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| 1 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 2 | A novel motion tracking system for evaluation of functional rehabilitation of the upper limbs显示文摘Upper limb function impairment is one of the most common sequelae of central nervous system injury, especially in stroke patients and when spinal cord injury produces tetraplegia. Conventional assessment methods cannot provide objective evaluation of patient performance and the effectiveness of therapies. The most common assessment tools are based on rating scales, which are inefficient when measuring small changes and can yield subjective bias. In this study, we designed an inertial sensor-based monitoring system composed of five sensors to measure and analyze the complex movements of the upper limbs, which are common in activities of daily living. We developed a kinematic model with nine degrees of freedom to analyze upper limb and head movements in three dimensions. This system was then validated using a commercial optoelectronic system. These findings suggest that an inertial sensor-based motion tracking system can be used in patients who have upper limb impairment through data integration with a virtual reality-based neurorehabilitation system. | ngel Gil-Agudo Ana de los Reyes-Guzmán Iris Dimbwadyo-Terrer Benito Peasco-Martín Alberto Bernal-Sahún Patricia López-Monteagudo Antonio del Ama-Espinosa José Luis Pons | 2013 | Neural Regeneration Research2013，8，19： | 3 |
| 3 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
| 4 | Over-expression of cytochrome P450 CYP6CM1 is associated with high resistance to imidacloprid in the B and Q biotypes of Bemisia tabaci (Hemiptera: Aleyro- didae) 显示文摘 | Iris K Juergen B Bettina L | 2008 | Insect Biochemistry and Molecular Biology2008，38，6： | 1 |
| 5 | endothelial dysfunction in lacunar stroke: a systematic review显示文摘 | Iris LH Hugo TC Jan L | 2009 | Cerebrovasc Dis2009，27，5： | 1 |
| 6 | Pretreatment vascular endothelial growth factor(VEGF) and matrix metalloproteinase -9 (MMP-9) serum levels in patients with metastatic non - small lung cancer(NSCLC) 显示文摘 | Eckart L Anlje S Iris B | 2005 | Lung Cancer2005，50，： | 1 |
| 7 | Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET显示文摘 | Nguyen T V Brownell A L Iris Chen Y C Livni E Coyle J T Rosen B R Cavagna F Jenkins B G | | 0，，01： | 1 |
| 8 | Relationship of type Ⅱ diabetes and metformin use to ovarian cancer progression, survival, and chemo- sensitivity 显示文摘 | Iris L Romero A Cormick M | 2012 | Obstet Gynecol2012，119，1： | 1 |
| 9 | Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carci- nogenesis in genetically engineered mice显示文摘 | Iris L Ilyssa O Sujatha J | 2009 | Cancer Prey Res2009，2，9： | 1 |
| 10 | Resver- atrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity 显示文摘 | GUORONG L I CORALIA LUNA IRIS D | 2011 | Invest Ophthalmol Vis Sei2011，52，7： | 1 |
| 11 | Relationship of type Ⅱ diabetes and mefformin use to ovarian cancer progression, survival, and chemosensitivity显示文摘 | Iris L Romero A Cormick M | 2012 | Obstet Gynecol2012，119，1： | 1 |
| 12 | Disposition towards critical thinking: A study of chinese undergraduate nursing students显示文摘 | Yim W Diana L Iris L | 2000 | Journal of Advanced Nursing2000，32，1： | 1 |
| 13 | Ishikawa iterative process with errors for nonlinear equations of generalized monotone type in Banach spaces显示文摘 | (C)IRI(C)L B UME J S | 2005 | Math Nachr2005，278，10： | 1 |
| 14 | Research in information systems: An empirical study of diversity in the discipline and its journals 显示文摘 | Vessey Iris Ramesh R Glass R L | 2002 | Journal of Management Information Systems2002，19，2： | 1 |
| 15 | Preference toward a Thelpertype 1 response in patients with coronary spastic angina显示文摘 | Soejima H Irie A Miyamoto S et a l | 2003 | Circulation2003，107，17： | 1 |
| 16 | Associations between common polymorphisms in TP53 and p21WAF1/Cip1 and phenotypic features of breast cancer显示文摘 | Brenda L Iris l Paul R | 2002 | Carcinogenesis2002，23，2： | 1 |
| 17 | Mechanical properties of a resin-modified glass ionomer cement for luting: effect of adding spherical silica filler 显示文摘 | E L Irie M Nagaoka N | 2010 | Dent Mater J2010，29，3： | 1 |
| 18 | Associations between common polymorphisms in TP53 and p21WAF1/Cipl and phenotypic features of breast cancer 显示文摘 | Brenda L P Iris L S Paul R | 2002 | Carcinogenesis2002，23，2： | 1 |
| 19 | Research in information systems-an empirical study of diversity in the discipline and its journals显示文摘 | Vessey Iris Ramesh R Glass R L | 2002 | Journal of Management Information Systems2002，19，2： | 1 |
| 20 | Disposition towards critical thinking: a study of chinese undergraduate nursing students显示文摘 | YIM W DIANA L IRIS L | 2000 | J Adv Nuts2000，32，1： | 1 |
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