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| 1 | 面向21世纪的卒中新定义:美国心脏病学会和美国卒中学会声明显示文摘尽管脑血管病有着全球性影响且对其病理生理学的认识有了很多进步,但是'卒中'这一术语在临床实践、临床研究或公共卫生评估中的定义却不一致。传统的定义依据于临床,却没有考虑到科学技术的进步。美国心脏协会(AHA)和美国卒中协会(ASA)卒中分会组织了写作小组,为21世纪卒中新定义撰写专家共识性声明。中枢神经系统(CNS)梗死,指由缺血所导致的脑、脊髓或视网膜的细胞死亡,是基于持续性损害的神经病理学、神经影像学和(或)临床证据。CNS梗死表现为一个临床谱:缺血性卒中特指伴有明显症状的CNS梗死,而静息性梗死根据定义指未引起已知的症状的梗死。卒中也还包括脑出血和蛛网膜下腔出血。新定义的卒中结合了临床和组织学标准,可被用于实践、研究和公共卫生评估。 | 俞羚 董荃 宋叶平 江静雯 李卉 刘亮贤 苏爱萍 李焰生 Sacco RL Kasner SE Broderick JP Caplan LR Connors JJ Culebras A Elkind MS George MG Hamdan AD Higashida RT Hoh BL Janis LS Kase CS Kleindorfer DO Lee JM Moseley ME Peterson ED Turan TN Valderrama AL Vinters HV | 2013 | 神经病学与神经康复学杂志2013，10，2： | 188 |
| 2 | A meta-analysis of oxidative stress markers in schizophrenia显示文摘Oxidative stress has been identified as a possible element in the neuropathological processes of schizophrenia(SCZ).Alteration of oxidative stress markers has been reported in SCZ studies,but with inconsistent results.To evaluate the risk of oxidative stress to schizophrenia,a meta-analysis was conducted,including five markers of oxidative stress [thiobarbituric reactive substances(TBARS),nitric oxide(NO),catalase(CAT),glutathione peroxidase(GP) and superoxide dismutase(SOD)] in SCZ patients versus healthy controls.This study showed that TBARS and NO significantly increased in SCZ,while SOD activity significantly decreased in the disorganized type of SCZ patients.No significant effect size was found for the activities of GP and CAT in SCZ patients(P>0.05).Egger’s regression test observed no significant publication bias across the oxidative stress markers,but found high heterogeneities in all the 5 markers.The subgroup analysis suggested that the ethnicity,sample size of patients and sample sources may contribute to the heterogeneity of the results for TBARS,NO and SOD.The result further demonstrated the involvement of oxidative stress in the pathophysiology of schizophrenia. | ZHANG Ming1,2,ZHAO ZhongMing3,HE Lin1,2,4 & WAN ChunLing1,2 1 Bio-X Center,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),Shanghai Jiao Tong University,Shanghai 200030,China 2 Institutes for Nutritional Sciences,Shanghai Institute of Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China 3 Departments of Biomedical Informatics,Psychiatry,and Cancer Biology,Vanderbilt University Medical Center,Nashville,TN 37232,USA 4 Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China | 2010 | Science China(Life Sciences)2010，53，1： | 32 |
| 3 | Map and analysis of microsatellites in the genome of Populus: The first sequenced perennial plant显示文摘Environmental Sciences Division, Oak Ridge National Laboratory, TN, USA We mapped and analyzed the microsatellites throughout 284295605 base pairs of the unambiguously assembled sequence scaffolds along 19 chromosomes of the haploid poplar genome. Totally, we found 150985 SSRs with repeat unit lengths between 2 and 5 bp. The established microsatellite physical map demonstrated tr at SSRs were distributed relatively evenly across the genome of Populus. On average, These SSRs occurred every 1883 bp within the poplar genome and the SSR densities in intergenic regions, introns, exons and UTRs were 85.4%, 10.7%, 2.7% and 1.2%, respectively. We took di-, tri-, tetra-and pentamers as the four classes of repeat units and found that the density of each class of SSRs decreased with the repeat unit lengths except for the tetranucleotide repeats. It was noteworthy that the length diversification of microsatellite sequences was negatively correlated with their repeat unit length and the SSRs with shorter repeat units gained repeats faster than the SSRs with longer repeat units. We also found that the GC content of poplar sequence significantly correlated with densities of SSRs with uneven repeat unit lengths (tri-and penta-), but had no significant correlation with densities of SSRs with even repeat unit lengths (di-and tetra-). In poplar genome, there were evidences that the occurrence of different microsatellites was under selection and the GC content in SSR sequences was found to significantly relate to the functional importance of microsatellites. | LI ShuXian & YIN TongMing College of Environment and Forest Resources, Nanjing Forestry University, Nanjing 210037, China Environmental Sciences Division, Oak Ridge National Laboratory, TN, USA | 2007 | Science China(Life Sciences)2007，50，5： | 25 |
| 4 | TREATMENT OF METALS, POLYMER FILMS, AND FABRICS WITHA ONE ATMOSPHERE UNIFORM GLOW DISCHARGE PLASMA(OAUGDP) FOR INCREASED SURFACE ENERGY AND DIRECTIONAL ETCHING显示文摘Direct exposure of samples to the active species of air generated by a One Atmosphere Uniform Glow Discharge Plasma (OAUGDP) has been used to etch and to increase the surface energy of metallic surfaces, photoresist, polymer films, and nonwoven fab- rics. The OAUGDP is a non-thermal plasma with the classical characteristics of a DC normal glow discharge that operates in air (and other gases) at atmospheric pres- sure. Neither a vacuum system nor batch processing is necessary. A wide range of applications to metals, photoresist, films, fabrics, and polymeric webs can be accom- modated by direct exposure of the workpiece to the plasma in parallel-plate reactors. This technolopy is simple, it produces effects that can be obtained in no other way at one atmosphere; it generates minimal pollutants or unwanted by-products; and it is suitable for individual sample or online treatment of metallic surfaces, wafers, films, and fabrics. Early exposures of solid materials to the OAUGDP required minutes to produce rela- tively small increases of surface energy. These durations appeared too long for com- mercial application to fast-moving webs. Recent improvements in OAUGDP gas com- position, power density, plasma quality, recireulating gas flow, and impedance match- ing of the power supply to the parallel plate plasma reactor have made it possible to raise the surface energy of a variety of polymeric webs (PP, PET PE etc.) to levels of 60 to 70 dynes/cm with one second of exposure. In air plasmas, the high surface ener- gies are not durable, and fall to 50 dynes/cm after periods of weeks to months. Here, we report the exposure of metallic surfaces, photoresist, polymeric films, and nonwo- ven fabrics made of PP and PET to an impedance matched parallel plate OAUGDP for durations ranging from one second to several tens of seconds. Data will be re- ported on the surface energy, wettability, wickability, and aging effect of polymeric films and fabrics as functions of time of exposure, and time after exposure; the rate and uniformity of photoresist etching; and the production of sub-micron structures by OAUGDP etching at one atmosphere. | J. Reece Roth and Z. Y Chen (Plasma Sciences Laboratory, Department of Electrical and Computer Engineering, University of Tennessee, Knoxville, TN 37996-2100, USA) Peter P.- Y Tsai (Textiles and Nonwovens Development Center (TANDEC), University of Tenness | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，6： | 18 |
| 5 | 口服抗栓药物预防非瓣膜性房颤患者的卒中:美国心脏协会/美国卒中协会的科学建议显示文摘成年房颤患者的卒中发生率,依据合并症和既往脑血管事件史,为每年1%~20%不等(平均每年为4.5%)。对卒中风险的分层非常重要,因为用抗栓药降低房颤导致卒中的主要风险是出血。如华法令在减少缺血性事件风险的同时,每年有1%~12% | 戴若莲 糜建华 华驾略 董荃 苏爱萍 李焰生 Furie KL Goldstein LB Albers GW Khatri P Neyens R Turakhia MP Turan TN Wood KA | 2012 | 神经病学与神经康复学杂志2012，9，3： | 12 |
| 6 | 高温油藏内源微生物及其提高采收率潜力研究显示文摘大港孔店油田油藏特征、流体和微生物性质分析结果表明,属于高温生态环境,地层水矿化度较低,氮、磷浓度低,而且缺乏电子受体,主要的有机物来源是油气。油田采用经过除油处理的油藏产出水回注方式开发,油层中存在的微生物类型主要是厌氧嗜热菌,包括发酵菌(102个/mL^105个/mL),产甲烷菌(103个/mL);好氧菌主要存在于注水井周围。硫酸盐还原菌(SRB)还原速率0.002μgS2-/(L·d)~18.9μgS2-/(L·d),产甲烷菌产甲烷速率0.012μgCH4/(L·d)~16.2μgCH4/(L·d)。好氧菌能够氧化油形成生物质,部分氧化产物为挥发性脂肪酸和表面活性剂。产甲烷菌在油氧化菌液体培养基中产生CH4,CO2为好氧微生物和厌氧微生物的共同代谢产物。这些产物具有提高原油流动性的作用。用示踪剂研究了注入水渗流方向。通过综合分析,油藏微生物具有较大的潜力,基于激活油层菌的提高采收率方法在该油田是可行的。 | 冯庆贤 向廷生 Nazina TN 王建强 倪方天 | 2008 | 微生物学通报2008，35，4： | 9 |
| 7 | Circulating miRNA and cancer diagnosis显示文摘miRNAs are a class of small RNA molecules with regulatory function, and play an important role in tumor development and progression. It has been demonstrated that tumor-derived miRNAs exist in the circulating nucleic acids of cancer patients. This phenomenon implies that detection of the circulating miRNA may be an effective method for non-invasive diagnosis of cancer. In this review, we summarize the applications of the circulating miRNA as biomarkers in cancer diagnosis, as well as the latest research progress in this area. | TIE Yi1, LIU BinDong2, FU HanJiang1 & ZHENG XiaoFei1· 1 Beijing Institute of Radiation Medicine, Bejing 100850, China 2 Health Disparities/HIV Immed Ofc, Meharry Medical College, Nashville TN 37208, USA | 2009 | Science China(Life Sciences)2009，52，12： | 9 |
| 8 | Spatial patterns in temperature sensitivity of soil respiration in China: Estimation with inverse modeling显示文摘Temperature sensitivity of soil respiration (Q10) is an important parameter in modeling the effects of global warming on ecosystem carbon release. Experimental studies of soil respiration have ubiquitously indicated that Q10 has high spatial heterogeneity. However, most biogeochemical models still use a constant Q10 in projecting future climate change and no spatial pattern of Q10 values at large scales has been derived. In this study, we conducted an inverse modeling analysis to retrieve the spatial pattern of Q10 in China at 8 km spatial resolution by assimilating data of soil organic carbon into a proc-ess-based terrestrial carbon model (CASA model). The results indicate that the optimized Q10 values are spatially heterogeneous and consistent to the values derived from soil respiration observations. The mean Q10 values of different soil types range from 1.09 to 2.38, with the highest value in volcanic soil, and the lowest value in cold brown calcic soil. The spatial pattern of Q10 is related to environmental factors, especially precipitation and top soil organic carbon content. This study demonstrates that inverse modeling is a useful tool in deriving the spatial pattern of Q10 at large scales, with which being incorporated into biogeochemical models, uncertainty in the projection of future carbon dynamics could be potentially reduced. | ZHOU Tao1,2, SHI PeiJun1,2, HUI DaFeng3 & LUO YiQi4 1 State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China 2 Academy of Disaster Reduction and Emergency Management, Ministry of Civil Affairs & Ministry of Education, Beijing 100875, China 3 Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA 4 Department of Botany and Microbiology, University of Oklahoma, Norman, OK 73019, USA | 2009 | Science China(Life Sciences)2009，52，10： | 4 |
| 9 | Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation显示文摘 | Sato TN Tozawa Y Deutsch U | | 0，，： | 3 |
| 10 | FACILITATING REGIONAL SUSTAINABLE DEVELOPMENT THROUGH INTEGRATED MULTI-OBJECTIVE UTILIZATION, MANAGEMENT OF WATER RESOURCES IN THE LANCANG-MEKONG RIVER BASIN显示文摘The Lancnag Mekong River is the most important international river across China and Southeast Asia, If it is developed according to 'Great Mekong Subregional Cooperation Plan' [9] prepared by ADB, the area directly affected will be up to over 2.32 million km 2, the population over 220 million, and the natural environment, and socio-economic conditions within a large area will be greatly changed. 'Agreement on Cooperation for Sustainable Development of Mekong Basin' signed by the four riparian countries along the lower Mekong River on April 5, 1995 provides a new opportunity for sustainable development of the Basin. According to preliminary analysis, if the multipurpose utilization of the water resources is the target for carrying out integrated planning and management, and the efforts are made 1) to focus on energy exploitation on the Lancang River Mainstream and the tributaries of the lower Mekong River; 2) to build gated weirs at Tonle Sam; 3) to construct spillways at the Mekong Delta; 4) to facilitate flood dykes in big cities and on both banks of the mainstream which are concentrated with population and farmland and liable to be flooded, and 5) to strengthen networks for forecasting hydrological and meteorological conditions, then all problems such as power demand, irrigation, flood, salt water intrusion as well as acid water erosion to soil could be solved without constructing large cascaded stations and dams on the lower Mekong Mainstream. This will not only avoid input of great number of fund, large scale resettlement and land inundation, but also prevent aquatic organisms living in Mekong River from being injured due to dam construction, and promote the sustainable development of the Basin. | He Daming Centre for Environmental Evolution and Sustainable Development, Yunnan Institute of Geography, Kunming, China 650223 Hsiang te Kung Memphis University, TN 38152, USA | 1997 | Journal of Geographical Sciences1997，7，4： | 3 |
| 11 | Systematic review:glucose control and cardiovascular disease in type 2 diabetes显示文摘 | Kelly TN Bazzano LA Fonseca VA | | Annals of Internal Medicine0，，： | 2 |
| 12 | Turn- specific and pigment dependent differences in the stria vascularis of normal and gentamicintreated albino and pigmented guinea pigs显示文摘 | Conlee JW Jensen RP Parks TN | 1991 | Hear Res1991，55，1： | 2 |
| 13 | Large deviation principle for diffusion processes under a sublinear expectation显示文摘We represent the exponential moment of the Brownian functionals under a nonlinear expectation according to the solution to a backward stochastic differential equation.As an application,we establish a large deviation principle of the Freidlin and Wentzell type under the corresponding nonlinear probability for diffusion processes with a small diffusion coefficient. | CHEN ZengJing 1,2 & XIONG Jie 3,4,1 School of Mathematics,Shandong University,Jinan 250100,China 2 Department of Financial Engineering,Ajou University,Suwon 443749,Korea 3 Department of Mathematics,University of Macao,PO Box 3001,Macao,China 4 Department of Mathematics,University of Tennessee,Knoxville,TN 37996-1300,USA | 2012 | Science China Mathematics2012，55，11： | 2 |
| 14 | Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction显示文摘 | Lin H Lin TN Cheung WM | 2002 | Circulation2002，105，16： | 2 |
| 15 | Lifetime cost of stroke in the United States显示文摘 | Taylor TN Davis PH Torner JC | 1996 | Stroke1996，27，： | 1 |
| 16 | Presence of fetal RNA in maternal plasma显示文摘 | Poon LL Leung TN Lau TK | 2000 | Clin Chem2000，46，11： | 1 |
| 17 | Pyrrolizidine alkaloids in human diet显示文摘 | Prakash AS Pereira TN Reilly PE | 1999 | Mutat Res1999，443，12： | 1 |
| 18 | Mechanisms involved in the down-regulation of TCR zeta chain in tumor versus peripheral blood of oral cancer patients显示文摘 | Kulkarni DP Wadia PP Pradhan TN | 2009 | Int J Cancer2009，124，7： | 1 |
| 19 | Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation显示文摘 | Tozawa Y Deutsch U | 1995 | Nature1995，376，6535： | 1 |
| 20 | The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance显示文摘 | Eagar TN Karandikar NJ Bluestone JA | 2002 | Eur JImmun2002，32，4： | 1 |
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