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| 1 | Epigenomics of leukemia: from mechanisms to therapeutic applications 显示文摘 | Florean C Schnekenburger M Grandjenette C | 2011 | Epigenomics2011，3，5： | 1 |
| 2 | High content analysis of gamma-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer's disease显示文摘 | Florean C Zampese E Zanese M Brunello L Ichas F De Giorgi F | | 0，，08： | 1 |
| 3 | Epigenomics of leukemia:from mechanisms to therapeutic applications显示文摘 | Florean C Schnekenburger M Grandjenette C | 2011 | Epigenomics2011，3，5： | 1 |
| 4 | Reutilization and stabilization of wastes by the production of glass foams 显示文摘 | BERNARDO E CEDRO R FLOREAN M | 2007 | Ceramics International2007，33，： | 1 |
| 5 | Epig- enomics of leukemia: from mechanisms to therapeutic appli- cations 显示文摘 | Florean C Schnekenburger M Grandjenette C | 2011 | Epigenomics2011，3，5： | 1 |
| 6 | Epigenomics of leukemia: from mechanisms to therapeutic applicalions 显示文摘 | Florean C Schnekenburger M Grandjenette C | 2011 | Epigenomics2011，3，5： | 1 |
| 7 | Reutilization and stabilization of wastes by the production of glass foams显示文摘 | Bernardo E Cedro R Florean M | 2007 | Ceram Int2007，33，： | 1 |
| 8 | Reutilization and stabilization of wastes by the production of glass foams显示文摘 | Bernardo E Cedro R Florean M | 2007 | Ceramics International2007，33，96： | 1 |
| 9 | Reutilization and stabiliza- tion of wastes by the production of glass foams显示文摘 | Bernardo E Cedro R Florean M | 2007 | Ceramics Inter- national2007，33，6： | 1 |
| 10 | Characterization of Cnidoscolus quercifolius Pohl bark root extract and evaluation of cytotoxic effect on human tumor cell lines显示文摘Objective: To evaluate the chemical components of active extract from Cnidoscolus quercifolius root bark and its cytotoxic potential against several tumor strains. Methods: The high-performance liquid chromatography with diode-array detection and ~1H and ^(13)C nuclear magnetic resonance spectroscopy of the extract were used to distinguish the existence of possible functional groups in the root bark extract. The in vitro cytotoxic activity of methanol extract on human colon cancer cell lines was evaluated using OVCAR-8, SF-295, HCT-116, HL-60 strains and the samples were assessed by 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium bromide method. Results: The analysis of nuclear magnetic spectra of the active chloroform fraction revealed the presence of absorptions bands correspondent to a mixture of favelines such as neofavelanone, deoxofaveline or methyl-faveline, which structures were confirmed by ultraviolet spectra upon high-performance liquid chromatography with diode-array detection analysis. The active fraction showed cytotoxic effects in the tested strains, HCT-116, SF-295, OVCAR-8 and HL-60 cells with IC_(50) of 72 hours ranging from 4.95 to 15.23 μg/mL. Conclusions: The results suggest that the substances present in faveleira(Cnidoscolus quercifolius) root bark extract have a cytotoxic potential against several tumor lines, showing a broader antitumour potential, and in addition no adverse to healthy cells. Therefore, the root bark extract of Cnidoscolus quercifolius has a possibility of use for anticarcinogenic therapies. | Paulo Fernando Machado Paredes Selene Maia de Morais Fernando Cesar Rodrigues Brito Luiz Francisco Wemmenson Goncalves Moura Patricia de Araujo Rodrigues Stephen Rathinaraj Benjamin Francisco Ernani Alves Magalhaes Eridan Orlando Pereira Tramontina Florean Maria Izabel Florindo Guedes | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，7： | 0 |
| 11 | Antidiabetic effects of galactomannans from Adenanthera pavonina L.in streptozotocin-induced diabetic mice显示文摘Objective: To evaluate the antidiabetic effect of galactomannans extracted from Adenanthera pavonina's L.seeds(GAP) in streptozotocin(STZ) induced diabetic mice.Methods:The preliminary galactomannan yield from Adenanthera pavonina L.plant and extraction products composition were evaluated.Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, ~1H and ^(13)C nuclear magnetic resonance, and molecular weight by gel permeation chromatography have been employed to characterize the extracted galactomannan.The mice were divided in four groups: Normal control, diabetic control, GAP(1% and 2%) treated and standard drug treated groups.Diabetic mice received treatment daily for 30 d.Diabetes was induced by STZ at a single dose of 120 mg/kg.Body weight, water and food intake, fasting blood glucose, total cholesterol and triglycerides were measured.Histopathological analysis of pancreas and liver were performed to evaluate STZ-induced tissue injuries.Results: The isolated and extracted galactomannan from Adenanthera pavonina was confirmed by various chemical characterization methods.GAP exhibited a 1.46:1 mannose: galactose ratio, and high molar weight.Both GAP enriched food decreased glycaemia, total cholesterol and triacylglycerol.GAP didn't interfere on food intakes or body weight, although it increased water intake.Furthermore, the relative liver weight indicated toxic galactomannan effects on the histopathological changes of the pancreas in STZ induced diabetes.Conclusions: It is concluded that GAP is a natural product that contains potent galactomannan and is useful in preventing and treating diabetes. | Icaro Gusmao Pinto Vieira Francisca Noelia Pereira Mendes Sabrina Cesar da Silva Raquel Teixeira Terceiro Paim Bruno Bezerra da Silva Stephen Rathinaraj Benjamin Eridan Orlando Pereira Tramontina Florean Maria Izabel Florindo Guedes | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，2： | 0 |
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