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| 1 | Photocatalytic degradation of Rhodamine B under visible light with Nd-doped titanium dioxide films显示文摘Microporous titanium dioxide films were prepared by the sol-gel methods on glass substrates, using tetrabutyl titanate as source material. In order to absorb the visible light and increase the photocatalytic activities, different concentrations of neodymium ions (Nd/Ti molar ratio was 0.5%, 0.7%, 0.9%, and 1.1% respectively) were added into the sol. X-ray diffraction (XRD), X-ray photoelectron spectros-copy (XPS), and atom force microscopy (AFM) were applied to characterize the modified films. A kind of typical textile industry pollutant (Rhodamine B) was used to evaluate the photocatalytic activities of the films under visible light. The results showed that the activities of the films were improved by doping Nd ions into the sol. | WU Xiaohong SU Peibo LIU Huiling QI Lili | 2009 | Journal of Rare Earths2009，27，5： | 6 |
| 2 | Flexible organic thin-film transistors based on poly(3-hexylthiophene) films for nitrogen dioxide detection显示文摘Flexible nitrogen dioxide(NO_2) gas sensors based on organic thin-film transistors(OTFTs) were developed in this work, in which conductive indium tin oxide(ITO) coated polyethylene naphthalene-2,6-dicarboxylate(PEN) was designed for the flexible substrates, and poly methyl methacrylate(PMMA) and poly(3-hexylthiophene)(P3HT) was spin-coated as the gate dielectric layer and spray-deposited as the active layer, respectively. The effects of PMMA concentrations and P3HT solution volume on performances of flexible OTFTs were systematically investigated. The results showed that the optimized flexible OTFT exhibited high field-effect mobility(9.51×10^(–3) cm^2/(V s) at a gate bias of –50 V) and excellent response characteristics,including high sensitivity(up to 0.169 ppm^(–1)), good repeatability and selectivity. The flexibility of the developed OTFT sensor was also investigated, and the results showed that the electrical and gas-sensing properties were affected by the bending cycles,thus further work should be done for improving the flexibility of the sensor. This work provides an effective approach in developing high performance flexible OTFT NO_2 gas sensor. | YANG Jing XIE GuangZhong SU YuanJie ZHANG QiuPing DU HongFei TAI HuiLing DU XiaoSong JIANG YaDong | 2018 | Science China(Technological Sciences)2018，61，11： | 3 |
| 3 | Designing heterostructured FeP–CoP for oxygen evolution reaction:Interface engineering to enhance electrocatalytic performance显示文摘It is significant to develop highly efficient electrocatalysts for energy conversion systems.Interface engineering is one of the most feasible approaches to effectively enhance the electrocatalytic activity.Herein,the density functional theory(DFT)calculations predict that the potential barriers of Fe sites at the interface of FeP–CoP heterostructures are lower than that of Fe sites in FeP nanoparticles(NPs),Co sites in CoP NPs,or Co sites in heterostructures.Motivated by the DFT calculation results,FeP–CoP heterostructures have been designed and synthesized by a metal–organic frameworks(MOFs)confined-phosphorization method.The FeP–CoP exhibits the lowest overpotential of 230 mV at the current density of 10 mA·cm^(−2)for oxygen evolution reaction(OER),compared with FeP(470 mV)and CoP(340 mV),which outperforms most of transition metal-based catalysts.The Tafel analysis of FeP–CoP heterostructures shows an improved reaction kinetic pathway with the smallest slope of 90.3 mV·dec^(−1),as compared to the Tafel slopes of FeP NPs(137 mV·dec^(−1))and CoP NPs(114 mV·dec^(−1)).And the FeP–CoP shows extraordinary long-term stability over 24 h.The excellent activity and long-term stability of FeP–CoP derive from the synergistic effect between FeP and CoP. | Shuang Hou Ansai Zhang Qi Zhou Yingjie Wen Sixie Zhang Linfeng Su Xinjie Huang Tian Wang Kun Rui Cheng Wang Huiling Liu Zhiyi Lu Peilei He | 2023 | Nano Research2023，16，5： | 2 |
| 4 | CD133 + /CD44 + /Oct4 + /Nestin + stem-like cells isolated from Panc-1 cell line may contribute to multi-resistance and metastasis of pancreatic cancer显示文摘 | Dongqing Wang Haitao Zhu Ying Zhu Yanfang Liu Huiling Shen Ruigen Yin Zhijian Zhang Zhaoliang Su | 2012 | Acta Histochemica2012，，： | 1 |
| 5 | Adsorption behaviors of gas molecules on the surface of ZnO nanocrystals under UV irradiation显示文摘A UV-activated room temperature chemiresistive gas sensor based on ZnO nanocrystals film was fabricated. Its gas sensing properties under various conditions were also investigated in detail. The results shed new insight into the adsorption behaviors of gas molecules on the surface of ZnO nanocrystals under UV irradiation. The chemisorbed oxygen species(O^-2(ads)(hv)) induced by UV light govern the adsorption and desorption ways of other gas molecules on the surface of ZnO nanocrystals, which is dependent on the electron affinity of gas molecules. Gas molecules with higher electron affinity than oxygen molecules can be adsorbed on the surface by the competitive adsorption way, extracting electrons from the surface. Gas molecules with lower electron affinity than oxygen molecules are attracted by the adsorbed O^-2(ads)(hv)layer, releasing electrons to the surface. These processes can influence the gas sensing properties of the sensor. Our findings will pave the way for the fundamental understanding and design of UV-activated gas sensor in the future. | ZHANG QiuPing XIE GuangZhong DU HongFei YANG Jing SU YuanJie TAI HuiLing XU Ming ZHAO Kang | 2019 | Science China(Technological Sciences)2019，62，12： | 1 |
| 6 | Recombinant protein production in the filamentous fungus Trichoderma显示文摘Trichoderma is an ascomycete fungal genus widely distributed in the soils.Several species were selected,engineered and utilized for protein production for decades.The high extracellular secretion capability and eukaryotic post-translational modification machinery make Trichoderma spp.particularly interesting hosts.In this review,we summarized the recombinant proteins produced in Trichoderma since 2014,concerning their origins,hosts,promoters,terminators,signal peptides,yields and commonly used media.Meanwhile,strategies and merging trends in protein production and strain engineering are classified and summarized regarding codon optimization,promoter utilization,transcription factor regulation,post-translational modification and proteolytic degradation inhibition.With state-of-art biotechnologies and more available expression platforms,Trichoderma spp.could be more successful hosts to produce recombinant proteins as desired,i.e.better enzyme formula for efficient cellulose degradation or functional protein with high purity and yield. | Huiling Wei Mengyue Wu Aili Fan Haijia Su | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 1 |
| 7 | Th17 cell expansion in gastric cancer may contribute to cancer development and metastasis显示文摘 | Zhaoliang Su Yingkun Sun Haitao Zhu Yueqin Liu Xin Lin Huiling Shen Jianguo Chen Wenlin Xu Huaxi Xu | 2014 | Immunologic Research2014，，1： | 1 |
| 8 | Co-occurrence of genes for antibiotic resistance and arsenic biotransformation in paddy soils显示文摘Paddy soils are potential hotspots of combined contamination with arsenic(As) and antibiotics, which may induce co-selection of antibiotic resistance genes(ARGs) and As biotransformation genes (ABGs), resulting in dissemination of antimicrobial resistance and modification in As biogeochemical cycling. So far, little information is available for these coselection processes and specific patterns between ABGs and ARGs in paddy soils. Here, the16S rRNA amplicon sequencing and high-throughput quantitative PCR and network analysis were employed to investigate the dynamic response of ABGs and ARGs to As stress and manure application. The results showed that As stress increased the abundance of ARGs and mobile genetic elements (MGEs), resulting in dissemination risk of antimicrobial resistance. Manure amendment increased the abundance of ABGs, enhanced As mobilization and methylation in paddy soil, posing risk to food safety. The frequency of the co-occurrence between ABGs and ARGs, the host bacteria carrying both ARGs and ABGs were increased by As or manure treatment, and remarkably boosted in soils amended with both As and manure. Multidrug resistance genes were found to have the preference to be co-selected with ABGs, which was one of the dominant co-occurring ARGs in all treatments, and manure amendment increased the frequency of Macrolide-Lincosamide-Streptogramin B resistance(MLSB) to co-occur with ABGs. Bacillus and Clostridium of Firmicutes are the dominant host bacteria carrying both ABGs and ARGs in paddy soils. This study would extend our understanding on the co-selection between genes for antibiotics and metals, also unveil the hidden environmental effects of combined pollution. | Huiling Cui Dong Zhu Longjun Ding YifeiWang Jianqiang Su Guilan Duan Yongguan Zhu | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
| 9 | Research progress of the role of HGF/c-Met in the proliferation, invasion, angiogenesis and metastasis of cancer显示文摘The HGF/c-Met pathway plays an important role in the proliferation, invasion, angiogenesis, and metastasis of tumors. With the successful development of small molecule c-Met kinase inhibitors, this signal pathway has become the focus of oncology research. In this review, we discuss the basic mechanism, targeted therapy, and early results of clinical trials of the HGF/c-Met pathway. | Honghui Su Hongjun Fan Huiling Su | 2015 | Oncology and Translational Medicine2015，1，4： | 1 |
| 10 | Recent advances in solar-driven CO_(2) reduction over g-C_(3)N_(4)-based photocatalysts显示文摘The persistent increase of CO_(2) levels in the atmosphere,already exceeding 400 ppm,urges the exploration of CO_(2) emission reduction and recycling technologies.Ideally,photocatalytic conversion of CO_(2) into valuable hydrocarbons realizes solar-to-chemical energy conversion,which is a desirable“kill two birds with one stone”strategy;namely,CO_(2) photoreduction can simultaneously tackle energy shortage and keep global carbon balance.Graphitic carbon nitride(g-C_(3)N_(4))working on CO_(2) reduction reaction deserves a highlight not only for the metal-free feature that endows it with low cost,tunable electronic structure,and easy fabrication properties but also because of its strong reduction ability.The present review concisely summarizes the latest advances of g-C_(3)N_(4)-based photocatalysts toward CO_(2) reduction.It starts with the discussion of thermodynamics and dynamics aspects of the CO_(2) reduction process.Then the modification strategies to promote g-C_(3)N_(4)-based photocatalysts in CO_(2) photoreduction have been discussed in detail,including surface functionalization,molecule structure engineering,crystallization,morphology engineering,loading cocatalyst,and constructing heterojunction.Meanwhile,the intrinsic factors affecting CO_(2) reduction activity and selectivity are analyzed and summarized.In the end,the challenges and prospects for the future development of highly g-C_(3)N_(4)-based photocatalysts in CO_(2) reduction are also presented. | Quanlong Xu Zhihua Xia Jingmei Zhang Zhiyi Wei Qin Guo Huile Jin Hua Tang Shouzhu Li Xuecong Pan Zhi Su Shun Wang | 2023 | Carbon Energy2023，5，2： | 1 |
| 11 | shRNA-mediated knockdown of Bmi-1 inhibit lung adenocarcinoma cell migration and metastasis显示文摘 | Xiuxiang Meng Yifang Wang Xiangyu Zheng Chunqing Liu Benli Su Huiling Nie Baoxia Zhao Xinyu Zhao Hong Yang | 2012 | Lung Cancer2012，，： | 1 |
| 12 | MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN显示文摘 | Changju Qu Zhihui Liang JiaLing Huang Ruiying Zhao Chunhui Su Sumei Wang Xudan Wang Rong Zhang Mong-Hong Lee Huiling Yang | 2012 | Cell Cycle2012，，4： | 1 |
| 13 | Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice显示文摘Cancer and impaired tissue wound healing with ageing are closely related to the quality of life of the elderly population.Given the increased incidence of cancer and the population ageing trend globally,it is very important to explore how ageing impairs tissue wound healing and spontaneous cancer.In a murine model of DSS-induced acute colitis and AOM/DSS-induced colitis-associated cancer(CAC),we found ageing significantly decreases intestinal wound healing and simultaneous CAC initiation,although ageing does not affect the incidence of AOM-induced,sporadic non-inflammatory CRC.Mechanistically,reduced fibroblasts were observed in the colitis microenvironment of ageing mice.Through conditional lineage tracing,an important source of fibroblasts potentially derived from intestinal smooth muscle cells(ISMCs)was identified orchestrating intestinal wound healing and CAC initiation in young mice.However,the number of transformed fibroblasts from ISMCs significantly decreased in ageing mice,accompanied by decreased intestinal wound healing and decreased CAC initiation.ISMCs-fibroblasts transformation in young mice and reduction of this transformation in ageing mice were also confirmed by ex-vivo intestinal muscular layer culture experiments.We further found that activation of YAP/TAZ in ISMCs is required for the transformation of ISMCs into fibroblasts.Meanwhile,the reduction of YAP/TAZ activation in ISMCs during intestinal wound healing was observed in ageing mice.Conditional knockdown of YAP/TAZ in ISMCs of young mice results in reduced fibroblasts in the colitis microenvironment,decreased intestinal wound healing and decreased CAC initiation,similar to the phenotype of ageing mice.In addition,the data from intestine samples derived from inflammatory bowel disease(IBD)patients show that activation of YAP/TAZ also occurs in ISMCs from these patients.Collectively,our work reveals an important role of the ageing stromal microenvironment in intestinal wound healing and CAC initiation.Furthermore,our work also identified a potential source of fibroblasts involved in colitis and CAC. | Yi Liu Yanhong Ji Ruiyi Jiang Chao Fang Gang Shi Lin Cheng Yinan Zuo Yixin Ye Xiaolan Su Junshu Li Huiling Wang Yuan Wang Yi Lin Lei Dai Shuang Zhang Hongxin Deng | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 14 | Microglial Depletion does not Afect the Laterality of Mechanical Allodynia in Mice显示文摘Mechanical allodynia(MA),including punctate and dynamic forms,is a common and debilitating symptom suffered by millions of chronic pain patients.Some peripheral injuries result in the development of bilateral MA,while most injuries usually led to unilateral MA.To date,the control of such laterality remains poorly understood.Here,to study the role of microglia in the control of MA laterality,we used genetic strategies to deplete microglia and tested both dynamic and punctate forms of MA in mice.Surprisingly,the depletion of central microglia did not prevent the induction of bilateral dynamic and punctate MA.Moreover,in dorsal root ganglion-dorsal root-sagittal spinal cord slice preparations we recorded the low-threshold Aβ-fiber stimulation-evoked inputs and outputs of superficial dorsal horn neurons.Consistent with behavioral results,microglial depletion did not prevent the opening of bilateral gates for Aβpathways in the superficial dorsal horn.This study challenges the role of microglia in the control of MA laterality in mice.Future studies are needed to further understand whether the role of microglia in the control of MA laterality is etiology-or species-specific. | Quan Ma Dongmei Su Jiantao Huo Guangjuan Yin Dong Dong Kaifang Duan Hong Cheng Huiling Xu Jiao Ma Dong Liu Bin Mou Jiyun Peng Longzhen Cheng | 2023 | Neuroscience Bulletin2023，39，8： | 0 |
| 15 | Correction:Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice显示文摘The original version of this article unfortunately contained one error.The authors found that in the middle panel of Fig.2A,the example traces recorded from a contralateral dorsal horn neuron of the capsaicin-treated mouse were wrong,and the corrected Fig.2 was as follows. | Quan Ma Dongmei Su Jiantao Huo Guangjuan Yin Dong Dong Kaifang Duan Hong Cheng Huiling Xu Jiao Ma Dong Liu Bin Mou Jiyun Peng Longzhen Cheng | 2023 | Neuroscience Bulletin2023，39，11： | 0 |
| 16 | GF方案与TP方案一线治疗晚期非小细胞肺癌的临床对照研究(英文)显示文摘Objective: The aim of the study was to evaluate the efficacies of initial gemcitabine plus cisplatin (GP) and paclitaxel plus cisplatin (TP) 1st-line chemotherapies for advanced non-small cell lung cancer (NSCLC) and observe their side effects. Methods: Eighty-one cases were randomly divided into two groups: GP group and TP group. In GP group, administered gemcitabine (GEM) 1000 mg/m2 on days 1 and 8; i.v. cisplatin (DDP) 30 mg/m2 from days 2 to 4 on a 28-day cycle. In TP group, administered paclitaxel (PTX) 175 mg/m2 on day 1, i.v. DDP 30 mg/m2 from days 2 to 4 on a 28-day cycle. Results: GP group had an overall response rate (ORR; CR+PR) of 45.0% (18/40). TP had an overall response rate of 43.2% (16/37). Short-term ORR had no significant difference between two groups (χ2 = 0.527, P = 0.957). GP had median survival time of 11 months and 37.7% of one-year survival rate, while TP showed 11 months of median survival time and 31.7% of one-year survival rate. Survival had no significant difference between two groups (χ2 = 0.140, P = 0.708). However, main side effects varied. Thrombocytopenia of GP group was significantly more than that of TP group, while peripheral neuritis, nausea/vomiting and myalgia of TP group were significantly more than those of GP group. Conclusion: Both GP and TP regimens had no significant difference in short-term treatment effect and survival rate for initial treatment of advanced NSCLC. However, side effects related to GP regimen treatment were slighter. Therefore, it was considered as the preferred initial first-line treatment for NSCLC. | Kun Chen Qiang Lin Chunlin Chang Yannan Zhao Yue'e Liu Na Wang Huiling Su Yuehua Huang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，11： | 0 |
| 17 | Redundant Data Detection and Deletion to Meet Privacy Protection Requirements in Blockchain-Based Edge Computing Environment显示文摘With the rapid development of information technology,IoT devices play a huge role in physiological health data detection.The exponential growth of medical data requires us to reasonably allocate storage space for cloud servers and edge nodes.The storage capacity of edge nodes close to users is limited.We should store hotspot data in edge nodes as much as possible,so as to ensure response timeliness and access hit rate;However,the current scheme cannot guarantee that every sub-message in a complete data stored by the edge node meets the requirements of hot data;How to complete the detection and deletion of redundant data in edge nodes under the premise of protecting user privacy and data dynamic integrity has become a challenging problem.Our paper proposes a redundant data detection method that meets the privacy protection requirements.By scanning the cipher text,it is determined whether each sub-message of the data in the edge node meets the requirements of the hot data.It has the same effect as zero-knowledge proof,and it will not reveal the privacy of users.In addition,for redundant sub-data that does not meet the requirements of hot data,our paper proposes a redundant data deletion scheme that meets the dynamic integrity of the data.We use Content Extraction Signature(CES)to generate the remaining hot data signature after the redundant data is deleted.The feasibility of the scheme is proved through safety analysis and efficiency analysis. | Zhang Lejun Peng Minghui Su Shen Wang Weizheng Jin Zilong Su Yansen Chen Huiling Guo Ran Sergey Gataullin | 2024 | China Communications2024，21，3： | 0 |
| 18 | Neuroprotective effects of low-concentration alpha-tocopherol Confocal laser microscopy observations显示文摘BACKGROUND:Alpha-tocopherol(α-tocopherol) can effectively relieve neuronal damage induced by oxygen-centered free radicals.However,the effective dose remains controversial. OBJECTIVE:To evaluate the protective effects of low-concentrationα-tocopherol on neuronal membranes. DESIGN,TIME AND SETTING:Contrast observation and in vitro study,performed at Laboratory of Neurosurgery,Tianjin Huanhu Hospital between April and September 2006. MATERIALS:Fetal cortical neurons were derived from two 14-day pregnant SD rats,andα-tocopherol was provided by Sigma,USA. METHODS:The neurons were randomly assigned to six groups:(1) normal:neurons were cultured under normal conditions;(2) oxidative damage:oxidative free radicals was damaged using the Fenton reaction;(3)α-tocopherol:neurons were cultured in different concentrations ofα-tocopherol 10,20,40,and 80 mg/L for 2 hours,respectively. MAIN OUTCOME MEASURES:Neuronal membrane damage was observed using a confocal laser microscope,and malonaldehyde production was detected using the thiobarbituric acid method. RESULTS:At normal,biological concentrations(10 mg/L),α-tocopherol induced no change in the damaged neurons(P>0.05).However,at a concentration of 80 mg/L,the number of damaged neurons was significantly reduced,compared with the damage group(P<0.05). Malonaldehyde levels following 80 mg/Lα-tocopherol treatment were less than the oxygen free radical damage group(P<0.05),but greater than the control group(P<0.01). CONCLUSION:A concentration of 80 mg/Lα-tocopherol can effectively protect the neuronal Gel membrane from oxidative damage. | Weilun Liang Huiling Huang Qiaoli Wu Chen Wang Wenzhi Zhang Xin Su Dashi Zhi | 2009 | Neural Regeneration Research2009，4，2： | 0 |
| 19 | Structure engineering of PtCu_(3)/C catalyst from disordered to ordered intermetallic compound with heat-treatment for the methanol electrooxidation reaction显示文摘Platinum based alloys are hereinto the mostly used methanol oxidation catalysts.However,there are limited ways to improve the methanol oxidation reaction(MOR)performance of catalysts in terms of both activity and stability.Herein we developed a simple heat-treatment method to synthesize PtCu_(3)/C intermetallic compound catalyst with lattice compression.The as-prepared PtCu_(3)/C-1000 exhibited high specific activity of 3.23 mA·cm^(-1) and mass activity of 1,200 mA·mgPt^(-1),which is much higher than the PtCu_(3)/C-untreated and commercial Pt/C catalysts,respectively.The XAS and DFT results shows the high activity of the catalyst towards MOR comes from the tightening of the Pt-M bond,which leads to the decrease of Fermi energy level and the make it difficulty in adsorbing carbon intermediates,thus releasing more active sites to promote the improvement of MOR performance.Moreover,the PtCu_(3)/C-1000 shows better stability which is due to the surface-rich Pt prevents Cu from dissolution. | Zihao Xing Jun Li Shun Wang Chenliang Su Huile Jin | 2022 | Nano Research2022，15，5： | 0 |
| 20 | Insight into the effect of gel drying temperature on the structure and desulfurization performance of ZnO/SiO_(2)adsorbents显示文摘A series of ZnO/SiO_(2) adsorbents were prepared by a sol-gel method using tetraethyl orthosilicate,ethylene glycol(EG)and nitrates as precursors.The effect of gel drying temperature on the structure and desulfurization performance of the adsorbents were investigated in detail.It is found that the low drying temperature led to a weak interaction among EG,Si AOH/H_(2)O and the nitrates in the gel system,which caused the oxidation of EG by NO3-and formed zinc glyoxylate complex during the gel calcination process,whereas this oxidation process also occurred at a high drying temperature during the gel drying process.The formed zinc glyoxylate complex promoted the generation of monodentate carbonate on the surface of Zn O,which resulted in the inferior desulfurization performance of adsorbents despite they have smaller Zn O nanoparticles.The gel dried at 120°C formed the hydrogen bonds between EG and Si AOH/H_(2)O and a strong interaction between zinc oxo-clusters and NO3-was also found in the gel system,which avoided the oxidation of EG by NO3-during the preparation process and the Zn O nanoparticles with sizes of 6 nm were formed by a combustion method.The adsorbent affords a highest sulfur capacity of 104.9 mg·g^(-1) in this case.In addition,the gel drying temperature has a significant influence on the textural properties of the adsorbents except their surface area. | Chao Yang Zhelin Su Yeshuang Wang Huiling Fan Meisheng Liang Zhaohui Chen | 2023 | Chinese Journal of Chemical Engineering2023，56，4： | 0 |
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