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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation显示文摘 | Jose A. Rodríguez-Navarro Laura Rodríguez María J. Casarejos Rosa M. Solano Ana Gómez Juan Perucho Ana María Cuervo Justo García de Yébenes María A. Mena | 2010 | Neurobiology of Disease2010，，3： | 2 |
| 3 | The epidemi- ology of sepsis in Colombia: a prospective muhicenter co- hort study in ten university hospitals显示文摘 | Rodriguez F Barrera L De La Rosa G | 2011 | Crit Care Med2011，39，7： | 1 |
| 4 | Neurophysiological evidence of corticospinal tract abnormality in patients with Parkin mutations 显示文摘 | De Rosa A Volpe G Marcantonio L | 2006 | Neurol2006，253，3： | 1 |
| 5 | A key role of leptin in the control of regulatory T cell proliferation显示文摘 | De Rosa V Procaccini C Cali G | 2007 | Immunity2007，26，2： | 1 |
| 6 | Mood disorder as a manifestation of primary hy- poparathyroidism:A case report显示文摘 | Regis G Rosa Alcina J S Barros Antonio RB de Lima | 2014 | Journal of Medical Case Reports2014，8，4： | 1 |
| 7 | Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells 显示文摘 | Sanchez-Sanchez N Riol-Blanco L de la Rosa G | 2004 | Blood2004，104，3： | 1 |
| 8 | Glutathione deficiency is associated with impaired survival in HIV disease 显示文摘 | HERZENBERG L A DE ROSA S C DUBS J G | 1997 | Proc Nat Acad Sci1997，94，5： | 1 |
| 9 | How cyclodextrin incorporation affects the properties of protein-loaded PLGA-based microspheres:the case of insulin/hydroxypropyl-beta-cyclodextrin system显示文摘 | De Rosa G Larobina D Immacolata La Rotonda M | 2005 | J Control Release2005，102，1： | 1 |
| 10 | Macroscopic and histological effects of magnetic field exposi- tion in the process of tissue reparation in Wistar rats显示文摘 | Bertolino G De Freitas Braga A De Oliveira Limado Couto Rosa K | 2006 | Arch Der- matol Res2006，298，： | 1 |
| 11 | 查看详情显示文摘 | De Rosa C Auriemma F De Lucia G Resconi L | | 0，，： | 1 |
| 12 | D-direct is a signifi- cant prognostic factor in patients with suspected infection and sep- sis显示文摘 | Rodelo JR De la Rosa G Valencia ML | 2012 | Am J Emerg Med2012，30，9： | 1 |
| 13 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 14 | Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure显示文摘 | Galasso G De Rosa R Piscione F | 2010 | Eur J Heart Fail2010，12，12： | 1 |
| 15 | A key role of leptin in the control of regulatory T cell proliferation显示文摘 | De Rosa V Procaecini C Call G | 2007 | Immunity2007，26，2： | 1 |
| 16 | Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses显示文摘 | de la Rosa G Yang D Tewary P | 2008 | J Immunol2008，180，10： | 1 |
| 17 | Regulated recruitment of DC-SIGN to cell-cell contact regions during zymosan-induced human dendritic cell aggregation显示文摘 | Yanez MM Samaneigo R | 2005 | J Leukoc Biol2005，77，5： | 1 |
| 18 | Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells显示文摘 | Sanchez-Sanchez N Riol-Blanco L De La Rosa G | 2004 | Blood2004，104，： | 1 |
| 19 | Gel and solid matrix systems for the controlled delivery of drug carrier -associated nucleic acids显示文摘 | E Fattal G De Rosa A Bochot | 2004 | International Journal of Pharmaceutics2004，277，： | 1 |
| 20 | Infective endocarditis in patients with human immunodeficiency virus infection 显示文摘 | CICALINI S FORCINA G DE ROSA F G | 2001 | J Infect2001，42，4： | 1 |
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