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| 1 | Mutants, Overexpressors, and Interactors of Arabidopsis Plastocyanin Isoforms: Revised Roles of Plastocyanin in Photosynthetic Electron Flow and Thylakoid Redox State显示文摘二相应 plastocyanin isoforms 被基因 PETE1 和 PETE2 编码为 Arabidopsis thaliana 的原子染色体。PETE2 抄本被表示在更加高水平和 PETE2 蛋白质是更丰富的 isoform。在 PETE 基因的空变化导致了植物,指明的 pete1 和 pete2,与减少的 plastocyanin 内容。尽管有在超过 90% 减少 plastocyanin 层次,而 pete1 大美人种,然而,它的自己上的一个 pete2 0 变化仅仅稍微影响光合作用和生长的率,与大约 6080% 野类型的 plastocyanin 水平,没显示出任何改变。因此, plastocyanin 集中不在最佳的生长条件下面为光合的电子流动正在限制,也许为蛋白质暗示另外的可能的生理的角色。确实, plastocyanin 以前被建议了在 thylakoid 氧化还原作用反应与细胞色素 c6A (Cyt c6A ) 合作,但是我们不为在二蛋白质之间的一个物理相互作用发现证据,用在酵母的相互作用试金。我们在酵母相互作用试金观察了 Cyt c6A 的 homodimerization,而且 Cyt c6A homodimers 没能与 plastocyanin 交往。而且, atc6-1 pete1 的 phenotypic 分析和 atc6-1 pete2 加倍异种,每缺乏的 Cyt c6A 并且二编码 plastocyanin 基因之一,没能揭示任何基因相互作用。在 pete1 pete2 的 PETE1 或 PETE2 的 Overexpression 在实质上野类型的光合的性能的两倍猛烈变异的背景结果,排除二 plastocyanin isoforms 能在 thylakoid 有不同函数的可能性电子流动。 | Paolo Pesaresi Michael Scharfenberg Martin Weigel Irene Granlund Wolfgang R Schroder Giovanni Finazzi Fabrice Rappaport Simona Masiero Antonella Furini Peter Jahns Dario Leister | 2009 | Molecular Plant2009，2，2： | 7 |
| 2 | Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia显示文摘 | Nancy Freitag Irene Tirado-González Gabriela Barrientos Florian Herse Victor L. J. L. Thijssen Susanne M. Weedon-Fekj?r Herbert Schulz Gerd Wallukat Burghard F. Klapp Tania Nevers Surendra Sharma Anne Cathrine Staff Ralf Dechend Sandra M. Blois | 2013 | Proceedings of the National Academy of Sciences2013，，28： | 2 |
| 3 | Papillary thyroid cancer and inflammatory bowel disease:Is there a relationship?显示文摘AIM:To formally study age of diagnosis of papillary thyroid cancer(PTC) in inflammatory bowel disease(IBD) patients and evaluate the prevalence of PTC in IBD patients compared to a control population.pothesis that patients with IBD are more likely to be diagnosed with PTC than a control population.A retrospective cohort analysis was performed using the University of Pennsylvania Health System's electronic database.Outpatients from 1998-2009 were included in the search,and patients in the cohort were selected based on ICD-9 codes.Inclusion criteria included the diagnosis of Crohn's disease(CD) or ulcerative colitis(UC) and the concurrent diagnosis of thyroid cancer in comparison to a control population.Using these methods 912 patients with CD and 1774 with UC were compared to 1638 diverticulitis and 19 447 asthma controls.Statistics were performed using corrected chisquare analysis.The primary outcome for this study was the diagnosis of PTC.Approval to conduct this study was obtained by the Institutional Review Board at the University of Pennsylvania.RESULTS:The mean age was 47.5 years(range:18-102 years) and 66% patients were female.An analysis of variance model was used to compare the age of PTC diagnosis between the CD,UC,asthma and diverticulitis groups,and a statistically significant difference in age at PTC diagnosis was noted across all groups(F = 6.35,df = 3,P = 0.0006).The age of PTC diagnosis in CD patients was statistically significantly lower than UC,asthma,and diverticulitis patients(average PTC diagnosis age for CD 25,UC 49,asthma 45,diverticulitis 63).After covarying for sex and age in 2009,the difference in age at PTC diagnosis remained statistically significant(F = 4.13,df = 3,P = 0.0089).A total of 86 patients were diagnosed with PTC.Nine patients(0.5%) with UC were diagnosed with PTC.Patients with UC were not shown to be more likely to develop PTC [odds ratio(OR):1.544,95%CI 0.767-3.108] compared to asthma controls.Four patients(0.4%) with CD were diagnosed with PTC.Patients with CD were not shown to be more likely to develop PTC(OR:1.334,95%CI 0.485-3.672) compared to a control population with asthma.Nine patients(0.5%) with a history of diverticulitis were diagnosed with PTC.Patients with diverticulitis were not shown to be more likely to develop PTC(OR:1.673,95%CI 0.831-3.368) compared to asthma controls.Patients with CD or UC were not less likely to develop PTC compared to those with diverticulitis(CD OR:0.80,95%CI 0.25-2.60;UC OR:0.92,95%CI 0.37-2.33).None of the patients used immunosuppressant medications prior to the diagnosis of PTC(azathioprine,6-mercaptopurine,and methotrexate).CONCLUSION:There is a significant difference in age of diagnosis of PTC in patients with CD compared to patients with UC and the control populations studied. | Irene S Sonu Wojciech Blonski Ming Valerie Lin James Lewis Faten Aberra Gary R Lichtenstein | 2013 | World Journal of Gastroenterology2013，19，7： | 2 |
| 4 | Management of Evans syndrome显示文摘 | Alice N Irene R | 2006 | Br J Haematol2006，132，2： | 1 |
| 5 | Effects of pre-commercial thinning on growth and reproduction in post-fire regeneration of Pinus halepensis Mill显示文摘 | IRENE R ENCAMA R G FELIPE B | 2013 | Annals of Forest Science2013，70，4： | 1 |
| 6 | Design and development of a satellite constellation using collaborative optimization显示文摘 | Irene A B John R O | | 0，，06： | 1 |
| 7 | Trichostatin A reverses skewed expression of CD154,interleukin-10 and interferon-g gene and protein expression in lupus T cells显示文摘 | Nilamadhab M Doris R B Irene M | 2001 | Proc Natl Acad Sci USA2001，98，5： | 1 |
| 8 | Hydrogel matrix entrapping PLGA-paclitaxel microspheres: drug delivery with near zero-order release and implantability advantages for malignant brain tumour chemotherapy 显示文摘 | Sudhir H R Irene K William B K | 2009 | Pharmaceutical Research2009，26，9： | 1 |
| 9 | Relationship between vasospasm, cerebral perfusion, and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage 显示文摘 | Jan WD Mienke R Irene C | 2009 | Neuroradiology2009，51，12： | 1 |
| 10 | Endocrine disruption caused by oral administration of atrazine in European quail (Coturnix coturnix coturnix)显示文摘 | Irene de la C R Valdehita A Soler F | 2012 | Comparative Biochemistry and Physiology2012，156，： | 1 |
| 11 | Incidence and risk factors for agranulocytosis in Latin American countries—the Latin Study显示文摘 | Nelson Hamerschlak Eliane Maluf Alexandre Biasi Cavalcanti álvaro Avezum Júnior José Eluf-Neto Roberto Passeto Falc?o Irene Gyongyvér Heidemarie Lorand-Metze Daniel Goldenberg Cézar Leite Santana Daniela de Oliveira Werneck Rodrigues Leny Nascimento da Mo | 2008 | European Journal of Clinical Pharmacology2008，，9： | 1 |
| 12 | A review of the housing requirements of domestic cats(Felis silvestric catus) kept in the home显示文摘 | Irene R | 2005 | Applied AnimalBehaviour Science2005，93，： | 1 |
| 13 | Ambient Air Pollution and Lipoprotein-Associated Phospholipase A^sub 2^ in Survivors of Myocardial Infarction显示文摘 | Brüske Irene Hampel Regina Baumg?rtner Zita Rückerl Regina Greven Sonja Koenig Wolfgang Peters Annette Schneider Alexandra | 2011 | Environmental Health Perspectives2011，，7： | 1 |
| 14 | Characterization of vacuum brazed joints for superconducting cavities显示文摘 | Irene C Emilio R Katya B | 2004 | Microchimica Acta2004，147，3： | 1 |
| 15 | Age estimation from pulp/tooth area ratio in maxillary incisors among Egyptians using dental radiographic images显示文摘 | Jaklin F Z Irene A F Sahar R H | | 0，，： | 1 |
| 16 | Congenital Hypothyroidism and Nonimmune Hydrops Fetalis: Associated? 显示文摘 | Irene Kessel Imad R Makhoul Polo Sujov | 1999 | Pediatrics1999，103，1： | 1 |
| 17 | Endotoxin-lnduced expression of mrrine bactericidal permeability/increasing protein is mediated exclusively by ToI1/IL-1 receptor domain-containing adaptor inducing IFN-β-dependent pathways显示文摘 | Melanie K Irene W Martin R | 2006 | J Immunol2006，176，： | 1 |
| 18 | Design and development of a satellite constellation using collaborative optimization 显示文摘 | Irene A B John R O | 2004 | Journal of Spacecraft and Rockets2004，41，6： | 1 |
| 19 | Algal growth control by terrestrial leaf litter:A realistic tool显示文摘 | IRENE R JOHN W MIKE S | 1999 | Toxicon1999，395，396： | 1 |
| 20 | Maximum-likelihood multiresolution laser radar range imaging显示文摘 | Donald R Greer Irene Fung Jeffrey H Shapiro | 1997 | IEEE Transations on Image Processing1997，6，1： | 1 |
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