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| 1 | IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。 | Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright | 2018 | Cellular & Molecular Immunology2018，15，5： | 17 |
| 2 | Soluble CD40 ligand in prediction of acute severe pancreatitis显示文摘瞄准:在胰腺炎严厉估计可溶的 CD40L (sCD40L ) 的早可预测性。方法:在 2000 年 2 月和 2003 年 2 月之间,有尖锐胰腺炎的 279 个连续病人有希望地在我们的学习被注册。在这份报告, 40 个病人与温和并且有严重胰腺炎的 40 个病人随机被学习。sCD40L 集中被测量在承认以后的 48 个小时。结果:sCD40L 层次显著地更高在在严重胰腺炎的承认以后的 48 个小时比在温和胰腺炎。用 1000 的截止,检测疾病的一堂严重功课的 sCD40L 的 pg/L,敏感和特性为 CRP 与 72% 和 81% 相比分别地是 78% 和 62% 。发现那 CRP 的逻辑回归分析统计上是唯一的能检测疾病的一堂严重功课的重要标记。结论:这些调查结果显示 CRP 仍然是一个珍贵标记而 sCD40L 层次应该在进一步的研究被估计,决定尖锐胰腺炎的严厉和预后。 | Jean Louis Frossard Philippe Morel Brenda Kwak Catherine Pastor Thierry Berney Léo Buhler Alain Von Laufen Sandrine Demulder Francois Mach | 2006 | World Journal of Gastroenterology2006，12，10： | 2 |
| 3 | Trespassing on the Tracks: A Review of Railway Pedestrian Safety Researeh显示文摘 | BRENDA L | 2006 | Journal of Safety Research2006，，37： | 1 |
| 4 | Rencet Advances on the Nutritional Effects Associated with the Use of Garlic as a Supplement显示文摘 | Harunobu A Brenda LP Hiromichi M et a l | 2001 | American Society for Nutritional Sciences2001，35，： | 1 |
| 5 | Reduced Connexin43 Expression Limits Neointima Formation After Balloon Distension Injury in Hypercholesterolemic Mice显示文摘 | Christos E. Chadjichristos Christian M. Matter Isabelle Roth Esther Sutter Graziano Pelli Thomas F. Lüscher Marc Chanson Brenda R. Kwak | 2006 | Circulation2006，，24： | 1 |
| 6 | Determination ofchromium valence over the range Cr(0)-Cr( VI) by e-lectron energy loss spectroscopy显示文摘 | Tyrone L Daulton Brenda J | 2006 | Ultramicroscopy2006，106，7： | 1 |
| 7 | Improvlng image quality in poor visibility conditions using a physical model for contrast degrsdation 显示文摘 | Oakley John P Satherley Brenda L | 1998 | IEEE Transactions on Image Processing1998，7，2： | 1 |
| 8 | Fibroblasts potentiate blood vessel formationpartially through secreted factor TIMP-1显示文摘 | Hua L Bo C Brenda L | 2008 | Angiogenesis2008，11，： | 1 |
| 9 | Effect of postharvest processing on texture profile analysis of cooked rice 显示文摘 | Elaine T C Brenda G L Bong K M | 1995 | Crereal Chemistry1995，75，2： | 1 |
| 10 | Modeling singlecomponent protein adsorption to the cation exchange s sepharrosee FF显示文摘 | GRAHAM L S BRENDA J H HOWARD A C | 1990 | Journal of Chromatography A1990，498，： | 1 |
| 11 | Myeoplasmas and Ureaplasmas as Neonatal Pathogens 显示文摘 | Ken B W Brenda K Robert L S | 2005 | Clin Micro Rev2005，18，4： | 1 |
| 12 | Antiumor and antimestastatic activity of interleukin - 12 against murine tumors显示文摘 | Brenda MJ Luistro L Warrier RR | 1993 | J Exp Med1993，178，4： | 1 |
| 13 | A miniature microbial fuel cell operating with an aerobic anode chamber显示文摘 | Bradley R R Ricky R Brenda L | 2007 | Journal of Power Sources2007，165，： | 1 |
| 14 | Why Zijinshan copper bioheapleaching plant works efficiently at low microbial activity-study on leaching kinetics of copper sulfides and its implications 显示文摘 | Ruan R M Zou G Zhong S P Wu Z L Chan Brenda Wang D Z | 2013 | Minerals Engineering2013，48，4： | 1 |
| 15 | Polyacrylates in flame retardant treatments of textile fabrics显示文摘 | JOHN V BENINATE BRENDA J TRASK GEORGE L DRAKE | 1984 | Journal of Fire Sciences1984，2，： | 1 |
| 16 | Determination of chromium valence over the range Cr(0) -Cr(Ⅵ) by electron energy loss spectroscopy显示文摘 | Tyrone L Daulton Brenda J | 2006 | Ultramicroscopy2006，106，7： | 1 |
| 17 | Practice guidelines forobstetric anesthesia : an updated report by the American So-ciety of Anesthesiologists Task Force on Obstetric Anesthe-sia and the society for obstetric anesthesia and perinatology显示文摘 | Jeffrey L Joy L Brenda A | 2016 | Anesthesiology2016，124，： | 1 |
| 18 | MASSETTI & Pauline Magee-Egan Does Corporate Social Responsibility Orientation Vary by Position in the Organizational Hierarchy? 显示文摘 | ANGELIDIS BRENDA L | 2008 | Review of Business2008，，： | 1 |
| 19 | Microbial indicators of faecal contamination in water: a current perspective 显示文摘 | PAM T BRENDA M CASSANDRA L | 2005 | Water Air SoilPollu2005，166，： | 1 |
| 20 | Health benefits of Bitter Melon(Momordica charantia)显示文摘 | Edralin A L Gerard G D Brenda J S | | 0，，： | 1 |
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