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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression显示文摘 | María J. Bueno Ignacio Pérez de Castro Marta Gómez de Cedrón Javier Santos George A. Calin Juan C. Cigudosa Carlo M. Croce José Fernández-Piqueras Marcos Malumbres | 2008 | Cancer Cell2008，，： | 2 |
| 3 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 4 | Generation of planar and helical elliptical gears by application of rack-cutter, hob, and shaper 显示文摘 | Litvin F L Ignacio G P Kenji Y | 2007 | Comput Methods Appl Mech Engrg2007，196，： | 1 |
| 5 | Growth hormone reduces mortality and bacterial translocation in irradiated rats显示文摘 | Ignacio A Isabel P Antonio G | 1998 | Acta Oncologica1998，37，： | 1 |
| 6 | Fire hazard in bridges: review, assessment and repair strategies 显示文摘 | Maria G Ignacio P Z Venkatesh K | 2012 | Engineering Structures2012，35，1： | 1 |
| 7 | Growth hormone reduces mortality and bacterial translocation in irradiated rats显示文摘 | Ignacio A Isabel P Antonio G | 1998 | Acta Oncologica1998，37，1： | 1 |
| 8 | De- sign, generation and stress analysis of face-gear drive with helical pinion 显示文摘 | LITIVIN F L IGNACIO G P ALFONSO F | 2005 | Computer Methods in Applied Mechanics and Engineering2005，194，9： | 1 |
| 9 | Aflatoxin (B1, B2, G1, and G2) Contamination in Rice of Mexico and Spain, from Local Sources or Imported显示文摘 | Elena Suárez‐Bonnet Magda Carvajal Ignacio Méndez‐Ramírez Pável Castillo‐Urueta Josefina Cortés‐Eslava Sandra Gómez‐Arroyo José María Melero‐Vara | 2013 | Journal of Food Science2013，，11： | 1 |
| 10 | Dynamic modeling and classical control theory for supply chain management显示文摘 | Edgar P Ignacio G Erik Y | 2000 | Computers and Chemical Engineering2000，24，27： | 1 |
| 11 | Generalized comcept of meshing and comtact of involute crossed helical gear and its application显示文摘 | FAYDOR L L IGNACIO G P ALFONSO F | 2005 | Computer Methods in Applied Mechanics and Engineering2005，194，3435： | 1 |
| 12 | Formation mechanisms and characterization of black and white cobalt electrdeposition onto stainless steel显示文摘 | ENRIQUE B MANUEL P P NIKOLA B IGNACIO G | 2000 | Journal of Electrochemical Society2000，147，5： | 1 |
| 13 | New insights into evaluation of kinetic parameters for potentiostic metal deposition with underpotential and overpotential deposition process显示文摘 | MANUEL P P IGNACIO G NIKOLA B | 2000 | J Chem Phys B2000，104，： | 1 |
| 14 | Effects of thinning intensity on radial growth patterns and temperature sensitivity in Pinus canariensis afforestations on Tenerife Island, Spain显示文摘 | Gonzalo P L Ignacio G VicenteR | 2011 | Annals of Forest Science2011，68，： | 1 |
| 15 | Detailed characterization of potentiostatic current transients with 2D-2D and 2D-3D nucleation transitions显示文摘 | Manuel P P Margarita M H Ignacio G | 1998 | Surf Sci1998，399，： | 1 |
| 16 | Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression显示文摘 | Mara J Bueno Ignacio Pérez de Castro Marta G ómez de Cedrón | 2008 | Cancer Ce112008，13，6： | 1 |
| 17 | Generation of Planar and Helical Elliptical Gears by Application of Rackcutter, Hob, and Shaper显示文摘 | FAYDOR L L IGNACIO G P KENJI Y | 2007 | Computer Methods in Applied Mechanics and Engineering2007，196，4144： | 1 |
| 18 | Silver electrocrystallization on vitreous carbon from ammonium hydroxide solutions 显示文摘 | Manuel P P Ma T R Ignacio G | 1996 | J Electrochem Soc1996，143，5： | 1 |
| 19 | Identification of different silver nucleation processes on vitreous carbon surfaces from an ammonia electrolytic bath显示文摘 | MARGARITA M H MANUEL P P NIKOLA B IGNACIO G | 1998 | J Electroanal Chem1998，443，： | 1 |
| 20 | Detailed characterization of potentiostatic current transients with 2D-2D and 2D-3D nucleation transitions显示文摘 | MARGARITA M H MANUEL P P NIKOLA B IGNACIO G | 1998 | Surf Sci1998，399，： | 1 |
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