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| 1 | Multidisciplinary management of gastric and gastroesophageal cancers显示文摘Carcinomas of the stomach and gastroesophageal junction are among the fi ve top leading cancer types worldwide. In spite of radical surgical R0 resections being the basis of cure of gastric cancer,surgery alone provides long-term survival in only 30% of patients with advanced International Union Against Cancer (UICC) stages in Western countries because of the high risk of recurrence and metachronous metastases. However,recent large phase-Ⅲ Studies improved the diagnostic and therapeutic options in gastric cancers,indicating a more multidisciplinary management of the disease. Multimodal strategies combining dif-ferent neoadjuvant and/or adjuvant protocols have clearly improved the gastric cancer prognosis when combined with surgery with curative intention. In particular,the perioperative (neoadjuvant,adjuvant) chemotherapy is now a well-established new standard of care for advanced tumors. Adjuvant therapy alone should be carefully discussed after surgical resection,mainly in individual patients with large lymph node positive tumors when neoadjuvant therapy could not be done. The palliative treatment options have also been remarkably improved with new chemotherapeutic agents and will further be enhanced with targeted therapies such as different monoclonal antibodies. This article reviews the most relevant literature on the multidisciplinary management of gastric and gastro-esophageal cancer,and discusses future strategies toimprove locoregional failures. | Markus Moehler Orestis Lyros Ines Gockel Peter R Galle Hauke Lang | 2008 | World Journal of Gastroenterology2008，14，24： | 17 |
| 2 | Atypical anastomotic malignancies of small bowel after subtotal gastrectomy with BillorthⅡgastroenterostomy for peptic ulcer:Report of three cases and review of the literature显示文摘AIM To present patients who developed small-bowel malignancy at the level of the gastrointestinal anastomosis decades after a subtotal gastrectomy for ulcer,to review relevant literature,and to attempt to interpret the reasons those cancers developed to these postsurgical non-gastric sights.METHODS For the current retrospective study and review of literature,the surgical and histopathological records dated from January 1,1993 to December 31,2017 of our department were examined,searching for patients who have undergone surgical treatment of small-bowel malignancy to identify those who have undergone subtotal gastrectomy for benign peptic ulcer.A systematic literature search was also conducted using Pub Med,EMBASE,and Cochrane Library to identify similar cases.RESULTS We identified three patients who had developed smallintestine malignancy at the level of the gastrointestinal anastomosis decades after a subtotal gastrectomy with Billroth Ⅱ gastroenterostomy for benign peptic ulcertwo patients with adenocarcinoma originated in the Braun anastomosis and one patient with lymphoma of the efferent loop.All three patients were submitted to surgical resection of the tumor with Roux-en-Y reconstruction of the digestive tract.In the literature review,we only found one case of primary small-intestinal cancer that originated in the efferent loop after Billroth Ⅱ gastrectomy because of duodenal ulcer but none reporting Braun anastomosis adenocarcinoma following partial gastrectomy for benign disease.We also did not find any case of efferent loop lymphoma following gastrectomy.CONCLUSION Anastomotic gastric cancer following distal gastrectomy for peptic ulcer is a well-established clinical entity.However,malignancies of the afferent or efferent loop of the gastrointestinal anastomosis are extremely uncommon.The substantial diversion of the potent carcinogenic pancreaticobiliary secretions through the Braun anastomosis and the stomach hypochlorhydria,allowing the formation of carcinogenic factors from food,are the two most prominent pathogenetic mechanisms for those tumors. | Efstathios Kotidis Orestis Ioannidis Manousos George Pramateftakis Konstantinos Christou Ioannis Kanellos Konstantinos Tsalis | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 4 |
| 3 | Assessing the impact of the maritime silk road显示文摘The plans for the Maritime Silk Road affect the existing liner services.The purpose of this paper is to quantify using the terms of network theory the impact of these plans and to project the effects on the fleet,utilization,port throughput,and carbon footprint.The analysis is based on publicly available information and reasonable fleet deployment assumptions.It also considers current and alternative routing schedules from Shanghai to Europe.The impact of existing and expected emission control areas(ECAs)along the port chains is also considered. | Orestis Schinas Arnd Graf von Westarp | 2017 | Journal of Ocean Engineering and Science2017，2，3： | 3 |
| 4 | LINX^(■) reflux management system to bridge the “treatment gap” in gastroesophageal reflux disease: A systematic review of 35 studies显示文摘BACKGROUND Gastroesophageal reflux disease(GERD) occurs when the reflux of stomach contents causes troublesome symptoms and/or complications. When medical therapy is insufficient, surgical therapy is indicated and, until now, Laparoscopic fundoplication(LF) constitutes the gold-standard method. However, magnetic sphincter augmentation(MSA) using the LINX^® Reflux Management System has recently emerged and disputes the standard therapeutic approach.AIM To investigate the device’s safety and efficacy in resolving GERD symptoms.METHODS This is a systematic review conducted in accordance to the PRISMA guidelines.We searched MEDLINE, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL databases from inception until September 2019.RESULTS Overall, 35 studies with a total number of 2511 MSA patients were included and analyzed. Post-operative proton-pump inhibitor(PPI) cessation rates reached 100%, with less bloating symptoms and a better ability to belch or vomit in comparison to LF. Special patient groups(e.g., bariatric or large hiatal-hernias)had promising results too. The most common postoperative complication was dysphagia ranging between 6% and 83%. Dilation due to dysphagia occurred in 8% of patients with typical inclusion criteria. Esophageal erosion may occur in up to 0.03% of patients. Furthermore, a recent trial indicated MSA as an efficient alternative to double-dose PPIs in moderate-to-severe GERD.CONCLUSION The findings of our review suggest that MSA has the potential to bridge the treatment gap between maxed-out medical treatment and LF. However, further studies with longer follow-up are needed for a better elucidation of these results. | Dimitrios Schizas Aikaterini Mastoraki Eleni Papoutsi Vassilis G Giannakoulis Prodromos Kanavidis Diamantis Tsilimigras Dimitrios Ntourakis Orestis Lyros Theodore Liakakos Dimitrios Moris | 2020 | World Journal of Clinical Cases2020，8，2： | 3 |
| 5 | Midgut neuroendocrine tumor presenting with acute intestinal ischemia显示文摘Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors,commonly called carcinoids,account for about 2/3 of all neuroendocrine tumors,they are relatively rare. Small intestine neuroendocrine tumors originate from intestinal enterochromaffin cells and represent about 1/4 of small intestine neoplasms. They can be asymptomatic or cause nonspecific symptoms,which usually leads to a delayed diagnosis. Imaging modalities can aid diagnosis and surgery remains the mainstay of treatment. We present a case of a jejunal neuroendocrine tumor that caused nonspecific symptoms for about 1 year before manifesting with acute mesenteric ischemia. Abdominal X-rays revealed pneumatosis intestinalis and an abdominal ultrasound and computed tomography confirmed the diagnosis. The patient was submitted to segmental enterectomy. Histopathological study demonstrated a neuroendocrine tumor with perineural and arterial infiltration and lymph node metastasis. The postoperative course was uneventful and the patient denied any adjuvant treatment. | Ioannis Mantzoros Natalia Antigoni Savvala Orestis Ioannidis Styliani Parpoudi Lydia Loutzidou Despoina Kyriakidou Angeliki Cheva Vasileios Intzos Konstantinos Tsalis | 2017 | World Journal of Gastroenterology2017，23，45： | 2 |
| 6 | Structural and morphological characterization of synthetic chrysotile single crystals 显示文摘 | Falini G Oresti E | 2002 | Chemical Communications2002，，14： | 1 |
| 7 | Defense mechanisms in inflammatory bowel disease显示文摘 | Thomas N. Hyphantis John K. Triantafillidis Sofia Pappa Christos Mantas Anna Kaltsouda Peter Cherakakis Yannis Alamanos Orestis N. Manousos Venetsanos G. Mavreas | 2005 | Journal of Gastroenterology2005，，1： | 1 |
| 8 | Towards an integrative model of place identification: Dimensionality and predictors of intrapersonal-level place preferences显示文摘 | Orestis Droseltis Vivian L. Vignoles | 2009 | Journal of Environmental Psychology2009，，1： | 1 |
| 9 | Pradeep Bhandari Managing difficult polyps:techniques and pitfalls显示文摘 | Shareef Tholoor Orestis Tsagkournis Peter Basford | 2013 | Annals of Gastroenterology2013，26，： | 1 |
| 10 | Morphological and Chemical/Physical Characterization of Synthetic Chrysotile Nanotube 显示文摘 | Oresti E F Hochella M F | 2005 | Advanced Functional Materials2005，15，6： | 1 |
| 11 | Quality of Life in Glaucoma and Its Relationship with Visual Function显示文摘 | Patricia Nelson Peter Aspinall Orestis Papasouliotis Bruce Worton Colm O’Brien | 2003 | Journal of Glaucoma2003，，2： | 1 |
| 12 | WikiSensing:从大数据到数据产品显示文摘随着智慧城市应用及个人智能移动装置的普及,目前正处在一个传感数据爆炸的年代。虽然已存在一些传感数据存储和管理平台,但数据的真正价值并没有被充分挖掘。没有一个平台能在数据存储的基础上,将数据转化为可用的产品,这成为大数据和传感网络研究中的一个重要课题。探讨了设计此平台面临的主要问题和需求,并提出了解决方案——Wiki Sensing平台。在Wiki Sensing中,用弹性的传感数据存储、灵活的传感数据检索、方便的应用开发环境和有效的数据产品市场,来支持从传感大数据到数据产品的整个生命周期。系统可以让使用者融合不同来源的传感数据,整合多样的分析模型,快速建构出数据应用产品。此外,给出了Wiki Sensing的平台特性,并展示了其如何有效地发掘传感数据的价值。 | 吴超 李骏翔 Dilshan Silva David Birch Orestis Tsinalis 李漾 严舒琳 马娅婕 郭毅可 | 2015 | 计算机科学与探索2015，9，10： | 1 |
| 13 | Morphological and Chemical/Physical Characterization of Synthetic Chrysotile Nanotube显示文摘 | Oresti E F Hochella M F | 2005 | Advanced Functional Materials2005，15，6： | 1 |
| 14 | Nutrition Support in Acute Pancreatitis显示文摘 | Orestis Ioannidis Athina Lavrentieva Dimitrios Botsios | 2008 | Journal of the Pancreas2008，5，4： | 1 |
| 15 | Effects of albumin/glutaraldehyde glue on healing of colonic anastomosis in rats显示文摘AIM To evaluate the effect of local surgical adhesive glue(albumin/glutaraldehyde-Bioglue) on the healing of colonic anastomoses in rats.METHODS Forty Albino-Wistar male rats were randomly divided into two groups, with two subgroups of ten animals each. In the control group, an end-to-end colonic anastomosis was performed after segmental resection. In the Bioglue group, the anastomosis was protected with extraluminar application of adhesive glue containing albumin and glutaraldehyde. Half of the rats were sacrificed on the fourth and the rest on the eighth postoperative day. Anastomoses were resected and macroscopically examined. Bursting pressures were calculated and histological features were graded. Other parameters of healing, such as hydroxyproline and collagenase concentrations, were evaluated. The experimental data were summarized and computed from the results of a one-way ANOVA. Fisher's exact test was applied to compare percentages. RESULTS Bursting pressures, adhesion formation, inflammatory cell infiltration, and collagen deposition were significantly higher on the fourth postoperative day in the albumin/glutaraldehyde group than in the control group. Furthermore, albumin/glutaraldehyde significantly increased adhesion formation, inflammatory cell infiltration, neoangiogenesis, and collagen deposition on the eighth postoperative day. There was no difference in fibroblast activity or hydroxyproline and collagenase concentrations. CONCLUSION Albumin/glutaraldehyde, when applied on colonic anastomoses, promotes their healing in rats. Therefore, the application of protective local agents in colonic anastomoses leads to better outcomes. | Kalliopi Despoudi Ioannis Mantzoros Orestis Ioannidis Aggeliki Cheva Nikolaos Antoniou Dimitrios Konstantaras Savvas Symeonidis Manousos George Pramateftakis Efstathios Kotidis Stamatis Angelopoulos Konstantinos Tsalis | 2017 | World Journal of Gastroenterology2017，23，31： | 0 |
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