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		题名	作者	年代	出处	被引量
	1	Rituximab-induced IgG hypogammaglobulinemia in children with nephrotic syndrome and normal pre-treatment IgG values显示文摘BACKGROUND In paediatric patients with complicated nephrotic syndrome(NS), rituximab(RTX) administration can induce persistent IgG hypogammaglobulinemia among subjects showing low basal immunoglobulin G(IgG) levels.AIM To evaluate the effect of RTX on IgG levels and infections in patients with complicated NS and normal basal IgG levels.METHODS We consecutively enrolled all patients with complicated NS and normal basal IgG levels undergoing the first RTX infusion from January 2008 to January 2016. Basal IgG levels were dosed after 6 wk of absent proteinuria and with a maximal interval of 3 mo before RTX infusion. The primary outcome was the onset of IgG hypogammaglobulinemia during the follow-up according to the IgG normal values for age [mean ± standard deviation(SD)].RESULTS We enrolled 20 patients with mean age at NS diagnosis of 4.2 ± 3.3 years. The mean age at the first RTX infusion was 10.9 ± 3.5 years. Eleven out of twenty patients(55%) developed IgG hypogammaglobulinemia. None of these patients showed severe or recurrent infections. Only one patient suffered from recurrent acute otitis media and underwent substitutive IgG infusion. Three patients undergoing only the two 'starting doses' experienced normalization of IgG levels. Using Kaplan-Meier analysis, the cumulative proportion of patients free of IgG hypogammaglobulinemia was 57.8% after the first RTX dose, 51.5% after the third dose, 44.1% after the fourth dose, and 35.5% after the fifth dose.CONCLUSION RTX can induce IgG hypogammaglobulinemia in patients with pre-RTX IgG normal values. None of the treated patients showed severe infections.	Pierluigi Marzuillo Stefano Guarino Tiziana Esposito Anna Di Sessa Sara Immacolata Orsini Daniela Capalbo Emanuele Miraglia del Giudice Angela La Manna	2019	World Journal of Clinical Cases2019，7，9：	2
	2	How cyclodextrin incorporation affects the properties of protein-loaded PLGA-based microspheres:the case of insulin/hydroxypropyl-beta-cyclodextrin system显示文摘	De Rosa G Larobina D Immacolata La Rotonda M	2005	J Control Release2005，102，1：	1
	3	How cyclodextrin incorporation affects the properties of protein-loaded PLGA-based microspheres:the case of insulin/hydroxypropyl-β-cyclodextrin system显示文摘	De Rosa G Larobina D Immacolata La Rotonda M	2005	J Controlled Release2005，102，1：	1
	4	Solubilization of tropicamide by hydroxypropyl-β-cyclodextrin and water-soluble polymers: in vitro/in vivo studies显示文摘	Brunella Cappello Claudia Carmignani Maria Iervolino M Immacolata La Rotonda M Fabrizio Saettone	2001	International Journal of Pharmaceutics2001，，1：	1
	5	How cyclodextrin incorporation afects the properties of protein-loaded PIGA-based microspheres: the case of insulin/bydroxypropyl-betacyclodextrirt system 显示文摘	De Rosa G Larobina D Immacolata La Rotonda M	2005	J Gontrol Release2005，102，1：	1
	6	How cyclodextrin incorporation affects the properties of protein-loaded PLGA-based microspheres:the case of insulin/hydroxypropyl-β-cyclodextrin system显示文摘	De Rosa G Larobina D Immacolata La Rotonda M	2005	J Control Release2005，102，1：	1
	7	How cyclodextrin incorpation affects the properties of protein-loaded PLGA-based microspheres:the case of insulin/hydroxypropyl-beta-cyclodextrin system显示文摘	DE ROSA G LAROBINA D IMMACOLATA LA	2005	J Control Release2005，102，1：	1
	8	Modulation of drug release from hydrogels by using cyclodextrins: the case of nicardipine/β-cyclodextrin system in crosslinked polyethylenglycol显示文摘	Fabiana Quaglia Giovanna Varricchio Agnese Miro Maria Immacolata La Rotonda Domenico Larobina Giuseppe Mensitieri	2001	Journal of Controlled Release2001，，3：	1
	9	SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells显示文摘	Marcello Persico Roberta Russo Eliana Persico Monica Svelto Daniela Spano Immacolata Andolfo Vincenzo La Mura Mario Capasso Claudio Tiribelli Roberto Torella Achille Iolascon	2009	Clinical Chemistry and Laboratory Medicine2009，，10：	1

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