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| 1 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 2 | Direct inscription of Bragg gratings in coated fibers by an infrared femtosecond laser显示文摘 | AMOS M IGOR Y | 2006 | OHies Letters2006，31，： | 1 |
| 3 | Solving inverse initial - value boundary - value problems via genetic algorithm 显示文摘 | Charles L K Igor Y Keith N | 2000 | Engineering Application of ArtificialIntelligence2000，13，6： | 1 |
| 4 | AFM study of membrane proteins,cytochrome P450 2B4,and NADPH -cytochrome P450 reductase and their complex formation显示文摘 | OLGA I K IGOR V Y YURI O I | 1999 | Archives of Biochem and Biophysic1999，371，1： | 1 |
| 5 | Analysis of burst conditions of shielded pressure vessels subjected to space debris impact显示文摘 | IGOR Y T | 2005 | Journal of Pressure Vessel Technology2005，127，11： | 1 |
| 6 | Photoresponse analysis and pixel shape optimization for CMOS active pixel sensors显示文摘 | IGOR S ORLY Y P | 2003 | IEEE Transactions on Electron Devices2003，50，1： | 1 |
| 7 | Prediction of CMOS APS design enabling J maximum photo response for scalable CMOS technologies 显示文摘 | IGOR S ORLY Y P | 2004 | IEEE Transactions on Electron Devices2004，51，2： | 1 |
| 8 | On the impact response of electrified carbon fiber polymer matrix composites:Effects of electric currentintensityandduration显示文摘 | ROBERT L S IGOR Y T OLESYAI Z | 2008 | Composites Science and Technology2008，68，3： | 1 |
| 9 | Accuracy of local topo graphic variables derived from digital elevation mod els 显示文摘 | IGOR V FLORINSK Y | 1998 | International Journal of Geographical lnfor mation Sciences1998，12，1： | 1 |
| 10 | Highly dispersed gold on activated carbon fibers for low-temperature CO oxidation显示文摘 | Dmitri A B Igor Y Elena I S | 2004 | J Catal2004，224，： | 1 |
| 11 | Moisture migration in soft - panned confections during engrossing and aging as observed by magnetic resonance imaging 显示文摘 | Troutman Michelle Y Mastikhin Igor V Balcom Brace J | 2001 | Fcocl Engineering2001，48，3： | 1 |
| 12 | 显示文摘 | Galaev Igor Y Mattiasson Bo | 1999 | Trends in Biotechnology1999，17，8： | 1 |
| 13 | Robust stability check of fractional order linear time invariant systems with interval uncertainties显示文摘 | Chen Y Q Ahn H S Igor P | 2006 | Signal Processing2006，86，10： | 1 |
| 14 | ‘Smart’ polymers and what they could do in biotechnology and medicine显示文摘 | Igor Y Galaev Bo Mattiasson | 1999 | Trends in Biotechnology1999，，8： | 1 |
| 15 | Quantum confinement in ZnO nanorods 显示文摘 | Gu Y Igor Kuskovsky L Yin M | 2004 | Appl Phys Lett2004，85，17： | 1 |
| 16 | Modeling of performance characteristics of OLED 显示文摘 | IGOR Y G | 2000 | Synthetic Metals2000，，： | 1 |
| 17 | Associated Morbidity of Blepharitis显示文摘 | Arie Y N Shlomo V Igor K | | 0，，06： | 1 |
| 18 | Anomalous increase of friction in the vicinity of nano-size defects显示文摘 | Igor Y S | 2002 | Tribology Letters2002，12，2： | 1 |
| 19 | Molecular Determinants of the Response of Gliololastomas to EGFR Kinase Inhibitors显示文摘 | Ingo K Maria Y Igor V | 2006 | N Engl J Med2006，354，8： | 1 |
| 20 | Short-Distance Ultra-Wideband Radar' s Theory and Designing显示文摘 | Igor Y Immoreev Sergey V Samkov TAO Teh-Ho | | 0，，03： | 1 |
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