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| 1 | Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes显示文摘Mitochondrial DNA(mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair system.This explains an increased mutation rate of mtDNA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDNA molecules within the same mitochondrion.In diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis. | Dimitry A Chistiakov Igor A Sobenin Yuri V Bobryshev Alexander N Orekhov | 2012 | World Journal of Cardiology2012，4，5： | 17 |
| 2 | Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects显示文摘A gastrointestinal(GI) transmural defect is defined as total rupture of the GI wall,and these defects can be divided into three categories: perforations,leaks,and fistulas. Surgical management of these defects is usually challenging and may be associated with high morbidity and mortality rates. Recently,several novel endoscopic techniques have been developed,and endoscopy has become a firstline approach for therapy of these conditions. The use of endoscopic vacuum therapy(EVT) is increasing with favorable results. This technique involves endoscopic placement of a sponge connected to a nasogastric tube into the defect cavity or lumen. This promotes healing via five mechanisms,including macrodeformation,microdeformation,changes in perfusion,exudate control,and bacterial clearance,which is similar to the mechanisms in which skin wounds are treated with commonly employed wound vacuums. EVT can be used in the upper GI tract,small bowel,biliopancreatic regions,and lower GI tract,with variable success rates and a satisfactory safety profile. In this article,we review and discuss the mechanism of action,materials,techniques,efficacy,and safety of EVT in the management of patients with GI transmural defects. | Diogo Turiani Hourneaux de Moura Bruna Furia Buzetti Hourneaux de Moura Michael A Manfredi Kelly E Hathorn Ahmad N Bazarbashi Igor Braga Ribeiro Eduardo Guimaraes Hourneaux de Moura Christopher C Thompson | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 6 |
| 3 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 4 | Human enamel thickness and ENAM polymorphism显示文摘The tooth enamel development gene, enamelin(ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism(SNP) C14625T(rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status,controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel.Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner(P = 0.040)when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure. | Diane M Daubert Joanna L Kelley Yuriy G Udod Carolina Habor Chris G Kleist Ilona K Furman Igor N Tikonov Willie J Swanson Frank A Roberts | 2016 | International Journal of Oral Science2016，8，2： | 2 |
| 5 | Effects of sex steroids and their inhibitors on endocrine parameters and gender growth differences in Eurasian perch (Percafluviatilis)juveniles显示文摘 | Syaghalirwa N M Mandiki Igor Babiakl | 2005 | Steroids2005，70，： | 1 |
| 6 | Piperidine-CO2-H20 molecular com- plex显示文摘 | Jiang H M Igor N | 2003 | JMol Struct2003，645，： | 1 |
| 7 | QSPR modeling of cycloalkanes properties by correlation weighting of extended graph valence shells显示文摘 | Igor V N Ozad M N | 2003 | Journal of Molecular Structure (Theochem)2003，637，： | 1 |
| 8 | Solving inverse initial - value boundary - value problems via genetic algorithm 显示文摘 | Charles L K Igor Y Keith N | 2000 | Engineering Application of ArtificialIntelligence2000，13，6： | 1 |
| 9 | Liposome- encapsulated vincristine, vinblastine and vinorelbine:A comparative study of drug loading and retention显示文摘 | IGOR V ZHIGALTSEVA T MAURERB N | 2005 | J Controlled Release2005，104，1： | 1 |
| 10 | Apparent disaggregation of colloids in a magnetically treated crude oil显示文摘 | Igor N E Konstantin A K | 2009 | Energy & Fuels2009，23，8： | 1 |
| 11 | 显示文摘 | Savina Irina N Mattiasson Bo Galaeva Igor Yu | 2005 | Polymer2005，46，23： | 1 |
| 12 | Investigation of contact phenomena at cubic boron nitride-filler metal interface during electron beam brazing显示文摘 | Igor L P Alexey A S Irina G N | 1997 | Diamond and Related Materials1997，6，8： | 1 |
| 13 | Synthesis of glucose esters from cellulose in ionic liquids 显示文摘 | IGOR I DOORSLAER C V MERTENS G N | 2011 | Holzforschung2011，66，4： | 1 |
| 14 | The relationship between precipitation nomalies and satellite - derived vegetation activity in Central Asia 显示文摘 | Ursula G Vahid N Igor K | 2013 | Global and Planetary Change2013，110，： | 1 |
| 15 | A cyber- physical experimentation environment for the security analysis of networked industrial control systems 显示文摘 | BILA G CHRISTOS S IGOR N F | 2012 | Computers and Electrical Engineering2012，38，5： | 1 |
| 16 | DNA polymorphism in the living fossil Ginkgo biloba from the Eastern United States显示文摘 | Ruhul H Kuddus Nayema N Kuddus Igor Dvorchik | 2002 | Genome2002，45，： | 1 |
| 17 | Free-standing and oriented mesoporous silica films grown at the air-water interface 显示文摘 | YANG H COOMBS N IGOR S | 1996 | Nature1996，381，6583： | 1 |
| 18 | AgBr/Al-MCM-41 visible-light photocatalyst for gas-phase decomposition of CH3CHO显示文摘 | SHALINI R UMA S IGOR N M | 2005 | J Catal2005，233，： | 1 |
| 19 | Association of Low Striatal Dopamine D^sub 2^ Receptor Availability With Nicotine Dependence Similar to That Seen With Other Drugs of Abuse显示文摘 | Fehr Christoph Yakushev Igor Hohmann Nina Buchholz Hans-Georg Landvogt Christian Deckers Hanna Eberhardt Alexandra Kl?ger Marie Smolka Michael N Scheurich Armin Dielentheis Thomas Schmidt Lutz G R?sch Frank Bartenstein Peter Gründer Gerhard | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 20 | Modified indirect porcine circovirus(PCV)type 2-based and recombinant capsid protein (ORF2)-based enzyme-linked immunosorbent assays for detection of antibodies to PCV显示文摘 | Perry A Igor M | 2002 | Clinical Diagnostic Lab Immunol2002，9，： | 1 |
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