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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Affective temperaments and ego defense mechanisms associated with somatic symptom severity in a large sample显示文摘 | Hyphantis TN Taunay TC Macedo DS | 2013 | Affect Disord2013，150，2： | 1 |
| 3 | Sense of Coherence and Defense Style Predict Sleep Difficulties in Early Non-metastatic Colorectal Cancer显示文摘 | Hyphantis T Goulia P Zerdes I | 2016 | Dig Dis Sci2016，61，1： | 1 |
| 4 | Personality variables as predictors of early non-metastatic eolorectal cancer patients' psychological distress and health-related quality of life: a one-year prospective study显示文摘 | Hyphantis T Paika V Aimyroudi A et ai | 2011 | J Psy- chosom Res2011，70，5： | 1 |
| 5 | Depression in diabetes mellitus: a comprehensive review显示文摘 | Andreoulakis E Hyphantis T Kandylis D | 2012 | Hippokrati- a2012，16，3： | 1 |
| 6 | Defense mechanisms in inflammatory bowel disease显示文摘 | Thomas N. Hyphantis John K. Triantafillidis Sofia Pappa Christos Mantas Anna Kaltsouda Peter Cherakakis Yannis Alamanos Orestis N. Manousos Venetsanos G. Mavreas | 2005 | Journal of Gastroenterology2005，，1： | 1 |
| 7 | Somatization is associated with physical health-related quality of life inde- pendent of anxiety and depression in cancer, glaucoma and rheumatological disorders 显示文摘 | Hyphantis T Tomenson B Paika V | 2009 | Qual Life Res2009，18，8： | 1 |
| 8 | Personality traits, defense mechanisms and hostility features associated with somatic symptom severity in both health and disease显示文摘 | Hyphantis T Goulia P Carvalho AF | 2013 | Psychosom Res2013，75，4： | 1 |
| 9 | Defense mechanisms in inflammatory bowel disease显示文摘 | Hyphantis TN Triantafillidis JK Pappa S | 2005 | J Gastroenterol2005，40，： | 1 |
| 10 | Ego mechanisms of defense are associated with patients' preference of treatment modality independent of psychological dis- tress in end-stage renal disease显示文摘 | Hyphantis T Katsoudas S Voudiclari S | 2010 | Patient Prefer Ad- herence2010，244，： | 1 |
| 11 | The impact of psychological functioning upon systemic sclerosis patients' qualityof life显示文摘 | Hyphantis TN Tsifetaki N Siafaka V | | 0，，02： | 1 |
| 12 | Psycho?dynamic interpersonal therapy and improvement in interpersonal difficulties in people with severe irritable bowel syndrome 显示文摘 | Hyphantis T Guthrie E Tomenson B et a1 | 2009 | Pain2009，145，12： | 1 |
| 13 | Psychiatric manifestations and personality traits associated with compliance with glaucoma treatment显示文摘 | Chrisavgi Pappa Thomas Hyphantis Sofia Pappa Miltiadis Aspiotis Maria Stefaniotou Georgios Kitsos Konstantinos Psilas Venetsanos Mavreas | 2006 | Journal of Psychosomatic Research2006，，5： | 1 |
| 14 | Defense mechanisms in inflammatory bowel disease显示文摘 | Hyphantis TN Triantafillidis JK Pappa S Mantas C Kaltsouda A Cherakakis P | 2005 | J Gastroenterol2005，40，1： | 1 |
| 15 | Defense mechanisms in inflammatory bowel disease 显示文摘 | Hyphantis TN Triantafillidis JK Pappa S | 2005 | J Gastroenterol2005，40，1： | 1 |
| 16 | Personality variables as pre- dictors of early non-metastatic colorectal cancer patients' psycho- logical distress and health-related quality of life: a one-year pro- spective study显示文摘 | Hyphantis T Paika V Almyroudi A | 2011 | Psychosom Res2011，70，5： | 1 |
| 17 | Personalityvariables as predictors of early non-metastatic colorectalcancer patients’ psychological distress and health-relatedquality of life:a one-year prospective study显示文摘 | Hyphantis T Paika V Almyroudi A | 2011 | J Psycho-som Res2011，70，5： | 1 |
| 18 | Somatization is asso- ciated with physical health-related quality of life independent of anxiety and depression in cancer, glaucoma and rheumatological disorders显示文摘 | Hyphantis T Tomenson B Paika V | 2009 | Qual Life Res2009，18，： | 1 |
| 19 | The impact of psychological functioning upon systemic sclerosis patients' quality of life显示文摘 | Hyphantis TN Tsifetaki N Siafaka V | 2007 | Setnin Arthritis Rheum2007，37，： | 1 |
| 20 | The impact of psychological functioning upon systemic sclerosis patients' qualityof life显示文摘 | Hyphantis T N Tsifetaki N Siafaka V | 2007 | Semin Arthritis Rheum2007，37，2： | 1 |
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