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| 1 | Consensus statement on the epidemiology,diagnosis,prevention,and management of cow's milk protein allergy in the Middle East:a modified Delphi-based study显示文摘Background This study aimed to develop an expert consensus regarding the epidemiology,diagnosis,and management of cow’s milk protein allergy(CMPA)in the Middle East.Methods A three-step modified Delphi method was utilized to develop the consensus.Fifteen specialized pediatricians participated in the development of this consensus.Each statement was considered a consensus if it achieved an agreement level of>80%.Results The experts agreed that the double-blind placebo-controlled oral challenge test(OCT)should be performed for 2-A weeks using an amino acid formula(AAF)in formula-fed infants or children with suspected CMPA.Formula-fed infants with confirmed CMPA should be offered a therapeutic formula.The panel stated that an extensively hydrolyzed formula(eHF)is indicated in the absence of red flag signs.At the same time,the AAF is offered for infants with red flag signs,such as severe anaphylactic reactions.The panel agreed that infants on an eHF with resolved symptoms within 2-4 weeks should continue the eHF with particular attention to the growth and nutritional status.On the other hand,an AAF should be considered for infants with persistent symptoms;the AAF should be continued if the symptoms resolve within 2-4 weeks,with particular attention to the growth and nutritional status.In cases with no symptomatic improvements after the introduction of an AAF.other measures should be followed.The panel developed a management algorithm,which achieved an agreement level of 90.9%.Conclusion This consensus document combined the best available evidence and clinical experience to optimize the management of CMPA in the Middle East. | Moustafa A.El-Hodhod Mortada H.F.El-Shabrawi Ahmed AIBadi Ahmed Hussein AM Almehaidib Basil Nasrallah Ebtsam Mohammed AIBassam Hala El Feghali Hasan M.Isa Khaled Al Saraf Maroun Sokhn Mehdi Adeli Najwa Mohammed Mousa Al-Sawi Pierre Hage Suleiman Al-Hammadi | 2021 | World Journal of Pediatrics2021，17，6： | 3 |
| 2 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 3 | Correlation between Fibroscan and laboratory tests in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis patients for assessing liver fibrosis显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD) is a spectrum of disease ranging from simple steatosis to non-alcoholic steatohepatitis(NASH), through to advanced fibrosis and cirrhosis. Many patients with NAFLD remain undiagnosed and recognizing those at risk is very crucial. Although liver biopsy is the gold standard method for diagnosing and staging NAFLD, non-invasive imaging and lab modalities are also very promising in diagnosing these diseases.AIM To explore some of these non-invasive modalities in this context and assess how they hold up in terms of making a diagnosis while avoiding an invasive procedure like a liver biopsy.METHODS This study was conducted on NAFLD/NASH patients(n = 73) who underwent Fibroscan examinations at Saint George Hospital University Medical Center over 17 mo in order to assess liver fibrosis. Obtained Fibroscan results were correlated to laboratory tests and calculated aspartate transaminase(AST)/alanine transaminase(ALT) ratio, AST platelet ratio index(APRI) score and Fibrosis-4 score.RESULTS A significant age difference was observed across fibrosis stages of investigated patients. The mean stiffness score was 9.48 ± 11.77 KPa. A significant negative correlation was observed between ALT, AST, Albumin, gamma-glutamyl transferase, cholesterol, LDL, HDL, triglycerides, and ALP when compared across fibrosis stages. On the other hand, a significant positive correlation was found between Bilirubin, PT INR, partial thromboplastin time, glucose, and Platelet count when compared across fibrosis stages, in addition to AST/ALT ratio, APRI, and Fib-4 scores.CONCLUSION This study showed that Ultrasound alone is not efficient in the assessment of advancement of liver disease. Furthermore, the high positive relation between AST/ALT ratio, APRI and Fib-4 scores with fibrosis stages in NAFLD patients suggests that they could be used clinically in combination with Fibroscan to predict significant fibrosis and cirrhosis and to avoid liver biopsy. | Layal Al Nanaf Mohammed Hussein Kamareddine Emilie Fayad Aniqa Hussain Said Farhat | 2022 | World Journal of Hepatology2022，14，4： | 1 |
| 4 | Video-assisted axillary surgery for cancer: non-randomized comparison with conventional techniques 显示文摘 | Hussein O EI-Nahhas W EI-Saed A el al | 2007 | Breast2007，16，5： | 1 |
| 5 | Patient and tumour biology predict survival beyond the M ilan criteria in liver transplantation for hepatocellular carcinoma显示文摘 | Andreas Andreou Safak Gül Andreas Pascher Wenzel Sch?ning Hussein Al‐Abadi Marcus Bahra Fritz Klein Timm Denecke Benjamin Strücker Gero Puhl Johann Pratschke Daniel Seehofer | 2015 | HPB2015，，2： | 1 |
| 6 | Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and threedimensional in vitro models显示文摘BACKGROUND Colorectal cancer(CRC) is the second leading cause of cancer-related mortality.Cancer stem cells(CSCs) in CRC, which are spared by many chemotherapeutics,have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone(DIQ) has shown promising effects on targeting colon cancer.However, there is limited research on the effects of DIQ on eradicating CSCs in CRC.AIM To investigate the anticancer potential of DIQ on colon CSCs in two-dimensional(2D) and three-dimensional(3D) models using colonospheres and patient-derived organoids.METHODS Various 2D methods have been used to assess the effect and the mechanism of DIQ on HCT116and HT29 cell lines including cell proliferation and viability assays, migration and invasion assays,immunofluorescence staining, and flow cytometry. The potency of DIQ was also assessed in 3D culture using the sphere formation assay and colon cancer patient-derived organoid model.RESULTS Our results showed that DIQ significantly inhibited cell proliferation, migration, and invasion in HCT116 and HT29 cell lines. DIQ treatment induced apoptosis along with an accumulation of HCT116 and HT29 cancer cells in the sub-G1 region and an increase in reactive oxygen species in both CRC cell lines. DIQ reduced sphere-forming and self-renewal ability of colon cancer HCT116and HT29 stem/progenitor cells at sub-toxic doses of 1 μmol/L. Mechanistically, DIQ targets CSCs by downregulating the main components of stem cell-related-catenin, AKT, and ERK oncogenic signaling pathways. Potently, DIQ displayed a highly significant decrease in both the count and the size of the organoids derived from colon cancer patients as compared to control and 5-fluorouracil conditions.CONCLUSION This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation. | Alissar Monzer Kevork Wakimian Farah Ballout Samar Al Bitar Amani Yehya Mariam Kanso Nour Saheb Ayman Tawil Samer Doughan Maher Hussein Deborah Mukherji Walid Faraj Hala Gali-Muhtasib Wassim Abou-Kheir | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
| 7 | Drug delivery system for an anticaneer agent, chlorogenate-Zn/A l-layered double hydroxide nanohybrid synthesised using direct co-precipitation and ion exchange methods显示文摘 | Farahnaz Barahuiea Mohd Zobir Hussein Palanisamy Arulselvanb el al | 2014 | Journal of Solid State Chemistry2014，217，： | 1 |
| 8 | Occurrence and predictors of futile recanalization following endovascular treatment among patients with acute ischemic stroke: a muhicenter study 显示文摘 | Hussein HM Georgiadis AL Vazquez G | 2010 | AJNR Am J Neuroradiol2010，31，3： | 1 |
| 9 | Serum IL-6 and IL-12 levels in breast cancer patients显示文摘 | Hussein MZ Al Fikky A Abdel Bar I et al | 2004 | Egypt J Immunol2004，11，2： | 1 |
| 10 | Leukemia cutis:case report and review of literature显示文摘 | Hussein MR Al bshabshe AA Dalati T | 2010 | Appl Immunohistochem Mol Morphol2010，18，2： | 1 |
| 11 | Chemical Composition of Portulaca Oleracea显示文摘 | Mohamed Al Hussein AS | 1994 | Plant Foods Hum Nutr1994，45，1： | 1 |
| 12 | Occurrence and predictors of futile recanalization following endovascular treatment among patients with acute ischemic stroke: amuhieenter study显示文摘 | Hussein HM Georgiadis AL Vazquez G | 2010 | Am J Neuroradiol2010，31，： | 1 |
| 13 | Occurrence and predictors of futile recanalization following endovaseular treatment among patients with acute ischemic stroke: a muhicenter study 显示文摘 | Hussein HM Georgiadis AL Vazquez G | 2010 | AJNR Am J Neuroradiol2010，31，： | 1 |
| 14 | Influence of aging parameters on the mechanical properties of 6063 aluminium alloy显示文摘 | SIDDIQUI RAFIQ A Abdullah Hussein A Al - Belushi Khamis R | 2000 | Journal of Materials Processing Technology2000，102，13： | 1 |
| 15 | Is continent cutaneous urinary diversion a suitable alternative to orthotopic bladder substitute and ileal conduit after cystectomy?显示文摘 | Al Hussein Al Awamlh B Wang LC Nguyen DP | 2014 | BJU Int2014，，： | 1 |
| 16 | Controlled-release approaches towards the chemotherapy of tuberculosis显示文摘 | SAIFULLAH B HUSSEIN MZ AL ALI SH | 2012 | Int J Nanomedicine2012，7，： | 1 |
| 17 | Serum IL-6 and IL-12 levels in breast cancer patients显示文摘 | Hussein M Z Al Fikky A Abdel Bar I etal | 2004 | Egypt J Immunol2004，11，2： | 1 |
| 18 | Role of combined L-arginine and prostaglandin E1 in renal ischemia-reperfusion injury显示文摘 | Mahmoud IM Hussein AA Sarhan ME et al | 2007 | Nephron Physiol2007，105，4： | 1 |
| 19 | The value of tomographic ventilation/perfusion scin-tigraphy (V/PSPECT) for follow-up and prediction of recurrence in pulmonary embolism 显示文摘 | Alaa AI Massimo MI Hussein AL | 2012 | Thromb Res2012，130，： | 1 |
| 20 | Coronary stent thrombosis in patients with chronic renal insufficiency显示文摘 | El-Menyar A Hussein H Al Suwaidi J | 2010 | Angiology2010，61，3： | 1 |
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