显示文摘 | Liang-Liang Yu Jia-Guo Wu Ning Dai Hong-Gang Yu Jian-Μin Si | 2011 | Oncology Reports2011，，5： | 1 |
| 11 | Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet显示文摘 | Woo Young Jang Ki Beom Bae Sung Hyun Kim Dong Hun Yu Hei Jung Kim Young Rae Ji Seo Jin Park Jun Koo Yi Nari Kim Si Jun Park Min-Cheol Kang Ja In Jeong Sang-Joon Park Sang Gyu Lee Inkyu Lee Myoung Ok Kim Zae Young Ryoo | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 12 | High-dose Helical Tomotherapy With Concurrent Full-dose Chemotherapy for Locally Advanced Pancreatic Cancer显示文摘 | Jee Suk Chang Michael L.C. Wang Woong Sub Koom Hong In Yoon Yoonsun Chung Si Young Song Jinsil Seong | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，5： | 1 |
| 13 | Role of T-type Calcium Channels in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in Neonatal Rats显示文摘In the current study,we sought to investigate whether T-type Ca^(2+)channels(TCCs)in the brain are involved in generating post-anesthetic hyperexcitatory behaviors(PAHBs).We found that younger rat pups(postnatal days 9-11)had a higher incidence of PAHBs and higher PAHB scores than older pups(postnatal days16-18)during emergence from sevoflurane anesthesia.The power spectrum of the theta oscillations(4 Hz-8 Hz)in the prefrontal cortex was significantly enhanced in younger pups when PAHBs occurred,while there were no significant changes in older pups.Both the power of theta oscillations and the level of PAHBs were significantly reduced by the administration of TCC inhibitors.Moreover,the sensitivity of TCCs in the medial dorsal thalamic nucleus to sevoflurane was found to increase with age by investigating the kinetic properties of TCCs in vitro.TCCs were activated by potentiated GABAergic depolarization with a sub-anesthetic dose of sevoflurane(1%).These data suggest that(1)TCCs in the brain contribute to the generation of PAHBs and the concomitant electroencephalographic changes;(2)the stronger inhibitory effect of sevoflurane contributes to the lack of PAHBs in older rats;and(3)the contribution of TCCs to PAHBs is not mediated by a direct effect of sevoflurane on TCCs. | Feng-Yan Shen Byung-Gun Lim Wen Wen Yu Zhang Bo Cao Yue-Guang Si Li-Qing Ma Meng Deng Yang In Kim Young-Beom Kim Ying-Wei Wang | 2020 | Neuroscience Bulletin2020，36，5： | 1 |
| 14 | Carbon--based novel sorbent for removing gas--phase mercury 显示文摘 | Si Hyun Lee Young Jun Rhirn Sung Pill Cho Jeom In Baek | 2006 | Fuel2006，85，： | 1 |
| 15 | Psychosocial Aspects of Acne Vulgaris:A Community-based Study with Korean Adolescents显示文摘 | Do JE Cho SM In SI | 2009 | Annals of Dermatology2009，21，2： | 1 |
| 16 | System ic treatm en t insevere cases of recurrent apht-hous st om ati t i s显示文摘 | JM ari a A ngel a M art ins M i m ura Si lvi o Kenj i H i rota Norber to NobuoSugaya et a 1 | 2011 | Cl inics2011，64，3： | 1 |
| 17 | Hereditary palmoplantar keratoderma and deafness resulting from genetic mutation of Connexin 26 显示文摘 | Lee JY In SI Kim H J | 2010 | J Korean Med Sci2010，25，10： | 1 |
| 18 | Poems of China显示文摘 | Chin Si - in Ljerka Tot - Naumova Biljana Gruneska | 1997 | Kuhuren zhivot1997，，： | 1 |
| 19 | The oxidant - antioxidant system and cognitive functions in patients undergoing elective abdominal operations under various general anesthesia modes 显示文摘 | Pasechnik IN Meshcheriakov AA Kontarev SI | 2009 | Anesteziol Reanimato12009，，4： | 1 |
| 20 | FOLFIRINOX vs gemcitabine/nab-paclitaxel for treatment of metastatic pancreatic cancer: Single-center cohort study显示文摘BACKGROUND FOLFIRINOX and gemcitabine plus nab-paclitaxel(Gem+nabPTX)were recently introduced for metastatic pancreatic cancer treatment.However,studies that compared these two regimens and studies in Asian populations are lacking.AIM To compare the treatment outcomes of FOLFIRINOX and Gem+nabPTX regimen for metastatic pancreatic cancer treatment in Korean population.METHODS Patients with metastatic or recurrent pancreatic cancer treated with FOLFIRINOX(n=86)or Gem+nabPTX(n=81)as the first-line since January 2015 were identified using the Severance Hospital Pancreatic Cancer Cohort Registry.Treatment efficacy,treatment-related adverse events and economic aspects were compared.RESULTS Patients in the FOLFIRINOX group were significantly younger(54 vs 65 years;P<0.001)and had better performance statuses at diagnosis.The median overall survival(10.7 vs 12.1 mo;P=0.157),progression-free survival(8.0 vs 8.4 mo;P=0.134),and objective response rates(33.7%vs 46.9%;P=0.067)were not significantly different when compared with Gem+nabPTX group.Grade≥3 neutropenia and gastrointestinal adverse events were more common in the FOLFIRINOX group.The drug costs of both regimens were similar.CONCLUSION Treatment efficacy and economic burdens were comparable between the two regimens.But,the details of adverse event were different.Gem+nabPTX regimen might be considered preferentially in certain conditions. | In Rae Cho Huapyong Kang Jung Hyun Jo Hee Seung Lee Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Chansik An Mi-Suk Park Seungmin Bang | 2020 | World Journal of Gastrointestinal Oncology2020，12，2： | 1 |
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