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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Phase joint transform sequential correlator for nonlinear binary correlations 显示文摘 | Joaquin O Pascuala G M Ignacio M | 2005 | Optics Communications2005，，245： | 1 |
| 3 | Trends in the Structure and Bonding of Noble Metal Clusters 显示文摘 | Eva M F Jose M S M Ignacio L G | 2004 | Phys Rev B2004，70，16： | 1 |
| 4 | Measuring efficiency of sun & beach tourism destination 显示文摘 | Medina L F Ignacio G G Sandra M M | 2012 | Annals of Tourism Re- search2012，，39： | 1 |
| 5 | Aflatoxin (B1, B2, G1, and G2) Contamination in Rice of Mexico and Spain, from Local Sources or Imported显示文摘 | Elena Suárez‐Bonnet Magda Carvajal Ignacio Méndez‐Ramírez Pável Castillo‐Urueta Josefina Cortés‐Eslava Sandra Gómez‐Arroyo José María Melero‐Vara | 2013 | Journal of Food Science2013，，11： | 1 |
| 6 | Detecting drought induced environmental changes in a Mediterranean wetland by remote sensing显示文摘 | Ignacio M Jose N Ignacio G | 2010 | Applied Geography2010，30，2： | 1 |
| 7 | Rough vaccines in animal brucellosis:Structural and genetic basis and present status显示文摘 | Ignacio M Maria J G Daniel M | 2004 | Vet Res2004，35，： | 1 |
| 8 | Detailed characterization of potentiostatic current transients with 2D-2D and 2D-3D nucleation transitions显示文摘 | Manuel P P Margarita M H Ignacio G | 1998 | Surf Sci1998，399，： | 1 |
| 9 | Diagnosis of Lung Cancer in Small Biopsies and Cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification显示文摘 | Travis William D Brambilla Elisabeth Noguchi Masayuki Nicholson Andrew G Geisinger Kim Yatabe Yasushi Ishikawa Yuichi Wistuba Ignacio Flieder Douglas B Franklin Wilbur Gazdar Adi Hasleton Philip S Henderson Douglas W Kerr Keith M Petersen I | 2013 | Archives of Pathology & Laboratory Medicine2013，，5： | 1 |
| 10 | Soy isoflavonoids exhibit in vitro biological activities of loop diuretics 显示文摘 | Rosa M Ignacio G Jose M | 1998 | Am J Clin Nutr1998，68，： | 1 |
| 11 | Identification of different silver nucleation processes on vitreous carbon surfaces from an ammonia electrolytic bath显示文摘 | MARGARITA M H MANUEL P P NIKOLA B IGNACIO G | 1998 | J Electroanal Chem1998，443，： | 1 |
| 12 | Detailed characterization of potentiostatic current transients with 2D-2D and 2D-3D nucleation transitions显示文摘 | MARGARITA M H MANUEL P P NIKOLA B IGNACIO G | 1998 | Surf Sci1998，399，： | 1 |
| 13 | Soy isoflavonoids exhibit in vitro biological activities of loop diuretics显示文摘 | Rosa M Ignacio G Jose M | 1998 | Am J Clin Nutr1998，68，： | 1 |
| 14 | Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization显示文摘 | Ignacio M Ricardo C Teresa G | 2003 | J Pharmacol Exp Ther2003，304，： | 1 |
| 15 | Anterior segment changes after posterior chamber phakic intraocular lens implantation显示文摘 | Ignacio JA Jose M Julian G | 2001 | Ophthalmology2001，108，： | 1 |
| 16 | Differences between carbon nanofibers produced using Fe and Ni catalysts in a floating catalyst reactor 显示文摘 | IGNACIO M G JOSE V JUAN A C JOSE L G | 2006 | Carbon2006，44，8： | 1 |
| 17 | Safety of posterior chamber phakic intraocular lenses for the correction of high myopia显示文摘 | Ignacio Jiménez-Alfaro José M Ben??tez del Castillo Julian Garc??a-Feijoó Javier G Gil de Bernabé José M Serrano de la Iglesia | 2001 | Ophthalmology2001，，1： | 1 |
| 18 | Determination of lead and cadmium using an ionic liquid and dispersive liquid -liquid microextraction followed by electrothermal atomic absorption spectrometry 显示文摘 | Ignacio L G Yesica V M Manuel H C | 2013 | Talanta2013，110，： | 1 |
| 19 | Glutathione and itsrelationship with intracellular redox status,oxidative stress and cellproliferation/death显示文摘 | JoséM M Cristina P G Ignacio N D C | 2002 | The International Journal of Biochemistry&Cell Biology2002，34，5： | 1 |
| 20 | Rough vaccines in animal brucellosis:Structural and genetic basis and present status显示文摘 | Ignacio M Maria J G Daniel M | 2004 | Vet Res2004，35，： | 1 |
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