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| 1 | 5-羟色胺与结肠动力关系研究显示文摘5-羟色胺(5-HT)参与调节肠道多种功能。5-HT制剂广泛用于临床治疗结肠动力相关性疾病,但具体作用机制不甚清楚。本文围绕5-HT与结肠动力的关系进行综述。 | 俞媛洁 陈继红 罗和生 Jan D Huizinga | 2014 | 胃肠病学和肝病学杂志2014，23，1： | 8 |
| 2 | 胃结肠反射的研究概况显示文摘胃结肠反射是胃肠道生理现象之一,参与功能性胃肠疾病的发生和发展,具有潜在的临床价值。胃结肠反射的研究方法主要为肌电图和结肠测压法,可见餐后结肠尖峰突发波或结肠动力指数增加。近年应用测压法发现餐后结肠具有特定的运动模式,但胃结肠反射的表现方式和机制仍不清楚。本文就胃结肠反射的研究概况作一综述。 | 黄敏 陈继红 谭诗云 罗和生 Jan D HUIZINGA | 2016 | 胃肠病学2016，21，8： | 5 |
| 3 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 4 | Physi ology, injury, and recovery of interstitial cells of Cajal: basic and clinical science显示文摘 | HUIZINGA J D ZARATE N FARRUGIA G | 2009 | Gastroenterology2009，137，： | 1 |
| 5 | Genetic classification of petroleum systems显示文摘 | Demaison D Huizinga B J | 1991 | AAPG Bulletin1991，75，10： | 1 |
| 6 | W/KIT gene required for imerstitial-eells of cajal and for intestinal pacemaker activity显示文摘 | Huizinga J D Thuneberg L Kluppel M | 1995 | Nature1995，373，6512： | 1 |
| 7 | Interstitial Ceils of Cajal 显示文摘 | Al-Sajeel D Huizinga D | 2012 | Sultan Qaboos Univ Med J2012，12，： | 1 |
| 8 | W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity显示文摘 | HUIZINGA J D THUNEBERG L KLUPPEL M | 1995 | Nature1995，373，6512： | 1 |
| 9 | ERG K^+ currents regulate pacemaker activity in ICC显示文摘 | Zhu Y Golden C M Ye J Wang X Y Akbarali H I Huizinga J D | 2003 | Am J Physiol Gastrointest Liver Physiol2003，285，： | 1 |
| 10 | Rheumatoid arthritis 显示文摘 | Scott D L Wolfe F Huizinga T W | 2010 | Lancet2010，376，9746： | 1 |
| 11 | Muscarinic regulation of ether-a-go-go-related gene K+ currents in interstitial cells of Cajal显示文摘 | McKay C M Huizinga J D | 2006 | J Pharmacol Exp Ther2006，319，3： | 1 |
| 12 | Rheumatoid ar- thritis 显示文摘 | SCOOT D L WOLFE F HUIZINGA T W | 2010 | Lancet2010，376，9746： | 1 |
| 13 | About the presence of interstitial cells of Cajal outside the musculature of the gastrointestinal tract显示文摘 | Huizinga J D Faussone-Pellegrini M S | 2005 | J Cell Mol Med2005，9，2： | 1 |
| 14 | 17 (c-kit) and CD34 positive ICC and associated CD34 positive fibroblasts defines a subpopulation of chronic intestinal pseudo-obstruction 显示文摘 | Streutker J Huizinga D Campbell F | 2003 | Am Surg Pathol2003，27，2： | 1 |
| 15 | The joint–gut axis in inflammatory bowel diseases显示文摘 | Lianne K.P.M. Brakenhoff Désirée M. van der Heijde Daniel W. Hommes Tom W.J. Huizinga Herma H. Fidder | 2009 | Journal of Crohn’s and Colitis2009，，3： | 1 |
| 16 | Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors显示文摘 | Sircar K Hewlett B R Huizinga J D | 1999 | Am J Surg Pathol1999，23，4： | 1 |
| 17 | Interstitial cells of Cajal as targets for pharmacological intervention in gastrointestinal motor disorders显示文摘 | Huizinga J D Thuneberg L Vanderwinden J M | 1997 | Trends Pharmacol Sci1997，18，10： | 1 |
| 18 | Structural characterization of interstitial cells of Cajal in myenteric plexusand muscle layers of canine colon显示文摘 | BEREZIN I HUIZINGA J D DANIEL E E | 1990 | Can J Physiol Pharmaeol1990，68，： | 1 |
| 19 | Interstitial Cells of Cajal as Precursors of Gastrointestinal Stromal Tumours显示文摘 | Sircar K Hewiett B R Huizinga J D | 1999 | Am J Surg Pathol1999，23，4： | 1 |
| 20 | Interstitial cells of caj-al as precu-rsors of gastrointestinal stromal tumors显示文摘 | Sircar K Hewlett B R Huizinga J D | 1999 | Am J Surg Pathol1999，23，4： | 1 |
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