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| 1 | Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis显示文摘电压依赖者阴离子隧道(VDAC ) 1 是 mitochondrial 的主要隧道外部膜(妈妈) 和它被建议了是渗透转变毛孔(PTP ) 的部分, mitochondrial 渗透转变(MPT ) 的一个通常认为的 multiprotein 建筑群候选人代理人。在单个实时房间水平工作,我们发现 VDAC1 的 overexpression 在 mitochondrial 触发 MPT 内部膜(MIM ) 。相反地,在 MPT 的抑制的 silencing VDAC1 表示结果由导致亚硒酸盐的氧化应力引起了。这 MOM-MIM 串音被 Cyclosporin A 和 mitochondrial Cyclophilin D,然而并非由 Bcl-2 和 Bcl-XL 调制, PTP 的陈述语气操作。VDAC1 依赖的 MPT 雇佣包含反应的氧种类和 p38-MAPK 的一个积极反馈环,并且在第二包括 Bax 激活,细胞色素 c 版本和 caspase 触发正规 apoptotic 回答 3 激活。我们的数据因此支持在 MOM 包含 VDAC1 的 PTP 建筑群的一个模型,并且显示 VDAC1 依赖的 MPT 是在氧化导致压力的 apoptosis 起一个原因的作用的在上游的机制。 | Flora Tomasello Angela Messina Lydia Lartigue Laura Schembri Chantal Medina Simona Reina Didier Thoraval Marc Crouzet Frangois Ichas Vito De Pinto Francesca De Giorgi | 2009 | Cell Research2009，19，12： | 6 |
| 2 | Regulation of the permeability transition pore skeletal muscle mitochondria显示文摘 | Fontaine E Eriksson O Ichas F | 1998 | J Bid Chem1998，273，12： | 3 |
| 3 | Salvage transjugular intrahepatic portosystemic shunt for uncontrolled variceal bleeding in patients with decompensated cirrhosis显示文摘 | Daniel Azoulay Denis Castaing Pietro Majno Faouzi Saliba Philippe Icha?? Allaoua Smail Valérie Delvart Monzer Danaoui Didier Samuel Henri Bismuth | 2001 | Journal of Hepatology2001，，5： | 1 |
| 4 | Effects of the anaesthetic propofol on the calcium - induced permeability transition of rat heart mitochondria:Direct pore inhibition and shift of the gating potential显示文摘 | Sztark F Ichas F Ouhabi R | 1995 | FEBS Lett1995，368，1： | 1 |
| 5 | Regulation of the permeability transition pore skeletal muscle mitochondria显示文摘 | Fontaine E Eriksson O Ichas F | 1998 | Biol Chem1998，273，12： | 1 |
| 6 | Immunophenotypic Profile of Adult Acute Myeloid Leukemia (AML) :Analysis 267 Cases in Thailand显示文摘 | Auewara kul C U Promsuw icha O U-pratya Y | 2003 | Asian Pac J Allergy Immunol2003，，： | 1 |
| 7 | Regulation of the permeability transition pore in skeletal muscle mitochondrial显示文摘 | Fontaine E Eriksson O Ichas F | 1998 | J Biol Chem1998，273，12： | 1 |
| 8 | Spatial relational memory requires hippocampal adult neurogenesis显示文摘 | Dupret D Revest JM Koehl M Ichas F De Giorgi F Costet P Abrous DN Piazza PV | 2008 | PLoS ONE2008，3，： | 1 |
| 9 | Spatial relational memory requires hippocampal adult neurogenesis显示文摘 | Dupret D Revest JM Koehl M Ichas F De Giorgi F Costet P Abrous DN Piazza PV | 2008 | PLoS ONE2008，3，： | 1 |
| 10 | Prospective identification of tumorigenic breast cancer cells显示文摘 | AI-Hajj M W icha M S Benito Hemandez A | 2003 | Proc Natl Acad Sci USA2003，100，7： | 1 |
| 11 | High content analysis of gamma-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer's disease显示文摘 | Florean C Zampese E Zanese M Brunello L Ichas F De Giorgi F | | 0，，08： | 1 |
| 12 | organelles capable of generating and conveying electrical and calcium signals 显示文摘 | ICHAS F JOUAVILLE1 Mitochondria are excitable L S MAZAT J P | 1997 | Cell1997，89，： | 1 |
| 13 | Mitochondria are excitable organenes capable of generating and conveying electrical and lal-cium signals显示文摘 | Jouaville L S Mazat J P | 1997 | Cell1997，89，7： | 1 |
| 14 | Modulation of cell calcium signals by mitochondria显示文摘 | Laurence S. Jouaville Fran?ois Ichas Jean-Pierre Mazat | 1998 | Molecular and Cellular Biochemistry (-)1998，，1： | 1 |
| 15 | Regulation of the permeability transition pore in skeletal muscle mitochondria显示文摘 | Eriksson O Ichas F | 1998 | J Biol Chem1998，273，12： | 1 |
| 16 | A model of mitochondrial Ca^2+ -induced Ca^2+ release simulating the Ca^2+ oscillations and spikes generated by mitochondria 显示文摘 | Selivanov V A Ichas F Holmuhamedov E | 1998 | Biophys Chem1998，72，12： | 1 |
| 17 | From calcium signaling to cell death: two conformations for the mitochondria permeability transition proe, Switching from low-to high-conductance state 显示文摘 | Ichas F Mazat J P | 1998 | Biochem Biophs Acta1998，1366，： | 1 |
| 18 | Solid polymer electrolyte water Electrolysis: Electrocatalysis and long-term stability 显示文摘 | Andolffto F Durand R Ichas A M | 1994 | International Journal of Hydrogen Energy1994，19，： | 1 |
| 19 | Liver transplantation for hepatopulmonary syndrome: A ten-year experience in Paris, France显示文摘 | Camille Taille Jacquès Cadranel Agnes Bellocq Gabriel Thabut Olivier Soubrane Fran?ois Durand Philippe Icha? Christophe Duvoux Jacques Belghiti Yvon Calmus Hervé Mal | 2003 | Transplantation2003，，9： | 1 |
| 20 | A ubiquinone - binding site regulates the mitochondrial permeability transition pore显示文摘 | Fontaine E Ichas F Bernardi P | 1998 | J Biol Chem1998，273，25： | 1 |
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